Results 11 to 20 of about 10,037 (206)

Biological functions and therapeutic applications of human mucosal-associated invariant T cells [PDF]

Journal of Biomedical Science
Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T lymphocytes that bridge innate and adaptive immunity. Characterized by their semi-invariant T cell receptor (TCR) and abundant localization in mucosal tissues, MAIT cells ...
Ying Fang, Yuning Chen, Siyue Niu, Zibai Lyu, Yanxin Tian, Xinyuan Shen, Yan-Ruide Li, Lili Yang   +7 more
doaj   +2 more sources

IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells [PDF]

iScience
Summary: IL-23 signaling plays a key role in the pathogenesis of chronic inflammatory and infectious diseases, yet the cellular targets and signaling pathways affected by this cytokine remain poorly understood.
Laetitia Camard, Tharshana Stephen, Hanane Yahia-Cherbal, Vincent Guillemot, Sébastien Mella, Victoire Baillet, Hélène Lopez-Maestre, Daniele Capocefalo, Laura Cantini, Claire Leloup, Julie Marsande, Katherine Garro, Juan Sienes Bailo, Ambre Dangien, Natalia Pietrosemoli, Milena Hasan, Huimeng Wang, Sidonia B.G. Eckle, Anne M. Fourie, Carrie Greving, Barbara Joyce-Shaikh, Raphaelle Parker, Daniel J. Cua, Elisabetta Bianchi, Lars Rogge   +24 more
doaj   +2 more sources

Mucosal-associated invariant T cells for cancer immunotherapy. [PDF]

Mol Ther, 2023
Li YR, Zhou K, Wilson M, Wilson M, Kramer A, Zhu Y, Dawson N, Yang L.   +7 more
europepmc   +2 more sources

Human mucosal associated invariant T cells detect bacterially infected cells. [PDF]

PLoS Biology, 2010
Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution
Marielle C Gold, Stefania Cerri, Susan Smyk-Pearson, Meghan E Cansler, Todd M Vogt, Jacob Delepine, Ervina Winata, Gwendolyn M Swarbrick, Wei-Jen Chua, Yik Y L Yu, Olivier Lantz, Matthew S Cook, Megan D Null, David B Jacoby, Melanie J Harriff, Deborah A Lewinsohn, Ted H Hansen, David M Lewinsohn   +17 more
doaj   +1 more source

The alterations of circulating mucosal-associated invariant T cells in polycystic ovary syndrome

Frontiers in Endocrinology, 2022
BackgroundPolycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting reproductive age females and an important cause of infertility.
Hong Zhou, Junting Xu, Ling Hong, Yanping Jia, Lilo Valerie Burk, Fengli Chi, Mei Zhao, Xiaohong Guan, Dan Liu, Xiangjie Yin, Yiqiao Zhang, Xiaoming Teng, Liyan Duan, Liyan Duan, Kunming Li   +14 more
doaj   +1 more source

ROLE OF MUCOSAL-ASSOCIATED INVARIANT T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2021
The etiology of inflammatory and autoimmune diseases is complex and not yet fully understood. Their pathogenesis includes mechanisms in which both innate and adaptive immune cells are involved. Mucosal-associated invariant T (MAIT) cells are immune cells
rehab mekkawy, Omnia El-badawy, Helal F. Hetta, Doaa K. Abd El-hafez, Khaled M. Hassanein   +4 more
doaj   +1 more source

Emerging Roles of Mucosal-Associated Invariant T Cells in Rheumatology

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells are an unconventional T cell subset expressing a semi-invariant TCR and recognize microbial riboflavin metabolites presented by major histocompatibility complex class 1-related molecule (MR1).
Yanmei Li, Jun Du, Wei Wei
doaj   +1 more source

Mucosal-Associated Invariant T Cells in Regenerative Medicine

Frontiers in Immunology, 2017
Although antibiotics to inhibit bacterial growth and small compounds to interfere with the productive life cycle of human immunodeficiency virus (HIV) have successfully been used to control HIV infection, the recent emergence of the drug-resistant ...
Hiroshi Wakao, Chie Sugimoto, Shinzo Kimura, Rika Wakao   +3 more
doaj   +1 more source

Mucosal-Associated Invariant T Cells in Autoimmune Diseases

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells are innate T cells restricted by MHC-related molecule 1 (MR1). MAIT cells express semi-invariant T-cell receptors TRAV1-2-TRAJ33/12/20 in humans and TRAV1-TRAJ33 in mice.
Asako Chiba, Goh Murayama, Sachiko Miyake   +2 more
doaj   +1 more source

Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients

Frontiers in Immunology, 2018
Recent studies have highlighted the heterogeneity of asthma. Distinct patient phenotypes (symptoms, age at onset, atopy, and lung function) may result from different pathogenic mechanisms, including airway inflammation, remodeling, and immune and ...
Guillaume Lezmi, Guillaume Lezmi, Guillaume Lezmi, Maria Leite-de-Moraes, Maria Leite-de-Moraes   +4 more
doaj   +1 more source