Results 31 to 40 of about 31,798 (239)

Workflow for high-dimensional flow cytometry analysis of T cells from tumor metastases

Life Science Alliance, 2022
We describe an improved method for the high-dimensional flow cytometry analysis of conventional and rare unconventional T cells infiltrating tumor liver metastases.
Cristina Faccani, Gianluca Rotta, Francesca Clemente, Maya Fedeli, Danilo Abbati, Francesco Manfredi, Alessia Potenza, Achille Anselmo, Federica Pedica, Guido Fiorentini, Chiara Villa, Maria P Protti, Claudio Doglioni, Luca Aldrighetti, Chiara Bonini, Giulia Casorati, Paolo Dellabona, Claudia de Lalla   +17 more
doaj   +1 more source

The accumulation of Vγ4 T cells with aging is associated with an increased adaptive Vγ4 T cell response after foodborne Listeria monocytogenes infection of mice

Immunity & Ageing, 2022
Background It is generally accepted that aging has detrimental effects on conventional T cell responses to systemic infections. However, most pathogens naturally invade the body through mucosal barriers.
Camille Khairallah, Timothy H. Chu, Zhijuan Qiu, Jessica N. Imperato, Daniella Yang, Brian S. Sheridan   +5 more
doaj   +1 more source

Immunological effects of nivolumab immunotherapy in patients with oral cavity squamous cell carcinoma

BMC Cancer, 2020
Background Although checkpoint blockades have become widely used, the immunological impact in cancer patients, especially those with oral cavity squamous cell carcinoma (OCSCC), has not been well studied.
Ying Xiong, David M. Neskey, Joshua D. Horton, Chrystal M. Paulos, Hannah M. Knochelmann, Kent E. Armeson, M. Rita I. Young   +6 more
doaj   +1 more source

Comprehensive Analysis of the ILCs and Unconventional T Cells in Virus Infection: Profiling and Dynamics Associated with COVID-19 Disease for a Future Monitoring System and Therapeutic Opportunities

Cells, 2022
This review is a comprehensive analysis of the effects of SARS-CoV-2 infection on Unconventional T cells and innate lymphoid cells (ILCs). COVID-19 affected patients show dysregulation of their adaptive immune systems, but many questions remain unsolved ...
Elena Lo Presti, Andrea De Gaetano, Giovanni Pioggia, Sebastiano Gangemi   +3 more
doaj   +1 more source

Casting a wider net: Immunosurveillance by nonclassical MHC molecules.

PLoS Pathogens, 2019
Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a
M Patricia D'Souza, Erin Adams, John D Altman, Michael E Birnbaum, Cesar Boggiano, Giulia Casorati, Yueh-Hsiu Chien, Anthony Conley, Sidonia Barbara Guiomar Eckle, Klaus Früh, Timothy Gondré-Lewis, Namir Hassan, Huang Huang, Lakshmi Jayashankar, Anne G Kasmar, Nina Kunwar, Judith Lavelle, David M Lewinsohn, Branch Moody, Louis Picker, Lakshmi Ramachandra, Nilabh Shastri, Peter Parham, Andrew J McMichael, Jonathan W Yewdell   +24 more
doaj   +1 more source

Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections

Frontiers in Immunology, 2021
Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor (TCR) α chain and are restricted by the highly conserved antigen presenting molecule MR1.
Matthew D. Edmans, Matthew D. Edmans, Timothy K. Connelley, Siddharth Jayaraman, Christina Vrettou, Martin Vordermeier, Martin Vordermeier, Jeffrey Y. W. Mak, Jeffrey Y. W. Mak, Ligong Liu, Ligong Liu, Ligong Liu, David P. Fairlie, David P. Fairlie, David P. Fairlie, Emmanuel Atangana Maze, Tiphany Chrun, Paul Klenerman, Sidonia B. G. Eckle, Elma Tchilian, Lindert Benedictus, Lindert Benedictus   +21 more
doaj   +1 more source

Re-Evaluating Human Cytomegalovirus Vaccine Design: Prediction of T Cell Epitopes

Vaccines, 2023
HCMV vaccine development has traditionally focused on viral antigens identified as key targets of neutralizing antibody (NAb) and/or T cell responses in healthy adults with chronic HCMV infection, such as glycoprotein B (gB), the glycoprotein H-anchored ...
Peter A. Barry, Smita S. Iyer, Laura Gibson   +2 more
doaj   +1 more source

Intracellular radar: Understanding γδ T cell immune surveillance and implications for clinical strategies in oncology

Frontiers in Oncology, 2022
T cells play a key role in anticancer immunity, with responses mediated through a diversity of αβ or γδ T cell receptors. Although αβ and γδ T cells stem from common thymic precursors, the development and subsequent biological roles of these two subsets ...
Anne B. C. Cherry, Nicholas A. Gherardin, Hafiz I. Sikder   +2 more
doaj   +1 more source

Graft-infiltrating host dendritic cells play a key role in organ transplant rejection

Nature Communications, 2016
Blocking T cell activation in organ transplantation is important to prevent rejection. Here the authors show that unconventional monocyte-derived host dendritic cells enter allogeneic grafts to amplify the T cell response outside lymph nodes.
Quan Zhuang, Quan Liu, Sherrie J. Divito, Qiang Zeng, Karim M. Yatim, Andrew D. Hughes, Darling M. Rojas-Canales, A. Nakao, William J. Shufesky, Amanda L. Williams, Rishab Humar, Rosemary A. Hoffman, Warren D. Shlomchik, Martin H. Oberbarnscheidt, Fadi G. Lakkis, Adrian E. Morelli   +15 more
doaj   +1 more source

Tumor Lipids of Pediatric Papillary Renal Cell Carcinoma Stimulate Unconventional T Cells

Frontiers in Immunology, 2020
Papillary renal cell carcinoma (PRCC) is a rare entity in children with no established therapy protocols for advanced diseases. Immunotherapy is emerging as an important therapeutic tool for childhood cancer.
Nadine Lehmann, Nadine Lehmann, Claudia Paret, Claudia Paret, Khalifa El Malki, Khalifa El Malki, Alexandra Russo, Alexandra Russo, Marie Astrid Neu, Marie Astrid Neu, Arthur Wingerter, Arthur Wingerter, Larissa Seidmann, Sebastian Foersch, Nicole Ziegler, Nicole Ziegler, Lea Roth, Lea Roth, Nora Backes, Nora Backes, Roger Sandhoff, Joerg Faber, Joerg Faber   +22 more
doaj   +1 more source