Results 61 to 70 of about 738,827 (285)

Plasmacytoid Dendritic Cells Contribute to the Protective Immunity Induced by Intranasal Treatment with Fc-fused Interleukin-7 against Lethal Influenza Virus Infection [PDF]

, 2019
Developing a novel vaccine that can be applied against multiple strains of influenza virus is of utmost importance to human health. Previously, we demonstrated that the intranasal introduction of Fc-fused IL-7 (IL-7-mFc), a long-acting cytokine fusion ...
Choi Dong-Hoon, Choi Young Woo, Kang Moon Cheol, Lee Seung-Woo, Park Han Wook, Park Yunji, Sung Young Chul   +6 more
core   +1 more source

Lineage Differentiation Program of Invariant Natural Killer T Cells [PDF]

, 2017
Invariant natural killer T (iNKT) cells are innate T cells restricted by CD1d molecules. They are positively selected in the thymic cortex and migrate to the medullary area, in which they differentiate into 3 different lineages.
Dong-il Kwon, You Jeong Lee
core   +1 more source

Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells [PDF]

The Journal of Immunology, 2016
Abstract Although Notch signaling plays important roles in lineage commitment and differentiation of multiple cell types including conventional T cells, nothing is currently known concerning Notch function in innate-like T cells. We have found that the homeostasis of several well-characterized populations of innate-like T cells including
Vijaykumar Chennupati, Ute Koch, Manuel Coutaz, Leonardo Scarpellino, Fabienne Tacchini-Cottier, Sanjiv A Luther, Freddy Radtke, Dietmar Zehn, H Robson MacDonald   +8 more
openaire   +2 more sources

Early interferon-γ production in human lymphocyte subsets in response to nontyphoidal Salmonella demonstrates inherent capacity in innate cells.

PLoS ONE, 2010
BackgroundNontyphoidal Salmonellae frequently cause life-threatening bacteremia in sub-Saharan Africa. Young children and HIV-infected adults are particularly susceptible.
Tonney S Nyirenda, Anna E Seeley, Wilson L Mandala, Mark T Drayson, Calman A MacLennan   +4 more
doaj   +1 more source

Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-like Mechanism [PDF]

Cell Reports, 2019
Chronic exposure to tumor-associated antigens inactivates cognate T cells, restricting the repertoire of tumor-specific effector T cells. This problem was studied here by transferring TCR transgenic CD4 T cells into recipient mice that constitutively express a cognate self-antigen linked to MHC II on CD11c-bearing cells.
Crystal Morales Del Valle, Joseph R. Maxwell, Maria M. Xu, Antoine Menoret, Payal Mittal, Naomi Tsurutani, Adam J. Adler, Anthony T. Vella   +7 more
openaire   +3 more sources

Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer. [PDF]

, 2019
Human (gamma delta) γδ T cells are unconventional innate-like lymphocytes displaying a broad array of anti-tumor activities with promising perspectives in cancer immunotherapy.
Bruni E, Cazzetta V, Cimino M, Dieli F, Donadon M, Leonardi G, Mavilio D., Mikulak J, Spata G, Torzilli G   +9 more
core   +1 more source

Distinct activation thresholds of human conventional and innate-like memory T cells [PDF]

JCI Insight, 2016
Conventional memory CD8+ T cells and mucosal-associated invariant T cells (MAIT cells) are found in blood, liver, and mucosal tissues and have similar effector potential following activation, specifically expression of IFN-γ and granzyme B. To better understand each subset's unique contributions to immunity and pathology, we interrogated inflammation ...
Chloe K, Slichter, Andrew, McDavid, Hannah W, Miller, Greg, Finak, Brenda J, Seymour, John P, McNevin, Gabriela, Diaz, Julie L, Czartoski, M Juliana, McElrath, Raphael, Gottardo, Martin, Prlic   +10 more
openaire   +2 more sources

Cellular networks controlling Th2 polarization in allergy and immunity [PDF]

, 2012
In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of ...
Kool, Mirjam, Hammad, Hamida, Lambrecht, Bart   +2 more
core   +1 more source

BCL11B depletion induces the development of highly cytotoxic innate T cells out of IL-15 stimulated peripheral blood αβ CD8+ T cells

OncoImmunology, 2022
BCL11B, an essential transcription factor for thymopoiesis, regulates also vital processes in post-thymic lymphocytes. Increased expression of BCL11B was recently correlated with the maturation of NK cells, whereas reduced BCL11B levels were observed in ...
Hannes Forkel, Piotr Grabarczyk, Maren Depke, Sascha Troschke-Meurer, Stefan Simm, Elke Hammer, Stephan Michalik, Christian Hentschker, Björn Corleis, Lucie Loyal, Maxi Zumpe, Nikolai Siebert, Anca Dorhoi, Andreas Thiel, Holger Lode, Uwe Völker, Christian A. Schmidt   +16 more
doaj   +1 more source

Innate-like T cells in liver disease

Trends in Immunology
Mammalian innate-like T cells (ILTCs), including mucosal-associated invariant T (MAIT), natural killer T (NKT), and γδ T cells, are abundant tissue-resident lymphocytes that have recently emerged as orchestrators of hepatic inflammation, tissue repair, and immune homeostasis.
Albert Ying-Po Yang, Kilian Wistuba-Hamprecht, Tim F. Greten, Benjamin Ruf   +3 more
openaire   +3 more sources