Harnessing Unconventional T Cells and Innate Lymphoid Cells to Prevent and Treat Hematological Malignancies: Prospects for New Immunotherapy [PDF]
Biomolecules, 2022 Unconventional T cells and innate lymphoid cells (ILCs) make up a heterogeneous set of cells that characteristically show prompt responses toward specific antigens.
Alessandro Allegra +4 more
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Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection [PDF]
Frontiers in Immunology, 2020 The intestinal mucosa is enriched for unconventional T-cells, including mucosal associated invariant T-cells (MAIT), invariant natural killer T-cells (iNKT) and γδ T-cells. These cells are activated by bacterial metabolites, lipid antigens and cytokines,
Magalli Magnoumba +17 more
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Comprehensive Analysis of the ILCs and Unconventional T Cells in Virus Infection: Profiling and Dynamics Associated with COVID-19 Disease for a Future Monitoring System and Therapeutic Opportunities [PDF]
Cells, 2022 This review is a comprehensive analysis of the effects of SARS-CoV-2 infection on Unconventional T cells and innate lymphoid cells (ILCs). COVID-19 affected patients show dysregulation of their adaptive immune systems, but many questions remain unsolved ...
Elena Lo Presti +3 more
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Unconventional T cells in brain homeostasis, injury and neurodegeneration [PDF]
Frontiers in Immunology, 2023 The interaction between peripheral immune cells and the brain is an important component of the neuroimmune axis. Unconventional T cells, which include natural killer T (NKT) cells, mucosal-associated invariant T (MAIT) cells, γδ T cells, and other poorly
Mengfei Lv +4 more
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Targeted multi-omic analysis of human skin tissue identifies alterations of conventional and unconventional T cells associated with burn injury [PDF]
eLife, 2023 Burn injuries are a leading cause of unintentional injury, associated with a dysfunctional immune response and an increased risk of infections. Despite this, little is known about the role of T cells in human burn injury.
Daniel R Labuz +6 more
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Unconventional T cells in anti-cancer immunity [PDF]
Frontiers in ImmunologyUnlike conventional T cells that detect peptide antigens loaded to major histocompatibility complex (MHC) molecules, unconventional T cells respond to non-peptidic metabolite antigens presented by MHC class I-like proteins, such as CD1 and MHC-related ...
Ariel Laub +4 more
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Development of Unconventional T Cells Controlled by MicroRNA [PDF]
Frontiers in Immunology, 2019 Post-transcriptional gene regulation through microRNA (miRNA) has emerged as a major control mechanism of multiple biological processes, including development and function of T cells. T cells are vital components of the immune system, with conventional T
Samantha J. Winter, Andreas Krueger
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Harnessing Unconventional T Cells for Immunotherapy of Tuberculosis [PDF]
Frontiers in Immunology, 2020 Even if the incidence of tuberculosis (TB) has been decreasing over the last years, the number of patients with TB is increasing worldwide. The emergence of multidrug-resistant and extensively drug-resistant TB is making control of TB more difficult ...
Marco P. La Manna +11 more
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Exploring the role of unconventional T cells in rheumatoid arthritis [PDF]
Frontiers in ImmunologyRheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by sustained synovial inflammation and the gradual destruction of joint structures.
Tangqing Xu +6 more
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Tumor Lipids of Pediatric Papillary Renal Cell Carcinoma Stimulate Unconventional T Cells [PDF]
Frontiers in Immunology, 2020 Papillary renal cell carcinoma (PRCC) is a rare entity in children with no established therapy protocols for advanced diseases. Immunotherapy is emerging as an important therapeutic tool for childhood cancer.
Nadine Lehmann +22 more
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