Results 61 to 70 of about 12,026,666 (219)

Factors Influencing Functional Heterogeneity in Human Mucosa-Associated Invariant T Cells

Frontiers in Immunology, 2018
Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the monomorphic MHC class I-related (MR1) molecule.
Joana Dias, Caroline Boulouis, Michał J. Sobkowiak, Kerri G. Lal, Kerri G. Lal, Kerri G. Lal, Johanna Emgård, Marcus Buggert, Tiphaine Parrot, Jean-Baptiste Gorin, Edwin Leeansyah, Edwin Leeansyah, Johan K. Sandberg   +12 more
doaj   +1 more source

CD161+ MAIT cells are severely reduced in peripheral blood and lymph nodes of HIV-infected individuals independently of disease progression. [PDF]

PLoS ONE, 2014
Mucosal-associated invariant T (MAIT) cells are characterized by the combined expression of the semi-invariant T cell receptor (TCR) Vα7.2, the lectin receptor CD161, as well as IL-18R, and play an important role in antibacterial host defense of the gut.
Johanna Maria Eberhard, Philip Hartjen, Silke Kummer, Reinhold E Schmidt, Maximilian Bockhorn, Clara Lehmann, Ashwin Balagopal, Joachim Hauber, Jan van Lunzen, Julian Schulze zur Wiesch   +9 more
doaj   +1 more source

Varicella Zoster Virus infects mucosal associated Invariant T cells

Frontiers in Immunology, 2023
IntroductionMucosal Associated Invariant T (MAIT) cells are innate-like T cells that respond to conserved pathogen-derived vitamin B metabolites presented by the MHC class I related-1 molecule (MR1) antigen presentation pathway.
Shivam K. Purohit, Alexandra J. Corbett, Barry Slobedman, Allison Abendroth   +3 more
doaj   +1 more source

Use of a MAIT Activating Ligand, 5-OP-RU, as a Mucosal Adjuvant in a Murine Model of Vibrio cholerae O1 Vaccination

Pathogens and Immunity, 2022
Background: Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in the mucosa with capacity for B-cell help. We hypothesize that targeting MAIT cells, using a MAIT-activating ligand as an adjuvant, could improve mucosal vaccine ...
Owen Jensen, Shubhanshi Trivedi, Kelin Li, Jeffrey Aubé, J. Scott Hale, Edward T. Ryan, Daniel T Leung   +6 more
doaj   +1 more source

Mucosal-Associated Invariant T Cells Display a Poor Reconstitution and Altered Phenotype after Allogeneic Hematopoietic Stem Cell Transplantation

Frontiers in Immunology, 2017
Mucosal-associated invariant T (MAIT) cells are innate-like T cells which are important in the defense against certain bacteria and yeast. The reconstitution of MAIT cells after allogeneic hematopoietic stem cell transplantation (HSCT) is not known.
Martin Solders, Tom Erkers, Laia Gorchs, Thomas Poiret, Mats Remberger, Mats Remberger, Isabelle Magalhaes, Helen Kaipe, Helen Kaipe   +8 more
doaj   +1 more source

Stepwise development of MAIT cells in mouse and human. [PDF]

PLoS Biology, 2009
Mucosal-associated invariant T (MAIT) cells display two evolutionarily conserved features: an invariant T cell receptor (TCR)alpha (iTCRalpha) chain and restriction by the nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC ...
Emmanuel Martin, Emmanuel Treiner, Livine Duban, Lucia Guerri, Hélène Laude, Cécile Toly, Virginie Premel, Anne Devys, Ivan C Moura, Florence Tilloy, Stéphane Cherif, Gabriella Vera, Sylvain Latour, Claire Soudais, Olivier Lantz   +14 more
doaj   +1 more source

High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile [PDF]

, 2020
Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here, we demonstrate that CD26 and CD94 define transcriptionally, phenotypically, and functionally distinct Vδ2+ T cell subsets ...
Nguyen-Robertson, Catriona V., Kent, Stephen J., Wheatley, Adam, Berzins, Stuart, Kelleher, Anthony D., Pellicci, DG, Kristensen, Anne, Juno, Jennifer, Tan, Hyon Xhi, Nguyen-Robertson, Catriona, Kelleher, AD, Nguyen-Robertson, CV, Pellicci, Daniel, Wragg, Kathleen, Parsons, MS, Juno, JA, Wheatley, Adam K., Juno, Jennifer A., Tan, Hyon, Berzins, SP, Berzins, Stuart P., Tan, HX, Kent, SJ, Parsons, Matthew S., Wragg, Kathleen M., Kristensen, Anne B., Kristensen, AB, Wheatley, AK, Kent, Stephen, Parsons, Matthew, Wragg, KM, Pellicci, Daniel G., Kelleher, Anthony   +32 more
core   +1 more source

MAIT cells in metabolic diseases

Molecular Metabolism, 2019
Metabolic diseases represent a wide category of alterations affecting metabolism. These pathologies are notably marked by inflammation that implicates the immune system. Mucosal Associated Invariant (MAI)T cells are immune cells expressing a semi-invariant TCR able to recognize bacterial and fungal vitamin B metabolites.
Bertrand, Léo, Lehuen, Agnès
openaire   +4 more sources

Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection: A Case-Control Study [PDF]

, 2015
Mucosal-associated invariant T (MAIT) cells are an abundant antibacterial innate-like lymphocyte population. There are conflicting reports as to their fate in HIV infection.
Cosgrove, Cormac, Goulder, Philip, Günthard, Huldrych F, Cosgrove, C, Rauch, A, Willberg, CB, Ussher, James E, Phalora, Prabhjeet, Hannaway, Rachel F, Rauch, Andri, Phillips, Rodney E, Ussher, JE, Klenerman, Paul, Phalora, P, Günthard, HF, Klenerman, P, Goulder, P, Willberg, Christian B, Hannaway, R, Phillips, RE   +19 more
core   +1 more source

Biofabrication of 3D Breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors

Biofabrication, 2022
Immunotherapy has revolutionized cancer treatment with the advent of advanced cell engineering techniques aimed at targeted therapy with reduced systemic toxicity.
Madhuri Dey, Myong Hwan Kim, Momoka Nagamine, Ece Karhan, L. Kozhaya, M. Dogan, D. Unutmaz, I. Ozbolat   +7 more
semanticscholar   +1 more source