Results 31 to 40 of about 19,288 (276)

Mucosal-associated invariant T cells restrict allergic airway inflammation [PDF]

Journal of Allergy and Clinical Immunology, 2020
We report that MAIT cells repress group 2 innate lymphoid cell activation and restrict allergen-induced airway inflammation and airway hyperresponsiveness.
Longyun, Ye, Jiexue, Pan, Muhammad Asghar, Pasha, Xiaofei, Shen, Shanti S, D'Souza, Ivan Ting Hin, Fung, Yinna, Wang, Bingnan, Guo, Dale D, Tang, Qi, Yang   +9 more
openaire   +2 more sources

Mucosal associated invariant T cells: Powerhouses of the lung. [PDF]

Immunol Lett
The lungs face constant environmental challenges from harmless molecules, airborne pathogens and harmful agents that can damage the tissue. The lungs' immune system includes numerous tissue-resident lymphocytes that contribute to maintain tissue homeostasis and to the early initiation of immune responses.
López-Rodríguez JC, Barral P.
europepmc   +4 more sources

Neutrophils suppress mucosal‐associated invariant T cells in humans [PDF]

European Journal of Immunology, 2020
Abstract Mucosal‐associated invariant T (MAIT) cells are innate‐like T lymphocytes that are abundant in mucosal tissues and the liver where they can respond rapidly to a broad range of riboflavin producing bacterial and fungal pathogens. Neutrophils, which are recruited early to sites of infection, play a nonredundant role in pathogen
Marion Schneider, Rachel F. Hannaway, Rajesh Lamichhane, Sara M. de la Harpe, Joel D.A. Tyndall, Andrea J. Vernall, Anthony J. Kettle, James E. Ussher   +7 more
openaire   +2 more sources

Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling [PDF]

, 2016
The antimicrobial responsiveness and function of unconventional human T cells are poorly understood, with only limited access to relevant specimens from sites of infection.
Bowen, Timothy, Brook, Amy C., Colmont, Chantal S., Donovan, Kieron L., Eberl, Matthias, Fraser, Donald J., Friberg, Ida M., Johnson, David W., Kift-Morgan, Ann, Liuzzi, Anna Rita, Lopez-Anton, Melisa, Moser, Bernhard, Roberts, Gareth W., Toleman, Mark A., Topley, Nicholas, Zhang, Jingjing   +15 more
core   +1 more source

Role of innate T cells in anti-bacterial immunity [PDF]

, 2015
Innate T cells are a heterogeneous group of αβ and γδ T cells that respond rapidly (
Aggarwal, Arigoni, Battistini, Behr, Bendelac, Berzins, Berzofsky, Billerbeck, Bonneville, Brandes, Brennan, Brigl, Brigl, Buchmeier, Carreno, Carvalho, Chackerian, Chua, Cohen, Collins, Darmoise, De Libero, DiTirro, Dusseaux, Eguchi, Espinosa, Fergusson, Fernandez, Fletcher, Fujita, Gao, Georgel, Giabbai, Godfrey, Gold, Gold, Grimaldi, Harly, He, Horikoshi, Ivanov, Joyce, Joyee, Kalyan, Kawakami, Kee, Kinjo, Kinjo, Kinjo, Kjer-Nielsen, Kroca, Lanier, Le Bourhis, Leslie, Lo, Luoma, Maggi, Martin, Mattner, Meierovics, Miyagawa, Morita, Nauciel, Olszak, Paget, Paget, Paget, Paget, Park, Pechhold, Reantragoon, Reantragoon, Russano, Sada-Ovalle, Salio, Sandstrom, Sarikonda, Seach, Shin, Silva, Skeen, Sriram, Stanic, Takahashi, Tessmer, Tilloy, Tupin, Turtle, Uldrich, Ussher, van der Sluijs, Van Kaer, Vavassori, Voyle, Wingender, Wong, Wong, Wu, Xiao, Yuling, Zheng   +100 more
core   +1 more source

Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis [PDF]

, 2018
Subclinical gut inflammation occurring in patients affected by spondyloarthritis (SpA) is correlated with the severity of spine inflammation. Several evidences indicate that dysbiosis occurs in SpA, and that may modulate intestinal permeability and ...
Ciccia F., Ferrante A., Guggino G., Rizzo A.   +3 more
core   +1 more source

Double Positive Thymocytes Select Mucosal-Associated Invariant T Cells [PDF]

The Journal of Immunology, 2013
Abstract NKT and mucosal-associated invariant T (MAIT) cells express semi-invariant TCR and restriction by nonclassical MHC class Ib molecules. Despite common features, the respective development of NKT and MAIT subsets is distinct. NKTs proliferate extensively and acquire effector properties prior to thymic export.
Natalie, Seach, Lucia, Guerri, Lionel, Le Bourhis, Yvonne, Mburu, Yue, Cui, Stéphanie, Bessoles, Claire, Soudais, Olivier, Lantz   +7 more
openaire   +2 more sources

Recognition of vitamin B metabolites by mucosal-associated invariant T cells [PDF]

, 2013
The mucosal-associated invariant T-cell antigen receptor (MAIT TCR) recognizes MR1 presenting vitamin B metabolites. Here we describe the structures of a human MAIT TCR in complex with human MR1 presenting a non-stimulatory ligand derived from folic acid
A Bendelac, AG Leslie, AW Schuttelkopf, C Cosgrove, DG Pellicci, DI Godfrey, DI Godfrey, DI Godfrey, DI Godfrey, DN Garboczi, E Girardi, E Girardi, E Leeansyah, E Treiner, F Tilloy, FE Tynan, G Vera, J Rossjohn, KS Wun, L Kjer-Nielsen, L Kjer-Nielsen, L Le Bourhis, L Le Bourhis, MC Gold, MC Gold, NA Borg, O Patel, PH Zwart, R Reantragoon, S Gras, S Huang, S Huang, SJ Turner, TS Mikkelsen, WJ Chua, X-Z Tang, Y Miyazaki   +36 more
core   +1 more source

Mucosal associated invariant T cells: Don't forget your vitamins [PDF]

Cell Research, 2012
T lymphocytes express clonal receptors, called T cell receptors (TCRs), which specifically recognize antigens presented in combination with major histocompatibility molecules (MHC). To date, T cell antigens can be broadly categorized into two classes: peptides and lipids.
Mary H, Young, Laurent, Gapin
openaire   +2 more sources

Recipient mucosal-associated invariant T cells control GVHD within the colon [PDF]

, 2018
Mucosal-associated invariant T (MAIT) cells are a unique innate-like T cell subset that responds to a wide array of bacteria and yeast through recognition of riboflavin metabolites presented by the MHC class I–like molecule MR1.
Andrea S. Henden, Andrew D. Clouston, Antiopi Varelias, Cooke, David P. Fairlie, Geoffrey R. Hill, Hill, Hill, James McCluskey, Jamie Rossjohn, Jasmin Straube, Jeffrey Y.W. Mak, Kate H. Gartlan, Kate L. Ormerod, Kjer-Nielsen, Lars Kjer-Nielsen, Leanne Cooper, Mak, Mark D. Bunting, Martin, Motoko Koyama, Nancy Lachner, Olivier Lantz, Patel, Philip Hugenholtz, Rachel D. Kuns, Renee J. Robb, Steven W. Lane, Stuart D. Olver, Treiner, van Wilgenburg   +30 more
core   +3 more sources