Developmental trajectory of unconventional T cells of the cynomolgus macaque thymus [PDF]
HeliyonAs nonhuman primates are immunologically the closest model to humans, a comprehensive understanding of T-cell development in these species is crucial. However, the differentiation pathways in which thymocytes participate, along with their heterogeneity ...
Sung Min Choi +2 more
doaj +2 more sources
Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol-Related Liver Disease. [PDF]
Alcohol Clin Exp Res, 2020 BACKGROUND: Liver is enriched in several innate-like unconventional T cells, but their role in alcohol-related liver disease (ALD) is not fully understood. Studies in several acute alcohol feeding models but not in chronic alcoholic steatohepatitis (ASH)
Marrero I +7 more
europepmc +2 more sources
Tuberculosis preventive therapy in postpartum women with HIV modifies M. tuberculosis-specific and nonspecific immune responses [PDF]
Frontiers in ImmunologyBackgroundTuberculosis (TB) has significant morbidity in pregnant and postpartum women with HIV (pregnant and PPWWHIV). TB preventive therapy (TPT) is recommended in pregnant and PPWWHIV with documented or presumed latent TB infection (LTBI).
Damayanti Yengkhom +10 more
doaj +2 more sources
Unconventional T cells – New players in antifungal immunity
Clinical Immunology, 2021 Life-threatening invasive fungal diseases (IFD) are increasing in incidence, especially in immunocompromised patients and successful resolution of IFD requires a variety of different immune cells. With the limited repertoire of available antifungal drugs
Dunne, Margaret R. +4 more
core +6 more sources
The Emerging Roles and Therapeutic Potential of Unconventional T Cells in Sepsis [PDF]
Journal of Inflammation ResearchShuaipeng Gu,1 Peidong Zhang,1 Cong Zhang,1 Tingxuan Tang,2 Teding Chang,1 Liming Dong,1 Wei Gao,1,* Zhaohui Tang1,* 1Department of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, Tongji Hospital, Tongji ...
Gu S +7 more
doaj +2 more sources
Phenotypical and Functional Characterization of Cytotoxic Unconventional T-Cells
, 2021 During the last two decades, the immunology field has been focused on the study of conventional T-cells, leading to important advances in identification of specific subsets involved in promoting and suppressing immune response in patients with cancer ...
Ranieri E., Gigante M.
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The role of unconventional T cells in COVID-19. [PDF]
Ir J Med Sci, 2022 AbstractCOVID-19 is a respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first documented in late 2019, but within months, a worldwide pandemic was declared due to the easily transmissible nature of the virus.
Orumaa K, Dunne MR.
europepmc +5 more sources
Unconventional functions of MR1 restricted T-cells
, 2023 The non-polymorphic MHC class I-related protein 1 (MR1) is an antigen presenting receptor that displays endogenous or microbial-derived metabolic intermediates.
Delowar Akther, Hossain
core +3 more sources
Early-life imprinting of unconventional T cells and tissue homeostasis [PDF]
Science, 2021 Michael G Constantinides +1 more
exaly +2 more sources
Natural killer cells and unconventional T cells in COVID-19. [PDF]
Curr Opin Virol, 2021 NK cells and diverse populations of unconventional T cells, such as MAIT cells, γδ T cells, invariant NKT cells, and DNTɑβ cells are important early effector lymphocytes. While some of these cells, such as NK cell and MAIT cells, have well-established roles in antiviral defense, the function of other populations remains more elusive. Here, we summarize
Björkström NK, Ponzetta A.
europepmc +3 more sources