PLZF play as an indirect facilitator of thymic retention for the innate-like T-cells to aquire innate-like functions. [PDF]
Cell Death Dis, 2018 Cao X +13 more
europepmc +4 more sources
Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions
Viruses, 2022 Bats are reservoirs of a large number of viruses of global public health significance, including the ancestral virus for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the causative agent of coronavirus disease 2019 (COVID-19). Although
Wan Rong Sia +6 more
doaj +1 more source
Innate‐like
Immunology, 2018 SummaryNew data in the worlds of both innate‐like CD8+ T‐cells and natural killer (NK) cells have, in parallel, clarified some of the phenotypes of these cells and also their associated functions. While these cells are typically viewed entirely separately, the emerging innate functions of T‐cells and, similarly, the adaptive functions of NK cells ...
Ayako Kurioka +2 more
openaire +2 more sources
RELA tunes innate-like interferon I/III responses in human T cells
Journal of Experimental Medicine, 2023 In innate immune cells, intracellular sensors such as cGAS-STING stimulate type I/III interferon (IFN) expression, which promotes antiviral defense and immune activation. However, how IFN-I/III expression is controlled in adaptive cells is poorly understood.
Jeremiah, Nadia +7 more
openaire +2 more sources
Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses [PDF]
, 2014 Background: Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface. Methods: We measured MAIT cell frequencies and antibody
Aktar, Amena +13 more
core +8 more sources
Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]
, 2008 Alum is used as a vaccine adjuvant and induces T<sub>h</sub>2 responses and T<sub>h</sub>2-driven antibody isotype production against co-injected antigens.
A. S. McKee +45 more
core +1 more source
Close encounters of lymphoid cells and bacteria
Frontiers in Immunology, 2016 During infections, the first reaction of the host against microbial pathogens is carried out by innate immune cells, which recognize conserved structures on pathogens, called pathogen-associated molecular patterns (PAMPs).
Aranzazu Cruz-Adalia, Esteban Veiga
doaj +1 more source
MAVS expressed by hematopoietic cells is critical for control of West Nile virus infection and pathogenesis [PDF]
, 2016 West Nile virus (WNV) is the most important cause of epidemic encephalitis in North America. Innate immune responses, which are critical for control of WNV infection, are initiated by signaling through pathogen recognition receptors, RIG-I and MDA5, and ...
Diamond, Michael S +5 more
core +2 more sources
Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis
eLife, 2020 Sepsis is a systemic inflammatory response to infection and a leading cause of death. Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in mucosal tissues that recognize bacterial ligands.
Shubhanshi Trivedi +12 more
doaj +1 more source
Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages
Frontiers in Immunology, 2018 Lymphocytes are an integral component of the immune system. Classically, all lymphocytes were thought to perpetually recirculate between secondary lymphoid organs and only traffic to non-lymphoid tissues upon activation. In recent years, a diverse family
Chun Chou, Ming O. Li
doaj +1 more source