Mucosal-Associated Invariant T Cells: New Insights into Antigen Recognition and Activation
Frontiers in Immunology, 2017 Mucosal-associated invariant T (MAIT) cells, a novel subpopulation of innate-like T cells that express an invariant T cell receptor (TCR)α chain and a diverse TCRβ chain, can recognize a distinct set of small molecules, vitamin B metabolites, derived ...
Xingxing Xiao +3 more
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Molecular insights into metabolite antigen recognition by mucosal-associated invariant T cells [PDF]
Curr Opin Immunol, 2023 Metabolite-based T-cell immunity is emerging as a major player in antimicrobial immunity, autoimmunity, and cancer. Here, small-molecule metabolites were identified to be captured and presented by the major histocompatibility complex class-I-related ...
Awad, W +4 more
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Biological functions and therapeutic applications of human mucosal-associated invariant T cells [PDF]
Journal of Biomedical ScienceMucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T lymphocytes that bridge innate and adaptive immunity. Characterized by their semi-invariant T cell receptor (TCR) and abundant localization in mucosal tissues, MAIT cells ...
Ying Fang +7 more
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Mucosal-associated invariant T cells in hematological malignancies: Current knowledge, pending questions [PDF]
Frontiers in Immunology, 2023 Non-classical HLA restricted T cell subsets such as γδ T and NK-T cells are showing promises for immune-based therapy of hematological malignancies. Mucosal-Associated Invariant T cells (MAIT) belong to this family of innate-like T cell subsets and are ...
Emmanuel Treiner +2 more
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Mucosal‐associated invariant T cells modulate innate immune cells and inhibit colon cancer growth [PDF]
Scand J ImmunolMucosal-associated invariant T (MAIT) cells are innate-like T cells that can be activated by microbial antigens and cytokines and are abundant in mucosal tissues including the colon.
Beswick, Ellen J. +8 more
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Mucosal-associated invariant T (MAIT) cells: an evolutionarily conserved T cell subset
Microbes and Infection, 2005 International audienceBesides mainstream TCRalphabeta T cells harboring a very diverse repertoire, two subsets display an evolutionarily conserved invariant repertoire. This striking conservation indicates important and unique functions.
Ivan Cruz Moura +11 more
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Role of mucosal-associated invariant T cells in coronavirus disease 2019 vaccine immunogenicity [PDF]
Curr Opin VirolMucosal-associated invariant T (MAIT) cells are an unconventional T cell population that are highly abundant in humans. They possess a semi-invariant T cell receptor (TCR) that recognises microbial metabolites formed during riboflavin biosynthesis ...
Klenerman, Paul +2 more
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Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications [PDF]
J Inflamm (Lond)Mucosal-associated invariant T (MAIT) cells are an atypical subset of T lymphocytes, which have a highly conserved semi-constant αβ chain of T-cell receptor (TCR) and recognize microbe-derived vitamin B metabolites via major histocompatibility complex ...
Xue Lin, Ye Wang, Yanqi He
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The alterations of circulating mucosal-associated invariant T cells in polycystic ovary syndrome
Frontiers in Endocrinology, 2022 BackgroundPolycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting reproductive age females and an important cause of infertility.
Hong Zhou +14 more
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Mucosal-Associated Invariant T cell in liver diseases [PDF]
International Journal of Biological Sciences, 2020 Mucosal-associated invariant T cells (MAIT cells) are a new population of innate immune cells, which are abundant in the liver and play complex roles in various liver diseases. In this review, we summarize MAIT cells in the liver diseases in recent studies, figure out the role of MAIT cells in various liver disease, including Alcoholic liver disease ...
Zhang, Yujue, Kong, Derun, Wang, Hua
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