Distal Lck Promoter–Driven Cre Shows Cell Type–Specific Function in Innate-like T Cells
ImmunoHorizons, 2021 Innate-like T cells, including invariant NKT cells, mucosal-associated invariant T (MAIT) cells, and γ δ T (γδT) cells, are groups of unconventional T lymphocytes. They play important roles in the immune system.
M. G. Figueroa +3 more
semanticscholar +1 more source
Tissue-resident lymphocytes: sentinel of the transformed tissue
Journal for ImmunoTherapy of Cancer, 2017 Tumor cells can be detected and cleared by lymphocytes in a process termed cancer immunosurveillance. However, the contributing cell types had not been fully characterized.
Saïda Dadi, Ming O. Li
doaj +1 more source
Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance
Cells, 2020 Butyrophilin and butyrophilin-like proteins select γδ T cells and direct the migration of γδ T cell subsets to distinct anatomical sites. γδ T cells expressing Vδ2 paired with Vγ9 (Vγ9Vδ2 T cells) are the
Oliver Nussbaumer, Martin Thurnher
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Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]
, 2008 Alum is used as a vaccine adjuvant and induces T<sub>h</sub>2 responses and T<sub>h</sub>2-driven antibody isotype production against co-injected antigens.
White, Janice +11 more
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Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation. [PDF]
PLoS ONE, 2014 Interleukin (IL)-4 is a cytokine classically associated with CD4(+) T helper type 2 differentiation, but has been recently shown to also be required for the development of CD8(+) innate-like lymphocytes.
Shannon A Carty +2 more
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Innate immunity and early liver inflammation
Frontiers in Immunology, 2023 The innate system constitutes a first-line defence mechanism against pathogens. 80% of the blood supply entering the human liver arrives from the splanchnic circulation through the portal vein, so it is constantly exposed to immunologically active ...
Jordi Yang Zhou, Jordi Yang Zhou
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Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions
Viruses, 2022 Bats are reservoirs of a large number of viruses of global public health significance, including the ancestral virus for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the causative agent of coronavirus disease 2019 (COVID-19). Although
Wan Rong Sia +6 more
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Innate immune activation in experimental autoimmune myocarditis [PDF]
, 2007 Dilated cardiomyopathy (DCM) is a leading cause of heart failure and frequently results from postinfectious autoimmunity. Its pathophysiology is modeled by experimental autoimmune myocarditis (EAM), a CD4+ T-cell mediated murine model of ...
Marty, René Roger
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Close encounters of lymphoid cells and bacteria
Frontiers in Immunology, 2016 During infections, the first reaction of the host against microbial pathogens is carried out by innate immune cells, which recognize conserved structures on pathogens, called pathogen-associated molecular patterns (PAMPs).
Aranzazu Cruz-Adalia, Esteban Veiga
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Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis
eLife, 2020 Sepsis is a systemic inflammatory response to infection and a leading cause of death. Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in mucosal tissues that recognize bacterial ligands.
Shubhanshi Trivedi +12 more
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