Results 31 to 40 of about 738,827 (285)

Allotransplantation Is Associated With Exacerbation of CD8 T-Cell Senescence: The Particular Place of the Innate CD8 T-Cell Component

Frontiers in Immunology, 2021
Immunosenescence is a physiological process that is associated with changes in the immune system, particularly among CD8 T-cells. Recent studies have hypothesized that senescent CD8 T-cells are produced with chronologic age by chronic stimulation ...
Lauren Daniel, Lauren Daniel, Marion Tassery, Clara Lateur, Antoine Thierry, Antoine Thierry, Antoine Thierry, André Herbelin, André Herbelin, Jean-Marc Gombert, Jean-Marc Gombert, Jean-Marc Gombert, Alice Barbarin, Alice Barbarin   +13 more
doaj   +1 more source

Innate-like recognition of microbes by invariant natural killer T cells [PDF]

Current Opinion in Immunology, 2009
Invariant natural killer T cells (iNKT cells) express a restricted T cell antigen receptor (TCR) repertoire and they respond rapidly to glycolipid antigens presented by CD1d. These glycolipid antigens have hexose sugars in alpha-linkage to two types of lipids that can bind to CD1d.
Mitchell, Kronenberg, Yuki, Kinjo
openaire   +2 more sources

A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties [PDF]

, 2017
The Ly49E receptor is preferentially expressed on murine innate-like lymphocytes, such as epidermal V gamma 3 T cells, intestinal intraepithelial CD8 alpha alpha(+) T lymphocytes, and CD49a(+) liver natural killer (NK) cells.
Biswas, Aindrila, Diefenbach, Andreas, Dunay, Ildiko Rita, Filtjens, Jessica, Gronke, Konrad, Kerre, Tessa, Leclercq, Georges, Martens, Liesbet, Matthys, Patrick, Plum, Jean, Saeys, Yvan, Taghon, Tom, Taveirne, Sylvie, Van Acker, Aline, Van Ammel, Els, Vandekerckhove, Bart   +15 more
core   +2 more sources

Innate lymphocytes: Role in alcohol-induced immune dysfunction

Frontiers in Immunology, 2022
Alcohol use is known to alter the function of both innate and adaptive immune cells, such as neutrophils, macrophages, B cells, and T cells. Immune dysfunction has been associated with alcohol-induced end-organ damage.
Karla Ruiz-Cortes, Daniel N. Villageliu, Derrick R. Samuelson   +2 more
doaj   +1 more source

Tissue-resident lymphocytes: sentinel of the transformed tissue

Journal for ImmunoTherapy of Cancer, 2017
Tumor cells can be detected and cleared by lymphocytes in a process termed cancer immunosurveillance. However, the contributing cell types had not been fully characterized.
Saïda Dadi, Ming O. Li
doaj   +1 more source

Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance

Cells, 2020
Butyrophilin and butyrophilin-like proteins select γδ T cells and direct the migration of γδ T cell subsets to distinct anatomical sites. γδ T cells expressing Vδ2 paired with Vγ9 (Vγ9Vδ2 T cells) are the
Oliver Nussbaumer, Martin Thurnher
doaj   +1 more source

Altered Innate-like T Cell Development in Vα14-Jα18 TCRα Transgenic Mice [PDF]

ImmunoHorizons, 2020
Abstract CD1d-restricted invariant NKT (iNKT) cells are innate-like T cells that respond to glycolipids, a class of Ags that are invisible to conventional T cells. iNKT cells develop in the thymus where they receive strong “agonist” TCR signals.
Lau, Irene, de Amat Herbozo, Carolina, Kuypers, Meggie, Lin, Qiaochu, Paget, Christophe, Mallevaey, Thierry   +5 more
openaire   +4 more sources

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis [PDF]

, 2017
Chronic lymphocytic leukemia (CLL) is characterized by the expansion of malignant CD5(+) B lymphocytes in blood, bone marrow and lymphoid organs. CD1d-restricted invariant Natural Killer T (iNKT) cells are innate-like T lymphocytes strongly implicated in
Azzimonti, Laura, Bellone, Matteo, Bertilaccio, Maria Teresa, Caligaris Cappio, Federico, Capri, Miriam, Casorati, Giulia, de Lalla, Claudia, Delfanti, Gloria, Dellabona, Paolo, DI NAPOLI, Arianna, Doglioni, Claudio, Franceschi, Claudio, Ghia, Paolo, Gorini, Francesca, Gulino, Alessandro, Ranghetti, Pamela, Scarfò, Lydia, Scielzo, Cristina   +17 more
core   +1 more source

Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation. [PDF]

PLoS ONE, 2014
Interleukin (IL)-4 is a cytokine classically associated with CD4(+) T helper type 2 differentiation, but has been recently shown to also be required for the development of CD8(+) innate-like lymphocytes.
Shannon A Carty, Gary A Koretzky, Martha S Jordan   +2 more
doaj   +1 more source

Innate immunity and early liver inflammation

Frontiers in Immunology, 2023
The innate system constitutes a first-line defence mechanism against pathogens. 80% of the blood supply entering the human liver arrives from the splanchnic circulation through the portal vein, so it is constantly exposed to immunologically active ...
Jordi Yang Zhou, Jordi Yang Zhou
doaj   +1 more source