Results 101 to 110 of about 12,026,666 (219)

Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients

Military Medical Research, 2022
Background Mucosal-associated invariant T (MAIT) cells are systemically depleted in human immunodeficiency virus type 1 (HIV-1) infected patients and are not replenished even after successful combined antiretroviral therapy (cART).
Peng Xia, Xu-Dong Xing, Cui-Xian Yang, Xue-Jiao Liao, Fu-Hua Liu, Hui-Huang Huang, Chao Zhang, Jin-Wen Song, Yan-Mei Jiao, Ming Shi, Tian-Jun Jiang, Chun-Bao Zhou, Xi-Cheng Wang, Qing He, Qing-Lei Zeng, Fu-Sheng Wang, Ji-Yuan Zhang   +16 more
doaj   +1 more source

Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing

, 2023
International audienceTissue repair processes maintain proper organ function following mechanical or infection-related damage. In addition to antibacterial properties, mucosal associated invariant T (MAIT) cells express a tissue repair transcriptomic ...
Perrin, Laetitia, Premel, Virginie, Aractingi, Selim, Mestdagh, Martin, Alphonse, Aurélia, Yvorra, Thomas, Alkobtawi, Mansour, Darbois, Aurélie, Golub, Rachel, Lantz, Olivier, Zaiss, Dietmar, El Morr, Yara, Bugaut, Hélène, Legoux, François, Rodriguez, Raphaël, Salou, Marion, Colombeau, Ludovic, Du Halgouet, Anastasia   +17 more
core   +1 more source

Riboflavin Attenuates Influenza Virus Through Cytokine-Mediated Effects on the Diversity of the Gut Microbiota in MAIT Cell Deficiency Mice

Frontiers in Microbiology, 2022
Influenza is a serious respiratory disease that continues to threaten global health. Mucosa-associated invariant T (MAIT) cells use T-cell receptors (TCRs) that recognize microbial riboflavin derived intermediates presented by the major ...
Y. Li, C. Shi, Yu-ting Zhang, Haibin Huang, Yanlong Jiang, Jianzhong Wang, Xin Cao, Nan Wang, Yan Zeng, Guilian Yang, Wen-Tao Yang, Chun-feng Wang   +11 more
semanticscholar   +1 more source

Single Cell Multi‐Omics Revealing the Important Role of MR1 Mediated MAIT Cells in Maintaining Rejection for Liver Transplantation

Cell Proliferation, EarlyView.
This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai, Xinqiang Li, Xin Zhou, Xueteng Wang, Zhuoyu Jia, Ruidong Ding, Yurong Luo, Ye Wang, Shipeng Li, Wenxing Sun, Dongxing Wu, Dahong Teng, Kai Zhao, Guanghui Pei, Jinzhen Cai, Bin Wu   +15 more
wiley   +1 more source

Mucosal-associated invariant T cells predict increased acute graft-versus-host-disease incidence in patients receiving allogeneic hematopoietic stem cell transplantation

Cancer Cell International, 2022
Background Mucosal-associated invariant T (MAIT) cells are innate-like T cells, some studies have reported that the number of circulating MAIT cells reduced in patients with acute graft-versus-host-disease (aGVHD) development.
Zhao Wang, Sudong Zhang, Xiaoyu Zhang, Li Liu, Lukun Zhou, Yuyan Shen, Rongli Zhang, Yi He, Donglin Yang, Erlie Jiang, Xiaoming Feng, Jiaxi Zhou, Tao Cheng, Mingzhe Han, Sizhou Feng   +14 more
doaj   +1 more source

MAIT cells altered phenotype and cytotoxicity in lupus patients are linked to renal disease severity and outcome

Frontiers in Immunology, 2023
IntroductionSystemic lupus erythematosus (SLE) is an autoimmune disease in which circulating immune complexes can cause different types of glomerulonephritis, according to immune deposits and to the type of glomerular cell injury.
Elena Litvinova, Carine Bounaix, Guillaume Hanouna, Jennifer Da Silva, Laura Noailles, Lucie Beaudoin, Michael Padden, Nessrine Bellamri, Agnès Lehuen, Eric Daugas, Eric Daugas, Renato C. Monteiro, Renato C. Monteiro, Héloïse Flament, Héloïse Flament   +14 more
doaj   +1 more source

MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis

Science Advances
Mucosal-associated invariant T (MAIT) cells are antimicrobial T cells abundant in the gut, but mechanisms for their migration into tissues during inflammation are poorly understood.
Yichao Zheng, Fei Han, Zhengyu Wu, Bingjie Wang, Xingchi Chen, Caroline Boulouis, Y. Jiang, A. Ho, Dan He, W. Sia, Jeffrey Y. W. Mak, D. Fairlie, Lin-Fa Wang, J. Sandberg, Peter E. Lobie, Shaohua Ma, E. Leeansyah   +16 more
semanticscholar   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source

The molecular basis underpinning the potency and specificity of MAIT cell antigens [PDF]

, 2020
Mucosal-associated invariant T (MAIT) cells are activated by microbial riboflavin-based metabolite antigens when presented by MR1. How modifications to the potent antigen 5-OP-RU affect presentation by MR1 and MAIT cell activation remains unclear.
Fairlie, David P., Keller, Andrew N., Mak, Jeffrey Y.W., Liu, Ligong, Awad, Wael, McCluskey, James, Ler, Geraldine J.M., Xin Yi Lim, Xu, Weijun, Lim, Xin Yi, Jérôme Le Nours, Le Nours, Jérôme, Jeffrey Y. W. Mak, Weijun Xu, Eckle, Sidonia B. G., Andrew N. Keller, Eckle, Sidonia B.G., Sidonia B. G. Eckle, Alexandra J. Corbett, Jamie Rossjohn, Ler, Geraldine J. M., Corbett, Alexandra J., Ligong Liu, Mak, Jeffrey Y. W., Rossjohn, Jamie, Geraldine J. M. Ler, James McCluskey, David P. Fairlie, Wael Awad   +28 more
core   +1 more source

Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals

Nature Communications, 2021
Mucosal-associated invariant T (MAIT) cells have important functions in immune responses against pathogens and in diseases, but mechanisms controlling MAIT cell development and effector lineage differentiation remain unclear. Here, we report that IL-2/IL-
Huishan Tao, Yun Pan, S. Chu, Lei Li, Jinhai Xie, Peng Wang, Shimeng Zhang, Srija Reddy, J. Sleasman, X. Zhong   +9 more
semanticscholar   +1 more source