Results 21 to 30 of about 502,944 (241)

Normality sensing licenses local T cells for innate-like tissue surveillance [PDF]

Nature Immunology, 2022
Abstract The increasing implication of lymphocytes in general physiology and immune surveillance outside of infection poses the question of how their antigen receptors might be involved. Here, we show that macromolecular aggregates of intraepidermal γδ T cell antigen receptors (TCRs) in the mouse skin aligned with and depended on ...
Duncan R. McKenzie, Rosie Hart, Nourdine Bah, Dmitry S. Ushakov, Miguel Muñoz-Ruiz, Regina Feederle, Adrian C. Hayday   +6 more
openaire   +4 more sources

Unraveling the phenotypic states of human innate-like T cells: Comparative insights with conventional T cells and mouse models. [PDF]

Cell Rep
The "innate-like" T cell compartment, known as Tinn, represents a diverse group of T cells that straddle the boundary between innate and adaptive immunity. We explore the transcriptional landscape of Tinn compared to conventional T cells (Tconv) in the human thymus and blood using single-cell RNA sequencing (scRNA-seq) and flow cytometry.
Loh L, Carcy S, Krovi HS, Domenico J, Spengler A, Lin Y, Torres J, Prabakar RK, Palmer W, Norman PJ, Stone M, Brunetti T, Meyer HV, Gapin L.   +13 more
europepmc   +4 more sources

Memory CD8 + T Cells: Innate-Like Sensors and Orchestrators of Protection [PDF]

Trends in Immunology, 2016
Recent findings have revealed roles for systemic and mucosa-resident memory CD8(+) T cells in the orchestration of innate immune responses critical to host defense upon microbial infection. Here we integrate these findings into the current understanding of the molecular and cellular signals controlling memory CD8(+) T cell reactivation and the ...
Grégoire, Lauvau, Marie, Boutet, Tere M, Williams, Shu Shien, Chin, Laurent, Chorro   +4 more
openaire   +2 more sources

Heterogeneity of circulating CD4+CD8+ double-positive T cells characterized by scRNA-seq analysis and trajectory inference

Scientific Reports, 2022
The frequency of CD4+CD8+ double-positive (DP) T cells is highly associated with a variety of diseases. Recently, we used high-throughput single-cell RNA sequencing to show that circulating DP T cells in cynomolgus monkeys comprise nine heterogeneous ...
Sung Min Choi, Hi Jung Park, Eun A Choi, Kyeong Cheon Jung, Jae Il Lee   +4 more
doaj   +1 more source

Target tumor microenvironment by innate T cells

Frontiers in Immunology, 2022
The immunosuppressive tumor microenvironment (TME) remains one of the most prevailing barriers obstructing the implementation of effective immunotherapy against solid-state cancers.
Yan-Ruide Li, Matthew Wilson, Lili Yang, Lili Yang, Lili Yang, Lili Yang   +5 more
doaj   +1 more source

Innate-like recognition of microbes by invariant natural killer T cells [PDF]

Current Opinion in Immunology, 2009
Invariant natural killer T cells (iNKT cells) express a restricted T cell antigen receptor (TCR) repertoire and they respond rapidly to glycolipid antigens presented by CD1d. These glycolipid antigens have hexose sugars in alpha-linkage to two types of lipids that can bind to CD1d.
Mitchell, Kronenberg, Yuki, Kinjo
openaire   +2 more sources

Allotransplantation Is Associated With Exacerbation of CD8 T-Cell Senescence: The Particular Place of the Innate CD8 T-Cell Component

Frontiers in Immunology, 2021
Immunosenescence is a physiological process that is associated with changes in the immune system, particularly among CD8 T-cells. Recent studies have hypothesized that senescent CD8 T-cells are produced with chronologic age by chronic stimulation ...
Lauren Daniel, Lauren Daniel, Marion Tassery, Clara Lateur, Antoine Thierry, Antoine Thierry, Antoine Thierry, André Herbelin, André Herbelin, Jean-Marc Gombert, Jean-Marc Gombert, Jean-Marc Gombert, Alice Barbarin, Alice Barbarin   +13 more
doaj   +1 more source

Innate lymphocytes: Role in alcohol-induced immune dysfunction

Frontiers in Immunology, 2022
Alcohol use is known to alter the function of both innate and adaptive immune cells, such as neutrophils, macrophages, B cells, and T cells. Immune dysfunction has been associated with alcohol-induced end-organ damage.
Karla Ruiz-Cortes, Daniel N. Villageliu, Derrick R. Samuelson   +2 more
doaj   +1 more source

Tissue-resident lymphocytes: sentinel of the transformed tissue

Journal for ImmunoTherapy of Cancer, 2017
Tumor cells can be detected and cleared by lymphocytes in a process termed cancer immunosurveillance. However, the contributing cell types had not been fully characterized.
Saïda Dadi, Ming O. Li
doaj   +1 more source

Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance

Cells, 2020
Butyrophilin and butyrophilin-like proteins select γδ T cells and direct the migration of γδ T cell subsets to distinct anatomical sites. γδ T cells expressing Vδ2 paired with Vγ9 (Vγ9Vδ2 T cells) are the
Oliver Nussbaumer, Martin Thurnher
doaj   +1 more source