Results 71 to 80 of about 19,288 (276)

Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis

Arthritis Research & Therapy, 2019
Background Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise bacterial metabolites presented by MHC class I-related protein 1 (MR1). Bacterial dysbiosis has been implicated in auto-inflammatory disease development.
Hester Koppejan, Diahann T. S. L. Jansen, Marjolijn Hameetman, Ranjeny Thomas, Rene E. M. Toes, Floris A. van Gaalen   +5 more
doaj   +1 more source

MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors

Frontiers in Immunology, 2020
Mucosal-associated invariant T (MAIT) cells are innate-like T cells present at considerable frequencies in human blood and barrier tissues, armed with an expanding array of effector functions in response to homeostatic perturbations.
Ali Amini, Ali Amini, Declan Pang, Carl-Philipp Hackstein, Carl-Philipp Hackstein, Paul Klenerman, Paul Klenerman   +6 more
doaj   +1 more source

Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses [PDF]

, 2014
Background: Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface. Methods: We measured MAIT cell frequencies and antibody
Aktar, Amena, Bhuiyan, Taufiqur R., Calderwood, Stephen B., Charles, Richelle C., Chowdhury, Fahima, Harris, Jason B., Hoq, Mohammad Rubel, Khan, Ashraful I., Leung, Daniel T., Nishat, Naoshin S., Qadri, Firdausi, Rahman, M. Arifur, Ryan, Edward T., Uddin, Taher   +13 more
core   +3 more sources

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Mucosal-Associated Invariant T Cells: New Insights into Antigen Recognition and Activation

Frontiers in Immunology, 2017
Mucosal-associated invariant T (MAIT) cells, a novel subpopulation of innate-like T cells that express an invariant T cell receptor (TCR)α chain and a diverse TCRβ chain, can recognize a distinct set of small molecules, vitamin B metabolites, derived ...
Xingxing Xiao, Xingxing Xiao, Jianping Cai, Jianping Cai   +3 more
doaj   +1 more source

Molecular analyses define Vα7.2-Jα33+ MAIT cell depletion in HIV infection: a case-control study [PDF]

, 2015
Mucosal-associated invariant T (MAIT) cells are an abundant antibacterial innate-like lymphocyte population. There are conflicting reports as to their fate in HIV infection.
Cosgrove, Cormac, Goulder, Philip, Günthard, Huldrych F, Hannaway, Rachel F, Klenerman, Paul, Phalora, Prabhjeet, Phillips, Rodney E, Rauch, Andri, Ussher, James E, Willberg, Christian B   +9 more
core   +2 more sources

A Systematic Study of GelMA‐Carbopol Bioinks for High‐Fidelity Extrusion 3D Bioprinting at Physiological Temperatures

Advanced Healthcare Materials, EarlyView.
Gonzalez Martinez and collaborators develop a strategy to formulate high performance GelMA‐based bioinks with low solids contents. The resulting bioinks enable 3D bioprinting at 37 °C of high‐fidelity structures with tunable mechanical properties that support high cell viability and function.
David A. González‐Martínez, Aidee V. Arizpe Tafoya, Eduardo González‐Martínez, Mabel Barreiro Carpio, Laura Daniela Serrano Andrade, Christopher T. N. Chow, Mohammadhossein Dabaghi, Jeremy A. Hirota, Jose M. Moran‐Mirabal   +8 more
wiley   +1 more source

Characterization of Human Mucosal‐associated Invariant T (MAIT) Cells

Current Protocols in Immunology, 2019
AbstractMucosal‐associated invariant T (MAIT) cells are a subset of unconventional T cells restricted by the major histocompatibility complex (MHC) class I–like molecule MHC‐related protein 1 (MR1). MAIT cells are found throughout the body, especially in human blood and liver.
Souter, Michael N.T., Loh, Liyen, Li, Shihan, Meehan, Bronwyn S., Gherardin, Nicholas A., Godfrey, Dale I., Rossjohn, Jamie, Fairlie, David P., Kedzierska, Katherine, Pellicci, Daniel G., Chen, Zhenjun, Kjer-Nielsen, Lars, Corbett, Alexandra J., McCluskey, James, Eckle, Sidonia B. G.   +14 more
openaire   +4 more sources

Mucosal-Associated Invariant T Cells in Chronic Inflammatory Liver Disease [PDF]

Seminars in Liver Disease, 2018
AbstractThe broadening field of microbiome research has led to a substantial reappraisal of the gut–liver axis and its role in chronic liver disease. The liver is a central immunologic organ that is continuously exposed to food and microbial-derived antigens from the gastrointestinal tract.
Fabian J, Bolte, Barbara, Rehermann
openaire   +2 more sources

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source