Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cells. [PDF]
Geroscience, 2022 Singh P +4 more
europepmc +2 more sources
Hypersensitivities following allergen antigen recognition by unconventional T cells. [PDF]
Allergy, 2020 AbstractConventional T cells recognise protein‐derived antigens in the context of major histocompatibility complex (MHC) class Ia and class II molecules and provide anti‐microbial and anti‐tumour immunity. Conventional T cells have also been implicated in type IV (also termed delayed‐type or T cell–mediated) hypersensitivity reactions in response to ...
de Lima Moreira M +6 more
europepmc +5 more sources
MAIT cells come to the rescue in cancer immunotherapy? [PDF]
, 2020 Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk +2 more
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Unconventional T Cell Targets for Cancer Immunotherapy [PDF]
Immunity, 2018 Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility complex (MHC) class I and MHC class II molecules, respectively. However, unconventional T cells, which interact with MHC class Ib and MHC-I like molecules, are also ...
Godfrey, Dale I. +4 more
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Unconventional T cells – New players in antifungal immunity
Clinical Immunology, 2021 Life-threatening invasive fungal diseases (IFD) are increasing in incidence, especially in immunocompromised patients and successful resolution of IFD requires a variety of different immune cells. With the limited repertoire of available antifungal drugs there is a need for more effective therapeutic strategies. This review interrogates the evidence on
Dunne, Margaret R. +4 more
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Special Issue “Gamma Delta T Cells in Immune Response against Viruses”
Viruses, 2022 γδ T cells are members of ‘unconventional’ T cells that combine the properties of adaptive T lymphocytes and innate cells such as NK cells [...]
Eric Champagne
doaj +1 more source
The multisensory regulation of unconventional T cell homeostasis
Seminars in Immunology, 2022 Unconventional T cells typically group γδ T cells, invariant Natural Killer T cells (NKT) and Mucosal Associated Invariant T (MAIT) cells. With their pre-activated status and biased tropism for non-lymphoid organs, they provide a rapid (innate-like) and efficient first line of defense against pathogens at strategical barrier sites, while they can also ...
Julie, Darrigues +3 more
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Unconventional RORγt+ T Cells Drive Hepatic Ischemia Reperfusion Injury [PDF]
The Journal of Immunology, 2013 Abstract An emerging body of evidence suggests a pivotal role of CD3+ T cells in mediating early ischemia reperfusion injury (IRI). However, the precise phenotype of T cells involved and the mechanisms underlying such T cell–mediated immune responses in IRI, as well as their clinical relevance, are poorly understood.
Eggenhofer, E. +13 more
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UcTCRdb: An unconventional T cell receptor sequence database with online analysis functions
Frontiers in Immunology, 2023 Unlike conventional major histocompatibility complex (MHC) class I and II molecules reactive T cells, the unconventional T cell subpopulations recognize various non-polymorphic antigen-presenting molecules and are typically characterized by simplified ...
Yunsheng Dou, Shiwen Shan, Jian Zhang
doaj +1 more source
The dialogue between unconventional T cells and the microbiota [PDF]
Mucosal Immunology, 2020 The mammalian immune system is equipped with unconventional T cells that respond to microbial molecules such as glycolipids and small-molecule metabolites, which are invisible to conventional CD4 and CD8 T cells. Unconventional T cells include invariant natural killer T (iNKT) cells and mucosa-associated invariant T (MAIT) cells, which are involved in ...
Qiaochu Lin +3 more
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