Results 11 to 20 of about 29,619 (221)

MAIT Cell Activation and Functions [PDF]

Frontiers in Immunology, 2020
Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict conservation across 150 million years of mammalian evolution, implying they must fulfill critical immunological function(s). MAIT cells are defined by their expression of a semi-invariant αβ TCR which recognizes biosynthetic derivatives of riboflavin synthesis ...
Timothy S. C. Hinks, Xia-Wei Zhang, Xia-Wei Zhang   +2 more
openaire   +4 more sources

MAIT cells and the microbiome

Frontiers in Immunology, 2023
Mucosal associated invariant T (MAIT) cells are innate-like T lymphocytes, strikingly enriched at mucosal surfaces and characterized by a semi-invariant αβ T cell receptor (TCR) recognizing microbial derived intermediates of riboflavin synthesis presented by the MHC-Ib molecule MR1.
Maisha F. Jabeen, Maisha F. Jabeen, Timothy S. C. Hinks, Timothy S. C. Hinks   +3 more
openaire   +5 more sources

Effects of interleukin-23 on the activation of mucosal-associated invariant T cells from oral lichen planus

Journal of International Medical Research, 2023
Objective Oral lichen planus (OLP) is a T cell-mediated inflammatory condition in the oral cavity. Mucosal-associated invariant T (MAIT) cells are gaining more relevance in immune diseases because they can be activated by cytokines without T cell ...
Fang Wang, Xiu-Li Zhang, Jing-Ya Yang, Gang Zhou   +3 more
doaj   +1 more source

Study of Metacognitive Awareness in Colombian University Teachers

Papeles, 2020
A study was conducted about metacognitive skills reported by 118 university teachers in Bogotá through a metacognitive awareness inventory for teachers (MAIT).
Andrea Barrera-Bernal , José Bayona-Umbarila   +1 more
doaj   +1 more source

Involvement of impaired CD8+ mucosal-associated invariant T cells and myeloid-derived suppressor cells in polycystic ovary syndrome

Reproductive Biology and Endocrinology, 2021
Background Immune dysfunction is one of the mechanisms to promote polycystic ovary syndrome (PCOS). Various immune cells have been reported to be involved in the development of PCOS.
Mengting Zhu, Yuping Xu, Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Peipei Guo, Huanhuan Jiang, Yunxia Cao   +8 more
doaj   +1 more source

In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells

Frontiers in Immunology, 2022
IntroductionMucosal-associated invariant T (MAIT) cells might play a role in B cell hyperactivity and local inflammation in primary Sjögren’s syndrome (pSS), just like previously studied mucosa-associated CCR9+ and CXCR5+ T helper cells.
Anneline C. Hinrichs, Anneline C. Hinrichs, Aike A. Kruize, Helen L. Leavis, Joel A. G. van Roon, Joel A. G. van Roon   +5 more
doaj   +1 more source

MAIT cells come to the rescue in cancer immunotherapy? [PDF]

, 2020
Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk, Venken, Koen, Łukasik, Zuzanna   +2 more
core   +2 more sources

Varicella Zoster Virus infects mucosal associated Invariant T cells

Frontiers in Immunology, 2023
IntroductionMucosal Associated Invariant T (MAIT) cells are innate-like T cells that respond to conserved pathogen-derived vitamin B metabolites presented by the MHC class I related-1 molecule (MR1) antigen presentation pathway.
Shivam K. Purohit, Alexandra J. Corbett, Barry Slobedman, Allison Abendroth   +3 more
doaj   +1 more source

Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections

Frontiers in Immunology, 2021
Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor (TCR) α chain and are restricted by the highly conserved antigen presenting molecule MR1.
Matthew D. Edmans, Matthew D. Edmans, Timothy K. Connelley, Siddharth Jayaraman, Christina Vrettou, Martin Vordermeier, Martin Vordermeier, Jeffrey Y. W. Mak, Jeffrey Y. W. Mak, Ligong Liu, Ligong Liu, Ligong Liu, David P. Fairlie, David P. Fairlie, David P. Fairlie, Emmanuel Atangana Maze, Tiphany Chrun, Paul Klenerman, Sidonia B. G. Eckle, Elma Tchilian, Lindert Benedictus, Lindert Benedictus   +21 more
doaj   +1 more source

The Activation of Mucosal-Associated Invariant T (MAIT) Cells Is Affected by Microbial Diversity and Riboflavin Utilization in vitro

Frontiers in Microbiology, 2020
Recent research has demonstrated that MAIT cells are activated by individual bacterial or yeasts species that possess the riboflavin biosynthesis pathway.
Jannike L. Krause, Stephanie S. Schäpe, Florian Schattenberg, Susann Müller, Grit Ackermann, Ulrike E. Rolle-Kampczyk, Nico Jehmlich, Arkadiusz Pierzchalski, Martin von Bergen, Martin von Bergen, Gunda Herberth   +10 more
doaj   +1 more source