Results 21 to 30 of about 29,659 (107)

Human unconventional T cells in Plasmodium falciparum infection [PDF]

Seminars in Immunopathology, 2020
Malaria is an old scourge of humankind and has a large negative impact on the economic development of affected communities. Recent success in malaria control and reduction of mortality seems to have stalled emphasizing that our current intervention tools need to be complemented by malaria vaccines.
Mathias Schmaler, Nina Orlova-Fink, Tobias Rutishauser, Salim Abdulla, Claudia Daubenberger   +4 more
openaire   +4 more sources

Natural killer cells and unconventional T cells in COVID-19

Current Opinion in Virology, 2021
NK cells and diverse populations of unconventional T cells, such as MAIT cells, γδ T cells, invariant NKT cells, and DNTɑβ cells are important early effector lymphocytes. While some of these cells, such as NK cell and MAIT cells, have well-established roles in antiviral defense, the function of other populations remains more elusive. Here, we summarize
Björkström, Niklas K, Ponzetta, Andrea
openaire   +2 more sources

Unconventional T cells in brain homeostasis, injury and neurodegeneration

Frontiers in Immunology, 2023
The interaction between peripheral immune cells and the brain is an important component of the neuroimmune axis. Unconventional T cells, which include natural killer T (NKT) cells, mucosal-associated invariant T (MAIT) cells, γδ T cells, and other poorly defined subsets, are a special group of T lymphocytes that recognize a wide range of nonpolymorphic
Mengfei Lv, Mengfei Lv, Zhaolong Zhang, Yu Cui, Yu Cui   +4 more
openaire   +3 more sources

Unconventional T cells in anti-cancer immunity

Frontiers in Immunology
Unlike conventional T cells that detect peptide antigens loaded to major histocompatibility complex (MHC) molecules, unconventional T cells respond to non-peptidic metabolite antigens presented by MHC class I-like proteins, such as CD1 and MHC-related protein 1 (MR1). Semi-invariant mucosal-associated invariant T (MAIT) cells, γδ T cells, and invariant
Ariel Laub, Ariel Laub, Nathalia Rodrigues de Almeida, Shouxiong Huang, Shouxiong Huang   +4 more
openaire   +3 more sources

Unconventional RORγt+ T Cells Drive Hepatic Ischemia Reperfusion Injury [PDF]

The Journal of Immunology, 2013
Abstract An emerging body of evidence suggests a pivotal role of CD3+ T cells in mediating early ischemia reperfusion injury (IRI). However, the precise phenotype of T cells involved and the mechanisms underlying such T cell–mediated immune responses in IRI, as well as their clinical relevance, are poorly understood.
Eggenhofer, E., Rovira, J., Sabet-Baktach, M., Groell, A., Scherer, M. N., Dahlke, M.-H., Farkas, S. A., Loss, M., Koehl, G. E., Lang, S. A., Melter, M., Schlitt, H. J., Geissler, E. K., Kroemer, A.   +13 more
openaire   +2 more sources

Renal double negative T cells: unconventional cells in search of a function [PDF]

Annals of Translational Medicine, 2019
In studying the role of adaptive immunity in disease, investigators have focused extensively on CD8 + T cells (effector T cells) and CD4+ T cells (helper T cells). For many years, double negative (DN) T cells (CD4− CD8−) have been neglected by immunologists due to their overall rarity and lack of clear expression markers, making them difficult to ...
Raphael A, Nemenoff, Emily K, Kleczko, Katharina, Hopp   +2 more
openaire   +2 more sources

Exploring the role of unconventional T cells in rheumatoid arthritis. [PDF]

Front Immunol
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by sustained synovial inflammation and the gradual destruction of joint structures. Although conventional T cells have historically been viewed as central to RA pathogenesis, increasing attention has recently focused on unconventional T cell subsets, such as natural killer T (NKT)
Xu T, Cai H, Liu J, Mao X, Chen Y, Chen M, Wang Y.   +6 more
europepmc   +3 more sources

T cell responses in hepatitis C: the good, the bad and the unconventional

Gut, 2011
Over recent years, it has become increasingly accepted that virus-specific CD4+ and CD8+ T cell responses play a major role in outcome and pathogenesis of hepatitis C virus (HCV) infection. Indeed, while the emergence of strong and multispecific T cell responses may correlate with spontaneous viral clearance, the virus has developed several mechanisms ...
Klenerman, Paul, Thimme, Robert
openaire   +5 more sources

The clinical landscape of CAR-engineered unconventional T cells

Trends in Cancer
Unconventional T cells, such as invariant natural killer T (iNKT), γδ T, and mucosal-associated invariant T (MAIT) cells, play a pivotal role in bridging innate and adaptive immunity. Their capacity for rapid tumor targeting and effective modulation of the tumor microenvironment (TME) makes them promising candidates for cancer immunotherapy.
Yan-Ruide Li, Yichen Zhu, Yuning Chen, Lili Yang   +3 more
openaire   +2 more sources

Identification of immunosenescence of unconventional T cells in hepatocellular carcinoma

Computational Biology and Chemistry
Accumulation of senescent cells is a recognized feature in hepatocellular carcinoma (HCC), but their specific types and prognostic implications remain under investigation. This study aimed to delineate senescent cell types and their senescent patterns in HCC using publicly available bulk and single-cell mRNA sequencing data. Through gene expression and
Rumei Li, Zhaoxi Li, Wanrong Luo, Xiaotong Zhu, Baoming Luo   +4 more
openaire   +2 more sources