Results 41 to 50 of about 4,910,474 (212)

Number of colonic MAIT cell TCRB sequences found, and their overlap with blood MAIT cells.

, 2023
Number of colonic MAIT cell TCRB sequences found, and their overlap with blood MAIT cells.
Donna M. Shows (17334267), James D. Lord (17334270), Andrew J. Konecny (17334264)   +2 more
core   +1 more source

Stepwise development of MAIT cells in mouse and human. [PDF]

PLoS Biology, 2009
Mucosal-associated invariant T (MAIT) cells display two evolutionarily conserved features: an invariant T cell receptor (TCR)alpha (iTCRalpha) chain and restriction by the nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC ...
Emmanuel Martin, Emmanuel Treiner, Livine Duban, Lucia Guerri, Hélène Laude, Cécile Toly, Virginie Premel, Anne Devys, Ivan C Moura, Florence Tilloy, Stéphane Cherif, Gabriella Vera, Sylvain Latour, Claire Soudais, Olivier Lantz   +14 more
doaj   +1 more source

High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile [PDF]

, 2020
Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here, we demonstrate that CD26 and CD94 define transcriptionally, phenotypically, and functionally distinct Vδ2+ T cell subsets ...
Nguyen-Robertson, Catriona V., Kent, Stephen J., Wheatley, Adam, Berzins, Stuart, Kelleher, Anthony D., Pellicci, DG, Kristensen, Anne, Juno, Jennifer, Tan, Hyon Xhi, Nguyen-Robertson, Catriona, Kelleher, AD, Nguyen-Robertson, CV, Pellicci, Daniel, Wragg, Kathleen, Parsons, MS, Juno, JA, Wheatley, Adam K., Juno, Jennifer A., Tan, Hyon, Berzins, SP, Berzins, Stuart P., Tan, HX, Kent, SJ, Parsons, Matthew S., Wragg, Kathleen M., Kristensen, Anne B., Kristensen, AB, Wheatley, AK, Kent, Stephen, Parsons, Matthew, Wragg, KM, Pellicci, Daniel G., Kelleher, Anthony   +32 more
core   +1 more source

MAIT cell activation augments adenovirus vector vaccine immunogenicity [PDF]

, 2021
Mucosal-associated invariant T (MAIT) cells are innate sensors of viruses and can augment early immune responses and contribute to protection. We hypothesized that MAIT cells may have inherent adjuvant activity in vaccine platforms that use replication ...
Sharpe, Hannah, Provine, Nicholas M, Amini, Ali, Lambe, Teresa, Fitzpatrick, Michael, Hutchings, Claire, Troise, Fulvia, Spencer, Alexandra J, Klenerman, Paul, Capone, Stefania, Garner, Lucy, Dold, Christina, Raymond, Meriel, Hinks, Timothy, Silva-Reyes, Laura, FitzPatrick, Michael E. B, Folgori, Antonella, Morgan, Sophie B, Barnes, E, Hinks, Timothy S. C, Chinnakannan, Senthil, Morgan, Sophie, Rollier, Christine, Amini, A, Spencer, Alexandra, Provine, Nicholas, Oguti, Blanche, Barnes, Eleanor, Pollard, Andrew, Ulaszewska, Marta, Garner, Lucy C, Silva Reyes, Laura   +31 more
core   +1 more source

Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma

Frontiers in Immunology, 2019
Oesophageal adenocarcinoma (OAC) is an aggressive malignancy with poor prognosis, and incidence is increasing rapidly in the Western world. Mucosal-associated invariant T (MAIT) cells recognize bacterial metabolites and kill infected cells, yet their ...
Ashanty M. Melo, Aisling M. O'Brien, James J. Phelan, Susan A. Kennedy, Nicole A. W. Wood, Natacha Veerapen, Gurdyal S. Besra, Niamh E. Clarke, Emma K. Foley, Akshaya Ravi, Finbar MacCarthy, Dermot O'Toole, Narayamasami Ravi, Narayamasami Ravi, John V. Reynolds, John V. Reynolds, Melissa J. Conroy, Andrew E. Hogan, Andrew E. Hogan, Jacintha O'Sullivan, Margaret R. Dunne   +20 more
doaj   +1 more source

Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection: A Case-Control Study [PDF]

, 2015
Mucosal-associated invariant T (MAIT) cells are an abundant antibacterial innate-like lymphocyte population. There are conflicting reports as to their fate in HIV infection.
Cosgrove, Cormac, Goulder, Philip, Günthard, Huldrych F, Cosgrove, C, Rauch, A, Willberg, CB, Ussher, James E, Phalora, Prabhjeet, Hannaway, Rachel F, Rauch, Andri, Phillips, Rodney E, Ussher, JE, Klenerman, Paul, Phalora, P, Günthard, HF, Klenerman, P, Goulder, P, Willberg, Christian B, Hannaway, R, Phillips, RE   +19 more
core   +2 more sources

Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese Women

Sports, 2021
(1) Background: Obesity is a major global public health concern as it is associated with many of the leading causes of preventable deaths. Exercise reduces obesity-induced inflammation; however, it is unknown how exercise training may impact mucosal ...
Lauren C. Bates, Erik D. Hanson, Michael M. Levitt, Bryan Richie, Elise Erickson, David B. Bartlett, Melody D. Phillips   +6 more
doaj   +1 more source

Mouse models illuminate MAIT cell biology

, 2021
The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based antigens recognised by these specialised T cells.
Wang, H, Chen, Z, Corbett, AJ, McCluskey, J   +3 more
core   +1 more source

Persistent deficiency of mucosa-associated invariant T (MAIT) cells during alcohol-related liver disease

Cell & Bioscience, 2021
Background Alcohol-related liver disease (ALD) is a major cause of chronic liver diseases. Inflammatory response is a basic pathological feature of ALD.
Yujue Zhang, Yuanyuan Fan, Wei He, Yi Han, Huarui Bao, Renjun Yang, Bingbing Wang, Derun Kong, Hua Wang   +8 more
doaj   +1 more source

Isolation and Characterization of MAIT Cells from Tumor Tissues

, 2019
Mucosal-associated invariant T (MAIT) cell infiltration has been demonstrated in colorectal and hepatocellular carcinoma, and their ability to produce Th1- and Th17-associated cytokines, as well as their cytotoxic function, suggests that MAIT cells may ...
Quiding-Järbrink, Marianne,, William Rodin, Sundström, Patrik,, Patrik Sundström, Marianne Quiding Järbrink, Rodin, William,   +5 more
core   +1 more source