Unconventional T cells in brain homeostasis, injury and neurodegeneration [PDF]
Frontiers in Immunology, 2023 The interaction between peripheral immune cells and the brain is an important component of the neuroimmune axis. Unconventional T cells, which include natural killer T (NKT) cells, mucosal-associated invariant T (MAIT) cells, γδ T cells, and other poorly
Mengfei Lv +4 more
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The duplexity of unconventional T cells in cancer [PDF]
International Journal of Biochemistry and Cell Biology, 2022 Unconventional T cells and their involvement in cancer are understudied in comparison to conventional T cells, but recent findings indicate that these cells play important roles in both cancer progression and inhibition.
Robert Wiesheu, Seth B Coffelt
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Unconventional T cells and kidney disease [PDF]
Nature Reviews Nephrology, 2021 Unconventional T cells are a diverse and underappreciated group of relatively rare lymphocytes that are distinct from conventional CD4+ and CD8+ T cells, and that mainly recognize antigens in the absence of classical restriction through the major ...
Lionel Couzi +2 more
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Unconventional T cells in anti-cancer immunity [PDF]
Frontiers in ImmunologyUnlike conventional T cells that detect peptide antigens loaded to major histocompatibility complex (MHC) molecules, unconventional T cells respond to non-peptidic metabolite antigens presented by MHC class I-like proteins, such as CD1 and MHC-related ...
Ariel Laub +4 more
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Exploring the role of unconventional T cells in rheumatoid arthritis [PDF]
Frontiers in ImmunologyRheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by sustained synovial inflammation and the gradual destruction of joint structures.
Tangqing Xu +6 more
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Unconventional T Cells in IgA Nephropathy [PDF]
Kidney International ReportsZizhang Sheng, Nicholas J. Steers
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Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge
Nature Reviews Immunology, 2020 T cell lineages are defined by specialized functions and differential expression of surface antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the best studied of the T cell subsets, but ‘unconventional’ T cells have ...
Daniel G Pellicci +2 more
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The role of unconventional T cells in maintaining tissue homeostasis [PDF]
Seminars in Immunology, 2022 Michael G Constantinides
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Targeted multi-omic analysis of human skin tissue identifies alterations of conventional and unconventional T cells associated with burn injury [PDF]
eLife, 2023 Burn injuries are a leading cause of unintentional injury, associated with a dysfunctional immune response and an increased risk of infections. Despite this, little is known about the role of T cells in human burn injury.
Daniel R Labuz +6 more
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Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells. [PDF]
PLoS Pathogens, 2006 Control of virus infection is mediated in part by major histocompatibility complex (MHC) Class Ia presentation of viral peptides to conventional CD8 T cells.
Douglas C Braaten +6 more
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