Results 11 to 20 of about 10,087 (235)
Mucosal-associated invariant T cells for cancer immunotherapy. [PDF]
Mol Ther, 2023 Human mucosal-associated invariant T (MAIT) cells are characterized by their expression of an invariant TCR α chain Vα7.2-Jα33/Jα20/Jα12 paired with a restricted TCR β chain. MAIT cells recognize microbial peptides presented by the highly conserved MHC class I-like molecule MR1 and bridge the innate and acquired immune systems to mediate augmented ...
Li YR +7 more
europepmc +5 more sources
Mucosal-Associated Invariant T Cells in Regenerative Medicine [PDF]
Frontiers in Immunology, 2017 Although antibiotics to inhibit bacterial growth and small compounds to interfere with the productive life cycle of human immunodeficiency virus (HIV) have successfully been used to control HIV infection, the recent emergence of the drug-resistant ...
Hiroshi Wakao +3 more
doaj +3 more sources
Mucosal-Associated Invariant T Cells in Autoimmune Diseases
Frontiers in Immunology, 2018 Mucosal-associated invariant T (MAIT) cells are innate T cells restricted by MHC-related molecule 1 (MR1). MAIT cells express semi-invariant T-cell receptors TRAV1-2-TRAJ33/12/20 in humans and TRAV1-TRAJ33 in mice.
Asako Chiba +2 more
doaj +3 more sources
Emerging Roles of Mucosal-Associated Invariant T Cells in Rheumatology [PDF]
Frontiers in Immunology, 2022 Mucosal-associated invariant T (MAIT) cells are an unconventional T cell subset expressing a semi-invariant TCR and recognize microbial riboflavin metabolites presented by major histocompatibility complex class 1-related molecule (MR1).
Yanmei Li, Jun Du, Wei Wei
doaj +3 more sources
The Immune Modulating Properties of Mucosal-Associated Invariant T Cells [PDF]
Frontiers in Immunology, 2020 Mucosal-associated invariant T (MAIT) cells are unconventional T lymphocytes that express a semi-invariant T cell receptor (TCR) recognizing microbial vitamin B metabolites presented by the highly conserved major histocompatibility complex (MHC) class I ...
Melina Ioannidis +2 more
doaj +4 more sources
Human mucosal associated invariant T cells detect bacterially infected cells. [PDF]
PLoS Biology, 2010 Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution
Marielle C Gold +17 more
doaj +5 more sources
Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients [PDF]
Frontiers in Immunology, 2018 Recent studies have highlighted the heterogeneity of asthma. Distinct patient phenotypes (symptoms, age at onset, atopy, and lung function) may result from different pathogenic mechanisms, including airway inflammation, remodeling, and immune and ...
Guillaume Lezmi +4 more
doaj +3 more sources
The role of mucosal associated invariant T cells in antimicrobial immunity [PDF]
Frontiers in Immunology, 2015 Mucosal associated invariant T (MAIT) cells are an innate-like T cell subset prevalent in humans and distributed throughout the blood and mucosal sites. Human MAIT cells are defined by the expression of the semi-invariant TCRα chain TRAV1-2/TRAJ12/20/33 ...
Ruth J Napier +9 more
doaj +3 more sources
The role of mucosal-associated invariant T cells in visceral leishmaniasis
Frontiers in Immunology, 2022 Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by ...
Marcela de Lima Moreira +24 more
doaj +4 more sources
Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections [PDF]
Frontiers in Immunology, 2018 The immune system has been traditionally divided into two arms called innate and adaptive immunity. Typically, innate immunity refers to rapid defense mechanisms that set in motion within minutes to hours following an insult.
François Trottein +6 more
doaj +4 more sources