Results 41 to 50 of about 29,272 (220)

Die Kämpfe únd schláchten—the struggles and battles of innate-like effector T lymphocytes with microbes

Frontiers in Immunology, 2023
The large majority of lymphocytes belong to the adaptive immune system, which are made up of B2 B cells and the αβ T cells; these are the effectors in an adaptive immune response.
Sebastian Joyce, Sebastian Joyce, Gosife Donald Okoye, John P. Driver   +3 more
doaj   +1 more source

Where do MAIT cells fit in the family of unconventional T cells?

PLoS Biology, 2009
Mucosal-associated invariant T cells are newly identified subpopulation of T cells. A new study highlights their developmental pathway and functional features that allow these cells to assume a unique position in the family of unconventional T cells.
Laurent Gapin
doaj   +3 more sources

ZBTB Transcription Factors: Key Regulators of the Development, Differentiation and Effector Function of T Cells

Frontiers in Immunology, 2021
The development and differentiation of T cells represents a long and highly coordinated, yet flexible at some points, pathway, along which the sequential and dynamic expressions of different transcriptional factors play prominent roles at multiple steps.
Zhong-Yan Cheng, Ting-Ting He, Xiao-Ming Gao, Ying Zhao, Jun Wang   +4 more
doaj   +1 more source

Effects of BCG vaccination on donor unrestricted T cells in two prospective cohort studies

EBioMedicine, 2022
Summary: Background: Non-protein antigen classes can be presented to T cells by near-monomorphic antigen-presenting molecules such as CD1, MR1, and butyrophilin 3A1.
Anele Gela, Melissa Murphy, Miguel Rodo, Kate Hadley, Willem A. Hanekom, W.Henry Boom, John L. Johnson, Daniel F. Hoft, Simone A. Joosten, Tom H.M. Ottenhoff, Sara Suliman, D.Branch Moody, David M. Lewinsohn, Mark Hatherill, Chetan Seshadri, Elisa Nemes, Thomas J. Scriba, Libby Briel, Hellen Veldtsman, Nondumiso Khomba, Bernadette Pienaar, Hadn Africa, Marcia Steyn   +22 more
doaj   +1 more source

Casting a wider net: Immunosurveillance by nonclassical MHC molecules.

PLoS Pathogens, 2019
Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a
M Patricia D'Souza, Erin Adams, John D Altman, Michael E Birnbaum, Cesar Boggiano, Giulia Casorati, Yueh-Hsiu Chien, Anthony Conley, Sidonia Barbara Guiomar Eckle, Klaus Früh, Timothy Gondré-Lewis, Namir Hassan, Huang Huang, Lakshmi Jayashankar, Anne G Kasmar, Nina Kunwar, Judith Lavelle, David M Lewinsohn, Branch Moody, Louis Picker, Lakshmi Ramachandra, Nilabh Shastri, Peter Parham, Andrew J McMichael, Jonathan W Yewdell   +24 more
doaj   +1 more source

Workflow for high-dimensional flow cytometry analysis of T cells from tumor metastases

Life Science Alliance, 2022
We describe an improved method for the high-dimensional flow cytometry analysis of conventional and rare unconventional T cells infiltrating tumor liver metastases.
Cristina Faccani, Gianluca Rotta, Francesca Clemente, Maya Fedeli, Danilo Abbati, Francesco Manfredi, Alessia Potenza, Achille Anselmo, Federica Pedica, Guido Fiorentini, Chiara Villa, Maria P Protti, Claudio Doglioni, Luca Aldrighetti, Chiara Bonini, Giulia Casorati, Paolo Dellabona, Claudia de Lalla   +17 more
doaj   +1 more source

An Unconventional View of T Cell Reconstitution After Allogeneic Hematopoietic Cell Transplantation

Frontiers in Oncology, 2021
Allogeneic hematopoietic cell transplantation (allo-HCT) is performed as curative-intent therapy for hematologic malignancies and non-malignant hematologic, immunological and metabolic disorders, however, its broader implementation is limited by high ...
Hana Andrlová, Marcel R. M. van den Brink, Marcel R. M. van den Brink, Marcel R. M. van den Brink, Kate A. Markey, Kate A. Markey   +5 more
doaj   +1 more source

Functional phenotyping of circulating human cytotoxic T cells and NK cells using a 16-color flow cytometry panel

STAR Protocols, 2022
Summary: Cytotoxic T lymphocytes and natural killer (NK) cells are key effector cells in immune defenses against intracellular pathogens and cancer. In human blood, effector T and NK cytotoxic cells comprise a diverse and relatively rare group of cells ...
Gisele V. Baracho, Nihan Kara, Stephanie Rigaud, Evelyn Lo, Stephanie J. Widmann, Aaron J. Tyznik   +5 more
doaj   +1 more source

Vγ9Vδ2 T-cell immunotherapy in blood cancers: ready for prime time?

Frontiers in Immunology, 2023
In the last years, the tumor microenvironment (TME) has emerged as a promising target for therapeutic interventions in cancer. Cancer cells are highly dependent on the TME to growth and evade the immune system.
Claudia Giannotta, Federica Autino, Massimo Massaia, Massimo Massaia   +3 more
doaj   +1 more source

Simultaneous Enhancement of Performance and Stability in Dual‐Gate a‐IGZO Thin‐Film Transistors via Single‐Step Laser Annealing for Capacitor‐Less DRAM

Advanced Functional Materials, EarlyView.
A single‐step laser annealing strategy is presented for dual‐gate a‐IGZO TFTs. The steep thermal gradient induces graded oxygen doping in the channel and simultaneous WOx removal at the contacts, enabling concurrent interface and contact engineering.
Sihyeon Kwon, Junil Kim, Geuntae Park, Minseok Kim, Woohyun Hwang, Wanki Kim, Daewon Ha, Byeongmoon Lee, Jae Eun Jang, Hyuk‐Jun Kwon   +9 more
wiley   +1 more source