Results 61 to 70 of about 102,674 (250)

A Novel Peptide-Based SILAC Method to Identify the Posttranslational Modifications Provides Evidence for Unconventional Ubiquitination in the ER-Associated Degradation Pathway. [PDF]

, 2013
The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for disposing misfolded proteins from the endoplasmic reticulum by inducing their ubiquitination and degradation.
Anania, Veronica, Bustos, Daisy, COSCOY, Laurent, Kirkpatrick, Donald, Lill, Jennie   +4 more
core   +3 more sources

Vγ9Vδ2 T-cell immunotherapy in blood cancers: ready for prime time?

Frontiers in Immunology, 2023
In the last years, the tumor microenvironment (TME) has emerged as a promising target for therapeutic interventions in cancer. Cancer cells are highly dependent on the TME to growth and evade the immune system.
Claudia Giannotta, Federica Autino, Massimo Massaia, Massimo Massaia   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Unconventional T Cell Immunity in the Lungs of Young Children with Cystic Fibrosis

Frontiers in Bioscience-Landmark, 2022
Background: People with Cystic Fibrosis (CF) develop pulmonary inflammation, chronic infection and structural lung damage early in life, with these manifestations being prevalent among preschool children and infants.
Rebecca McElroy, Ghazal Alipour Talesh, Christopher M. Harpur, Rosemary Carzino, Alexandra J. Corbett, Daniel G. Pellicci, Sarath Ranganathan, Philip Sutton   +7 more
doaj   +1 more source

Disorder promotes ferromagnetism: Rounding of the quantum phase transition in Sr_{1-x}Ca_xRuO_3 [PDF]

, 2012
The subtle interplay of randomness and quantum fluctuations at low temperatures gives rise to a plethora of unconventional phenomena in systems ranging from quantum magnets and correlated electron materials to ultracold atomic gases.
B. Dóra, C. Svoboda, D. Nozadze, F. Hrahsheh, H. Yamada, I. Kézsmárki, L. Demkó, M. Kawasaki, S. Bordács, S. Sachdev, T. Vojta, Y. Tokura   +11 more
core   +3 more sources

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

Maze solvers demystified and some other thoughts

, 2017
There is a growing interest towards implementation of maze solving in spatially-extended physical, chemical and living systems. Several reports of prototypes attracted great publicity, e.g.
A Adamatzky, A Adamatzky, A Adamatzky, A Adamatzky, AD Moore, AD Moore, AD Moore, Alexander E. Dubinov, Andrew Adamatzky, Aswathi Nair, C Scherber, CY Lee, D Tolmachiev, DR Reyes, F Rubin, HS Hele-Shaw, HS Hele-Shaw, I Lagzi, Jitka Čejková, K Agladze, K Yokawa, Lionel Tarassenko, MH Dickinson, MJ Fuerstman, R McFee, Simon Ayrinhac   +25 more
core   +1 more source

A novel unconventional T cell population enriched in Crohn’s disease

Gut, 2022
Objective One of the current hypotheses to explain the proinflammatory immune response in IBD is a dysregulated T cell reaction to yet unknown intestinal antigens. As such, it may be possible to identify disease-associated T cell clonotypes by analysing the peripheral and intestinal T-cell receptor (TCR ...
Elisa Rosati, Gabriela Rios Martini, Mikhail V Pogorelyy, Anastasia A Minervina, Frauke Degenhardt, Mareike Wendorff, Soner Sari, Gabriele Mayr, Antonella Fazio, Christel Marie Dowds, Charlotte Hauser, Florian Tran, Witigo von Schönfels, Julius Pochhammer, Maria A Salnikova, Charlot Jaeckel, Johannes Boy Gigla, Sanaz Sedghpour Sabet, Matthias Hübenthal, Esther Schiminsky, Stefan Schreiber, Philip C Rosenstiel, Alexander Scheffold, Paul G Thomas, Wolfgang Lieb, Bernd Bokemeyer, Maria Witte, Konrad Aden, Alexander Hendricks, Clemens Schafmayer, Jan-Hendrick Egberts, Ilgar Z Mamedov, Petra Bacher, Andre Franke   +33 more
openaire   +2 more sources

Control of Polarization and Polar Helicity in BiFeO3 by Epitaxial Strain and Interfacial Chemistry

Advanced Functional Materials, EarlyView.
In BiFeO3 thin films, the interplay of interfacial chemistry, electrostatics, and epitaxial strain is engineered to stabilize homohelicity in polarization textures at the domain scale. The synergistic use of a Bi2O2‐terminated Aurivillius buffer layer and a highly anisotropic compressive epitaxial strain offers new routes to control the polar‐texture ...
Elzbieta Gradauskaite, Lilia Huynh, Natascha Gray, Quintin N. Meier, Marta D. Rossell, Morgan Trassin   +5 more
wiley   +1 more source

The accumulation of Vγ4 T cells with aging is associated with an increased adaptive Vγ4 T cell response after foodborne Listeria monocytogenes infection of mice

Immunity & Ageing, 2022
Background It is generally accepted that aging has detrimental effects on conventional T cell responses to systemic infections. However, most pathogens naturally invade the body through mucosal barriers.
Camille Khairallah, Timothy H. Chu, Zhijuan Qiu, Jessica N. Imperato, Daniella Yang, Brian S. Sheridan   +5 more
doaj   +1 more source