Results 41 to 50 of about 502,944 (241)

CD8+ T-cell immunity orchestrated by iNKT cells

Frontiers in Immunology, 2023
CD8+ T cells belonging to the adaptive immune system play key roles in defending against viral infections and cancers. The current CD8+ T cell-based immunotherapy has emerged as a superior therapeutic avenue for the eradication of tumor cells and long ...
Yingyu Qin, Xueyang Bao, Mingzhu Zheng
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Convergence of the innate and adaptive immunity during human aging

Frontiers in Immunology, 2016
Aging is associated with profound changes in the human immune system, a phenomenon referred to as immunosenescence. This complex immune remodeling affects the adaptive immune system and the CD8+ T cell compartment in particular, leading to the ...
Branca Isabel Pereira, Arne A Akbar
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Regulation and function of innate-like T cells

, 2021
KLRB1, encoding for CD161, is one of the most favourable prognostic pan-cancer genes. It is expressed by NK- and T-cell subsets, particularly by innate-like T cells such as MAIT and γδT cells. CD161-expressing T-cell subsets share a transcriptional and functional phenotype, including the ability to be activated by cytokines in a T-cell receptor ...
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Distinct activation thresholds of human conventional and innate-like memory T cells [PDF]

JCI Insight, 2016
Conventional memory CD8 + T cells and mucosal-associated invariant T cells (MAIT cells) are found in blood, liver, and mucosal tissues and have similar effector potential following activation, specifically expression of IFN-γ and granzyme B.
Chloe K. Slichter, Andrew McDavid, Hannah W. Miller, Greg Finak, Brenda J. Seymour, John P. McNevin, Gabriela Diaz, Julie L. Czartoski, M. Juliana McElrath, Raphael Gottardo, Martin Prlic   +10 more
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IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection. [PDF]

PLoS Pathogens, 2015
Memory-like CD8+ T cells expressing eomesodermin are a subset of innate T cells initially identified in a number of genetically modified mice, and also exist in wild mice and human.
Ara Lee, Seung Pyo Park, Chan Hee Park, Byung Hyun Kang, Seong Hoe Park, Sang-Jun Ha, Kyeong Cheon Jung   +6 more
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Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells [PDF]

The Journal of Immunology, 2016
Abstract Although Notch signaling plays important roles in lineage commitment and differentiation of multiple cell types including conventional T cells, nothing is currently known concerning Notch function in innate-like T cells. We have found that the homeostasis of several well-characterized populations of innate-like T cells including
Chennupati, Vijaykumar, Koch, Ute, Coutaz, Manuel, Scarpellino, Leonardo, Tacchini-Cottier, Fabienne, Luther, Sanjiv A., Radtke, Freddy, Zehn, Dietmar, Macdonald, H. Robson   +8 more
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Early interferon-γ production in human lymphocyte subsets in response to nontyphoidal Salmonella demonstrates inherent capacity in innate cells.

PLoS ONE, 2010
BackgroundNontyphoidal Salmonellae frequently cause life-threatening bacteremia in sub-Saharan Africa. Young children and HIV-infected adults are particularly susceptible.
Tonney S Nyirenda, Anna E Seeley, Wilson L Mandala, Mark T Drayson, Calman A MacLennan   +4 more
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Dichotomous Regulation of Acquired Immunity by Innate Lymphoid Cells

Cells, 2020
The concept of innate lymphoid cells (ILCs) includes both conventional natural killer (NK) cells and helper ILCs, which resemble CD8+ killer T cells and CD4+ helper T cells in acquired immunity, respectively. Conventional NK cells are migratory cytotoxic
Takashi Ebihara
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Innate-like T cells in liver disease

Trends in Immunology
Mammalian innate-like T cells (ILTCs), including mucosal-associated invariant T (MAIT), natural killer T (NKT), and γδ T cells, are abundant tissue-resident lymphocytes that have recently emerged as orchestrators of hepatic inflammation, tissue repair, and immune homeostasis.
Albert Ying-Po Yang, Kilian Wistuba-Hamprecht, Tim F. Greten, Benjamin Ruf   +3 more
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BCL11B depletion induces the development of highly cytotoxic innate T cells out of IL-15 stimulated peripheral blood αβ CD8+ T cells

OncoImmunology, 2022
BCL11B, an essential transcription factor for thymopoiesis, regulates also vital processes in post-thymic lymphocytes. Increased expression of BCL11B was recently correlated with the maturation of NK cells, whereas reduced BCL11B levels were observed in ...
Hannes Forkel, Piotr Grabarczyk, Maren Depke, Sascha Troschke-Meurer, Stefan Simm, Elke Hammer, Stephan Michalik, Christian Hentschker, Björn Corleis, Lucie Loyal, Maxi Zumpe, Nikolai Siebert, Anca Dorhoi, Andreas Thiel, Holger Lode, Uwe Völker, Christian A. Schmidt   +16 more
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