Results 41 to 50 of about 29,619 (221)

MAIT cells in metabolic diseases

Molecular Metabolism, 2019
Metabolic diseases represent a wide category of alterations affecting metabolism. These pathologies are notably marked by inflammation that implicates the immune system. Mucosal Associated Invariant (MAI)T cells are immune cells expressing a semi-invariant TCR able to recognize bacterial and fungal vitamin B metabolites.
Bertrand, Léo, Lehuen, Agnès
openaire   +4 more sources

Mouse models illuminate MAIT cell biology

Molecular Immunology, 2021
The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based antigens recognised by these specialised T cells. Over the past few years, our understanding of the complexities of MAIT cell function has developed, as they find their place among the other better known cells of the immune ...
Wang, H, Chen, Z, McCluskey, J, Corbett, AJ   +3 more
openaire   +4 more sources

Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma

Frontiers in Immunology, 2019
Oesophageal adenocarcinoma (OAC) is an aggressive malignancy with poor prognosis, and incidence is increasing rapidly in the Western world. Mucosal-associated invariant T (MAIT) cells recognize bacterial metabolites and kill infected cells, yet their ...
Ashanty M. Melo, Aisling M. O'Brien, James J. Phelan, Susan A. Kennedy, Nicole A. W. Wood, Natacha Veerapen, Gurdyal S. Besra, Niamh E. Clarke, Emma K. Foley, Akshaya Ravi, Finbar MacCarthy, Dermot O'Toole, Narayamasami Ravi, Narayamasami Ravi, John V. Reynolds, John V. Reynolds, Melissa J. Conroy, Andrew E. Hogan, Andrew E. Hogan, Jacintha O'Sullivan, Margaret R. Dunne   +20 more
doaj   +1 more source

Peripheral and intestinal mucosal-associated invariant T cells in premature infants with necrotizing enterocolitis

Frontiers in Pharmacology, 2022
Background: Necrotizing enterocolitis (NEC) is a potentially fatal inflammatory gastrointestinal disease in preterm infants with unknown pathogenesis. Mucosal-associated invariant T (MAIT) cells primarily accumulate at sites where exposure to microbes is
Jiayi Tian, Chaoying Yan, Yanfang Jiang, Haohan Zhou, Liyuan Li, Jingjing Shen, Jian Wang, Hongyu Sun, Guang Yang, Wei Sun   +9 more
doaj   +1 more source

Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses [PDF]

, 2014
Background: Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface. Methods: We measured MAIT cell frequencies and antibody
Aktar, Amena, Bhuiyan, Taufiqur R., Calderwood, Stephen B., Charles, Richelle C., Chowdhury, Fahima, Harris, Jason B., Hoq, Mohammad Rubel, Khan, Ashraful I., Leung, Daniel T., Nishat, Naoshin S., Qadri, Firdausi, Rahman, M. Arifur, Ryan, Edward T., Uddin, Taher   +13 more
core   +3 more sources

Frequencies of CD8 and DN MAIT Cells Among Children Diagnosed With Type 1 Diabetes Are Similar to Age-Matched Controls

Frontiers in Immunology, 2021
Mucosal-associated invariant T (MAIT) cells have been implicated in various forms of autoimmunity, including type 1 diabetes (T1D). Here, we tested the hypothesis that CD8 and double negative (DN) MAIT cell frequencies were altered among diagnosed T1D ...
Robert Z. Harms, Katie R. Ostlund, Monina Cabrera, Monina Cabrera, Earline Edwards, Earline Edwards, Victoria B. Smith, Lynette M. Smith, Nora Sarvetnick, Nora Sarvetnick   +9 more
doaj   +1 more source

Diffractive lens fabricated with binary features less than 60 nm [PDF]

, 2000
We designed, fabricated, and characterized a binary diffractive lens with features less than 60nm. The lens was designed for operation in the red portion of the spectrum.
Dial, Oliver, Gao, Xiang, Mait, Joseph N., Prather, Dennis W., Scherer, Axel   +4 more
core   +1 more source

Human MAIT Cell Activation In Vitro [PDF]

, 2019
Mucosal-associated invariant T (MAIT) cells are an abundant innate-like T cell subset in humans, enriched in mucosal tissues and the liver. MAIT cells express a semi-invariant T cell receptor (TCR) and recognize microbial-derived riboflavin metabolites presented on the MHC Class I-like molecule MR1. In addition to activation via the TCR, MAIT cells can
Hagel, JP, Garner, LC, Bilton, M, Mehta, H, Leng, T, Hackstein, C-P, Phalora, P, Amini, A, Akther, HD, Provine, NM, Edmans, M, Willberg, CB, Klenerman, P   +12 more
openaire   +3 more sources

Mucosal-Associated Invariant T Cells Redistribute to the Peritoneal Cavity During Spontaneous Bacterial Peritonitis and Contribute to Peritoneal InflammationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Mucosal-associated invariant T (MAIT) cells are depleted from blood in patients with advanced liver disease and show features of immune dysfunction.
Oluwatomi Ibidapo-obe, Sven Stengel, Nilay Köse-Vogel, Stefanie Quickert, Philipp A. Reuken, Martin Busch, Michael Bauer, Andreas Stallmach, Tony Bruns   +8 more
doaj   +1 more source

MAITabolism2 – the emerging understanding of MAIT cell metabolism and their role in metabolic disease

Frontiers in Immunology, 2023
Mucosal associated invariant T (MAIT) cells are a population of unconventional innate T cells due to their non-MHC restriction and rapid effector responses.
Nidhi Kedia-Mehta, Nidhi Kedia-Mehta, Andrew E. Hogan, Andrew E. Hogan, Andrew E. Hogan   +4 more
doaj   +1 more source