Low mucosal-associated invariant T-cell number in peripheral blood of patients with immune thrombocytopenia and their response to prednisolone. [PDF]
PLoS ONE, 2018 Mucosal-associated invariant T (MAIT) cells help protect against certain infections and are related to some autoimmune diseases. Immune thrombocytopenia (ITP) is a relatively rare hematological autoimmune disease associated with low platelet count.
Takaaki Maekawa +11 more
doaj +1 more source
Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections
Frontiers in Immunology, 2021 Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor (TCR) α chain and are restricted by the highly conserved antigen presenting molecule MR1.
Matthew D. Edmans +21 more
doaj +1 more source
Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19
Frontiers in Immunology, 2021 BackgroundMucosal-associated invariant T (MAIT) cells are considered to participate of the host immune response against acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, single-cell transcriptomic profiling of MAIT ...
Jijing Shi +10 more
doaj +1 more source
Regulation and heterogeneity of human mucosal-associated invariant T (MAIT) cells in blood and liver
, 2021 Mucosal-associated invariant T (MAIT) cells are an abundant population of innate-like, effector memory T cells, that secrete proinflammatory cytokines and exhibit direct cytotoxic activity.
Garner, Lucy catherine
core +1 more source
Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells [PDF]
, 2022 OBJECTIVE Mucosal-associated invariant T (MAIT) cells are the most abundant T cells in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1.
Magdalena Filipowicz Sinnreich +45 more
core +1 more source
Frontiers in Immunology, 2017 Mucosal-associated invariant T (MAIT) cells are innate-like T cells which are important in the defense against certain bacteria and yeast. The reconstitution of MAIT cells after allogeneic hematopoietic stem cell transplantation (HSCT) is not known.
Martin Solders +8 more
doaj +1 more source
iNKT and MAIT Cell Alterations in Diabetes [PDF]
Frontiers in Immunology, 2015 Type 1 diabetes (T1D) and type 2 diabetes (T2D) are multifactorial diseases with different etiologies in which chronic inflammation takes place. Defects in invariant natural killer T (iNKT) cell populations have been reported in both T1D and T2D patients, mouse models and our recent study revealed mucosal-associated invariant T (MAIT) cell defects in ...
Magalhaes, Isabelle +2 more
openaire +4 more sources
Mucosal-associated invariant T (MAIT) cells produce growth factors and influence the regeneration of hepatic spheroids [PDF]
, 2022 openContesto: Il fegato è un importante sito immunologico che riceve prodotti batterici, tossine e antigeni di varia natura dal tratto gastrointestinale. Per operare una difesa efficace si basa principalmente su un solido sistema immunitario innato e il
TASIN, IRENE
core
Frontiers in Pharmacology, 2022 Background: Necrotizing enterocolitis (NEC) is a potentially fatal inflammatory gastrointestinal disease in preterm infants with unknown pathogenesis. Mucosal-associated invariant T (MAIT) cells primarily accumulate at sites where exposure to microbes is
Jiayi Tian +9 more
doaj +1 more source
Frequencies of Circulating MAIT Cells Are Diminished in Chronic HCV, HIV and HCV/HIV Co-Infection and Do Not Recover during Therapy. [PDF]
PLoS ONE, 2016 Mucosal-associated invariant T (MAIT) cells comprise a subpopulation of T cells that can be activated by bacterial products and cytokines to produce IFN-γ. Since little is known on MAIT cells during HCV infection, we compared their phenotype and function
Michelle Spaan +10 more
doaj +1 more source