Results 41 to 50 of about 10,390 (221)

MAITabolism2 – the emerging understanding of MAIT cell metabolism and their role in metabolic disease

Frontiers in Immunology, 2023
Mucosal associated invariant T (MAIT) cells are a population of unconventional innate T cells due to their non-MHC restriction and rapid effector responses.
Nidhi Kedia-Mehta, Nidhi Kedia-Mehta, Andrew E. Hogan, Andrew E. Hogan, Andrew E. Hogan   +4 more
doaj   +1 more source

Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells [PDF]

, 2022
OBJECTIVE Mucosal-associated invariant T (MAIT) cells are the most abundant T cells in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1.
Magdalena Filipowicz Sinnreich, Christoph J Zech, Paul Klenerman, Jaeger, Tina, Heigl, Andres, Tina Jaeger, Urs Duthaler, Ivanek, Robert, Kate Powell, Martin J Lett, Jürg Vosbeck, Jacquet, Maxime, Deborah Stroka, Mehta, Hema, Jan Hendrik Niess, Maxime Jacquet, Klenerman, Paul, Isabel Fofana, Niess, Jan Hendrik, Robert Ivanek, Stroka, Deborah, Kollmar, Otto, Hassan Melhem, Zech, Christoph J, Mertz, Kirsten D, Burri, Emanuel, Emanuel Burri, Powell, Kate, Hema Mehta, Keogh, Adrian, Marie-Anne Meier, Fofana, Isabel, Gieri Cathomas, Meier, Marie-Anne, Cathomas, Gieri, Vosbeck, Jürg, Filipowicz Sinnreich, Magdalena, Melhem, Hassan, Andres Heigl, Markus H Heim, Otto Kollmar, Lett, Martin J, Adrian Keogh, Heim, Markus H, Duthaler, Urs, Kirsten D Mertz   +45 more
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Number of colonic MAIT cell TCRB sequences found, and their overlap with blood MAIT cells.

, 2023
Number of colonic MAIT cell TCRB sequences found, and their overlap with blood MAIT cells.
Donna M. Shows (17334267), James D. Lord (17334270), Andrew J. Konecny (17334264)   +2 more
core   +1 more source

Frequencies of Circulating MAIT Cells Are Diminished in Chronic HCV, HIV and HCV/HIV Co-Infection and Do Not Recover during Therapy. [PDF]

PLoS ONE, 2016
Mucosal-associated invariant T (MAIT) cells comprise a subpopulation of T cells that can be activated by bacterial products and cytokines to produce IFN-γ. Since little is known on MAIT cells during HCV infection, we compared their phenotype and function
Michelle Spaan, Sebastiaan J Hullegie, Boris J B Beudeker, Kim Kreefft, Gertine W van Oord, Zwier M A Groothuismink, Marjolein van Tilborg, Bart Rijnders, Robert J de Knegt, Mark A A Claassen, Andre Boonstra   +10 more
doaj   +1 more source

MICADO SCAO: to be or not to be... in MAIT

, 2023
MICADO is the ELT first light instrument, an imager working at the diffraction limit of the telescope thanks to two adaptive optics (AO) modes: a single conjugate one (SCAO), available at the instrument first light and developed by the MICADO consortium, and a multi conjugate one (MCAO), developed by the MORFEO consortium.
Clenet, Yann, Buey, Tristan, Gendron, Eric, Karkar, Sonia, Vidal, Fabrice, Cohen, Mathieu, Chapron, Frédéric, Sevin, Arnaud, Thijs, Simone, Taburet, Sylvestre, Borgo, Bruno, Huet, Jean-Michel, Blin, Alexandre, Dupuis, Olivier, Gaudemard, Julien, Ferreira, Florian, Raffard, Jordan, Chemla, Fanny, Lapeyrère, Vincent, Guieu, Sylvain, Meyer, Eric, Gautherot, Nicolas, Tisserand, Emmanuel, Locatelli, Hervé, Meyer, François, Genet, Camille, Cloiseau, Kévin, Zidi, Amal, Kulcsár, Caroline, Raynaud, Henri-François, Sassolas, Benoît, Pinard, Laurent, Michel, Christophe, Gratadour, Damien, Dembet, Roderick, Collin, Claude, Ghouchou, Lahoucine, Baudoz, Pierre, Huby, Elsa, Rabien, Sebastian, Sturm, Eckhard, Davies, Ric   +41 more
openaire   +1 more source

Isolation and Characterization of MAIT Cells from Tumor Tissues

, 2019
Mucosal-associated invariant T (MAIT) cell infiltration has been demonstrated in colorectal and hepatocellular carcinoma, and their ability to produce Th1- and Th17-associated cytokines, as well as their cytotoxic function, suggests that MAIT cells may ...
Quiding-Järbrink, Marianne,, William Rodin, Sundström, Patrik,, Patrik Sundström, Marianne Quiding Järbrink, Rodin, William,   +5 more
core   +1 more source

MAIT cells in autoimmunity

Japanese Journal of Clinical Immunology, 2012
Mucosal associated invariant T (MAIT) cells are restricted by a nonpolymorphic MHC-related molecule-1 (MR1), and express an invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are selected in the thymus, but, interestingly, MAIT cells require B cells as well as commensal flora for their peripheral expansion.
openaire   +5 more sources

MAIT cells in the liver environment

, 2021
MAIT cells are an important innate T cell population capable of recognising riboflavin-derived ligands presented by the evolutionary conserved MR1 molecule.
Mehta, Hema
core   +1 more source

Human MAIT Cell Activation In Vitro [PDF]

, 2019
Mucosal-associated invariant T (MAIT) cells are an abundant innate-like T cell subset in humans, enriched in mucosal tissues and the liver. MAIT cells express a semi-invariant T cell receptor (TCR) and recognize microbial-derived riboflavin metabolites presented on the MHC Class I-like molecule MR1. In addition to activation via the TCR, MAIT cells can
Hagel, JP, Garner, LC, Bilton, M, Mehta, H, Leng, T, Hackstein, C-P, Phalora, P, Amini, A, Akther, HD, Provine, NM, Edmans, M, Willberg, CB, Klenerman, P   +12 more
openaire   +3 more sources

Mucosal Associated Invariant T cells in the human gastric mucosa and blood: Role in Helicobacter pylori infection

Frontiers in Immunology, 2015
Mucosal-associated invariant T (MAIT) cells represent a class of antimicrobial innate-like T cells that have been characterized in human blood, liver, lungs and intestine.
Jayaum S Booth, Jayaum S Booth, Rosangela eSalerno-Goncalves, Rosangela eSalerno-Goncalves, Thomas G Blanchard, Seema A. Patil, Seema A. Patil, Howard A. Kader, Anca M. Safta, Lindsay M. Morningstar, Steven J. Czinn, Bruce D. Greenwald, Bruce D. Greenwald, Marcelo B. Sztein, Marcelo B. Sztein, Marcelo B. Sztein   +15 more
doaj   +1 more source