Functions of mucosal associated invariant T cells in eye diseases [PDF]
Frontiers in ImmunologyMucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells
Chihiro Fukui +15 more
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A shotgun proteomic dataset of human mucosal-associated invariant T cells [PDF]
Data in BriefMucosal-associated invariant T (MAIT) cells represent a unique unconventional T cell population important in eliciting immunomodulatory responses in a range of diseases, including infectious diseases, autoimmunity and cancer.
Harshi Weerakoon +3 more
doaj +3 more sources
Herpes simplex virus type 1 impairs mucosal-associated invariant T cells [PDF]
mBioHerpes simplex virus type 1 (HSV-1) is a highly successful pathogen that infects mucosal sites and adopts an arsenal of strategies to manipulate host immunity.
Lauren Stern +11 more
doaj +3 more sources
The Immune Modulating Properties of Mucosal-Associated Invariant T Cells
Frontiers in Immunology, 2020 Mucosal-associated invariant T (MAIT) cells are unconventional T lymphocytes that express a semi-invariant T cell receptor (TCR) recognizing microbial vitamin B metabolites presented by the highly conserved major histocompatibility complex (MHC) class I ...
Melina Ioannidis +2 more
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Molecular insights into metabolite antigen recognition by mucosal-associated invariant T cells [PDF]
Curr Opin Immunol, 2023 Metabolite-based T-cell immunity is emerging as a major player in antimicrobial immunity, autoimmunity, and cancer. Here, small-molecule metabolites were identified to be captured and presented by the major histocompatibility complex class-I-related ...
Awad, W +4 more
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Clostridioides difficile Activates Human Mucosal-Associated Invariant T Cells [PDF]
Frontiers in Microbiology, 2018 Clostridioides difficile infection (CDI) causes severe inflammatory responses at the intestinal mucosa but the immunological mechanisms underlying CDI-related immunopathology are still incompletely characterized.
Isabel Bernal +13 more
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Estrogen Induced Regulation of Mucosal-Associated Invariant T Cells in Asthma [PDF]
Journal of Immunology ResearchAsthma affects over 300 million people worldwide, with increasing rates annually. Males have higher asthma prevalence in adolescence, while females exhibit higher rates in adulthood. Reduced mucosal-associated invariant T (MAIT) cells are found in severe
Shubhanshi Trivedi +9 more
doaj +2 more sources
The Role of Mucosal-Associated Invariant T Cells in Viral Infections and Their Function in Vaccine Development [PDF]
VaccinesMucosal-Associated Invariant T (MAIT) cells, which bridge innate and adaptive immunity, have emerged as an important player in viral infections despite their inability to directly recognize viral antigens. This review provides a comprehensive analysis of
Chie Sugimoto, Hiroshi Wakao
doaj +2 more sources
Mucosal associated invariant T cells: Powerhouses of the lung.
Immunol LettThe lungs face constant environmental challenges from harmless molecules, airborne pathogens and harmful agents that can damage the tissue. The lungs' immune system includes numerous tissue-resident lymphocytes that contribute to maintain tissue ...
P Barral (19450693) +1 more
core +2 more sources
Mucosal‐Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets [PDF]
MedCommMucosal‐associated invariant T (MAIT) cells are a highly conserved population of immune cells that can be activated via the major histocompatibility complex class I‐related protein pathway or cytokine pathways, playing a central role in immune ...
Cheng Zhu +10 more
doaj +2 more sources