Results 41 to 50 of about 13,362 (213)
Mucosa-associated invariant T cells are systemically depleted in simian immunodeficiency virus-infected rhesus macaques [PDF]
, 2016 Mucosa-associated invariant T (MAIT) cells contribute to host immune protection against a wide range of potential pathogens via the recognition of bacterial metabolites presented by the major histocompatibility complex class I-related molecule MR1 ...
Brenchley, Jason M. +8 more
core +1 more source
Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells [PDF]
, 2017 The major-histocompatibility-complex-(MHC)-class-I-related molecule MR1 can present activating and non-activating vitamin-B-based ligands to mucosal-associated invariant T cells (MAIT cells). Whether MR1 binds other ligands is unknown. Here we identified
A Kurioka +67 more
core +2 more sources
Frontiers in Immunology, 2017 Mucosal-associated invariant T (MAIT) cells are innate-like T cells which are important in the defense against certain bacteria and yeast. The reconstitution of MAIT cells after allogeneic hematopoietic stem cell transplantation (HSCT) is not known.
Martin Solders +8 more
doaj +1 more source
Mucosal-associated invariant T-cell frequency and function in blood and liver of HCV mono- and HCV/HIV co-infected patients with advanced fibrosis [PDF]
, 2017 __Background & Aims:__ Mucosal-associated invariant T (MAIT) cells are important innate T cells with antimicrobial and immunoregulatory activity, recently found to be depleted in blood of patients with HIV and HCV mono-infections.
Arends, J.E. (Joop) +8 more
core +1 more source
Frontiers in Immunology, 2019 Oesophageal adenocarcinoma (OAC) is an aggressive malignancy with poor prognosis, and incidence is increasing rapidly in the Western world. Mucosal-associated invariant T (MAIT) cells recognize bacterial metabolites and kill infected cells, yet their ...
Ashanty M. Melo +20 more
doaj +1 more source
Sports, 2021 (1) Background: Obesity is a major global public health concern as it is associated with many of the leading causes of preventable deaths. Exercise reduces obesity-induced inflammation; however, it is unknown how exercise training may impact mucosal ...
Lauren C. Bates +6 more
doaj +1 more source
Molecular analyses define Vα7.2-Jα33+ MAIT cell depletion in HIV infection: a case-control study [PDF]
, 2015 Mucosal-associated invariant T (MAIT) cells are an abundant antibacterial innate-like lymphocyte population. There are conflicting reports as to their fate in HIV infection.
Cosgrove, Cormac +9 more
core +2 more sources
Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection. [PDF]
, 2020 Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired ...
Ananworanich, Jintanat +23 more
core
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells [PDF]
, 2013 Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) alpha-chain, TRAV1-2-TRAJ33, and are activated by vitamin B metabolites bound by the major histocompatibility complex (MHC)-related class I-like molecule ...
Birkinshaw, Richard W. +19 more
core +3 more sources
Immunology & Cell Biology, 2018 AbstractMucosal‐associated invariant T (MAIT) cells, the most abundant T‐cell subset in humans, are increasingly being recognized for their importance in microbial immunity. MAIT cells accumulate in almost every mucosal tissue examined, including the lung, liver and intestinal tract, where they can be activated through T‐cell receptor (TCR) triggering ...
Erin W Meermeier +3 more
openaire +2 more sources