Results 81 to 90 of about 4,910,474 (212)

High pre-transplant Mucosal Associated Invariant T Cell (MAIT) count predicts favorable course of myeloid aplasia

Aims. Mucosal Associated Invariant T (MAIT) cells are unconventional T cells with anti-infective potential. MAIT cells detect and fight against microbes on mucosal surfaces and in peripheral tissues.
Jan Novak, Jitka Smetanova Brozova, Tomas Karel, Barbora Bacova, Ivana Karlova Zubata   +4 more
core   +1 more source

MAIT cell biology in context of liver transplantation

, 2021
Das 1-Jahres-Überleben von lebertransplantierten PatientInnen hat sich in den letzten 30 Jahren aufgrund der Einführung neuer Immunsuppressiva (IS) deutlich verbessert.
Thiel, Lion, Thiel, Lion Gabriel
core   +1 more source

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

Cell Reports, 2019
Summary: Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer+ cells derived from either human blood or murine
Timothy S.C. Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J. Pediongco, Bronwyn S. Meehan, Lyudmila Kostenko, Stephen J. Turner, Alexandra J. Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey   +12 more
doaj   +1 more source

The Leukocyte Landscape Across Mouse Strains and Tissues

Immunology &Cell Biology, EarlyView.
The blood, bone marrow, liver, lymph nodes, and spleen of naïve male mice contained unique immunobiomes which differed between commonly used strains. BALB‐derived strains exhibited helper‐ and innate‐biased immune profiles, C57BL/6J‐derived strains were enriched for cytotoxic and immune surveillance populations, and DBA/2 J mice displayed elevated γδ T
Ella Trolio, Sarah Dart, Liu Liu, Michaela Lucas, Amy Prosser   +4 more
wiley   +1 more source

MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis

International audienceIntestinal inflammation shifts microbiota composition and metabolism. How the host monitors and responds to such changes remains unclear.
Perrin, Laetitia, Mondot, Stanislas, Premel, Virginie, Franciszkiewicz, Katarzyna, Maurin, Mathieu, Mestdagh, Martin, Procopio, Emanuele, Furstenheim, Mariela, Dupré, Thierry, Lantz, Olivier, El Morr, Yara, Richon, Sophie, Legoux, Francois, Rodriguez, Raphaël, Salou, Marion, Bugaut, Helene, Colombeau, Ludovic, Philippe, Catherine, Darbois, Aurelie, Vorobev, Alexey, Morvan, Claire, Jneid, Bakhos, Du Halgouet, Anastasia   +22 more
core   +1 more source

Immune checkpoint blockade improves the activation and function of circulating mucosal-associated invariant T (MAIT) cells in patients with non-small cell lung cancer

OncoImmunology
Mucosal-associated invariant T (MAIT) cells constitute one of the most numerous unconventional T cell subsets, and are characterized by rapid release of Th1- and Th17-associated cytokines and increased cytotoxic functions following activation. MAIT cells
Patrik Sundström, Nikita Dutta, William Rodin, Andreas Hallqvist, Sukanya Raghavan, Marianne Quiding Järbrink   +5 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

MAIT cell diversity, function and impact on dendritic cells [PDF]

, 2020
T cells represent an important component of the immune system. Whilst early studies were largely focused on the role of conventional CD8+ and CD4+ T cells that recognize peptide-antigens in association with MCH molecules, more recently, T cells that ...
Philipp, Marie-Sophie
core  

The molecular basis underpinning the potency and specificity of MAIT cell antigens [PDF]

, 2020
Mucosal-associated invariant T (MAIT) cells are activated by microbial riboflavin-based metabolite antigens when presented by MR1. How modifications to the potent antigen 5-OP-RU affect presentation by MR1 and MAIT cell activation remains unclear.
Fairlie, David P., Keller, Andrew N., Mak, Jeffrey Y.W., Liu, Ligong, Awad, Wael, McCluskey, James, Ler, Geraldine J.M., Xin Yi Lim, Xu, Weijun, Lim, Xin Yi, Jérôme Le Nours, Le Nours, Jérôme, Jeffrey Y. W. Mak, Weijun Xu, Eckle, Sidonia B. G., Andrew N. Keller, Eckle, Sidonia B.G., Sidonia B. G. Eckle, Alexandra J. Corbett, Jamie Rossjohn, Ler, Geraldine J. M., Corbett, Alexandra J., Ligong Liu, Mak, Jeffrey Y. W., Rossjohn, Jamie, Geraldine J. M. Ler, James McCluskey, David P. Fairlie, Wael Awad   +28 more
core   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source