Results 21 to 30 of about 738,827 (285)

Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development

Frontiers in Immunology, 2021
Expression of tissue-restricted antigens (TRAs) in thymic epithelial cells (TECs) ensures negative selection of highly self-reactive T cells to establish central tolerance.
Huishan Tao, Lei Li, Nan-Shih Liao, Kimberly S. Schluns, Shirley Luckhart, John W. Sleasman, Xiao-Ping Zhong, Xiao-Ping Zhong, Xiao-Ping Zhong   +8 more
doaj   +1 more source

Innate-like T lymphocytes in chronic liver disease

Frontiers in Immunology, 2023
In addition to its metabolic activities, it is now clear that the liver hosts a number of diverse immune cell types that control tissue homeostasis.
Maria Papanastasatou, Mihalis Verykokakis   +1 more
doaj   +1 more source

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]

, 2020
CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun, Cloots, Eva, De Geest, Bruno, Drennan, Michael, Elewaut, Dirk, Gaublomme, Djoere, Govindarajan, Srinath, Gysens, Fien, Janssens, Sophie, Maelegheer, Margaux, Moody, D Branch, Venken, Koen, Verheugen, Eveline   +12 more
core   +2 more sources

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells [PDF]

, 2013
Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral ...
A Bendelac, A Bendelac, A Reschner, AK Savage, AM Fahrer, B Johnston, BM Sullivan, BN Weber, C Grégoire, C Kuylenstierna, C Paget, D Kovalovsky, DI Godfrey, DI Godfrey, DM Andrews, E Vivier, Gerald F Watts, H Sun, H Watarai, HD Marshall, J Shires, JE Gumperz, JL Matsuda, JL Matsuda, JL Matsuda, JM Coquet, Joonsoo Kang, K Inagaki-Ohara, K Miyazaki, L Gattinoni, L Gattinoni, LE Gordy, LL Lanier, M Brigl, M Brigl, M Brigl, M Maeda, M Salio, MA Cooper, Manfred Brigl, Michael B Brenner, MJ Townsend, MS Vincent, Nadia R Cohen, NC Fernandez, NR Cohen, NY Crowe, P Kastner, Patrick J Brennan, PD Thomas, PJ Brennan, RL O'Brien, S Honma, S Yu, T Kawamura, T Ota, T Walzer, T Willinger, Tal Shay, TSP Heng, V Cerundolo, W Huang da, X Yue, Y Makino   +63 more
core   +5 more sources

Heterogeneity of circulating CD4+CD8+ double-positive T cells characterized by scRNA-seq analysis and trajectory inference

Scientific Reports, 2022
The frequency of CD4+CD8+ double-positive (DP) T cells is highly associated with a variety of diseases. Recently, we used high-throughput single-cell RNA sequencing to show that circulating DP T cells in cynomolgus monkeys comprise nine heterogeneous ...
Sung Min Choi, Hi Jung Park, Eun A Choi, Kyeong Cheon Jung, Jae Il Lee   +4 more
doaj   +1 more source

Innate-like NKp30 ⁺ CD8 ⁺ T cells armed with TCR/CAR target tumor heterogeneity [PDF]

OncoImmunology, 2021
Intratumoral heterogeneity is frequently associated with tumor immune escape, with MHC-class I and antigen expression loss rendering tumor cells invisible to T cell killing, representing a major challenge for the design of successful adoptive transfer protocols for cancer immunotherapy.
Correia, Margareta P., Stojanovic, Ana, Wels, Winfried S., Cerwenka, Adelheid   +3 more
openaire   +3 more sources

Distinct blood and visceral adipose tissue regulatory T cell and innate lymphocyte profiles characterize obesity and colorectal cancer [PDF]

, 2017
Visceral adipose tissue (VAT) is a main site where metabolic and immunologic processes interplay to regulate, at local and systemic level, the inflammatory status and immune response.
Barbara Varano, Beatrice Scazzocchio, Gloria Donninelli, Ilenia Pacella, Lucia Conti, Manuela Del Cornò, Marina Pierdominici, Massimo D’Archivio, Roberta Masella, Rosaria Varì, Sandra Gessani, Silvia Piconese, Silvia Piconese, Vincenzo Barnaba, Vincenzo Barnaba   +14 more
core   +4 more sources

The transcription factor BCL-6 controls early development of innate-like T cells. [PDF]

Nat Immunol, 2020
Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation. How this program is initiated is currently unclear.
Gioulbasani M, Galaras A, Grammenoudi S, Moulos P, Dent AL, Sigvardsson M, Hatzis P, Kee BL, Verykokakis M.   +8 more
europepmc   +4 more sources

Target tumor microenvironment by innate T cells

Frontiers in Immunology, 2022
The immunosuppressive tumor microenvironment (TME) remains one of the most prevailing barriers obstructing the implementation of effective immunotherapy against solid-state cancers.
Yan-Ruide Li, Matthew Wilson, Lili Yang, Lili Yang, Lili Yang, Lili Yang   +5 more
doaj   +1 more source

Memory CD8 + T Cells: Innate-Like Sensors and Orchestrators of Protection [PDF]

Trends in Immunology, 2016
Recent findings have revealed roles for systemic and mucosa-resident memory CD8(+) T cells in the orchestration of innate immune responses critical to host defense upon microbial infection. Here we integrate these findings into the current understanding of the molecular and cellular signals controlling memory CD8(+) T cell reactivation and the ...
Grégoire, Lauvau, Marie, Boutet, Tere M, Williams, Shu Shien, Chin, Laurent, Chorro   +4 more
openaire   +2 more sources