Results 31 to 40 of about 12,530 (222)

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells [PDF]

, 2017
Mucosal-associated invariant T (MAIT) cells are activated by unstable antigens formed by reactions of 5-amino-6-D-ribitylaminouracil (a vitamin B2 biosynthetic intermediate) with glycolysis metabolites such as methylglyoxal.
Chen, Zhenjun, Corbett, Alexandra J., Fairlie, David P., Liu, Ligong, Mak, Jeffrey Y. W., McCluskey, James, Meehan, Bronwyn S., Reid, Robert C., Rossjohn, Jamie, Wang, Huimeng, Xu, Weijun   +10 more
core   +4 more sources

Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells, defined as CD161++TCR iVα7.2+ T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections.
Yean K. Yong, Yean K. Yong, Yean K. Yong, Alireza Saeidi, Hong Y. Tan, Hong Y. Tan, Hong Y. Tan, Hong Y. Tan, Mohamed Rosmawati, Philip F. Enström, Rami Al Batran, V. Vasuki, Indranil Chattopadhyay, Amudhan Murugesan, Ramachandran Vignesh, Adeeba Kamarulzaman, Adeeba Kamarulzaman, Jayakumar Rajarajeswaran, Abdul W. Ansari, Jamuna Vadivelu, James E. Ussher, Vijayakumar Velu, Marie Larsson, Esaki M. Shankar, Esaki M. Shankar, Esaki M. Shankar   +25 more
doaj   +1 more source

Mucosal-associated invariant T-cell frequency and function in blood and liver of HCV mono- and HCV/HIV co-infected patients with advanced fibrosis [PDF]

, 2017
__Background & Aims:__ Mucosal-associated invariant T (MAIT) cells are important innate T cells with antimicrobial and immunoregulatory activity, recently found to be depleted in blood of patients with HIV and HCV mono-infections.
Arends, J.E. (Joop), Beudeker, B.J.B. (Boris), Boonstra, P.A. (André), Claassen, M.A.A. (Mark), Heide-Mulder, M. (Marieke) van der, Knegt, R.J. (Robert) de, Oord, G.W. (Gertine) van, Schulze zur Wiesch, J. (Julian), Verbon, A. (Annelies)   +8 more
core   +1 more source

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression [PDF]

, 2017
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically ...
A Kurioka, A Mavropoulos, A Sattler, A Sattler, AJ Corbett, AL Taylor, Alexandra J. Corbett, AR Lussow, Arash Memarnejadian, Avinash Bhandoola, AY Tilahun, B Liang, C Carnaud, C Soudais, Christopher R. Shaler, CT Morita, D Grimaldi, D Robinson, E Lappin, E Leeansyah, E Leeansyah, EM Danielsen, F Guerville, F Tilloy, J Bae, J Jo, J Lopez-Sagaseta, J White, JA Mollick, James McCluskey, Jamie Rossjohn, JE Ussher, JJ Subleski, JK McCormick, JL Hayworth, JL Hayworth, JN Brouillard, John K. McCormick, Joshua Choi, K Ito, K Nakamura, K Takeda, K Tominaga, KJ Kasper, KJ Kasper, L Kjer-Nielsen, L Le Bourhis, L Leder, L Li, LA Edwards, LJ Howson, LS Berenson, M Dusseaux, M Lepore, M Maeurer, M Nakahira, M Reglinski, M Spaan, Mauro E. Tun-Abraham, MC Gold, N Seach, Olivier Lantz, P Dellabona, PA Szabo, PA Szabo, Patrick T. Rudak, Peter A. Szabo, R Podschun, R Reantragoon, RJ Napier, Roberto Hernandez-Alejandro, S Huang, S Porcelli, S.M. Mansour Haeryfar, SA Rieder, SM Borchardt, SM Haeryfar, TA Chau, W Salgado-Pabon, XZ Tang, Y Cui, Y Gao   +81 more
core   +12 more sources

Molecular analyses define Vα7.2-Jα33+ MAIT cell depletion in HIV infection: a case-control study [PDF]

