Results 51 to 60 of about 738,827 (285)

CD8+ T-cell immunity orchestrated by iNKT cells

Frontiers in Immunology, 2023
CD8+ T cells belonging to the adaptive immune system play key roles in defending against viral infections and cancers. The current CD8+ T cell-based immunotherapy has emerged as a superior therapeutic avenue for the eradication of tumor cells and long ...
Yingyu Qin, Xueyang Bao, Mingzhu Zheng
doaj   +1 more source

Ly49E Expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases [PDF]

, 2014
The Ly49E NK receptor is a unique inhibitory receptor, presenting with a high degree of conservation among mouse strains and expression on both NK cells and intraepithelial-localised T cells.
Devisscher, Lindsey, Filtjens, Jessica, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Taghon, Tom, Taveirne, Sylvie, Van Acker, Aline, Van Ammel, Els, Van Welden, Sophie, Vandekerckhove, Bart, Vanhees, Mandy   +11 more
core   +5 more sources

Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation [PDF]

, 2015
Group 3 ILCs (ILC3s) are innate sources of IL-22 and IL-17 and include lymphoid tissue-inducer (LTi)-like and NKp46(+) subsets. Both depend on RORγt and aryl hydrocarbon receptor, but NKp46(+)ILC3s also require Notch and T-bet for their development and ...
Artis, Basu, Becher, Buonocore, Cella, Christina Song, Constantinides, Daley, Diefenbach, Duarte, Dudakov, Eberl, Eberl, Eken, Ghoreschi, Griseri, Guo, Hepworth, Hepworth, Jacob S. Lee, Kamada, Kamanaka, Kiss, Klose, Klose, Kruglov, Lee, Longman, Magri, Marco Colonna, Marina Cella, Martin, Matthias Mack, Michelle L. Robinette, Mortha, Muñoz, Narni-Mancinelli, Ouyang, Pickard, Qiu, Qiu, Rankin, Rankin, Reynders, Robinette, Rodney D. Newberry, Rogers, Rutz, Satoh-Takayama, Satpathy, Sciumé, Seo, Shi, Sonnenberg, Sonnenberg, Srinivas, Susan Gilfillan, Sutton, Thaddeus S. Stappenbeck, Tumanov, Uhlig, Vonarbourg, Walisser, Wang, Zheng, Zigmond   +65 more
core   +2 more sources

Unraveling the phenotypic states of human innate-like T cells: Comparative insights with conventional T cells and mouse models. [PDF]

Cell Rep
The "innate-like" T cell compartment, known as Tinn, represents a diverse group of T cells that straddle the boundary between innate and adaptive immunity. We explore the transcriptional landscape of Tinn compared to conventional T cells (Tconv) in the human thymus and blood using single-cell RNA sequencing (scRNA-seq) and flow cytometry.
Loh L, Carcy S, Krovi HS, Domenico J, Spengler A, Lin Y, Torres J, Prabakar RK, Palmer W, Norman PJ, Stone M, Brunetti T, Meyer HV, Gapin L.   +13 more
europepmc   +4 more sources

TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica. [PDF]

, 2013
Our gastrointestinal tract is a portal of entry for a number of bacteria and viruses. Thus, this tissue must develop ways to induce antigen-specific T cell and antibody responses quickly.
DePaolo, R William, Kamdar, K, Karpus, WJ, Khakpour, S, Sugiura, Y, Young, G   +5 more
core   +1 more source

Convergence of the innate and adaptive immunity during human aging

Frontiers in Immunology, 2016
Aging is associated with profound changes in the human immune system, a phenomenon referred to as immunosenescence. This complex immune remodeling affects the adaptive immune system and the CD8+ T cell compartment in particular, leading to the ...
Branca Isabel Pereira, Arne A Akbar
doaj   +1 more source

IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection. [PDF]

PLoS Pathogens, 2015
Memory-like CD8+ T cells expressing eomesodermin are a subset of innate T cells initially identified in a number of genetically modified mice, and also exist in wild mice and human.
Ara Lee, Seung Pyo Park, Chan Hee Park, Byung Hyun Kang, Seong Hoe Park, Sang-Jun Ha, Kyeong Cheon Jung   +6 more
doaj   +1 more source

Evolutionary Underpinnings of Innate-Like T Cell Interactions with Cancer

Immunological Investigations, 2019
Cancers impose a significant health and economic burden. By harnessing the immune system, current immunotherapies have revolutionized the treatment against human cancers and potentially offer a long-term cure. Among others, innate-like T (iT) cells, including natural killer T cells, are promising candidates for immunotherapies.
Maureen, Banach, Jacques, Robert
openaire   +3 more sources

Identification of a porcine liver eomes-high-T-bet-low NK cell subset that resembles human liver resident NK cells [PDF]

, 2019
Natural killer (NK) cells are cells of the innate immunity and play an important role in the defense against viral infections and cancer, but also contribute to shaping adaptive immune responses. Long-lived tissue-resident NK cells have been described in
De Pelsmaeker, Steffi, Denaeghel, Sofie, Favoreel, Herman, Hermans, Leen   +3 more
core   +2 more sources

MAITs and their mates: “Innate-like” behaviors in conventional and unconventional T cells

Clinical and Experimental Immunology, 2023
Summary Most CD4 and CD8 T cells are restricted by conventional major histocompatibility complex (MHC) molecules and mount TCR-dependent adaptive immune responses. In contrast, MAIT, iNKT, and certain γδ TCR bearing cells are characterized by their abilities to recognize antigens presented by unconventional antigen-presenting molecules ...
Hackstein, C-P, Klenerman, P
openaire   +2 more sources