Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells [PDF]
Frontiers in Immunology, 2018 Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity.
Lucy C. Garner +3 more
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Mucosal-associated invariant T cells for cancer immunotherapy. [PDF]
Mol Ther, 2023 Human mucosal-associated invariant T (MAIT) cells are characterized by their expression of an invariant TCR α chain Vα7.2-Jα33/Jα20/Jα12 paired with a restricted TCR β chain. MAIT cells recognize microbial peptides presented by the highly conserved MHC class I-like molecule MR1 and bridge the innate and acquired immune systems to mediate augmented ...
Li YR +7 more
europepmc +5 more sources
Mucosal-Associated Invariant T Cells in Regenerative Medicine [PDF]
Frontiers in Immunology, 2017 Although antibiotics to inhibit bacterial growth and small compounds to interfere with the productive life cycle of human immunodeficiency virus (HIV) have successfully been used to control HIV infection, the recent emergence of the drug-resistant ...
Hiroshi Wakao +3 more
doaj +3 more sources
Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients [PDF]
Frontiers in Immunology, 2018 Recent studies have highlighted the heterogeneity of asthma. Distinct patient phenotypes (symptoms, age at onset, atopy, and lung function) may result from different pathogenic mechanisms, including airway inflammation, remodeling, and immune and ...
Guillaume Lezmi +4 more
doaj +3 more sources
The Immune Modulating Properties of Mucosal-Associated Invariant T Cells [PDF]
Frontiers in Immunology, 2020 Mucosal-associated invariant T (MAIT) cells are unconventional T lymphocytes that express a semi-invariant T cell receptor (TCR) recognizing microbial vitamin B metabolites presented by the highly conserved major histocompatibility complex (MHC) class I ...
Melina Ioannidis +2 more
doaj +4 more sources
Clostridioides difficile Activates Human Mucosal-Associated Invariant T Cells [PDF]
Frontiers in Microbiology, 2018 Clostridioides difficile infection (CDI) causes severe inflammatory responses at the intestinal mucosa but the immunological mechanisms underlying CDI-related immunopathology are still incompletely characterized.
Isabel Bernal +13 more
doaj +3 more sources
Emerging Roles of Mucosal-Associated Invariant T Cells in Rheumatology [PDF]
Frontiers in Immunology, 2022 Mucosal-associated invariant T (MAIT) cells are an unconventional T cell subset expressing a semi-invariant TCR and recognize microbial riboflavin metabolites presented by major histocompatibility complex class 1-related molecule (MR1).
Yanmei Li, Jun Du, Wei Wei
doaj +3 more sources
B cells modulate mucosal associated invariant T cell (MAIT) immune responses [PDF]
Frontiers in Immunology, 2014 A common finding when measuring T cell immunity to enteric bacterial vaccines in humans is the presence of background responses among individuals before immunization. Yet the nature of these background responses remains largely unknown. Recent findings
Rosangela eSalerno-Goncalves +2 more
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Mucosal‐Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets [PDF]
MedCommMucosal‐associated invariant T (MAIT) cells are a highly conserved population of immune cells that can be activated via the major histocompatibility complex class I‐related protein pathway or cytokine pathways, playing a central role in immune ...
Cheng Zhu +10 more
doaj +2 more sources
A shotgun proteomic dataset of human mucosal-associated invariant T cells [PDF]
Data in BriefMucosal-associated invariant T (MAIT) cells represent a unique unconventional T cell population important in eliciting immunomodulatory responses in a range of diseases, including infectious diseases, autoimmunity and cancer.
Harshi Weerakoon +3 more
doaj +2 more sources