Results 1 to 10 of about 19,139 (149)

Human mucosal associated invariant T cells detect bacterially infected cells. [PDF]

PLoS Biology, 2010
Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution
Marielle C Gold, Stefania Cerri, Susan Smyk-Pearson, Meghan E Cansler, Todd M Vogt, Jacob Delepine, Ervina Winata, Gwendolyn M Swarbrick, Wei-Jen Chua, Yik Y L Yu, Olivier Lantz, Matthew S Cook, Megan D Null, David B Jacoby, Melanie J Harriff, Deborah A Lewinsohn, Ted H Hansen, David M Lewinsohn   +17 more
doaj   +10 more sources

Varicella Zoster Virus infects mucosal associated Invariant T cells [PDF]

Frontiers in Immunology, 2023
IntroductionMucosal Associated Invariant T (MAIT) cells are innate-like T cells that respond to conserved pathogen-derived vitamin B metabolites presented by the MHC class I related-1 molecule (MR1) antigen presentation pathway.
Shivam K. Purohit, Alexandra J. Corbett, Barry Slobedman, Allison Abendroth   +3 more
doaj   +2 more sources

Mucosal-associated invariant T cells in patients with axial spondyloarthritis [PDF]

Frontiers in Immunology, 2023
BackgroundSeveral studies implicate Th17-cells and its cytokine (IL-17) in disease pathogenesis of spondyloarthritis (SpA), with available evidence supporting a pathogenic role of CD8+ T-cells.
Rienk Gerben van der Meer, Anneke Spoorenberg, Elisabeth Brouwer, Berber Doornbos-van der Meer, Annemieke M. H. Boots, Suzanne Arends, Wayel H. Abdulahad, Wayel H. Abdulahad   +7 more
doaj   +2 more sources

Functions of mucosal associated invariant T cells in eye diseases [PDF]

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells
Chihiro Fukui, Satoshi Yamana, Yanqi Xue, Mariko Shirane, Hiroki Tsutsui, Kenichiro Asahara, Keiko Yoshitomi, Takako Ito, Tantri Lestari, Eiichi Hasegawa, Nobuyo Yawata, Atsunobu Takeda, Koh-Hei Sonoda, Kensuke Shibata, Kensuke Shibata, Kensuke Shibata   +15 more
doaj   +2 more sources

Mucosal-Associated Invariant T Cells in Autoimmune Diseases

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells are innate T cells restricted by MHC-related molecule 1 (MR1). MAIT cells express semi-invariant T-cell receptors TRAV1-2-TRAJ33/12/20 in humans and TRAV1-TRAJ33 in mice.
Asako Chiba, Goh Murayama, Sachiko Miyake   +2 more
doaj   +3 more sources

TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses

Cell Reports, 2019
Summary: Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor (TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin biosynthesis, or via cytokines.
Rajesh Lamichhane, Marion Schneider, Sara M. de la Harpe, Thomas W.R. Harrop, Rachel F. Hannaway, Peter K. Dearden, Joanna R. Kirman, Joel D.A. Tyndall, Andrea J. Vernall, James E. Ussher   +9 more
doaj   +3 more sources

The role of mucosal-associated invariant T cells in visceral leishmaniasis [PDF]

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by ...
Marcela de Lima Moreira, Marcela de Lima Moreira, Luana Oliveira Borges-Fernandes, Marcelo Antônio Pascoal-Xavier, Marcelo Antônio Pascoal-Xavier, Ágata Lopes Ribeiro, Victória Hellena Silva Pereira, Troi Pediongco, Márcio Sobreira da Silva Araújo, Andréa Teixeira-Carvalho, Andrea Lucchesi de Carvalho, Maria Vitória Assumpção Mourão, Flávia Alves Campos, Marineide Borges, Mariângela Carneiro, Zhenjun Chen, Eleanor Saunders, Malcolm McConville, Moriya Tsuji, James McCluskey, Olindo Assis Martins-Filho, Sidonia Barbara Guiomar Eckle, Jordana Grazziela Alves Coelho-dos-Reis, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhães   +24 more
doaj   +2 more sources

The Role of Mucosal-Associated Invariant T Cells in Viral Infections and Their Function in Vaccine Development [PDF]

Vaccines
Mucosal-Associated Invariant T (MAIT) cells, which bridge innate and adaptive immunity, have emerged as an important player in viral infections despite their inability to directly recognize viral antigens. This review provides a comprehensive analysis of
Chie Sugimoto, Hiroshi Wakao
doaj   +2 more sources

Herpes simplex virus type 1 impairs mucosal-associated invariant T cells [PDF]

mBio
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that infects mucosal sites and adopts an arsenal of strategies to manipulate host immunity.
Lauren Stern, Zoe Emanuel, Renee Traves, Katherine Willis, Shivam K. Purohit, Carolyn Samer, Jeffrey Y. W. Mak, David P. Fairlie, David C. Tscharke, Alexandra J. Corbett, Allison Abendroth, Barry Slobedman   +11 more
doaj   +2 more sources

The role of mucosal associated invariant T cells in antimicrobial immunity

Frontiers in Immunology, 2015
Mucosal associated invariant T (MAIT) cells are an innate-like T cell subset prevalent in humans and distributed throughout the blood and mucosal sites. Human MAIT cells are defined by the expression of the semi-invariant TCRα chain TRAV1-2/TRAJ12/20/33 ...
Ruth J Napier, Erin J Adams, Erin J Adams, Erin J Adams, Marielle C Gold, Marielle C Gold, Marielle C Gold, David M Lewinsohn, David M Lewinsohn, David M Lewinsohn   +9 more
doaj   +3 more sources