Results 11 to 20 of about 29,659 (107)
Unconventional T cells and kidney disease [PDF]
Nature Reviews Nephrology, 2021 Unconventional T cells are a diverse and underappreciated group of relatively rare lymphocytes that are distinct from conventional CD4+ and CD8+ T cells, and that mainly recognize antigens in the absence of classical restriction through the major histocompatibility complex (MHC).
Hannah Kaminski +2 more
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The duplexity of unconventional T cells in cancer [PDF]
The International Journal of Biochemistry & Cell Biology, 2022 Unconventional T cells and their involvement in cancer are understudied in comparison to conventional T cells, but recent findings indicate that these cells play important roles in both cancer progression and inhibition. Here, we briefly review the dichotomous role of three unconventional T cell lineages: γδ T cells, MAIT cells and NKT cells.
Lawrence, Mark +2 more
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The role of unconventional T cells in COVID-19 [PDF]
Irish Journal of Medical Science (1971 -), 2021 AbstractCOVID-19 is a respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first documented in late 2019, but within months, a worldwide pandemic was declared due to the easily transmissible nature of the virus.
Kristen Orumaa, Margaret R. Dunne
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Mobilizing unconventional T cells [PDF]
Science, 2019 Modulating unconventional antigen presentation could treat infections and ...
Ottenhoff, T.H.M., Joosten, S.A.
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The dialogue between unconventional T cells and the microbiota [PDF]
Mucosal Immunology, 2020 The mammalian immune system is equipped with unconventional T cells that respond to microbial molecules such as glycolipids and small-molecule metabolites, which are invisible to conventional CD4 and CD8 T cells. Unconventional T cells include invariant natural killer T (iNKT) cells and mucosa-associated invariant T (MAIT) cells, which are involved in ...
Qiaochu Lin +3 more
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Harnessing Unconventional T Cells for Immunotherapy of Tuberculosis [PDF]
Frontiers in Immunology, 2020 Even if the incidence of tuberculosis (TB) has been decreasing over the last years, the number of patients with TB is increasing worldwide. The emergence of multidrug-resistant and extensively drug-resistant TB is making control of TB more difficult. Mycobacterium bovis bacillus Calmette-Guérin vaccine fails to prevent pulmonary TB in adults, and there
Marco P. La Manna +11 more
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The multisensory regulation of unconventional T cell homeostasis
Seminars in Immunology, 2022 Unconventional T cells typically group γδ T cells, invariant Natural Killer T cells (NKT) and Mucosal Associated Invariant T (MAIT) cells. With their pre-activated status and biased tropism for non-lymphoid organs, they provide a rapid (innate-like) and efficient first line of defense against pathogens at strategical barrier sites, while they can also ...
Julie, Darrigues +3 more
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Development of Unconventional T Cells Controlled by MicroRNA [PDF]
Frontiers in Immunology, 2019 Post-transcriptional gene regulation through microRNA (miRNA) has emerged as a major control mechanism of multiple biological processes, including development and function of T cells. T cells are vital components of the immune system, with conventional T cells playing a central role in adaptive immunity and unconventional T cells having additional ...
Winter, Samantha J., Krueger, Andreas
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An unconventional view of COVID-19 T cell immunity [PDF]
Journal of Experimental Medicine, 2020 In this issue of JEM, Jouan et al. (https://doi.org/10.1084/jem.20200872) report the activation and skewed function of unconventional T cells in severe COVID-19 patients. This may reflect a role in COVID-19 immunity or pathogenesis and potentially identifies new therapeutic targets for this disease.
Koay, Hui-Fern +2 more
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Unconventional T cells – New players in antifungal immunity
Clinical Immunology, 2021 Life-threatening invasive fungal diseases (IFD) are increasing in incidence, especially in immunocompromised patients and successful resolution of IFD requires a variety of different immune cells. With the limited repertoire of available antifungal drugs there is a need for more effective therapeutic strategies. This review interrogates the evidence on
Dunne, Margaret R. +4 more
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