Results 11 to 20 of about 10,766 (255)

Mucosal-associated invariant T cells in patients with axial spondyloarthritis [PDF]

Frontiers in Immunology, 2023
BackgroundSeveral studies implicate Th17-cells and its cytokine (IL-17) in disease pathogenesis of spondyloarthritis (SpA), with available evidence supporting a pathogenic role of CD8+ T-cells.
Rienk Gerben van der Meer, Anneke Spoorenberg, Elisabeth Brouwer, Berber Doornbos-van der Meer, Annemieke M. H. Boots, Suzanne Arends, Wayel H. Abdulahad, Wayel H. Abdulahad   +7 more
doaj   +4 more sources

The role of mucosal associated invariant T cells in antimicrobial immunity [PDF]

Frontiers in Immunology, 2015
Mucosal associated invariant T (MAIT) cells are an innate-like T cell subset prevalent in humans and distributed throughout the blood and mucosal sites. Human MAIT cells are defined by the expression of the semi-invariant TCRα chain TRAV1-2/TRAJ12/20/33 ...
Ruth J Napier, Erin J Adams, Erin J Adams, Erin J Adams, Marielle C Gold, Marielle C Gold, Marielle C Gold, David M Lewinsohn, David M Lewinsohn, David M Lewinsohn   +9 more
doaj   +5 more sources

Mucosal associated invariant T cells: Powerhouses of the lung.

Immunol Lett
The lungs face constant environmental challenges from harmless molecules, airborne pathogens and harmful agents that can damage the tissue. The lungs' immune system includes numerous tissue-resident lymphocytes that contribute to maintain tissue ...
P Barral (19450693), JC López-Rodríguez (19450690)   +1 more
core   +5 more sources

The role of mucosal-associated invariant T cells in visceral leishmaniasis [PDF]

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by ...
Marcela de Lima Moreira, Marcela de Lima Moreira, Luana Oliveira Borges-Fernandes, Marcelo Antônio Pascoal-Xavier, Marcelo Antônio Pascoal-Xavier, Ágata Lopes Ribeiro, Victória Hellena Silva Pereira, Troi Pediongco, Márcio Sobreira da Silva Araújo, Andréa Teixeira-Carvalho, Andrea Lucchesi de Carvalho, Maria Vitória Assumpção Mourão, Flávia Alves Campos, Marineide Borges, Mariângela Carneiro, Zhenjun Chen, Eleanor Saunders, Malcolm McConville, Moriya Tsuji, James McCluskey, Olindo Assis Martins-Filho, Sidonia Barbara Guiomar Eckle, Jordana Grazziela Alves Coelho-dos-Reis, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhães   +24 more
doaj   +5 more sources

Herpes simplex virus type 1 impairs mucosal-associated invariant T cells [PDF]

mBio
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that infects mucosal sites and adopts an arsenal of strategies to manipulate host immunity.
Lauren Stern, Zoe Emanuel, Renee Traves, Katherine Willis, Shivam K. Purohit, Carolyn Samer, Jeffrey Y. W. Mak, David P. Fairlie, David C. Tscharke, Alexandra J. Corbett, Allison Abendroth, Barry Slobedman   +11 more
doaj   +3 more sources

Ontogeny of human mucosal-associated invariant T cells and related T cell subsets [PDF]

Journal of Experimental Medicine, 2018
Mucosal-associated invariant T (MAIT) cells are semi-invariant V alpha 7.2(+) CD161(high)CD4(-)T cells that recognize microbial riboflavin precursor derivatives such as 5-OP-RU presented by MR1. Human MAIT cells are abundant in adult blood, but there are
Marie Tourret, Michel Peuchmaur, Jean-Hugues Dalle   +2 more
exaly   +8 more sources

Mucosal-Associated Invariant T Cells in Regenerative Medicine [PDF]

Frontiers in Immunology, 2017
Although antibiotics to inhibit bacterial growth and small compounds to interfere with the productive life cycle of human immunodeficiency virus (HIV) have successfully been used to control HIV infection, the recent emergence of the drug-resistant ...
Hiroshi Wakao, Chie Sugimoto, Shinzo Kimura, Rika Wakao   +3 more
doaj   +3 more sources

Mucosal-Associated Invariant T Cells in Rheumatic Diseases. [PDF]

Arthritis Rheumatol
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor and restriction by the major histocompatibility complex class I–related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines.
Lesturgie-Talarek M, Gonzalez V, Beaudoin L, Sénot N, Miceli-Richard C, Allanore Y, Lehuen A, Avouac J.   +7 more
europepmc   +3 more sources

Emerging Roles of Mucosal-Associated Invariant T Cells in Rheumatology [PDF]

Frontiers in Immunology, 2022
Mucosal-associated invariant T (MAIT) cells are an unconventional T cell subset expressing a semi-invariant TCR and recognize microbial riboflavin metabolites presented by major histocompatibility complex class 1-related molecule (MR1).
Yanmei Li, Jun Du, Wei Wei
doaj   +3 more sources

Mucosal-associated invariant T-cells in pulmonary pathophysiology. [PDF]

Curr Opin Pulm Med
Purpose of review Mucosal-associated invariant T-cells (MAIT) have been associated with lung cancer and pulmonary infections. The treatment of patients with cancer or infections includes host-directed therapies (HDTs). MAIT play a role in shaping the ‘milieu interne’ in cancer and infections and this review addresses the ...
Kamiki J, Gorgulho CM, Lérias JR, Maeurer MJ.   +3 more
europepmc   +3 more sources