Results 31 to 40 of about 502,944 (241)
The transcription factor BCL-6 controls early development of innate-like T cells. [PDF]
Nat Immunol, 2020 Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation. How this program is initiated is currently unclear.
Gioulbasani M +8 more
europepmc +4 more sources
Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation. [PDF]
PLoS ONE, 2014 Interleukin (IL)-4 is a cytokine classically associated with CD4(+) T helper type 2 differentiation, but has been recently shown to also be required for the development of CD8(+) innate-like lymphocytes.
Shannon A Carty +2 more
doaj +1 more source
Innate immunity and early liver inflammation
Frontiers in Immunology, 2023 The innate system constitutes a first-line defence mechanism against pathogens. 80% of the blood supply entering the human liver arrives from the splanchnic circulation through the portal vein, so it is constantly exposed to immunologically active ...
Jordi Yang Zhou, Jordi Yang Zhou
doaj +1 more source
Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions
Viruses, 2022 Bats are reservoirs of a large number of viruses of global public health significance, including the ancestral virus for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the causative agent of coronavirus disease 2019 (COVID-19). Although
Wan Rong Sia +6 more
doaj +1 more source
Close encounters of lymphoid cells and bacteria
Frontiers in Immunology, 2016 During infections, the first reaction of the host against microbial pathogens is carried out by innate immune cells, which recognize conserved structures on pathogens, called pathogen-associated molecular patterns (PAMPs).
Aranzazu Cruz-Adalia, Esteban Veiga
doaj +1 more source
Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis
eLife, 2020 Sepsis is a systemic inflammatory response to infection and a leading cause of death. Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in mucosal tissues that recognize bacterial ligands.
Shubhanshi Trivedi +12 more
doaj +1 more source
Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages
Frontiers in Immunology, 2018 Lymphocytes are an integral component of the immune system. Classically, all lymphocytes were thought to perpetually recirculate between secondary lymphoid organs and only traffic to non-lymphoid tissues upon activation. In recent years, a diverse family
Chun Chou, Ming O. Li
doaj +1 more source
Evolutionary Underpinnings of Innate-Like T Cell Interactions with Cancer
Immunological Investigations, 2019 Cancers impose a significant health and economic burden. By harnessing the immune system, current immunotherapies have revolutionized the treatment against human cancers and potentially offer a long-term cure. Among others, innate-like T (iT) cells, including natural killer T cells, are promising candidates for immunotherapies.
Maureen, Banach, Jacques, Robert
openaire +3 more sources
Innate‐like
Immunology, 2018 SummaryNew data in the worlds of both innate‐like CD8+ T‐cells and natural killer (NK) cells have, in parallel, clarified some of the phenotypes of these cells and also their associated functions. While these cells are typically viewed entirely separately, the emerging innate functions of T‐cells and, similarly, the adaptive functions of NK cells ...
Ayako Kurioka +2 more
openaire +2 more sources
Chronic Stress Physically Spares But Functionally Impairs Innate-Like Invariant T Cells [PDF]
SSRN Electronic Journal, 2020 The deleterious effects of psychological stress on mainstream T lymphocytes are well documented. However, how stress impacts innate-like T cells is unclear. We report that long-term stress surprisingly abrogates both T helper 1 (TH1)- and TH2-type responses orchestrated by invariant natural killer T (iNKT) cells.
Rudak, Patrick T. +12 more
openaire +4 more sources