Results 41 to 50 of about 10,766 (255)

ROLE OF MUCOSAL-ASSOCIATED INVARIANT T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2021
The etiology of inflammatory and autoimmune diseases is complex and not yet fully understood. Their pathogenesis includes mechanisms in which both innate and adaptive immune cells are involved. Mucosal-associated invariant T (MAIT) cells are immune cells
rehab mekkawy, Omnia El-badawy, Helal F. Hetta, Doaa K. Abd El-hafez, Khaled M. Hassanein   +4 more
doaj   +1 more source

Mucosal-Associated Invariant T (MAIT) Cells Are Impaired in Th17 Associated Primary and Secondary Immunodeficiencies. [PDF]

, 2016
The recently described Mucosal Associated Invariant T (MAIT) cells mediate specific recognition of bacterial and fungal vitamin B2 metabolites. As innate T cells, they possess broad effector responses, including IFN- including Iproduction, that are ...
Gabriela Barcenas-Morales, William Rae, Eren, E, Ramakrishnan, KA, Yifang Gao, Anthony P Williams, Gabriela Barcenas-Morales (2742679), Rainer Döffinger, Yifang Gao (2625715), Christian H. Ottensmeier (791349), Barcenas-Morales, G, William Rae (292476), Williams, AP, Anthony P. Williams (2742673), Rae, W, Faust, SN, Gao, Y, Saul N. Faust (415924), Keseva Ananth Ramakrishnan (2742676), Döffinger, R, Rainer Döffinger (2742682), Saul N Faust, Efrem Eren, Ottensmeier, CH, Efrem Eren (2742685), Christian H Ottensmeier, Keseva Ananth Ramakrishnan   +26 more
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Regulation and heterogeneity of human mucosal-associated invariant T (MAIT) cells in blood and liver

, 2021
Mucosal-associated invariant T (MAIT) cells are an abundant population of innate-like, effector memory T cells, that secrete proinflammatory cytokines and exhibit direct cytotoxic activity.
Garner, Lucy catherine
core   +1 more source

The role of mucosal‐associated invariant T cells in infectious diseases [PDF]

Immunology, 2016
SummaryMucosal‐associated invariant T (MAIT) cells are donor‐unrestricted lymphocytes that are surprisingly abundant in humans, representing 1–10% of circulating T cells and further enriched in mucosal tissues. MAIT cells recognize and are activated by small molecule ligands produced by microbes and presented by MR1, a highly conserved MHC‐related ...
Wong, E., Ndung'u, T., Kasprowicz, V.
openaire   +3 more sources

Neutrophils suppress mucosal‐associated invariant T cells in humans [PDF]

European Journal of Immunology, 2020
Abstract Mucosal‐associated invariant T (MAIT) cells are innate‐like T lymphocytes that are abundant in mucosal tissues and the liver where they can respond rapidly to a broad range of riboflavin producing bacterial and fungal pathogens. Neutrophils, which are recruited early to sites of infection, play a nonredundant role in pathogen
Marion Schneider, Rachel F. Hannaway, Rajesh Lamichhane, Sara M. de la Harpe, Joel D.A. Tyndall, Andrea J. Vernall, Anthony J. Kettle, James E. Ussher   +7 more
openaire   +2 more sources

Mucosal-Associated Invariant T Cells in T-Cell Non-Hodgkin Lymphomas: A Case Series

, 2022
SIMPLE SUMMARY: Mucosal-associated invariant T (MAIT) cells are a subgroup of T lymphocytes whose role has recently been investigated in several types of diseases, including cancer. However, little is known about these cells in lymphomas.
Persico, Marcello, Raffaella D’Auria, Giudice, Valentina, Selleri, Carmine, Giurato, Giorgio, Torre, Pietro, Rizzo, Francesca, Giorgio Giurato, Valentina Giudice, Alessandro Caputo, Carmine Selleri, Francesca Rizzo, Caputo, Alessandro, Pio ZEPPA, Benedetta Maria Motta, Casolaro, Vincenzo, Motta, Benedetta Maria, Brescia, Annalisa, Annalisa Brescia, Vincenzo Casolaro, Marcello Persico, D’Auria, Raffaella, Pietro Torre, Zeppa, Pio   +23 more
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Persistent deficiency of mucosal-associated invariant T cells during dermatomyositis

, 2020
International audienceObjectives: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that are important for antibacterial immunity and may have regulatory roles. MAIT cells are decreased during SLE.
Bagot, Martine, Branchtein, Mylene, Bachmeyer, Claude, Amoura, Zahir, Mathian, Alexis, Bengoufa, Djaouida, Cordoliani, Florence, Bouaziz, Jean-David, Bensussan, Armand, de Masson, Adèle, Monfort, Jean-Benoit, Le Buanec, Hélène, Frumholtz, Laure, Lepelletier, Clémence, Battistella, Maxime, Amode, Reyhan, Jachiet, Marie, Cassius, Charles, Chasset, François, Samri, Assia   +19 more
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Mucosal-Associated Invariant T Cell Interactions with Commensal and Pathogenic Bacteria: Potential Role in Antimicrobial Immunity in the Child

Frontiers in Immunology, 2017
Mucosal-associated invariant T (MAIT) cells are unconventional CD3+CD161high T lymphocytes that recognize vitamin B2 (riboflavin) biosynthesis precursor derivatives presented by the MHC-I related protein, MR1. In humans, their T cell receptor is composed
Liana Ghazarian, Sophie Caillat-Zucman, Sophie Caillat-Zucman, Véronique Houdouin, Véronique Houdouin   +4 more
doaj   +1 more source

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

Cell Reports, 2019
Summary: Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer+ cells derived from either human blood or murine
Timothy S.C. Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J. Pediongco, Bronwyn S. Meehan, Lyudmila Kostenko, Stephen J. Turner, Alexandra J. Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey   +12 more
doaj   +1 more source

Effector functions of mucosal associated invariant T cells in response to viral infections and vaccines

, 2023
The rapid propagation of host immune responses following nucleic-acid sensing is necessary for protection against viruses and vaccines. Cytokines, such as type I interferon (IFN), play a key role.
Amini, Ali
core   +1 more source