Results 21 to 30 of about 31,798 (239)

Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection

Frontiers in Immunology, 2020
The intestinal mucosa is enriched for unconventional T-cells, including mucosal associated invariant T-cells (MAIT), invariant natural killer T-cells (iNKT) and γδ T-cells. These cells are activated by bacterial metabolites, lipid antigens and cytokines,
Magalli Magnoumba, Alveera Singh, Paul Ogongo, Paul Ogongo, Julia Roider, Julia Roider, Osaretin Asowata, Michael Fehlings, Farina Karim, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Frank Anderson, Alasdair Leslie, Alasdair Leslie, Henrik Kløverpris, Henrik Kløverpris, Henrik Kløverpris   +17 more
doaj   +1 more source

The promiscuous development of an unconventional Qa1b-restricted T cell population

Frontiers in Immunology, 2023
MHC-E restricted CD8 T cells show promise in vaccine settings, but their development and specificity remain poorly understood. Here we focus on a CD8 T cell population reactive to a self-peptide (FL9) bound to mouse MHC-E (Qa-1b) that is presented in ...
Michael Manoharan Valerio, Kathya Arana, Jian Guan, Shiao Wei Chan, Xiaokun Yang, Nadia Kurd, Angus Lee, Nilabh Shastri, Laurent Coscoy, Ellen A. Robey   +9 more
doaj   +1 more source

Unconventional T Cell Targets for Cancer Immunotherapy [PDF]

Immunity, 2018
Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility complex (MHC) class I and MHC class II molecules, respectively. However, unconventional T cells, which interact with MHC class Ib and MHC-I like molecules, are also ...
Godfrey, Dale I., Le Nours, Jérôme, Andrews, Daniel M., Uldrich, Adam P., Rossjohn, Jamie   +4 more
openaire   +2 more sources

Beyond αβ T cells: NK, iNKT, and γδT cell biology in leukemic patients and potential for off-the-shelf adoptive cell therapies for AML

Frontiers in Immunology, 2023
Acute myeloid leukemia (AML) remains an elusive disease to treat, let alone cure, even after highly intensive therapies such as stem cell transplants. Adoptive cell therapeutic strategies based on conventional alpha beta (αβ)T cells are an active area of
Andrew Kent, Andrew Kent, Andrew Kent, Lyndsey S. Crump, Eduardo Davila, Eduardo Davila, Eduardo Davila, Eduardo Davila   +7 more
doaj   +1 more source

The multisensory regulation of unconventional T cell homeostasis

Seminars in Immunology, 2022
Unconventional T cells typically group γδ T cells, invariant Natural Killer T cells (NKT) and Mucosal Associated Invariant T (MAIT) cells. With their pre-activated status and biased tropism for non-lymphoid organs, they provide a rapid (innate-like) and efficient first line of defense against pathogens at strategical barrier sites, while they can also ...
Julie, Darrigues, Vicente, Almeida, Eller, Conti, Julie C, Ribot   +3 more
openaire   +2 more sources

Unconventional T cells – New players in antifungal immunity

Clinical Immunology, 2021
Life-threatening invasive fungal diseases (IFD) are increasing in incidence, especially in immunocompromised patients and successful resolution of IFD requires a variety of different immune cells. With the limited repertoire of available antifungal drugs there is a need for more effective therapeutic strategies. This review interrogates the evidence on
Dunne, Margaret R., Wagener, Johannes, Loeffler, Juergen, Doherty, Derek G., Rogers, Thomas R.   +4 more
openaire   +5 more sources

An unconventional view of COVID-19 T cell immunity [PDF]

Journal of Experimental Medicine, 2020
In this issue of JEM, Jouan et al. (https://doi.org/10.1084/jem.20200872) report the activation and skewed function of unconventional T cells in severe COVID-19 patients. This may reflect a role in COVID-19 immunity or pathogenesis and potentially identifies new therapeutic targets for this disease.
Koay, Hui-Fern, Fulford, Thomas S., Godfrey, Dale I.   +2 more
openaire   +3 more sources

Human unconventional T cells in Plasmodium falciparum infection [PDF]

Seminars in Immunopathology, 2020
Malaria is an old scourge of humankind and has a large negative impact on the economic development of affected communities. Recent success in malaria control and reduction of mortality seems to have stalled emphasizing that our current intervention tools need to be complemented by malaria vaccines.
Mathias Schmaler, Nina Orlova-Fink, Tobias Rutishauser, Salim Abdulla, Claudia Daubenberger   +4 more
openaire   +4 more sources

Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity

Journal of Immunology Research, 2021
Recently, cell-mediated immune response in malignant neoplasms has become the focus in immunotherapy against cancer. However, in leukemia, most studies on the cytotoxic potential of T cells have concentrated only on T cells that recognize peptide ...
Nilberto Dias de Araújo, Fábio Magalhães Gama, Mateus de Souza Barros, Thaís Lohana Pereira Ribeiro, Fabíola Silva Alves, Lilyane Amorim Xabregas, Andréa Monteiro Tarragô, Adriana Malheiro, Allyson Guimarães Costa   +8 more
doaj   +1 more source

Natural killer cells and unconventional T cells in COVID-19

Current Opinion in Virology, 2021
NK cells and diverse populations of unconventional T cells, such as MAIT cells, γδ T cells, invariant NKT cells, and DNTɑβ cells are important early effector lymphocytes. While some of these cells, such as NK cell and MAIT cells, have well-established roles in antiviral defense, the function of other populations remains more elusive. Here, we summarize
Björkström, Niklas K, Ponzetta, Andrea
openaire   +2 more sources