Results 1 to 10 of about 31,649 (108)

UcTCRdb: An unconventional T cell receptor sequence database with online analysis functions [PDF]

Frontiers in Immunology, 2023
Unlike conventional major histocompatibility complex (MHC) class I and II molecules reactive T cells, the unconventional T cell subpopulations recognize various non-polymorphic antigen-presenting molecules and are typically characterized by simplified ...
Yunsheng Dou, Shiwen Shan, Jian Zhang
doaj   +4 more sources

Harnessing Unconventional T Cells and Innate Lymphoid Cells to Prevent and Treat Hematological Malignancies: Prospects for New Immunotherapy

Biomolecules, 2022
Unconventional T cells and innate lymphoid cells (ILCs) make up a heterogeneous set of cells that characteristically show prompt responses toward specific antigens.
Alessandro Allegra, Marco Casciaro, Elena Lo Presti, Caterina Musolino, Sebastiano Gangemi   +4 more
doaj   +3 more sources

Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self [PDF]

Cell Reports, 2023
Summary: The endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP) plays a crucial role in shaping the peptide-major histocompatibility complex (MHC) class I repertoire and maintaining immune surveillance.
Kristina M. Geiger, Michael Manoharan, Rachel Coombs, Kathya Arana, Chan-Su Park, Angus Y. Lee, Nilabh Shastri, Ellen A. Robey, Laurent Coscoy   +8 more
doaj   +2 more sources

Tuberculosis preventive therapy in postpartum women with HIV modifies M. tuberculosis-specific and nonspecific immune responses [PDF]

Frontiers in Immunology
BackgroundTuberculosis (TB) has significant morbidity in pregnant and postpartum women with HIV (pregnant and PPWWHIV). TB preventive therapy (TPT) is recommended in pregnant and PPWWHIV with documented or presumed latent TB infection (LTBI).
Damayanti Yengkhom, Grace Montepiedra, Gaerolwe Masheto, Deo Wabwire, Lynda Stranix-Chibanda, Allen Matubu, Avy Violari, Gerhard Theron, Amita Gupta, Adriana Weinberg, Adriana Weinberg   +10 more
doaj   +2 more sources

Unconventional T cells in anti-cancer immunity

Frontiers in Immunology
Unlike conventional T cells that detect peptide antigens loaded to major histocompatibility complex (MHC) molecules, unconventional T cells respond to non-peptidic metabolite antigens presented by MHC class I-like proteins, such as CD1 and MHC-related ...
Ariel Laub, Ariel Laub, Nathalia Rodrigues de Almeida, Shouxiong Huang, Shouxiong Huang   +4 more
doaj   +3 more sources

Emerging features of MAIT cells and other unconventional T cell populations in human viral disease and vaccination. [PDF]

Semin Immunol, 2022
Hackstein CP, Klenerman P.
europepmc   +2 more sources

Dysfunctional states of unconventional T-cell subsets in cancer. [PDF]

J Leukoc Biol
Katsnelson EN, Spengler A, Domenico J, Couts KL, Loh L, Gapin L, McCarter MD, Tobin RP.   +7 more
europepmc   +2 more sources

Altered Populations of Unconventional T Cell Lineages in Patients with Langerhans Cell Histiocytosis. [PDF]

Sci Rep, 2018
Mitchell J, Kvedaraite E, von Bahr Greenwood T, Henter JI, Pellicci DG, Berzins SP, Kannourakis G.   +6 more
europepmc   +2 more sources

Targeted multi-omic analysis of human skin tissue identifies alterations of conventional and unconventional T cells associated with burn injury

eLife, 2023
Burn injuries are a leading cause of unintentional injury, associated with a dysfunctional immune response and an increased risk of infections. Despite this, little is known about the role of T cells in human burn injury.
Daniel R Labuz, Giavonni Lewis, Irma D Fleming, Callie M Thompson, Yan Zhai, Matthew A Firpo, Daniel T Leung   +6 more
doaj   +1 more source

Unconventional T cells in brain homeostasis, injury and neurodegeneration

Frontiers in Immunology, 2023
The interaction between peripheral immune cells and the brain is an important component of the neuroimmune axis. Unconventional T cells, which include natural killer T (NKT) cells, mucosal-associated invariant T (MAIT) cells, γδ T cells, and other poorly
Mengfei Lv, Mengfei Lv, Zhaolong Zhang, Yu Cui, Yu Cui   +4 more
doaj   +1 more source