Results 21 to 30 of about 297,440 (273)
Programme of Self-Reactive Innate-Like T Cell-Mediated Cancer Immunity
Nature, 2022 Cellular transformation induces phenotypically diverse populations of tumour-infiltrating T cells1–5, and immune checkpoint blockade therapies preferentially target T cells that recognize cancer cell neoantigens6,7.
Chun Chou +24 more
semanticscholar +3 more sources
The transcription factor BCL-6 controls early development of innate-like T cells [PDF]
Nature Immunology, 2020 Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation.
Marianthi Gioulbasani +8 more
semanticscholar +3 more sources
Sympathetic regulation of skin microbiota-induced innate-like T cells
The Journal of Immunology, 2023 Recent discoveries in microbiota-mediated neuroimmune crosstalk highlight how co-evolved systems collaboratively facilitate host fitness. However, in the skin – the largest and outermost protective barrier – little is known about the role of microbiota
I. Rao +6 more
semanticscholar +2 more sources
Interplay between innate-like T-cells and microRNAs in cancer immunity
Discover OncologyInnate-like T cells (ILTCs) have recently emerged as a new target of several cancer immunotherapies. Some unique features, such as rapid MHC-independent recognition of antigens, performing heterogeneous anti-tumor activities, and being less susceptible ...
Mohammad Javad Yousefi +7 more
doaj +3 more sources
Evolution of innate-like T cells and their selection by MHC class I-like molecules [PDF]
Immunogenetics, 2016 Until recently, major histocompatibility complex (MHC) class I-like-restricted innate-like αβT (iT) cells expressing an invariant or semi-invariant T cell receptor (TCR) repertoire were thought to be a recent evolutionary acquisition restricted to ...
Eva‐stina Edholm, M. Banach, J. Robert
semanticscholar +3 more sources
The Interplay Between Innate-Like B Cells and Other Cell Types in Autoimmunity
Frontiers in Immunology, 2018 Studies performed in animal models and in humans indicate that the innate arm of the immune system provides an essential role in the initial protection against potential insults and in maintaining tolerance to self-antigens.
Gregory J. Tsay +3 more
doaj +3 more sources
Distinct activation thresholds of human conventional and innate-like memory T cells [PDF]
JCI Insight, 2016 Conventional memory CD8+ T cells and mucosal-associated invariant T cells (MAIT cells) are found in blood, liver, and mucosal tissues and have similar effector potential following activation, specifically expression of IFN-γ and granzyme B.
Chloe K. Slichter +10 more
semanticscholar +3 more sources
Innate-like T cells in the immunopathogenesis of HIV-1 infection
, 2020 The immunodynamics of HIV infection have been studied for over three decades in the hopes of determining underlying mechanisms that contribute to the sustained immune dysfunction observed even in individuals on therapy.
Kerri Guth Lal (18662518)
core +2 more sources
The role of innate lymphocytes in regulating brain and cognitive function
Neurobiology of Disease, 2023 Mounting evidence indicates complex interaction between the immune system and the nervous system, challenging the traditional view about the immune privilege of the brain. Innate lymphoid cells (ILCs) and innate-like T cells are unique families of immune
Youwen Si +3 more
doaj +1 more source
Frontiers in Immunology, 2023 The large majority of lymphocytes belong to the adaptive immune system, which are made up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response.
Sebastian Joyce +3 more
doaj +1 more source