Results 91 to 100 of about 12,026,666 (219)
Development and Functions of MAIT Cells
Annual Review of ImmunologyMucosal-associated invariant T (MAIT) cells are evolutionarily conserved T cells that recognize microbial metabolites. They are abundant in humans and conserved during mammalian evolution, which suggests that they have important nonredundant functions.
Salou, Marion +2 more
openaire +2 more sources
A Unified Machine Learning Model for Relapse Prediction in Clinical Stage I Testicular Cancer
Andrology, EarlyView.ABSTRACT Background Approximately one‐fourth of patients with clinical stage I testicular cancer relapse. For decades, risk stratification has been based on different tumor characteristics for seminomas and non‐seminomas. Previous studies primarily used Cox proportional‐hazards models and included only a limited number of variables.
Thomas Wagner +7 more
wiley +1 more source
The role of mucosal-associated invariant T cells in visceral leishmaniasis
Frontiers in Immunology, 2022 Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections. Our understanding of the role of MAIT cells in parasitic infections, such as visceral leishmaniasis (VL) caused by ...
Marcela de Lima Moreira +24 more
doaj +1 more source
Infection control in the brain and the eye
Acta Ophthalmologica, EarlyView.Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester +2 more
wiley +1 more source
Frontiers in ImmunologyMucosal-associated invariant T (MAIT) cells recognize metabolite-derived ligands, but the identity of such ligands in the context of cancer remains poorly defined.
Yanqi Xue +33 more
doaj +1 more source
Current insights in mouse iNKT and MAIT cell development using single cell transcriptomics data
Seminars in Immunology, 2022 Innate T (Tinn) cells are a collection of T cells with important regulatory functions that have a crucial role in immunity towards tumors, bacteria, viruses, and in cell-mediated autoimmunity.
S. Krovi +4 more
semanticscholar +1 more source
T Cell Heterogeneity Shaped by Alternative Splicing Predicts Prognosis in Hepatocellular Carcinoma
Cancer Science, EarlyView.T cell‐specific alternative splicing events shape T cell heterogeneity in HCC. Single‐cell analysis identified two splicing‐defined T cell subpopulations with distinct functional profiles. Subpopulation‐associated splicing events were used to construct a prognostic model predicting patient survival.
Xiaohui Peng +11 more
wiley +1 more source
MAIT cell biology in context of liver transplantation
, 2021 Das 1-Jahres-Überleben von lebertransplantierten PatientInnen hat sich in den letzten 30 Jahren aufgrund der Einführung neuer Immunsuppressiva (IS) deutlich verbessert.
Thiel, Lion, Thiel, Lion Gabriel
core +1 more source
CellsMucosal-associated invariant T (MAIT) cells are abundant innate-like T lymphocytes in the human liver which can provide antimicrobial defense, amplify inflammatory processes and mediate tissue repair and fibrosis depending on microenvironmental cues.
Adiba I. Azad +2 more
openaire +3 more sources
PLoS ONE, 2015 Type 1A diabetes (T1D) is believed to be caused by immune-mediated destruction of β-cells, but the immunological basis for T1D remains controversial. Microbial diversity promotes the maturation and activation of certain immune subsets, including CD161 ...
Robert Z Harms +4 more
doaj +1 more source