Development of Unconventional T Cells Controlled by MicroRNA [PDF]
Frontiers in Immunology, 2019 Post-transcriptional gene regulation through microRNA (miRNA) has emerged as a major control mechanism of multiple biological processes, including development and function of T cells. T cells are vital components of the immune system, with conventional T
Samantha J. Winter, Andreas Krueger
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Harnessing Unconventional T Cells and Innate Lymphoid Cells to Prevent and Treat Hematological Malignancies: Prospects for New Immunotherapy [PDF]
Biomolecules, 2022 Unconventional T cells and innate lymphoid cells (ILCs) make up a heterogeneous set of cells that characteristically show prompt responses toward specific antigens.
Alessandro Allegra +4 more
doaj +5 more sources
Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection [PDF]
Frontiers in Immunology, 2020 The intestinal mucosa is enriched for unconventional T-cells, including mucosal associated invariant T-cells (MAIT), invariant natural killer T-cells (iNKT) and γδ T-cells. These cells are activated by bacterial metabolites, lipid antigens and cytokines,
Magalli Magnoumba +17 more
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Harnessing Unconventional T Cells for Immunotherapy of Tuberculosis [PDF]
Frontiers in Immunology, 2020 Even if the incidence of tuberculosis (TB) has been decreasing over the last years, the number of patients with TB is increasing worldwide. The emergence of multidrug-resistant and extensively drug-resistant TB is making control of TB more difficult ...
Marco P. La Manna +11 more
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Human unconventional T cells in Plasmodium falciparum infection [PDF]
Seminars in Immunopathology, 2020 Malaria is an old scourge of humankind and has a large negative impact on the economic development of affected communities. Recent success in malaria control and reduction of mortality seems to have stalled emphasizing that our current intervention tools
Tobias Rutishauser +2 more
exaly +8 more sources
A multilayered immune system through the lens of unconventional T cells [PDF]
Nature, 2021 The unconventional T cell compartment encompasses a variety of cell subsets that straddle the line between innate and adaptive immunity, often reside at mucosal surfaces and can recognize a wide range of non-polymorphic ligands.
Toufic Mayassi +2 more
exaly +3 more sources
Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors [PDF]
Cancers, 2021 International audienceThe vast majority of studies on T cell biology in tumor immunity have focused on peptide-reactive conventional T cells that are restricted to polymorphic major histocompatibility complex molecules.
Carolina De Amat Herbozo +2 more
exaly +4 more sources
Comprehensive Analysis of the ILCs and Unconventional T Cells in Virus Infection: Profiling and Dynamics Associated with COVID-19 Disease for a Future Monitoring System and Therapeutic Opportunities [PDF]
Cells, 2022 This review is a comprehensive analysis of the effects of SARS-CoV-2 infection on Unconventional T cells and innate lymphoid cells (ILCs). COVID-19 affected patients show dysregulation of their adaptive immune systems, but many questions remain unsolved ...
Elena Lo Presti +3 more
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Mechanisms of Bacterial Superinfection Post-influenza: A Role for Unconventional T Cells [PDF]
Frontiers in Immunology, 2019 Despite the widespread application of vaccination programs and antiviral drug treatments, influenza viruses are still among the most harmful human pathogens.
Christophe Paget +6 more
doaj +5 more sources
The Influence of Innate Lymphoid Cells and Unconventional T Cells in Chronic Inflammatory Lung Disease [PDF]
Frontiers in Immunology, 2019 The lungs are continuously subjected to environmental insults making them susceptible to infection and injury. They are protected by the respiratory epithelium, which not only serves as a physical barrier but also a reactive one that can release ...
Jessica G. Borger +3 more
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