Results 31 to 40 of about 297,440 (273)
Small Molecule Targeting Immune Cells: A Novel Approach for Cancer Treatment
Biomedicines, 2023 Conventional and cancer immunotherapies encompass diverse strategies to address various cancer types and stages. However, combining these approaches often encounters limitations such as non-specific targeting, resistance development, and high toxicity ...
Shilpi Singh +6 more
doaj +1 more source
Frontiers in Immunology, 2021 Expression of tissue-restricted antigens (TRAs) in thymic epithelial cells (TECs) ensures negative selection of highly self-reactive T cells to establish central tolerance.
Huishan Tao +8 more
doaj +1 more source
Tissue-resident and innate-like T cells in patients with advanced chronic liver disease
JHEP Reports, 2023 Summary Chronic liver disease results from the orchestrated interplay of components of innate and adaptive immunity in response to liver tissue damage.
O. Ibidapo-obe, T. Bruns
semanticscholar +1 more source
Nature Communications, 2021 Conventional T cells are selected by peptide-MHC expressed by cortical epithelial cells in the thymus, and not by cortical thymocytes themselves that do not express MHC I or MHC II.
H. Georgiev +4 more
semanticscholar +1 more source
Memory CD8 + T Cells: Innate-Like Sensors and Orchestrators of Protection [PDF]
Trends in Immunology, 2016 Recent findings have revealed roles for systemic and mucosa-resident memory CD8(+) T cells in the orchestration of innate immune responses critical to host defense upon microbial infection. Here we integrate these findings into the current understanding of the molecular and cellular signals controlling memory CD8(+) T cell reactivation and the ...
Grégoire, Lauvau +4 more
openaire +2 more sources
Scientific Reports, 2022 The frequency of CD4+CD8+ double-positive (DP) T cells is highly associated with a variety of diseases. Recently, we used high-throughput single-cell RNA sequencing to show that circulating DP T cells in cynomolgus monkeys comprise nine heterogeneous ...
Sung Min Choi +4 more
doaj +1 more source
Target tumor microenvironment by innate T cells
Frontiers in Immunology, 2022 The immunosuppressive tumor microenvironment (TME) remains one of the most prevailing barriers obstructing the implementation of effective immunotherapy against solid-state cancers.
Yan-Ruide Li +5 more
doaj +1 more source
Frontiers in Immunology, 2021 Immunosenescence is a physiological process that is associated with changes in the immune system, particularly among CD8 T-cells. Recent studies have hypothesized that senescent CD8 T-cells are produced with chronologic age by chronic stimulation ...
Lauren Daniel +13 more
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Innate-like recognition of microbes by invariant natural killer T cells [PDF]
Current Opinion in Immunology, 2009 Invariant natural killer T cells (iNKT cells) express a restricted T cell antigen receptor (TCR) repertoire and they respond rapidly to glycolipid antigens presented by CD1d. These glycolipid antigens have hexose sugars in alpha-linkage to two types of lipids that can bind to CD1d.
Mitchell, Kronenberg, Yuki, Kinjo
openaire +2 more sources
Innate lymphocytes: Role in alcohol-induced immune dysfunction
Frontiers in Immunology, 2022 Alcohol use is known to alter the function of both innate and adaptive immune cells, such as neutrophils, macrophages, B cells, and T cells. Immune dysfunction has been associated with alcohol-induced end-organ damage.
Karla Ruiz-Cortes +2 more
doaj +1 more source