Results 71 to 80 of about 13,362 (213)

T cells, the next big target in axSpA?

Arthritis &Rheumatology, Accepted Article.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells.
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study

Reproductive Biology and Endocrinology, 2019
Background Immune dysregulation is one of the mechanisms to promote endometriosis (EMS). Various T cell subpopulations have been reported to play different roles in the development of EMS.
Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Yuping Xu, Peipei Guo, Ya Chen, Ping Zhou, Zhaolian Wei, Huanhuan Jiang, Yunxia Cao   +10 more
doaj   +1 more source

MAIT cells and tumor immunity [PDF]

Science, 2020
Cancer Immunology Mucosal-associated invariant T (MAIT) cells are immune cells that recognize host microbial metabolites presented by major histocompatibility complex class I–related protein 1 (MR1). During bacterial infection, activation of MAIT cells leads to the elimination of the infected cells.
openaire   +1 more source

Globo‐H diagnostic stratification and identification of DUSP14 as a candidate target in colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Colorectal cancer (CRC) is increasingly complicated by drug‐resistant tumors that limit the effectiveness of anticancer therapies. Because resistance mechanisms vary among patients and can evolve over time, personalized treatment strategies are needed.
Keren Zohar, Marco Strecker, Thomas Wartmann, Wenjie Shi, Frederike Stelter, Maximilian Doelling, Mihailo Andric, Or Kakhlon, Christian Täger, Denny Schanze, Michael Linnebacher, Michael Naumann, Daniel E. Stange, Dörthe Jechorek, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Recipient mucosal-associated invariant T cells control GVHD within the colon [PDF]

, 2018
Mucosal-associated invariant T (MAIT) cells are a unique innate-like T cell subset that responds to a wide array of bacteria and yeast through recognition of riboflavin metabolites presented by the MHC class I–like molecule MR1.
Andrea S. Henden, Andrew D. Clouston, Antiopi Varelias, Cooke, David P. Fairlie, Geoffrey R. Hill, Hill, Hill, James McCluskey, Jamie Rossjohn, Jasmin Straube, Jeffrey Y.W. Mak, Kate H. Gartlan, Kate L. Ormerod, Kjer-Nielsen, Lars Kjer-Nielsen, Leanne Cooper, Mak, Mark D. Bunting, Martin, Motoko Koyama, Nancy Lachner, Olivier Lantz, Patel, Philip Hugenholtz, Rachel D. Kuns, Renee J. Robb, Steven W. Lane, Stuart D. Olver, Treiner, van Wilgenburg   +30 more
core   +3 more sources

Monocytes with trained immunity–like signatures are associated with acute anterior uveitis in ankylosing spondylitis

Interdisciplinary Medicine, EarlyView.
In ankylosing spondylitis‐acute anterior uveitis (AS‐AAU), trained immunity monocytes (Mono‐TI) differentiate into macrophages in the eye, retaining trained immunity features. Mono‐TI cells secrete pro‐inflammatory cytokines and chemokines, including IL‐1β, TNF‐α, and CCL3.
Yimeng Sun, Lu Zhang, Xinyu Yao, Yunfei Liu, Xin Li, Feng Wen, Yong Dai, Ye Dai, Ziyu Du, Dijie Qiao, Ziwei Meng, Cong Hu, Chun Yan, Wei Chi   +13 more
wiley   +1 more source

Altered CD161 bright CD8+ mucosal associated invariant T (MAIT)-like cell dynamics and increased differentiation states among juvenile type 1 diabetics.

PLoS ONE, 2015
Type 1A diabetes (T1D) is believed to be caused by immune-mediated destruction of β-cells, but the immunological basis for T1D remains controversial. Microbial diversity promotes the maturation and activation of certain immune subsets, including CD161 ...
Robert Z Harms, Kristina M Lorenzo, Kevin P Corley, Monina S Cabrera, Nora E Sarvetnick   +4 more
doaj   +1 more source

MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation

Allergy, EarlyView.
In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata, Jaclyn W. McAlees, Julie M. Hargis, Archana Shankar, Shouxiong Huang, Senad Divanovic, Ian P. Lewkowich   +6 more
wiley   +1 more source

A Unified Machine Learning Model for Relapse Prediction in Clinical Stage I Testicular Cancer

Andrology, EarlyView.
ABSTRACT Background Approximately one‐fourth of patients with clinical stage I testicular cancer relapse. For decades, risk stratification has been based on different tumor characteristics for seminomas and non‐seminomas. Previous studies primarily used Cox proportional‐hazards models and included only a limited number of variables.
Thomas Wagner, Ramtin Zargari Marandi, Jakob Lauritsen, Daniel Dawson Murray, Mikkel Bandak, Birgitte Grønkær Toft, Dan Berney, Gedske Daugaard   +7 more
wiley   +1 more source

Role of innate T cells in anti-bacterial immunity [PDF]

, 2015
Innate T cells are a heterogeneous group of αβ and γδ T cells that respond rapidly (
Aggarwal, Arigoni, Battistini, Behr, Bendelac, Berzins, Berzofsky, Billerbeck, Bonneville, Brandes, Brennan, Brigl, Brigl, Buchmeier, Carreno, Carvalho, Chackerian, Chua, Cohen, Collins, Darmoise, De Libero, DiTirro, Dusseaux, Eguchi, Espinosa, Fergusson, Fernandez, Fletcher, Fujita, Gao, Georgel, Giabbai, Godfrey, Gold, Gold, Grimaldi, Harly, He, Horikoshi, Ivanov, Joyce, Joyee, Kalyan, Kawakami, Kee, Kinjo, Kinjo, Kinjo, Kjer-Nielsen, Kroca, Lanier, Le Bourhis, Leslie, Lo, Luoma, Maggi, Martin, Mattner, Meierovics, Miyagawa, Morita, Nauciel, Olszak, Paget, Paget, Paget, Paget, Park, Pechhold, Reantragoon, Reantragoon, Russano, Sada-Ovalle, Salio, Sandstrom, Sarikonda, Seach, Shin, Silva, Skeen, Sriram, Stanic, Takahashi, Tessmer, Tilloy, Tupin, Turtle, Uldrich, Ussher, van der Sluijs, Van Kaer, Vavassori, Voyle, Wingender, Wong, Wong, Wu, Xiao, Yuling, Zheng   +100 more
core   +1 more source