Results 111 to 120 of about 10,390 (221)

MAIT cells protect against sterile lung injury

Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, have been recently linked to tissue protection and repair. Their role, especially in sterile lung injury, is unknown.
Klenerman, Paul, Lason, Wojciech, Li, Shuailin, Hinks, Timothy SC, Greco, Maria, Zhang, Xiawei   +5 more
core   +3 more sources

Lymphocytes MAIT

médecine/sciences, 2023
Morgane Mabire, Hélène Gilgenkrantz, Sophie Lotersztajn   +2 more
openaire   +1 more source

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.

PLoS Pathogens, 2015
Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules. MAIT cells
Edwin Leeansyah, Jenny Svärd, Joana Dias, Marcus Buggert, Jessica Nyström, Máire F Quigley, Markus Moll, Anders Sönnerborg, Piotr Nowak, Johan K Sandberg   +9 more
doaj   +1 more source

Potential of MAIT cells to modulate asthma

Allergology International
Despite recent advances in asthma treatments, the search for novel therapies remains necessary because there are still patients with recurrent asthma exacerbations and poor responses to the existing treatments. Since group 2 innate lymphoid cells (ILC2) play a pivotal role in asthma by triggering and exacerbating type 2 inflammation, controlling ILC2s ...
Yasuo Shimizu, Chie Sugimoto, Hiroshi Wakao   +2 more
openaire   +3 more sources

Mucosal-associated invariant T cells in cancer: dual roles, complex interactions and therapeutic potential

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells play diverse roles in cancer, infectious diseases, and immunotherapy. This review explores their intricate involvement in cancer, from early detection to their dual functions in promoting inflammation and ...
Mesut Yigit, Omer Faruk Basoglu, Derya Unutmaz   +2 more
doaj   +1 more source

MAIT cells in HIV infected and uninfected children.

, 2016
(A) FACS plot showing representative gating to identify CD8 MAIT cells in an HIV- and HIV+ subject. Plot shown is gated on CD8+ T cells. MAIT cells are identified as the Vα7.2+CD161+ population. (B) CD8+ MAIT cells in HIV-, ART-, and ART+ children.
Cihan Tastan (3079533), Tiina Ilmet (3079542), Max Kilberg (3079539), William Borkowsky (591602), Adam Kravietz (3079530), Derya Unutmaz (52436), Mengling Liu (136610), Mussa Mwamzuka (3079536), Aabid Ahmed (3079545), Alka Khaitan (3079527), Fatma Marshed (3079524)   +10 more
core   +1 more source

Liver transplant-facilitated CD161+Vα7.2+ MAIT cell recovery demonstrates clinical benefits in hepatic failure patients

Nature Communications
Mucosal-associated invariant T (MAIT) cells exert multifaceted effects such as anti-microbial activity, tissue repair, and pro-fibrotic effects across various disease settings. Nonetheless, their role in liver injury and hemostasis remains debated. Here,
Wei Wang, Chen Dai, Peng Zhu, Mi Wu, Haoquan Zhang, Qing Wei, Ting Zhou, Xiaosheng Tan, Ying Jiang, Xue Cheng, Zhihui Liang, Xiongwen Wu, Zhishui Chen, Xiufang Weng   +13 more
doaj   +1 more source

MAIT Cells with High PFN1 Expression Mediate Immune Activation and Metabolic Reprogramming in Psoriasis

Man-Ning Wu,1– 3 Yue-Min Zou,1– 3 Xiang-Nan Zhou,2,3 Sangwon Hong,1– 3 Lei Wang,2,3 Yan-Ping Bai2,3 1Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China; 2Department of Dermatology, China-Japan Friendship Hospital ...
Zou YM, Zhou XN, Bai YP, Wu MN, Hong S, Wang L   +5 more
core  

CD8 MAIT cells gradually recover with ART in HIV+ children.

, 2016
(A) CD8+ MAIT cells in ART- children before (pre-ART) and 10–21 months after ART initiation (post-ART). (B) CD8+ MAIT cells in ART+ children at baseline (T0) and at 10–21 month follow-up visit (T1). (C) Age in years at the time of ART initiation vs. fold
Cihan Tastan (3079533), Tiina Ilmet (3079542), Max Kilberg (3079539), William Borkowsky (591602), Adam Kravietz (3079530), Derya Unutmaz (52436), Mengling Liu (136610), Mussa Mwamzuka (3079536), Aabid Ahmed (3079545), Alka Khaitan (3079527), Fatma Marshed (3079524)   +10 more
core   +1 more source

Biologie des cellules MAIT chez la souris

, 2015
Mucosal-associated invariant T cells (MAIT) are innate lymphocytes that express a semi-invariant T cell receptor (iTCR) and are restricted by the major histocompatibility complex (MHC) related molecule, MR1. In human, MAIT cells are abundant in the blood
Cui, Yue
core