Results 31 to 40 of about 29,272 (220)
Human unconventional T cells in Plasmodium falciparum infection. [PDF]
Semin Immunopathol, 2020 Malaria is an old scourge of humankind and has a large negative impact on the economic development of affected communities. Recent success in malaria control and reduction of mortality seems to have stalled emphasizing that our current intervention tools need to be complemented by malaria vaccines.
Schmaler M +4 more
europepmc +6 more sources
Unconventional T Cell Targets for Cancer Immunotherapy [PDF]
Immunity, 2018 Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility complex (MHC) class I and MHC class II molecules, respectively. However, unconventional T cells, which interact with MHC class Ib and MHC-I like molecules, are also ...
Godfrey, Dale I. +4 more
openaire +2 more sources
Special Issue “Gamma Delta T Cells in Immune Response against Viruses”
Viruses, 2022 γδ T cells are members of ‘unconventional’ T cells that combine the properties of adaptive T lymphocytes and innate cells such as NK cells [...]
Eric Champagne
doaj +1 more source
Targeting Unconventional T Cells for Vaccination against Tuberculosis. [PDF]
Am J Respir Cell Mol Biol, 2020 Wilkinson KA, Cerrone M.
europepmc +4 more sources
The multisensory regulation of unconventional T cell homeostasis
Seminars in Immunology, 2022 Unconventional T cells typically group γδ T cells, invariant Natural Killer T cells (NKT) and Mucosal Associated Invariant T (MAIT) cells. With their pre-activated status and biased tropism for non-lymphoid organs, they provide a rapid (innate-like) and efficient first line of defense against pathogens at strategical barrier sites, while they can also ...
Julie, Darrigues +3 more
openaire +2 more sources
Unconventional T cells – New players in antifungal immunity
Clinical Immunology, 2021 Life-threatening invasive fungal diseases (IFD) are increasing in incidence, especially in immunocompromised patients and successful resolution of IFD requires a variety of different immune cells. With the limited repertoire of available antifungal drugs there is a need for more effective therapeutic strategies. This review interrogates the evidence on
Dunne, Margaret R. +4 more
openaire +5 more sources
An unconventional view of COVID-19 T cell immunity [PDF]
Journal of Experimental Medicine, 2020 In this issue of JEM, Jouan et al. (https://doi.org/10.1084/jem.20200872) report the activation and skewed function of unconventional T cells in severe COVID-19 patients. This may reflect a role in COVID-19 immunity or pathogenesis and potentially identifies new therapeutic targets for this disease.
Koay, Hui-Fern +2 more
openaire +3 more sources
Commensal bacteria maintain a Qa-1b-restricted unconventional CD8+ T population in gut epithelium
eLife, 2023 Intestinal intraepithelial lymphocytes (IELs) are characterized by an unusual phenotype and developmental pathway, yet their specific ligands and functions remain largely unknown. Here by analysis of QFL T cells, a population of CD8+ T cells critical for
Jian Guan +5 more
doaj +1 more source
Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes
Frontiers in Immunology, 2021 Mucosal surfaces, as a first barrier with the environment are especially susceptible to damage from both pathogens and physical trauma. Thus, these sites require tightly regulated repair programs to maintain barrier function in the face of such insults ...
Joshua R. Cox +4 more
doaj +1 more source