Results 61 to 70 of about 29,177 (237)

ZBTB Transcription Factors: Key Regulators of the Development, Differentiation and Effector Function of T Cells

Frontiers in Immunology, 2021
The development and differentiation of T cells represents a long and highly coordinated, yet flexible at some points, pathway, along which the sequential and dynamic expressions of different transcriptional factors play prominent roles at multiple steps.
Zhong-Yan Cheng, Ting-Ting He, Xiao-Ming Gao, Ying Zhao, Jun Wang   +4 more
doaj   +1 more source

Effects of BCG vaccination on donor unrestricted T cells in two prospective cohort studies

EBioMedicine, 2022
Summary: Background: Non-protein antigen classes can be presented to T cells by near-monomorphic antigen-presenting molecules such as CD1, MR1, and butyrophilin 3A1.
Anele Gela, Melissa Murphy, Miguel Rodo, Kate Hadley, Willem A. Hanekom, W.Henry Boom, John L. Johnson, Daniel F. Hoft, Simone A. Joosten, Tom H.M. Ottenhoff, Sara Suliman, D.Branch Moody, David M. Lewinsohn, Mark Hatherill, Chetan Seshadri, Elisa Nemes, Thomas J. Scriba, Libby Briel, Hellen Veldtsman, Nondumiso Khomba, Bernadette Pienaar, Hadn Africa, Marcia Steyn   +22 more
doaj   +1 more source

Workflow for high-dimensional flow cytometry analysis of T cells from tumor metastases

Life Science Alliance, 2022
We describe an improved method for the high-dimensional flow cytometry analysis of conventional and rare unconventional T cells infiltrating tumor liver metastases.
Cristina Faccani, Gianluca Rotta, Francesca Clemente, Maya Fedeli, Danilo Abbati, Francesco Manfredi, Alessia Potenza, Achille Anselmo, Federica Pedica, Guido Fiorentini, Chiara Villa, Maria P Protti, Claudio Doglioni, Luca Aldrighetti, Chiara Bonini, Giulia Casorati, Paolo Dellabona, Claudia de Lalla   +17 more
doaj   +1 more source

Casting a wider net: Immunosurveillance by nonclassical MHC molecules.

PLoS Pathogens, 2019
Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a
M Patricia D'Souza, Erin Adams, John D Altman, Michael E Birnbaum, Cesar Boggiano, Giulia Casorati, Yueh-Hsiu Chien, Anthony Conley, Sidonia Barbara Guiomar Eckle, Klaus Früh, Timothy Gondré-Lewis, Namir Hassan, Huang Huang, Lakshmi Jayashankar, Anne G Kasmar, Nina Kunwar, Judith Lavelle, David M Lewinsohn, Branch Moody, Louis Picker, Lakshmi Ramachandra, Nilabh Shastri, Peter Parham, Andrew J McMichael, Jonathan W Yewdell   +24 more
doaj   +1 more source

An Unconventional View of T Cell Reconstitution After Allogeneic Hematopoietic Cell Transplantation

Frontiers in Oncology, 2021
Allogeneic hematopoietic cell transplantation (allo-HCT) is performed as curative-intent therapy for hematologic malignancies and non-malignant hematologic, immunological and metabolic disorders, however, its broader implementation is limited by high ...
Hana Andrlová, Marcel R. M. van den Brink, Marcel R. M. van den Brink, Marcel R. M. van den Brink, Kate A. Markey, Kate A. Markey   +5 more
doaj   +1 more source

Unraveling Molecular Mechanisms Underlying the Development of Unconventional T Cells

, 2020
The thymus supports and guides the generation of a diverse repertoire of mature T cells from precursors derived from the bone marrow. In addition to conventional CD4 and CD8 T cells, innate-like T cells also develop in the thymus and share features of ...
Bastardo Blanco, Daniel Eduardo
core   +1 more source

Functional phenotyping of circulating human cytotoxic T cells and NK cells using a 16-color flow cytometry panel

STAR Protocols, 2022
Summary: Cytotoxic T lymphocytes and natural killer (NK) cells are key effector cells in immune defenses against intracellular pathogens and cancer. In human blood, effector T and NK cytotoxic cells comprise a diverse and relatively rare group of cells ...
Gisele V. Baracho, Nihan Kara, Stephanie Rigaud, Evelyn Lo, Stephanie J. Widmann, Aaron J. Tyznik   +5 more
doaj   +1 more source

