Results 101 to 110 of about 4,910,474 (212)

Cigarette smoke components modulate the MR1–MAIT axis

Tobacco smoking is prevalent across the world and causes numerous diseases. Cigarette smoke (CS) compromises immunity, yet little is known of the components of CS that impact T cell function.
Haw, TJ, Hansbro, Philip M, Hansbro, Nicole G, Awad, Wael, Gillis, Caitlin M, Galvao, Izabela, Howson, Lauren J, Mak, JYW, Albers, GJ, Corbett, AJ, Fairlie, David P, Corbett, Alexandra J, Hortle, Elinor, Donovan, Chantal, Hansbro, PM, Pai, TY, Horvat, Jay C, Johansen, MD, Xu, W, Howson, LJ, Haw, Tatt Jhong, Gillis, CM, Galvao, I, Pai, Tsung-Yu, Mayall, Jemma R, Rossjohn, Jamie, Patton, T, Das, S, Awad, W, Liu, Ligong, McCluskey, James, Mak, Jeffrey Y W, Liu, L, Xu, Weijun, Patton, Timothy, Donovan, C, Lim, Xin Yi, Albers, Gesa J, Hortle, E, Brown, AC, McCluskey, J, Fairlie, DP, Brown, Alexandra C, Rossjohn, J, Johansen, Matt D, Mayall, JR, Horvat, JC, Das, Shatarupa, Hansbro, NG, Lim, XY   +49 more
core   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

A Distinct Immune Signature Characterizes Cirrhosis in Ethiopian Individuals With Chronic HBV Infection

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 7, Page 951-964, October 2026.
Cirrhosis patients with untreated HBV in Ethiopia exhibit a distinct immune profile marked by depletion of NK cells, B cells, and T cells, alongside an expanded CD38+HLA‐DR+ CD8 T‐cell population. ABSTRACT Background and Aims The immune cell phenotype of African patients living with chronic hepatitis B virus (HBV) infection is rarely described, despite
Julia MacLeod, Fikadu G. Gudissa, Asiya Jeylan, Nega Berhe, Hailemichael Desalegn, Lasse Rossvoll, Asgeir Johannessen, Niklas K. Björkström, Dag Henrik Reikvam, Annika Niehrs   +9 more
wiley   +1 more source

Potential of MAIT cells to modulate asthma

Allergology International
Despite recent advances in asthma treatments, the search for novel therapies remains necessary because there are still patients with recurrent asthma exacerbations and poor responses to the existing treatments. Since group 2 innate lymphoid cells (ILC2) play a pivotal role in asthma by triggering and exacerbating type 2 inflammation, controlling ILC2s ...
Yasuo Shimizu, Chie Sugimoto, Hiroshi Wakao   +2 more
openaire   +3 more sources

Entering the Age of Specificity in T Cell Immunity

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT The discovery of MHC restriction, the resolution of peptide–MHC structure, and the identification of the T cell receptor gene quickly centered epitope‐level specificity as a core concern of T cell biology. Epitope mapping culminated in functional peptide‐based stimulation assays and tetramer staining, which together provide exquisite ...
Paul G. Thomas
wiley   +1 more source

The Role of Mucosal-Associated Invariant T Cells in Viral Infections and Their Function in Vaccine Development

Vaccines
Mucosal-Associated Invariant T (MAIT) cells, which bridge innate and adaptive immunity, have emerged as an important player in viral infections despite their inability to directly recognize viral antigens. This review provides a comprehensive analysis of
Chie Sugimoto, Hiroshi Wakao
doaj   +1 more source

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.

PLoS Pathogens, 2015
Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules. MAIT cells
Edwin Leeansyah, Jenny Svärd, Joana Dias, Marcus Buggert, Jessica Nyström, Máire F Quigley, Markus Moll, Anders Sönnerborg, Piotr Nowak, Johan K Sandberg   +9 more
doaj   +1 more source

The Rise and Fall of MAIT Cells with Age

Scandinavian Journal of Immunology, 2014
To the Editor We read with interest the article by Novak et al. recently published in the Scandinavian Journal of Immunology and write in support of their data. The authors describe the profound changes with age of peripheral circulating mucosal associated invariant T (MAIT) cells in a cohort of patients whose samples were obtained post-clinical ...
Walker LJ, Thamalingam H, Klennerman P
openaire   +3 more sources

Innate-like T cell subset commitment in the murine thymus is independent of TCR characteristics and occurs during proliferation

International audienceHow T-cell receptor (TCR) characteristics determine subset commitment during T-cell development is still unclear. Here, we addressed this question for innate-like T cells, mucosal-associated invariant T (MAIT) cells, and invariant ...
Perrin, Laetitia, Legoux, Francois, Aleksandra, Walczak, Mutala, Linda, Bilonda, Darbois, Aurelie, Mora, Thierry, Lantz, Olivier, K. Karnaukhov, Vadim, Le Gac, Anne‐laure   +8 more
core   +1 more source

Elucidating the Characteristics and Functionality of the Mouse Mucosal-Associated Mucosal Invariant T (MAIT) Cell Receptor

, 2023
Indiana University-Purdue University Indianapolis (IUPUI)Mucosal-associated invariant T cells (MAIT) are a subset of invariant, innate-like T-cells that are abundant in the gut lamina propria, kidney, lungs, and peripheral blood.
Shrinivasan, Rashmi
core   +1 more source