, 2015
Mucosal-associated invariant T (MAIT) cells are an abundant antibacterial innate-like lymphocyte population. There are conflicting reports as to their fate in HIV infection.
Cosgrove, Cormac, Goulder, Philip, Günthard, Huldrych F, Hannaway, Rachel F, Klenerman, Paul, Phalora, Prabhjeet, Phillips, Rodney E, Rauch, Andri, Ussher, James E, Willberg, Christian B   +9 more
core   +2 more sources

MAIT cells and microbial immunity [PDF]

Immunology & Cell Biology, 2018
AbstractMucosal‐associated invariant T (MAIT) cells, the most abundant T‐cell subset in humans, are increasingly being recognized for their importance in microbial immunity. MAIT cells accumulate in almost every mucosal tissue examined, including the lung, liver and intestinal tract, where they can be activated through T‐cell receptor (TCR) triggering ...
Erin W Meermeier, Melanie J Harriff, Elham Karamooz, David M Lewinsohn   +3 more
openaire   +2 more sources

MAITabolism2 – the emerging understanding of MAIT cell metabolism and their role in metabolic disease

Frontiers in Immunology, 2023
Mucosal associated invariant T (MAIT) cells are a population of unconventional innate T cells due to their non-MHC restriction and rapid effector responses.
Nidhi Kedia-Mehta, Nidhi Kedia-Mehta, Andrew E. Hogan, Andrew E. Hogan, Andrew E. Hogan   +4 more
doaj   +1 more source

Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection. [PDF]

, 2020
Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired ...
Ananworanich, Jintanat, Bolton, Diane L, Costanzo, Margaret C, Creegan, Matthew, Dias, Joana, Eller, Leigh Anne, Eller, Michael A, Kibuuka, Hannah, Kim, Dohoon, Kosgei, Josphat, Krebs, Shelly J, Lal, Kerri G, Leeansyah, Edwin, Maganga, Lucas, Michael, Nelson L, Nitayaphan, Sorachai, Paquin-Proulx, Dominic, Phuang-Ngern, Yuwadee, Robb, Merlin L, Sacdalan, Carlo, Sandberg, Johan K, Schuetz, Alexandra, Shacklett, Barbara L, Slike, Bonnie M   +23 more
core  

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells [PDF]

, 2017
The major-histocompatibility-complex-(MHC)-class-I-related molecule MR1 can present activating and non-activating vitamin-B-based ligands to mucosal-associated invariant T cells (MAIT cells). Whether MR1 binds other ligands is unknown. Here we identified
A Kurioka, AJ Corbett, AJ McCoy, AL Szymczak, Alexandra J Corbett, Andrew N Keller, Anthony W Purcell, Bronwyn S Meehan, BY Chua, Criselle D'Souza, Dale I Godfrey, David P Fairlie, DC Chatterji, DI Godfrey, E Treiner, EY Jones, F Koning, F Tilloy, HEG McWilliam, Huimeng Wang, I Kawachi, I Van Rhijn, IJ Skypala, James McCluskey, Jamie Rossjohn, JE Ussher, Jeffrey Y W Mak, L Kjer-Nielsen, L Le Bourhis, Lars Kjer-Nielsen, Ligong Liu, Lyudmila Kostenko, M Bharadwaj, M Dusseaux, M Lepore, M Salio, MC Gold, MD Winn, MHM Heemskerk, NA Gherardin, Nicholas A Gherardin, NM Davies, O Patel, P Emsley, PCD Hawkins, PD Adams, PF Fehlner, PJ Hashkes, PT Illing, R Reantragoon, R Reantragoon, Richard W Birkinshaw, S Gras, S Gras, S Huang, S Zelcer, SB Eckle, SB Eckle, Sidonia B G Eckle, SK Hoiseth, Troi Pediongco, V Krasniqi, VB Chen, VC Romão, Victoria A Hughes, Weijun Xu, WXDS Kabsch, Zhenjun Chen   +67 more
core   +2 more sources

CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study

Reproductive Biology and Endocrinology, 2019
Background Immune dysregulation is one of the mechanisms to promote endometriosis (EMS). Various T cell subpopulations have been reported to play different roles in the development of EMS.
Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Yuping Xu, Peipei Guo, Ya Chen, Ping Zhou, Zhaolian Wei, Huanhuan Jiang, Yunxia Cao   +10 more
doaj   +1 more source