Results 11 to 20 of about 31,798 (239)

Development of Unconventional T Cells Controlled by MicroRNA [PDF]

Frontiers in Immunology, 2019
Post-transcriptional gene regulation through microRNA (miRNA) has emerged as a major control mechanism of multiple biological processes, including development and function of T cells. T cells are vital components of the immune system, with conventional T
Samantha J. Winter, Andreas Krueger
doaj   +4 more sources

Harnessing Unconventional T Cells for Immunotherapy of Tuberculosis [PDF]

Frontiers in Immunology, 2020
Even if the incidence of tuberculosis (TB) has been decreasing over the last years, the number of patients with TB is increasing worldwide. The emergence of multidrug-resistant and extensively drug-resistant TB is making control of TB more difficult ...
Marco P. La Manna, Marco P. La Manna, Valentina Orlando, Valentina Orlando, Bartolo Tamburini, Bartolo Tamburini, Giusto D. Badami, Giusto D. Badami, Francesco Dieli, Francesco Dieli, Nadia Caccamo, Nadia Caccamo   +11 more
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Exploring the role of unconventional T cells in rheumatoid arthritis

Frontiers in Immunology
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by sustained synovial inflammation and the gradual destruction of joint structures.
Tangqing Xu, Hao Cai, Jianye Liu, Xingxing Mao, Yulong Chen, Minhao Chen, Youhua Wang   +6 more
doaj   +3 more sources

Unconventional T cells and kidney disease [PDF]

Nature Reviews Nephrology, 2021
Unconventional T cells are a diverse and underappreciated group of relatively rare lymphocytes that are distinct from conventional CD4+ and CD8+ T cells, and that mainly recognize antigens in the absence of classical restriction through the major histocompatibility complex (MHC).
Hannah Kaminski, Lionel Couzi, Matthias Eberl   +2 more
openaire   +2 more sources

A novel unconventional T cell population enriched in Crohn's disease. [PDF]

Gut, 2022
Objective One of the current hypotheses to explain the proinflammatory immune response in IBD is a dysregulated T cell reaction to yet unknown intestinal antigens. As such, it may be possible to identify disease-associated T cell clonotypes by analysing the peripheral and intestinal T-cell receptor (TCR ...
Rosati E, Rios Martini G, Pogorelyy MV, Minervina AA, Degenhardt F, Wendorff M, Sari S, Mayr G, Fazio A, Dowds CM, Hauser C, Tran F, von Schönfels W, Pochhammer J, Salnikova MA, Jaeckel C, Gigla JB, Sabet SS, Hübenthal M, Schiminsky E, Schreiber S, Rosenstiel PC, Scheffold A, Thomas PG, Lieb W, Bokemeyer B, Witte M, Aden K, Hendricks A, Schafmayer C, Egberts JH, Mamedov IZ, Bacher P, Franke A.   +33 more
europepmc   +3 more sources

The role of unconventional T cells in COVID-19 [PDF]

Irish Journal of Medical Science (1971 -), 2021
AbstractCOVID-19 is a respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first documented in late 2019, but within months, a worldwide pandemic was declared due to the easily transmissible nature of the virus.
Kristen Orumaa, Margaret R. Dunne
openaire   +3 more sources

Mobilizing unconventional T cells [PDF]

Science, 2019
Modulating unconventional antigen presentation could treat infections and ...
Ottenhoff, T.H.M., Joosten, S.A.
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The dialogue between unconventional T cells and the microbiota [PDF]

Mucosal Immunology, 2020
The mammalian immune system is equipped with unconventional T cells that respond to microbial molecules such as glycolipids and small-molecule metabolites, which are invisible to conventional CD4 and CD8 T cells. Unconventional T cells include invariant natural killer T (iNKT) cells and mucosa-associated invariant T (MAIT) cells, which are involved in ...
Qiaochu Lin, Meggie Kuypers, Dana J. Philpott, Thierry Mallevaey   +3 more
openaire   +2 more sources

Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells. [PDF]

PLoS Pathogens, 2006
Control of virus infection is mediated in part by major histocompatibility complex (MHC) Class Ia presentation of viral peptides to conventional CD8 T cells.
Douglas C Braaten, James Scott McClellan, Ilhem Messaoudi, Scott A Tibbetts, Kelly B McClellan, Janko Nikolich-Zugich, Herbert W Virgin   +6 more
doaj   +2 more sources

An Unconventional View of T Cell Reconstitution After Allogeneic Hematopoietic Cell Transplantation

Frontiers in Oncology, 2021
Allogeneic hematopoietic cell transplantation (allo-HCT) is performed as curative-intent therapy for hematologic malignancies and non-malignant hematologic, immunological and metabolic disorders, however, its broader implementation is limited by high ...
Hana Andrlová, Marcel R. M. van den Brink, Marcel R. M. van den Brink, Marcel R. M. van den Brink, Kate A. Markey, Kate A. Markey   +5 more
doaj   +1 more source