Results 81 to 90 of about 13,362 (213)

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Immune checkpoint blockade improves the activation and function of circulating mucosal-associated invariant T (MAIT) cells in patients with non-small cell lung cancer

OncoImmunology
Mucosal-associated invariant T (MAIT) cells constitute one of the most numerous unconventional T cell subsets, and are characterized by rapid release of Th1- and Th17-associated cytokines and increased cytotoxic functions following activation. MAIT cells
Patrik Sundström, Nikita Dutta, William Rodin, Andreas Hallqvist, Sukanya Raghavan, Marianne Quiding Järbrink   +5 more
doaj   +1 more source

Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients

Military Medical Research, 2022
Background Mucosal-associated invariant T (MAIT) cells are systemically depleted in human immunodeficiency virus type 1 (HIV-1) infected patients and are not replenished even after successful combined antiretroviral therapy (cART).
Peng Xia, Xu-Dong Xing, Cui-Xian Yang, Xue-Jiao Liao, Fu-Hua Liu, Hui-Huang Huang, Chao Zhang, Jin-Wen Song, Yan-Mei Jiao, Ming Shi, Tian-Jun Jiang, Chun-Bao Zhou, Xi-Cheng Wang, Qing He, Qing-Lei Zeng, Fu-Sheng Wang, Ji-Yuan Zhang   +16 more
doaj   +1 more source

T Cell Heterogeneity Shaped by Alternative Splicing Predicts Prognosis in Hepatocellular Carcinoma

Cancer Science, EarlyView.
T cell‐specific alternative splicing events shape T cell heterogeneity in HCC. Single‐cell analysis identified two splicing‐defined T cell subpopulations with distinct functional profiles. Subpopulation‐associated splicing events were used to construct a prognostic model predicting patient survival.
Xiaohui Peng, Zhenli Li, Xiuqing Dong, Zhixiong Cai, Chenfan Lu, Junjie Gao, Shuyue You, Yuwen Wang, Jianming Mao, Xiaolong Liu, Geng Chen, Yingchao Wang   +11 more
wiley   +1 more source

Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes [PDF]

, 2017
Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of pancreatic β-cells by the immune system that involves innate and adaptive immune cells.
Battaglia, Manuela, Beaudoin, Lucie, Beltrand, Jacques, Cagninacci, Lucie, Corbett, Alexandra, Da silva, Jennifer, Diedisheim, Marc, Kiaf, Badr, Lantz, Olivier, Lehuen, Agnès, McCluskey, James, Nel, Isabelle, Oshima, Masaya, Polak, Michel, Rossjohn, Jamie, Rouxel, Ophélie, Salou, Marion, Scharfmann, Raphael, Tard, Céline   +18 more
core   +4 more sources

Mucosal-associated invariant T cells predict increased acute graft-versus-host-disease incidence in patients receiving allogeneic hematopoietic stem cell transplantation

Cancer Cell International, 2022
Background Mucosal-associated invariant T (MAIT) cells are innate-like T cells, some studies have reported that the number of circulating MAIT cells reduced in patients with acute graft-versus-host-disease (aGVHD) development.
Zhao Wang, Sudong Zhang, Xiaoyu Zhang, Li Liu, Lukun Zhou, Yuyan Shen, Rongli Zhang, Yi He, Donglin Yang, Erlie Jiang, Xiaoming Feng, Jiaxi Zhou, Tao Cheng, Mingzhe Han, Sizhou Feng   +14 more
doaj   +1 more source

MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data [PDF]

, 2015
Single-cell transcriptomics reveals gene expression heterogeneity but suffers from stochastic dropout and characteristic bimodal expression distributions in which expression is either strongly non-zero or non-detectable.
Deng, Jingyuan, Finak, Greg, Gersuk, Vivian, Gottardo, Raphael, Linsley, Peter S., McDavid, Andrew, McElrath, M. Juliana, Miller, Hannah W., Prlic, Martin, Shalek, Alex, Slichter, Chloe K., Yajima, Masanao   +11 more
core   +3 more sources

MAIT cells: new guardians of the liver [PDF]

Clinical & Translational Immunology, 2016
The liver is an important immunological organ that remains sterile and tolerogenic in homeostasis, despite continual exposure to non‐self food and microbial‐derived products from the gut. However, where intestinal mucosal defenses are breached or in the presence of a systemic infection, the liver acts as a second 'firewall', because of its enrichment ...
Kurioka A, Walker LJ, Klenerman P, Willberg C   +3 more
openaire   +5 more sources

Single Cell Multi‐Omics Revealing the Important Role of MR1 Mediated MAIT Cells in Maintaining Rejection for Liver Transplantation

Cell Proliferation, EarlyView.
This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai, Xinqiang Li, Xin Zhou, Xueteng Wang, Zhuoyu Jia, Ruidong Ding, Yurong Luo, Ye Wang, Shipeng Li, Wenxing Sun, Dongxing Wu, Dahong Teng, Kai Zhao, Guanghui Pei, Jinzhen Cai, Bin Wu   +15 more
wiley   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source