Results 11 to 20 of about 7,761 (187)
Frontiers in Immunology, 2023 Mucosal associated invariant T (MAIT) cells are innate-like T lymphocytes, strikingly enriched at mucosal surfaces and characterized by a semi-invariant αβ T cell receptor (TCR) recognizing microbial derived intermediates of riboflavin synthesis presented by the MHC-Ib molecule MR1.
Maisha F. Jabeen +3 more
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Mucosal-Associated Invariant T Cells in Health and Disease. [PDF]
MedComm (2020)The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Zhao Y +5 more
europepmc +2 more sources
MAIT Cell Activation and Functions [PDF]
Frontiers in Immunology, 2020 Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict conservation across 150 million years of mammalian evolution, implying they must fulfill critical immunological function(s). MAIT cells are defined by their expression of a semi-invariant αβ TCR which recognizes biosynthetic derivatives of riboflavin synthesis ...
Timothy S. C. Hinks +2 more
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Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19
Frontiers in Immunology, 2021 BackgroundMucosal-associated invariant T (MAIT) cells are considered to participate of the host immune response against acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, single-cell transcriptomic profiling of MAIT ...
Jijing Shi +10 more
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Frontiers in Microbiology, 2020 Recent research has demonstrated that MAIT cells are activated by individual bacterial or yeasts species that possess the riboflavin biosynthesis pathway.
Jannike L. Krause +10 more
doaj +1 more source
The Journal of Immunology, 2014 Abstract The evolutionary conservation of T lymphocyte subsets bearing αβ TCRs using invariant α-chains is indicative of unique and important functions. Among these T lymphocytes, NKT cells that express an invariant TCRα-chain and recognize lipid Ags presented by the nonclassical MHC class I molecule CD1d are probably the most studied ...
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CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study
Reproductive Biology and Endocrinology, 2019 Background Immune dysregulation is one of the mechanisms to promote endometriosis (EMS). Various T cell subpopulations have been reported to play different roles in the development of EMS.
Caihua Li +10 more
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Frontiers in Immunology, 2022 Mucosal-associated invariant T (MAIT) cells, a blossoming member of the innate-like T cells, play a pivotal role in host defense through engaging the mucosal immunity.
Yasuo Shimizu +5 more
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Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections
Frontiers in Immunology, 2021 Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor (TCR) α chain and are restricted by the highly conserved antigen presenting molecule MR1.
Matthew D. Edmans +21 more
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Frequencies of Circulating MAIT Cells Are Diminished in Chronic HCV, HIV and HCV/HIV Co-Infection and Do Not Recover during Therapy. [PDF]
PLoS ONE, 2016 Mucosal-associated invariant T (MAIT) cells comprise a subpopulation of T cells that can be activated by bacterial products and cytokines to produce IFN-γ. Since little is known on MAIT cells during HCV infection, we compared their phenotype and function
Michelle Spaan +10 more
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