Results 41 to 50 of about 19,288 (276)

Mucosal-Associated Invariant T Cell Interactions with Commensal and Pathogenic Bacteria: Potential Role in Antimicrobial Immunity in the Child

Frontiers in Immunology, 2017
Mucosal-associated invariant T (MAIT) cells are unconventional CD3+CD161high T lymphocytes that recognize vitamin B2 (riboflavin) biosynthesis precursor derivatives presented by the MHC-I related protein, MR1. In humans, their T cell receptor is composed
Liana Ghazarian, Sophie Caillat-Zucman, Sophie Caillat-Zucman, Véronique Houdouin, Véronique Houdouin   +4 more
doaj   +1 more source

Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential [PDF]

, 2016
Ajudes rebudes: Marie Curie Career Integration Grant; Dexeus Foundation for Women's Health Research; i Contratos Ramón y CajalCD11c is an α integrin classically employed to define myeloid dendritic cells.
A Arakelyan, Annie Rodolosse, Antoni Tarrats, B Ljutic, C Sadhu, CC Denucci, CE Egan, D Fujiwara, D Ganguly, DC Bullard, DI Godfrey, DJ Pennington, DL Farber, DM Williams, E Billerbeck, E Gonzalez-Roca, GK Smyth, J Del Campo, Jamal Qualai, JC Grivel, JD Haas, JJ Moon, JM Fuller, Jon Cantero, JR Fergusson, JW Huleatt, K Kubota, LA Cooney, Lauro Sumoy, Lin-Xi Li, LS Cauley, LX Li, M Beyer, M Brandes, M Eberl, M Kuka, M Roederer, Marco Antonio Fernández, Meritxell Genescà, N Lycke, NA Bezman, OS Qureshi, PA Romagnoli, R. Keith Reeves, RT Trifonova, S Paul, S Tsai, SM Tan, Stephen J. McSorley, T Vorup-Jensen, YH Kim, Z Chen   +51 more
core   +5 more sources

Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis [PDF]

, 2019
OBJECTIVES: Alcoholic hepatitis (AH) develops in approximately 30% of chronic heavy drinkers. The immune system of patients with AH is hyperactivated, yet ineffective against infectious diseases.
Bolte, Bottcher, Chan, Chayanupatkul, Chiba, Corbett, Cosgrove, Degre, Dhanda, Dusseaux, Eckle, Fergusson, Fung, Gao, Gao, Gerart, Hegde, Hengst, Jampana, Jeffery, Jiang, Kjer-Nielsen, Kurioka, Leclercq, Leeansyah, Leeansyah, Li, Liangpunsakul, Liangpunsakul, Loh, Markwick, Mutlu, Nagy, O'Shea, Pasala, Patel, Puri, Rao, Reantragoon, Riva, Saberi, Slichter, Spaan, Tang, Tilloy, Ussher, van Wilgenburg, Wong, Yong   +48 more
core   +1 more source

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

Cell Reports, 2019
Summary: Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer+ cells derived from either human blood or murine
Timothy S.C. Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J. Pediongco, Bronwyn S. Meehan, Lyudmila Kostenko, Stephen J. Turner, Alexandra J. Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey   +12 more
doaj   +1 more source

Conventional, regulatory, and unconventional T cells in the immunologic response to helicobacter pylori [PDF]

, 2008
Infection by the gastroduodenal pathogen Helicobacter pylori elicits a complex immunologic response in the mucosa involving neutrophils, plasma cells, eosinophils, and lymphocytes, of which T cells are the principal orchestrators of immunity.
Moran, Anthony P., O'Keeffe, Joan
core   +1 more source

Peripheral and intestinal mucosal-associated invariant T cells in premature infants with necrotizing enterocolitis

Frontiers in Pharmacology, 2022
Background: Necrotizing enterocolitis (NEC) is a potentially fatal inflammatory gastrointestinal disease in preterm infants with unknown pathogenesis. Mucosal-associated invariant T (MAIT) cells primarily accumulate at sites where exposure to microbes is
Jiayi Tian, Chaoying Yan, Yanfang Jiang, Haohan Zhou, Liyuan Li, Jingjing Shen, Jian Wang, Hongyu Sun, Guang Yang, Wei Sun   +9 more
doaj   +1 more source

Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes [PDF]

, 2017
Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of pancreatic β-cells by the immune system that involves innate and adaptive immune cells.
Battaglia, Manuela, Beaudoin, Lucie, Beltrand, Jacques, Cagninacci, Lucie, Corbett, Alexandra, Da silva, Jennifer, Diedisheim, Marc, Kiaf, Badr, Lantz, Olivier, Lehuen, Agnès, McCluskey, James, Nel, Isabelle, Oshima, Masaya, Polak, Michel, Rossjohn, Jamie, Rouxel, Ophélie, Salou, Marion, Scharfmann, Raphael, Tard, Céline   +18 more
core   +4 more sources

Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges. [PDF]

, 2019
Introduction: Tuberculosis (TB) remains a major health threat and it is now clear that the current vaccine, BCG, is unable to arrest the global TB epidemic. A new vaccine is needed to either replace or boost BCG so that a better level of protection could
Barclay WR, Elena Stylianou, Helen McShane, Matthew J. Paul, Rajko Reljic, Resende Co T, Rodriguez A, Uranga S, Wong EA   +8 more
core   +1 more source

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells [PDF]

, 2017
The major-histocompatibility-complex-(MHC)-class-I-related molecule MR1 can present activating and non-activating vitamin-B-based ligands to mucosal-associated invariant T cells (MAIT cells). Whether MR1 binds other ligands is unknown. Here we identified
A Kurioka, AJ Corbett, AJ McCoy, AL Szymczak, Alexandra J Corbett, Andrew N Keller, Anthony W Purcell, Bronwyn S Meehan, BY Chua, Criselle D'Souza, Dale I Godfrey, David P Fairlie, DC Chatterji, DI Godfrey, E Treiner, EY Jones, F Koning, F Tilloy, HEG McWilliam, Huimeng Wang, I Kawachi, I Van Rhijn, IJ Skypala, James McCluskey, Jamie Rossjohn, JE Ussher, Jeffrey Y W Mak, L Kjer-Nielsen, L Le Bourhis, Lars Kjer-Nielsen, Ligong Liu, Lyudmila Kostenko, M Bharadwaj, M Dusseaux, M Lepore, M Salio, MC Gold, MD Winn, MHM Heemskerk, NA Gherardin, Nicholas A Gherardin, NM Davies, O Patel, P Emsley, PCD Hawkins, PD Adams, PF Fehlner, PJ Hashkes, PT Illing, R Reantragoon, R Reantragoon, Richard W Birkinshaw, S Gras, S Gras, S Huang, S Zelcer, SB Eckle, SB Eckle, Sidonia B G Eckle, SK Hoiseth, Troi Pediongco, V Krasniqi, VB Chen, VC Romão, Victoria A Hughes, Weijun Xu, WXDS Kabsch, Zhenjun Chen   +67 more
core   +2 more sources

Neutrophils Suppress Mucosal-Associated Invariant T Cells [PDF]

, 2019
AbstractMucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that are abundant in mucosal tissues and the liver where they can respond rapidly to a broad range of riboflavin producing bacterial and fungal pathogens. Neutrophils, which are recruited early to sites of infection, play a non-redundant role in pathogen clearance and are
Schneider, M, Hannaway, RF, Lamichhane, R, de la Harpe, SM, Tyndall, JDA, Vernall, AJ, Kettle, A, Ussher, JE   +7 more
openaire   +1 more source