Results 91 to 100 of about 4,910,474 (212)

MAIT cells promote cancer progression and regulatory T cell accumulation in bladder tumor microenvironment

Journal for ImmunoTherapy of Cancer
Background Mucosa-associated invariant T (MAIT) cells represent a unique population of innate-like T lymphocytes capable of detecting non-peptide antigens in the context of monomorphic antigen-presenting molecules.
Inbar A Habaz, Xuejin Ou, Nicole I Wang, Angela Schincaglia, Valeryia Shydlouskaya, Agetha Mahendran, Francisco M Martinez-Santiesteban, Dylan Doolabi, Yige Bao, Ahmad R Movasseghi, Julius Haruna, Nicholas E Power, Timothy J Scholl, Melissa J Huynh, Alp Sener, S M Mansour Haeryfar   +15 more
doaj   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

MAIT cell diversity, function and impact on dendritic cells [PDF]

, 2019
Completed under a Cotutelle arrangement between the University of Melbourne and Bonn University© 2019 Marie-Sophie PhilippT cells represent an important component of the immune system.
Philipp, Marie-Sophie
core   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Hantaan virus infection induces human mucosal-associated invariant T cell pyroptosis through IRE1α pathway

Communications Biology
Hantaan virus (HTNV) triggers an epidemic of hemorrhagic fever with renal syndrome (HFRS), which is predominantly prevalent in Asia. Mucosal-associated invariant T (MAIT) cells, categorized as innate-like T lymphocytes, perform crucial functions in the ...
Yusi Zhang, He Liu, Dalu Liu, Huiyuan Zhang, Ying Ma, Na Li, Chunmei Zhang, Manling Xue, Fenglan Wang, Xiaozhou Jia, Hui Zhang, Kang Tang, Xiaoyue Xu, Shijia Wang, Yiwen Wei, Xiaojing Yang, Jiajia Zuo, Lihua Chen, Boquan Jin, Yun Zhang   +19 more
doaj   +1 more source

Synovial Fluid Immune Cell Landscape in Juvenile Idiopathic Arthritis

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Synovial fluid immune cells in juvenile idiopathic arthritis were profiled using single‐cell multiomics and flow cytometry. The immune landscape in synovial fluid was markedly distinct from that of blood and was enriched for dendritic cells, CD56hi NK cells, γδ T cells, CD4+ T peripheral helper and regulatory T cells, tissue‐resident memory CD8+ T ...
Viola Pitkänen, Bella Lappalainen, Marja Rytkönen‐Nissinen, Terhi Remes‐Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna‐Maija Grönlund, Miika Arvonen, Liisa Kröger, Anna‐Mari Schroderus, Tuure Kinnunen   +10 more
wiley   +1 more source

MAIT cells and tumor immunity [PDF]

Science, 2020
Cancer Immunology Mucosal-associated invariant T (MAIT) cells are immune cells that recognize host microbial metabolites presented by major histocompatibility complex class I–related protein 1 (MR1). During bacterial infection, activation of MAIT cells leads to the elimination of the infected cells.
openaire   +1 more source

Herpes simplex virus type 1 impairs mucosal-associated invariant T cells

mBio
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that infects mucosal sites and adopts an arsenal of strategies to manipulate host immunity.
Lauren Stern, Zoe Emanuel, Renee Traves, Katherine Willis, Shivam K. Purohit, Carolyn Samer, Jeffrey Y. W. Mak, David P. Fairlie, David C. Tscharke, Alexandra J. Corbett, Allison Abendroth, Barry Slobedman   +11 more
doaj   +1 more source

Mucosal-Associated Invariant T Cells Redistribute to the Peritoneal Cavity During Spontaneous Bacterial Peritonitis and Contribute to Peritoneal InflammationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Mucosal-associated invariant T (MAIT) cells are depleted from blood in patients with advanced liver disease and show features of immune dysfunction.
Oluwatomi Ibidapo-obe, Sven Stengel, Nilay Köse-Vogel, Stefanie Quickert, Philipp A. Reuken, Martin Busch, Michael Bauer, Andreas Stallmach, Tony Bruns   +8 more
doaj   +1 more source

IFN‐γ‐Associated Signaling Networks in Interstitial Lung Disease Associated With Sjögren's Disease

Immunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
ABSTRACT Background Sjögren's disease (SD) is a chronic systemic autoimmune disorder that can affect multiple organ systems. Interstitial lung disease (ILD) is a clinically significant pulmonary manifestation of SD and is associated with impaired quality of life and increased mortality.
Qianqian Chen, Yuhan Li, Yiming Chen, Yuhua Su, Xiaodong Wang, Chunxiao Guan   +5 more
wiley   +1 more source