Results 31 to 40 of about 10,087 (235)

The role of mucosal‐associated invariant T cells in infectious diseases [PDF]

Immunology, 2016
SummaryMucosal‐associated invariant T (MAIT) cells are donor‐unrestricted lymphocytes that are surprisingly abundant in humans, representing 1–10% of circulating T cells and further enriched in mucosal tissues. MAIT cells recognize and are activated by small molecule ligands produced by microbes and presented by MR1, a highly conserved MHC‐related ...
Wong, E., Ndung'u, T., Kasprowicz, V.
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Neutrophils suppress mucosal‐associated invariant T cells in humans [PDF]

European Journal of Immunology, 2020
Abstract Mucosal‐associated invariant T (MAIT) cells are innate‐like T lymphocytes that are abundant in mucosal tissues and the liver where they can respond rapidly to a broad range of riboflavin producing bacterial and fungal pathogens. Neutrophils, which are recruited early to sites of infection, play a nonredundant role in pathogen
Marion Schneider, Rachel F. Hannaway, Rajesh Lamichhane, Sara M. de la Harpe, Joel D.A. Tyndall, Andrea J. Vernall, Anthony J. Kettle, James E. Ussher   +7 more
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The dynamics of mucosal-associated invariant T cells in multiple sclerosis [PDF]

SpringerPlus, 2016
Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelination, gliosis and axonal loss in the Central Nervous System. Although the etiology of the disease has remained enigmatic, recent studies have suggested a role of the innate-like T cells, called Mucosal Associated Invariant T cells (MAITs) in the pathophysiology.
Sugimoto, Chie, Hirotani, Makoto, Yoshikiyo, Kazunori, Koshimizu, Uichi, Wakao, Rika, Horinouchi, Takahiro, Mazaki, Yuichi, Higashi, Tsunehiko, Fukazawa, Toshiyuki, Fujita, Hiroyoshi, Sasaki, Hidenao, Wakao, Hiroshi   +11 more
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Clostridioides difficile Activates Human Mucosal-Associated Invariant T Cells

Frontiers in Microbiology, 2018
Clostridioides difficile infection (CDI) causes severe inflammatory responses at the intestinal mucosa but the immunological mechanisms underlying CDI-related immunopathology are still incompletely characterized.
Isabel Bernal, Isabel Bernal, Isabel Bernal, Julia Danielle Hofmann, Björn Bulitta, Frank Klawonn, Frank Klawonn, Annika-Marisa Michel, Dieter Jahn, Meina Neumann-Schaal, Meina Neumann-Schaal, Dunja Bruder, Dunja Bruder, Lothar Jänsch   +13 more
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Mucosal-Associated Invariant T Cell Interactions with Commensal and Pathogenic Bacteria: Potential Role in Antimicrobial Immunity in the Child

Frontiers in Immunology, 2017
Mucosal-associated invariant T (MAIT) cells are unconventional CD3+CD161high T lymphocytes that recognize vitamin B2 (riboflavin) biosynthesis precursor derivatives presented by the MHC-I related protein, MR1. In humans, their T cell receptor is composed
Liana Ghazarian, Sophie Caillat-Zucman, Sophie Caillat-Zucman, Véronique Houdouin, Véronique Houdouin   +4 more
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Peripheral and intestinal mucosal-associated invariant T cells in premature infants with necrotizing enterocolitis

Frontiers in Pharmacology, 2022
Background: Necrotizing enterocolitis (NEC) is a potentially fatal inflammatory gastrointestinal disease in preterm infants with unknown pathogenesis. Mucosal-associated invariant T (MAIT) cells primarily accumulate at sites where exposure to microbes is
Jiayi Tian, Chaoying Yan, Yanfang Jiang, Haohan Zhou, Liyuan Li, Jingjing Shen, Jian Wang, Hongyu Sun, Guang Yang, Wei Sun   +9 more
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Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

Cell Reports, 2019
Summary: Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer+ cells derived from either human blood or murine
Timothy S.C. Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J. Pediongco, Bronwyn S. Meehan, Lyudmila Kostenko, Stephen J. Turner, Alexandra J. Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey   +12 more
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Characterization of Human Mucosal‐associated Invariant T (MAIT) Cells

Current Protocols in Immunology, 2019
AbstractMucosal‐associated invariant T (MAIT) cells are a subset of unconventional T cells restricted by the major histocompatibility complex (MHC) class I–like molecule MHC‐related protein 1 (MR1). MAIT cells are found throughout the body, especially in human blood and liver.
Souter, Michael N.T., Loh, Liyen, Li, Shihan, Meehan, Bronwyn S., Gherardin, Nicholas A., Godfrey, Dale I., Rossjohn, Jamie, Fairlie, David P., Kedzierska, Katherine, Pellicci, Daniel G., Chen, Zhenjun, Kjer-Nielsen, Lars, Corbett, Alexandra J., McCluskey, James, Eckle, Sidonia B. G.   +14 more
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Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells

Nature Communications, 2020
Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental ...
S. Harsha Krovi, Jingjing Zhang, Mary Jessamine Michaels-Foster, Tonya Brunetti, Liyen Loh, James Scott-Browne, Laurent Gapin   +6 more
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B cells modulate mucosal associated invariant T cell (MAIT) immune responses

Frontiers in Immunology, 2014
A common finding when measuring T cell immunity to enteric bacterial vaccines in humans is the presence of background responses among individuals before immunization. Yet the nature of these background responses remains largely unknown. Recent findings
Rosangela eSalerno-Goncalves, Tasmia eRezwan, Marcelo B. Sztein   +2 more
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