Results 71 to 80 of about 297,440 (273)

Innate-like Gene Expression of Lung-resident Memory CD8+ T-cells During Experimental Human Influenza: A Clinical Study.

American Journal of Respiratory and Critical Care Medicine, 2021
RATIONALE Suboptimal vaccine immunogenicity and antigenic mismatch, compounded by poor uptake, means that influenza remains a major global disease. T-cells recognising peptides derived from conserved viral proteins could enhance vaccine-induced cross ...
S. Paterson, Satwik Kar, S. Ung, Zoe Gardener, Emma Bergstrom, S. Ascough, Mohini Kalyan, J. Żyła, J. Maertzdorf, H. Mollenkopf, J. Weiner, A. Jóźwik, Hannah Jarvis, Akhilesh Jha, B. Nicholson, T. Veldman, C. Woods, P. Mallia, O. Kon, S. Kaufmann, P. Openshaw, C. Chiu   +21 more
semanticscholar   +1 more source

Expression of genes related to anti-inflammatory pathways are modified among farmers' children [PDF]

, 2014
The hygiene hypothesis states that children exposed to higher loads of microbes such as farmers' children suffer less from allergies later in life. Several immunological mechanisms underpinning the hygiene hypothesis have been proposed such as a shift in
Loeliger, Susanne, Roduit, Caroline; https://orcid.org/, van Hage, Marianne, Göran Pershagen, Sennhauser, Felix, Lauener, Roger P., Remo Frei, Marianne van Hage (91132), IRAS RATIA2, Felix Sennhauser, Susanne Loeliger (254440), von Mutius, Erika, Erika von Mutius (105805), Caroline Roduit (254441), Gert Doekes (397763), as part of the Parsifal study team,, Christian Bieli (531936), Waser, Marco, Cezmi A Akdis, Christian Bieli, Mutius, Erika von, Annika Scheynius, Roduit, Caroline, Riedler, Josef, Göran Pershagen (147977), LS IRAS EEPI GRA (Gezh.risico-analyse), Braun-Fahrländer, Charlotte, Remo Frei (254425), Roger P. Lauener (254451), Caroline Roduit, Akdis, Cezmi A, Risk Assessment of Toxic and Immunomodulatory Agents, Lauener, Roger P, Cezmi A. Akdis (187641), Akdis, Cezmi A., Marco Waser, Pershagen, Göran, Erika von Mutius, Doekes, Gert, Gert Doekes, Felix Sennhauser (531938), Josef Riedler, Susanne Loeliger, Charlotte Braun-Fahrländer, Hage, Marianne van, Frei, Remo, Scheynius, Annika, as part of the PARSIFAL study team, Roger P Lauener, Annika Scheynius (31954), Josef Riedler (194501), Charlotte Braun-Fahrländer (18248), Bieli, Christian, Marianne van Hage, Marco Waser (531937)   +54 more
core   +1 more source

Gut Inflammation in Axial Spondyloarthritis Patients is Characterized by a Marked Type 17 Skewed Mucosal Innate‐like T Cell Signature

Arthritis & Rheumatology, 2023
Patients with spondyloarthritis (SpA) often present with microscopic signs of gut inflammation, a risk factor for progressive disease. We investigated whether mucosal innate‐like T cells are involved in dysregulated interleukin‐23 (IL‐23)/IL‐17 responses
C. Mortier, K. Quintelier, A. de Craemer, T. Renson, L. Deroo, E. Dumas, E. Verheugen, J. Coudenys, T. Decruy, Z. Lukasik, S. van Gassen, Y. Saeys, A. Hoorens, T. Lobatón, F. E. Van den Bosch, T. van de Wiele, K. Venken, D. Elewaut   +17 more
semanticscholar   +1 more source

Innate immunity in tuberculosis: myths and truth.

, 2008
Tuberculosis is the most important bacterial infection world wide. The causative agent, Mycobacterium tuberculosis survives and proliferates within macrophages.
Korbel, Daniel S, Bianca E. Schneider, Ulrich E. Schaible, Schaible, Ulrich E, Daniel S. Korbel, Schneider, Bianca E   +5 more
core   +1 more source

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells [PDF]

, 2007
Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ T cells. However, very little is known about the impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between peptide–major
Feeney, M, Allgaier, Rachel, Marcus Altfeld, Feeney, Margaret, Williams, KL, Sivamurthy, R, Pereyra, F, Allgaier, R, Rohini Sivamurthy, Stanley K. Mui, Rosenberg, Eric S, Allen, Todd M, Altfeld, M, Eric S. Rosenberg, Pereyra, Florencia, Rachel Allgaier, Trocha, Alicja, Todd M. Allen, Moza, Beenu, Allen, TM, Eric J. Sundberg, Mui, SK, Bruce D. Walker, Sundberg, EJ, Katie L. Williams, Gandhi, RT, Yu, Xu G, Rachel Allen, Daniel G. Kavanagh, Beenu Moza, Sundberg, Eric J, Alicja Trocha, Gandhi, Rajesh T, Moza, B, Margaret Feeney, Xu G. Yu, Rosenberg, ES, Mui, Stanley K, Mathias Lichterfeld, Florencia Pereyra, Walker, BD, Rajesh T. Gandhi, Sivamurthy, Rohini, Kavanagh, DG, Trocha, A, Lichterfeld, Mathias, Allen, R, Lichterfeld, M, Williams, Katie L, Allen, Rachel, ToshiYuki Miura, Miura, ToshiYuki, Walker, Bruce D, Miura, T, Yu, XG, Kavanagh, Daniel G, Altfeld, Marcus   +56 more
core   +1 more source

Role of non-canonical T cells in homeostasis and pathology

Медицинская иммунология
In addition to the subsets of T lymphocytes and innate lymphocytes (innate lymphoid cells), the well-known players in adaptive immunity, there is an intermediate group of lymphocytes (innate-like cells) that already possess the T cell receptor, but with ...
A. P. Toptygina
doaj   +1 more source

Harnessing the Power of Mucosal-Associated Invariant T (MAIT) Cells in Cancer Cell Therapy

Biomedicines, 2022
Mucosal-associated invariant T (MAIT) cells, a burgeoning type of the innate-like T cells, play a crucial role in maintaining immune homeostasis, particularly in host defense.
Chie Sugimoto, Hiroyoshi Fujita, Hiroshi Wakao   +2 more
doaj   +1 more source

Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes

Nature Immunology
Upregulation of diverse self-antigens that constitute components of the inflammatory response overlaps spatially and temporally with the emergence of pathogen-derived foreign antigens.
Yuanyuan You, Josefine Dunst, Kewei Ye, P. A. Sandoz, Annika Reinhardt, I. Sandrock, N. R. Comet, R. Sarkar, Emily Yang, E. Duprez, Judith Agudo, Brian D. Brown, Paul J. Utz, W. Kastenmüller, Carmen Gerlach, I. Prinz, Björn Önfelt, Taras Kreslavsky   +17 more
semanticscholar   +1 more source

Altered Innate-like T Cell Development in Vα14-Jα18 TCRα Transgenic Mice [PDF]

ImmunoHorizons, 2020
Abstract CD1d-restricted invariant NKT (iNKT) cells are innate-like T cells that respond to glycolipids, a class of Ags that are invisible to conventional T cells. iNKT cells develop in the thymus where they receive strong “agonist” TCR signals.
Lau, Irene, de Amat Herbozo, Carolina, Kuypers, Meggie, Lin, Qiaochu, Paget, Christophe, Mallevaey, Thierry   +5 more
openaire   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source