Results 61 to 70 of about 10,087 (235)

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Mucosal-associated invariant T (MAIT) cells are reduced and dysfunctional in acute melioidosis

Scientific Reports
Burkholderia pseudomallei (BP), the causative agent of melioidosis, is a major cause of sepsis in Southeast Asia, especially in people with diabetes mellitus (DM). The role of Mucosal-associated invariant T (MAIT) cells; innate-like T cells important for
Fazle Rabbi Chowdhury, Martha Zewdie, Priyanka Abraham, Srija Moulik, Hadiza Adebowale, Jennifer Hill, Md Robed Amin, Lovely Barai, Md Rokibul Hasan, Ayako Kurioka, Patpong Rongkard, Direk Limmathurotsakul, Nicholas P. J. Day, Parinya Chamnan, Paul Klenerman, Chris B. Willberg, Barbara Kronsteiner, Susanna J. Dunachie   +17 more
doaj   +1 more source

Differential Skewing of Circulating MR1-Restricted and γδ T Cells in Human Psoriasis Vulgaris

Frontiers in Immunology, 2020
Psoriasis vulgaris (PV) is a chronic, recurrent inflammatory dermatosis mediated by aberrantly activated immune cells. The role of the innate-like T cells, particularly gammadelta T (γδT) cells and MR1-restricted T lymphocytes, is incompletely explored ...
Vera Plužarić, Vera Plužarić, Mario Štefanić, Martina Mihalj, Martina Mihalj, Maja Tolušić Levak, Maja Tolušić Levak, Ivanka Muršić, Ljubica Glavaš-Obrovac, Martin Petrek, Peter Balogh, Stana Tokić   +11 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

MAIT Cell Activation and Functions

Frontiers in Immunology, 2020
Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict conservation across 150 million years of mammalian evolution, implying they must fulfill critical immunological function(s).
Timothy S. C. Hinks, Xia-Wei Zhang, Xia-Wei Zhang   +2 more
doaj   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Mucosal‐associated invariant T cells in autoimmune and immune‐mediated diseases

Immunology & Cell Biology, 2018
AbstractAutoimmune and inflammatory diseases have complex etiologies not fully understood. Both innate and adaptive immune cells are involved in the pathogenesis of these diseases. Mucosal‐associated invariant T (MAIT) cells express an invariant TCRα chain (Vα7.2‐Jα33 in humans and Vα19‐Jα33 in mice) and recognize the conserved MHC‐I‐related molecule ...
Rouxel, Ophélie, Lehuen, Agnès
openaire   +2 more sources

Role of CD1d- and MR1-Restricted T Cells in Asthma

Frontiers in Immunology, 2018
Innate T lymphocytes are a group of relatively recently identified T cells that are not involved in either innate or adaptive immunity. Unlike conventional T cells, most innate T lymphocytes express invariant T cell receptor to recognize exogenous non ...
Chiaki Iwamura, Toshinori Nakayama
doaj   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

Characterization and Purification of Mouse Mucosal‐Associated Invariant T (MAIT) Cells

Current Protocols in Immunology, 2019
AbstractThis unit describes the utility of various mouse models of infection and immunization for studying mucosal‐associated invariant T (MAIT) cell immunity: MAIT cells can be isolated from the lungs (or from other tissues/organs) and then identified and characterized by flow cytometry using MR1 tetramers in combination with a range of antibodies ...
Chen, Z, Wang, H, D'Souza, C, Koay, H-F, Meehan, B, Zhao, Z, Pediongco, T, Shi, M, Zhu, T, Wang, B, Kjer-Nielsen, L, Eckle, SBG, Rossjohn, J, Fairlie, DP, Godfrey, DI, Strugnell, RA, McCluskey, J, Corbett, AJ   +17 more
openaire   +6 more sources