Results 71 to 80 of about 738,827 (285)

Dichotomous Regulation of Acquired Immunity by Innate Lymphoid Cells

Cells, 2020
The concept of innate lymphoid cells (ILCs) includes both conventional natural killer (NK) cells and helper ILCs, which resemble CD8+ killer T cells and CD4+ helper T cells in acquired immunity, respectively. Conventional NK cells are migratory cytotoxic
Takashi Ebihara
doaj   +1 more source

Regulation and function of innate-like T cells

, 2022
KLRB1, encoding for CD161, is one of the most favourable prognostic pan-cancer genes. It is expressed by NK- and T-cell subsets, particularly by innate-like T cells such as MAIT and γδT cells. CD161-expressing T-cell subsets share a transcriptional and functional phenotype, including the ability to be activated by cytokines in a T-cell receptor ...
openaire   +2 more sources

Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection. [PDF]

, 2020
Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired ...
Ananworanich, Jintanat, Bolton, Diane L, Costanzo, Margaret C, Creegan, Matthew, Dias, Joana, Eller, Leigh Anne, Eller, Michael A, Kibuuka, Hannah, Kim, Dohoon, Kosgei, Josphat, Krebs, Shelly J, Lal, Kerri G, Leeansyah, Edwin, Maganga, Lucas, Michael, Nelson L, Nitayaphan, Sorachai, Paquin-Proulx, Dominic, Phuang-Ngern, Yuwadee, Robb, Merlin L, Sacdalan, Carlo, Sandberg, Johan K, Schuetz, Alexandra, Shacklett, Barbara L, Slike, Bonnie M   +23 more
core  

Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes [PDF]

, 2017
Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of pancreatic β-cells by the immune system that involves innate and adaptive immune cells.
Battaglia, Manuela, Beaudoin, Lucie, Beltrand, Jacques, Cagninacci, Lucie, Corbett, Alexandra, Da silva, Jennifer, Diedisheim, Marc, Kiaf, Badr, Lantz, Olivier, Lehuen, Agnès, McCluskey, James, Nel, Isabelle, Oshima, Masaya, Polak, Michel, Rossjohn, Jamie, Rouxel, Ophélie, Salou, Marion, Scharfmann, Raphael, Tard, Céline   +18 more
core   +4 more sources

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients [PDF]

, 2019
Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). ROR gamma t, the key Thelperl7 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including ...
Coudenys, Julie, Cypers, Heleen, Decruy, Tine, Elewaut, Dirk, Gyselbrecht, Lieve, Harcken, Christian, Hoyt, Kathleen, Hughes, Robert, Jacques, Peggy, Labadia, Mark E., Martens, Liesbet, Mortier, Céline, Nabozny, Gerald, Piette, Yves, Saeys, Yvan, Schryvers, Nadia, Smith, Dustin, Turner, Michael, Van Calenbergh, Serge, Van den Bosch, Filip, Van Gassen, Sofie, Varkas, Gaëlle, Venken, Koen, Verheugen, Eveline, Wahle, Joseph, Wang, Chao-Ting, Wayne, Anita L., Wittoek, Ruth   +27 more
core   +3 more sources

Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma? [PDF]

, 2016
Natural killer T (NKT) cells constitute a unique subset of innate-like T lymphocytes which differ from conventional T cells by recognizing lipid antigens presented by the non-polymorphic major histocompatibility complex (MHC) I-like molecule CD1d ...
Elewaut, Dirk, Favreau, Mérédis, Menu, Eline, Vanderkerken, Karin, Venken, Koen   +4 more
core   +2 more sources

Harnessing the Power of Mucosal-Associated Invariant T (MAIT) Cells in Cancer Cell Therapy

Biomedicines, 2022
Mucosal-associated invariant T (MAIT) cells, a burgeoning type of the innate-like T cells, play a crucial role in maintaining immune homeostasis, particularly in host defense.
Chie Sugimoto, Hiroyoshi Fujita, Hiroshi Wakao   +2 more
doaj   +1 more source

Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study [PDF]

, 2014
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of innate immune cells with a granulocyte-like or monocyte-like phenotype and a unique ability to suppress T-cell responses. MDSCs have been shown to accumulate in cancer
András Vida, Anjali Nair, Carla R Scanzello, Júlia Kurkó, Katalin Mikecz, Robert S Katz, Tibor T Glant, Zoltán Szekanecz   +7 more
core   +1 more source

Role of non-canonical T cells in homeostasis and pathology

Медицинская иммунология
In addition to the subsets of T lymphocytes and innate lymphocytes (innate lymphoid cells), the well-known players in adaptive immunity, there is an intermediate group of lymphocytes (innate-like cells) that already possess the T cell receptor, but with ...
A. P. Toptygina
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source