Results 21 to 30 of about 10,087 (235)

Biological functions and therapeutic applications of human mucosal-associated invariant T cells [PDF]

Journal of Biomedical Science
Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T lymphocytes that bridge innate and adaptive immunity. Characterized by their semi-invariant T cell receptor (TCR) and abundant localization in mucosal tissues, MAIT cells ...
Ying Fang, Yuning Chen, Siyue Niu, Zibai Lyu, Yanxin Tian, Xinyuan Shen, Yan-Ruide Li, Lili Yang   +7 more
doaj   +2 more sources

Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells [PDF]

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity.
Lucy C. Garner, Paul Klenerman, Paul Klenerman, Nicholas M. Provine   +3 more
doaj   +4 more sources

IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells [PDF]

iScience
Summary: IL-23 signaling plays a key role in the pathogenesis of chronic inflammatory and infectious diseases, yet the cellular targets and signaling pathways affected by this cytokine remain poorly understood.
Laetitia Camard, Tharshana Stephen, Hanane Yahia-Cherbal, Vincent Guillemot, Sébastien Mella, Victoire Baillet, Hélène Lopez-Maestre, Daniele Capocefalo, Laura Cantini, Claire Leloup, Julie Marsande, Katherine Garro, Juan Sienes Bailo, Ambre Dangien, Natalia Pietrosemoli, Milena Hasan, Huimeng Wang, Sidonia B.G. Eckle, Anne M. Fourie, Carrie Greving, Barbara Joyce-Shaikh, Raphaelle Parker, Daniel J. Cua, Elisabetta Bianchi, Lars Rogge   +24 more
doaj   +2 more sources

Mucosal-Associated Invariant T Cells in Rheumatic Diseases. [PDF]

Arthritis Rheumatol
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor and restriction by the major histocompatibility complex class I–related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines.
Lesturgie-Talarek M, Gonzalez V, Beaudoin L, Sénot N, Miceli-Richard C, Allanore Y, Lehuen A, Avouac J.   +7 more
europepmc   +3 more sources

Mucosal-associated invariant T-cells in pulmonary pathophysiology. [PDF]

Curr Opin Pulm Med
Purpose of review Mucosal-associated invariant T-cells (MAIT) have been associated with lung cancer and pulmonary infections. The treatment of patients with cancer or infections includes host-directed therapies (HDTs). MAIT play a role in shaping the ‘milieu interne’ in cancer and infections and this review addresses the ...
Kamiki J, Gorgulho CM, Lérias JR, Maeurer MJ.   +3 more
europepmc   +3 more sources

Mucosal-associated invariant T cells and disease [PDF]

Nature Reviews Immunology, 2019
Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate and adaptive immunity. They are activated by conserved bacterial ligands derived from vitamin B biosynthesis and have important roles in defence against bacterial and viral infections. However, they can also have various deleterious and protective functions in
Toubal, Amine, Nel, Isabelle, Lotersztajn, Sophie, Lehuen, Agnès   +3 more
openaire   +3 more sources

The alterations of circulating mucosal-associated invariant T cells in polycystic ovary syndrome

Frontiers in Endocrinology, 2022
BackgroundPolycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting reproductive age females and an important cause of infertility.
Hong Zhou, Junting Xu, Ling Hong, Yanping Jia, Lilo Valerie Burk, Fengli Chi, Mei Zhao, Xiaohong Guan, Dan Liu, Xiangjie Yin, Yiqiao Zhang, Xiaoming Teng, Liyan Duan, Liyan Duan, Kunming Li   +14 more
doaj   +1 more source

Mucosal-Associated Invariant T cell in liver diseases [PDF]

International Journal of Biological Sciences, 2020
Mucosal-associated invariant T cells (MAIT cells) are a new population of innate immune cells, which are abundant in the liver and play complex roles in various liver diseases. In this review, we summarize MAIT cells in the liver diseases in recent studies, figure out the role of MAIT cells in various liver disease, including Alcoholic liver disease ...
Zhang, Yujue, Kong, Derun, Wang, Hua
openaire   +2 more sources

ROLE OF MUCOSAL-ASSOCIATED INVARIANT T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2021
The etiology of inflammatory and autoimmune diseases is complex and not yet fully understood. Their pathogenesis includes mechanisms in which both innate and adaptive immune cells are involved. Mucosal-associated invariant T (MAIT) cells are immune cells
rehab mekkawy, Omnia El-badawy, Helal F. Hetta, Doaa K. Abd El-hafez, Khaled M. Hassanein   +4 more
doaj   +1 more source

Mucosal associated invariant T cells: Powerhouses of the lung.

Immunol Lett
The lungs face constant environmental challenges from harmless molecules, airborne pathogens and harmful agents that can damage the tissue. The lungs' immune system includes numerous tissue-resident lymphocytes that contribute to maintain tissue homeostasis and to the early initiation of immune responses.
López-Rodríguez JC, Barral P.
europepmc   +4 more sources