Results 41 to 50 of about 12,026,666 (219)

Investigating Vα7.2⁺/CD161^- T Cell and MAIT Cell Profiles Using Flow Cytometry in Healthy Subjects and Subjects with Atopic Dermatitis. [PDF]

Int J Mol Sci
This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2+/CD161− T cells in skin diseases, focusing on atopic dermatitis.
Singh P, Gaspar K, Szegedi A, Sajtos L, Barath S, Hevessy Z.   +5 more
europepmc   +2 more sources

Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity

Nature Immunology, 2021
Immune system dysfunction is paramount in coronavirus disease 2019 (COVID-19) severity and fatality rate. Mucosal-associated invariant T (MAIT) cells are innate-like T cells involved in mucosal immunity and protection against viral infections.
H. Flament, Matthieu Rouland, L. Beaudoin, A. Toubal, L. Bertrand, S. Lebourgeois, Camille Rousseau, Pauline Soulard, Zouriatou Gouda, Lucie Cagninacci, António C. Monteiro, M. Hurtado-Nedelec, Sandrine Luce, K. Bailly, M. Andrieu, B. Saintpierre, F. Letourneur, Y. Jouan, M. Si-Tahar, T. Baranek, C. Paget, C. Boitard, A. Vallet-Pichard, J. Gautier, N. Ajzenberg, B. Terrier, F. Pène, J. Ghosn, X. Lescure, Y. Yazdanpanah, B. Visseaux, D. Descamps, J. Timsit, R. Monteiro, A. Lehuen   +34 more
semanticscholar   +2 more sources

MAIT cells: Conserved watchers on the wall

Journal of Experimental Medicine
International audienceMAIT cells are innate-like T cells residing in barrier tissues such as the lung, skin, and intestine. Both the semi-invariant T cell receptor of MAIT cells and the restricting element MR1 are deeply conserved across mammals ...
Germain, Lilou, Legoux, François, Veloso, Pablo, Lantz, Olivier   +3 more
core   +4 more sources

MAIT cell activation augments adenovirus vector vaccine immunogenicity

Science, 2020
Vaccines get a help-MAIT Mucosal-associated invariant T (MAIT) cells are a T cell subset important for mucosal homeostasis. These cells recognize derivatives of microbiota-derived vitamin B2 precursors but can also be activated by certain cytokines in ...
N. Provine, Ali Amini, Lucy C. Garner, Alexandra J. Spencer, C. Dold, Claire L Hutchings, L. Silva Reyes, Michael E. B. FitzPatrick, Senthil Chinnakannan, B. Oguti, Meriel Raymond, M. Ulaszewska, F. Troise, H. Sharpe, S. Morgan, T. Hinks, T. Lambe, S. Capone, A. Folgori, E. Barnes, C. Rollier, A. Pollard, P. Klenerman   +22 more
semanticscholar   +3 more sources

Distinct MAIT cell phenotypes associated with sepsis clinical outcome in emergency department patients [PDF]

Clinical & Translational Immunology
Objectives Rapid diagnosis and intervention are critical for sepsis patient outcomes. However, diagnosis is challenging because of a heterogenic patient group as well as sometimes vague symptoms when the patient presents at the emergency department ...
Johanna Emgård, Iva Filipovic, Christian Unge, Laura M Palma Medina, Åsa Parke, Helena Bergsten, Kirsten Moll, Majda Dzidic, Helena Alpkvist, Hong Fang, Volkan Özenci, Niklas K Björkström, Mattias Svensson, Johan K Sandberg, Kristoffer Strålin, Anna Norrby‐Teglund   +15 more
doaj   +2 more sources

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

Cell Reports, 2019
Summary: Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer+ cells derived from either human blood or murine
Timothy S.C. Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J. Pediongco, Bronwyn S. Meehan, Lyudmila Kostenko, Stephen J. Turner, Alexandra J. Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey   +12 more
doaj   +2 more sources

Bacteroides ovatus-mediated CD27^- MAIT cell activation is associated with obesity-related T2D progression. [PDF]

Cell Mol Immunol, 2022
Li Y, Yang Y, Wang J, Cai P, Li M, Tang X, Tan Y, Wang Y, Zhang F, Wen X, Liang Q, Nie Y, Chen T, Peng X, He X, Zhu Y, Shi G, Cheung WW, Wei L, Chen Y, Lu Y.   +20 more
europepmc   +2 more sources

Comparative transcriptomes reveal pro-survival and cytotoxic programs of mucosal-associated invariant T cells upon Bacillus Calmette–Guérin stimulation

Frontiers in Cellular and Infection Microbiology, 2023
Mucosal-associated invariant T (MAIT) cells are protective against tuberculous and non-tuberculous mycobacterial infections with poorly understood mechanisms. Despite an innate-like nature, MAIT cell responses remain heterogeneous in bacterial infections.
Manju Sharma, Liang Niu, Xiang Zhang, Shouxiong Huang   +3 more
doaj   +1 more source

Frequencies of CD8 and DN MAIT Cells Among Children Diagnosed With Type 1 Diabetes Are Similar to Age-Matched Controls

Frontiers in Immunology, 2021
Mucosal-associated invariant T (MAIT) cells have been implicated in various forms of autoimmunity, including type 1 diabetes (T1D). Here, we tested the hypothesis that CD8 and double negative (DN) MAIT cell frequencies were altered among diagnosed T1D ...
Robert Z. Harms, Katie R. Ostlund, Monina Cabrera, Monina Cabrera, Earline Edwards, Earline Edwards, Victoria B. Smith, Lynette M. Smith, Nora Sarvetnick, Nora Sarvetnick   +9 more
doaj   +1 more source

MAIT cells and viruses [PDF]

Immunology & Cell Biology, 2018
AbstractMucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially derived metabolites. Functionally, they respond to bacteria and yeasts, which possess the riboflavin pathway, essential for production of such metabolites and which are presented on MR1.
James E Ussher, Christian B Willberg, Paul Klenerman   +2 more
openaire   +2 more sources