Results 1 to 10 of about 10,766 (255)

Mucosal-Associated Invariant T Cells in Autoimmune Diseases

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells are innate T cells restricted by MHC-related molecule 1 (MR1). MAIT cells express semi-invariant T-cell receptors TRAV1-2-TRAJ33/12/20 in humans and TRAV1-TRAJ33 in mice.
Asako Chiba, Goh Murayama, Sachiko Miyake   +2 more
doaj   +6 more sources

Mucosal-associated invariant T cells for cancer immunotherapy [PDF]

Molecular Therapy, 2023
Human mucosal-associated invariant T (MAIT) cells are characterized by their expression of an invariant TCR α chain Vα7.2-Jα33/Jα20/Jα12 paired with a restricted TCR β chain.
Yan-Ruide Li, Kuangyi Zhou, Adam Kramer   +2 more
exaly   +6 more sources

Functions of mucosal associated invariant T cells in eye diseases [PDF]

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells
Chihiro Fukui, Satoshi Yamana, Yanqi Xue, Mariko Shirane, Hiroki Tsutsui, Kenichiro Asahara, Keiko Yoshitomi, Takako Ito, Tantri Lestari, Eiichi Hasegawa, Nobuyo Yawata, Atsunobu Takeda, Koh-Hei Sonoda, Kensuke Shibata, Kensuke Shibata, Kensuke Shibata   +15 more
doaj   +5 more sources

Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells [PDF]

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity.
Lucy C. Garner, Paul Klenerman, Paul Klenerman, Nicholas M. Provine   +3 more
doaj   +9 more sources

Development of mucosal‐associated invariant T cells [PDF]

Immunology and Cell Biology, 2018
Mucosal-associated invariant T (MAIT) cells develop in the thymus and migrate into the periphery to become the largest antigen-specific αβ T-cell population in the human immune system.
Hui-Fern Koay, Dale I Godfrey, Daniel G Pellicci   +2 more
exaly   +6 more sources

The Immune Modulating Properties of Mucosal-Associated Invariant T Cells [PDF]

Frontiers in Immunology, 2020
Mucosal-associated invariant T (MAIT) cells are unconventional T lymphocytes that express a semi-invariant T cell receptor (TCR) recognizing microbial vitamin B metabolites presented by the highly conserved major histocompatibility complex (MHC) class I ...
Melina Ioannidis, Vincenzo Cerundolo, Mariolina Salio   +2 more
doaj   +6 more sources

Human mucosal associated invariant T cells detect bacterially infected cells. [PDF]

PLoS Biology, 2010
Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution
Marielle C Gold, Stefania Cerri, Susan Smyk-Pearson, Meghan E Cansler, Todd M Vogt, Jacob Delepine, Ervina Winata, Gwendolyn M Swarbrick, Wei-Jen Chua, Yik Y L Yu, Olivier Lantz, Matthew S Cook, Megan D Null, David B Jacoby, Melanie J Harriff, Deborah A Lewinsohn, Ted H Hansen, David M Lewinsohn   +17 more
doaj   +7 more sources

A shotgun proteomic dataset of human mucosal-associated invariant T cells [PDF]

Data in Brief
Mucosal-associated invariant T (MAIT) cells represent a unique unconventional T cell population important in eliciting immunomodulatory responses in a range of diseases, including infectious diseases, autoimmunity and cancer.
Harshi Weerakoon, John J. Miles, Michelle M. Hill, Ailin Lepletier   +3 more
doaj   +3 more sources

Clostridioides difficile Activates Human Mucosal-Associated Invariant T Cells [PDF]

Frontiers in Microbiology, 2018
Clostridioides difficile infection (CDI) causes severe inflammatory responses at the intestinal mucosa but the immunological mechanisms underlying CDI-related immunopathology are still incompletely characterized.
Isabel Bernal, Isabel Bernal, Isabel Bernal, Julia Danielle Hofmann, Björn Bulitta, Frank Klawonn, Frank Klawonn, Annika-Marisa Michel, Dieter Jahn, Meina Neumann-Schaal, Meina Neumann-Schaal, Dunja Bruder, Dunja Bruder, Lothar Jänsch   +13 more
doaj   +2 more sources

TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses

Cell Reports, 2019
Summary: Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor (TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin biosynthesis, or via cytokines.
Rajesh Lamichhane, Marion Schneider, Sara M. de la Harpe, Thomas W.R. Harrop, Rachel F. Hannaway, Peter K. Dearden, Joanna R. Kirman, Joel D.A. Tyndall, Andrea J. Vernall, James E. Ussher   +9 more
doaj   +3 more sources