Results 21 to 30 of about 29,177 (237)

Unconventional T cells in colon adenocarcinomas [PDF]

, 2023
Many factors influence the initiation and growth of tumours. The infiltration and activity of immune cells in the tumour microenvironment are widely recognised as key factors affecting the clinical outcome of cancer. In this context, conventional T cells
Rodin, William
core   +4 more sources

Hypersensitivities following allergen antigen recognition by unconventional T cells. [PDF]

Allergy, 2020
Conventional T cells recognise protein-derived antigens in the context of major histocompatibility complex (MHC) class Ia and class II molecules and provide anti-microbial and anti-tumour immunity.
de Lima Moreira M, Souter MNT, Chen Z, Loh L, McCluskey J, Pellicci DG, Eckle SBG.   +6 more
europepmc   +2 more sources

Tumor Lipids of Pediatric Papillary Renal Cell Carcinoma Stimulate Unconventional T Cells [PDF]

Frontiers in Immunology, 2020
Papillary renal cell carcinoma (PRCC) is a rare entity in children with no established therapy protocols for advanced diseases. Immunotherapy is emerging as an important therapeutic tool for childhood cancer.
Nadine Lehmann, Nadine Lehmann, Claudia Paret, Claudia Paret, Khalifa El Malki, Khalifa El Malki, Alexandra Russo, Alexandra Russo, Marie Astrid Neu, Marie Astrid Neu, Arthur Wingerter, Arthur Wingerter, Larissa Seidmann, Sebastian Foersch, Nicole Ziegler, Nicole Ziegler, Lea Roth, Lea Roth, Nora Backes, Nora Backes, Roger Sandhoff, Joerg Faber, Joerg Faber   +22 more
doaj   +2 more sources

MAITs and their mates: "Innate-like" behaviors in conventional and unconventional T cells. [PDF]

Clin Exp Immunol, 2023
Most CD4 and CD8 T cells are restricted by conventional major histocompatibility complex (MHC) molecules and mount TCR-dependent adaptive immune responses.
Hackstein CP, Klenerman P.
europepmc   +2 more sources

Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity [PDF]

Journal of Immunology Research, 2021
Recently, cell-mediated immune response in malignant neoplasms has become the focus in immunotherapy against cancer. However, in leukemia, most studies on the cytotoxic potential of T cells have concentrated only on T cells that recognize peptide ...
Nilberto Dias de Araújo, Fábio Magalhães Gama, Mateus de Souza Barros, Thaís Lohana Pereira Ribeiro, Fabíola Silva Alves, Lilyane Amorim Xabregas, Andréa Monteiro Tarragô, Adriana Malheiro, Allyson Guimarães Costa   +8 more
doaj   +2 more sources

Unconventional T Cell Targets for Cancer Immunotherapy [PDF]

Immunity, 2018
Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility complex (MHC) class I and MHC class II molecules, respectively. However,
Jérôme Le Nours, Le Nours, Jérôme, Dale I. Godfrey, Rossjohn, Jamie, Jamie Rossjohn, Uldrich, Adam P., Adam P. Uldrich, Godfrey, Dale I., Andrews, Daniel M., Daniel M. Andrews   +9 more
core   +4 more sources

Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling. [PDF]

J Exp Med
Unconventional T cells, including mucosal-associated invariant T (MAIT), natural killer T (NKT), and gamma-delta T (γδT) cells, comprise distinct T-bet+, IFN-γ+ and RORγt+, IL-17+ subsets which play differential roles in health and disease.
Xu C, Obers A, Qin M, Brandli A, Wong J, Huang X, Clatch A, Fayed A, Starkey G, D'Costa R, Gordon CL, Mak JYW, Fairlie DP, Beattie L, Mackay LK, Godfrey DI, Koay HF.   +16 more
europepmc   +2 more sources

Immuno-antibiotics: targeting microbial metabolic pathways sensed by unconventional T cells. [PDF]

Immunother Adv, 2021
Human Vγ9/Vδ2 T cells, mucosal-associated invariant T (MAIT) cells and other unconventional T cells are specialised in detecting microbial metabolic pathway intermediates that are absent in humans.
Eberl M, Oldfield E, Herrmann T.
europepmc   +2 more sources

Patients With Immunoglobulin A Nephropathy Show Abnormal Frequencies of B Cell Subsets, Unconventional T Cells, and High Levels of Galactose-Deficient IgA1–Coated Gut Bacteria [PDF]

Kidney International Reports
Introduction: Mucosal inflammation is involved in the pathophysiology of immunoglobulin-A nephropathy (IgAN); however, peripheral immune phenotype analyses of patients with IgAN often do not include unconventional T cells, the major subset in mucosal ...
Micaela Gentile, Nina Goerlich, I-Ju Lo, N. Eric Olson, Mark McConnell, Johannes Pospiech, Tobias Bohnenpoll, Philipp Skroblin, Olivier Radresa, Uwe Andag, Kirk N. Campbell, Kristin Meliambro, Luis Sanchez-Russo, Alberto Verlato, Enrico Fiaccadori, Seunghee Kim-Schulze, Maria Lanau, M. Loreto Fernandez-Lorente, Miguel Fribourg, Joaquin Manrique, Paolo Cravedi   +20 more
doaj   +2 more sources

Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients. [PDF]

J Exp Med, 2020
International audienceCOVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology.
Jouan Y, Guillon A, Gonzalez L, Perez Y, Boisseau C, Ehrmann S, Ferreira M, Daix T, Jeannet R, François B, Dequin PF, Si-Tahar M, Baranek T, Paget C.   +13 more
europepmc   +2 more sources