A novel unconventional T cell population enriched in Crohn’s disease

Gut, 2022
Objective One of the current hypotheses to explain the proinflammatory immune response in IBD is a dysregulated T cell reaction to yet unknown intestinal antigens. As such, it may be possible to identify disease-associated T cell clonotypes by analysing the peripheral and intestinal T-cell receptor (TCR ...
Elisa Rosati, Gabriela Rios Martini, Mikhail V Pogorelyy, Anastasia A Minervina, Frauke Degenhardt, Mareike Wendorff, Soner Sari, Gabriele Mayr, Antonella Fazio, Christel Marie Dowds, Charlotte Hauser, Florian Tran, Witigo von Schönfels, Julius Pochhammer, Maria A Salnikova, Charlot Jaeckel, Johannes Boy Gigla, Sanaz Sedghpour Sabet, Matthias Hübenthal, Esther Schiminsky, Stefan Schreiber, Philip C Rosenstiel, Alexander Scheffold, Paul G Thomas, Wolfgang Lieb, Bernd Bokemeyer, Maria Witte, Konrad Aden, Alexander Hendricks, Clemens Schafmayer, Jan-Hendrick Egberts, Ilgar Z Mamedov, Petra Bacher, Andre Franke   +33 more
openaire   +2 more sources

Vγ9Vδ2 T-cell immunotherapy in blood cancers: ready for prime time?

Frontiers in Immunology, 2023
In the last years, the tumor microenvironment (TME) has emerged as a promising target for therapeutic interventions in cancer. Cancer cells are highly dependent on the TME to growth and evade the immune system.
Claudia Giannotta, Federica Autino, Massimo Massaia, Massimo Massaia   +3 more
doaj   +1 more source

Human neutrophil clearance of bacterial pathogens triggers anti-microbial gamma delta T cell responses in early infection

, 2011
Human blood Vc9/Vd2 T cells, monocytes and neutrophils share a responsiveness toward inflammatory chemokines and are rapidly recruited to sites of infection.
Davey Martin S., Toleman Mark A., Davey, Martin S, Parish, T., Simon J. Davies, Gareth W Roberts, Williams, John David, Parish, T, Johnson, David W, John D Williams, David W Johnson, Davies, S. J., Tanya Parish, Brown, A. C., James A Chess, Chess, James Anthony, Johnson, D. W., Gareth W. Roberts, Lin Chan-Yu, Martin S. Davey, Heuston, Sinead, Toleman, Mark A., Heuston Sinéad, Cormac G. M. Gahan, Amanda C Brown, Martin S Davey, Johnson, David Westley, Roberts Gareth W., Gahan Cormac G. M., Davey, MS, Eberl, M, Gahan, C. G. M., Parish, Tanya, Chess, James A, Davies, Simon J, Hill, C., Moser Bernhard, Gahan, Cormac G M, James A. Chess, Williams, John D., Amanda C. Brown, Heuston, S., Brown, Amanda C., Moser, B, Brown, Amanda C, Davey, Martin S., Roberts, Gareth W., Johnson, David W., Toleman, MA, Toleman, Mark A, Davies Simon J., Gahan, CGM, David W. Johnson, Topley, N, Williams, John D, Bernhard Moser, Parish Tanya, Gahan, Cormac G., Topley Nicholas, Chess, JA, Moser, Bernhard, Williams, JD, Heuston, S, Johnson David W., Chess, James A., Gahan, Cormac G. M., Simon J Davies, Topley, Nicholas, Brown, AC, Hill Colin, Hill, C, Eberl, Matthias, Brown Amanda C., Davies, SJ, Mark A. Toleman, Cormac G M Gahan, Eberl Matthias, Mark A Toleman, Nicholas Topley, Hill, Colin, Chan-Yu Lin, Colin Hill, Toleman, Mark Alexander Howard, Roberts, GW, Lin, CY, Johnson, DW, Chess James A., Lin, Chan-Yu, Williams John D., Davies, Simon J., John D. Williams, Sinéad Heuston, Roberts, Gareth W, Matthias Eberl   +93 more
core   +1 more source