Results 121 to 130 of about 12,026,666 (219)

TCF/LEF family transcription factors: Molecular landscape and prognostic scoring in pan‐cancer

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
This study provides a comprehensive molecular landscape of TCF/LEF family transcription factors across 33 cancer types. We developed a TCF/LEF‐based prognostic score that correlates with immune infiltration, metabolic reprogramming and drug sensitivity, offering a robust transcriptomic signature for predicting patient survival and therapeutic response.
Zhengjun Yang, D. Q. Cai, Zhen Zhao, Zhixiang Jian, Mude Shi, Yajin Chen, Jueming Chen, Chunhua Qu, Diankui Cai   +8 more
wiley   +1 more source

MAIT cells promote cancer progression and regulatory T cell accumulation in bladder tumor microenvironment

Journal for ImmunoTherapy of Cancer
Background Mucosa-associated invariant T (MAIT) cells represent a unique population of innate-like T lymphocytes capable of detecting non-peptide antigens in the context of monomorphic antigen-presenting molecules.
Inbar A Habaz, Xuejin Ou, Nicole I Wang, Angela Schincaglia, Valeryia Shydlouskaya, Agetha Mahendran, Francisco M Martinez-Santiesteban, Dylan Doolabi, Yige Bao, Ahmad R Movasseghi, Julius Haruna, Nicholas E Power, Timothy J Scholl, Melissa J Huynh, Alp Sener, S M Mansour Haeryfar   +15 more
doaj   +1 more source

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini, E. Tartaglia, F. Cristofanelli, S. Gili, F. Maggi   +4 more
wiley   +1 more source

MAIT cells protect against sterile lung injury

Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, can exhibit a wide range of functional responses to different triggers via their T cell receptor (TCR) and/or cytokines.
Klenerman, Paul, Lason, Wojciech, Hinks, Timothy, Li, Shuailin, Greco, Maria, Zhang, Xiawei   +5 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1231-1244, June 2026.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Multi‐omics insights for deciphering prognosis‐related T cell subsets in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
An integrated multi‐omics analysis delineates the prognostic landscape of T‐cell subsets in hepatocellular carcinoma. DPT cells and HBEGF‐related signals are associated with poor survival in hepatocellular carcinoma. Endothelial‐derived HBEGF recruits DPT cells, which in turn up‐regulate the EMT signatures and drive the migration of hepatocellular ...
Guangzu Cui, Erya Hu, Qingping Peng, Xin Zhou, Yu Zhao, Haicong Liu, Xinwen Wang, Yihong Chen, Hong Shen, Shan Zeng, Jiayao Ma   +10 more
wiley   +1 more source

Cigarette smoke components modulate the MR1–MAIT axis

Tobacco smoking is prevalent across the world and causes numerous diseases. Cigarette smoke (CS) compromises immunity, yet little is known of the components of CS that impact T cell function.
Haw, TJ, Hansbro, Philip M, Hansbro, Nicole G, Awad, Wael, Gillis, Caitlin M, Galvao, Izabela, Howson, Lauren J, Mak, JYW, Albers, GJ, Corbett, AJ, Fairlie, David P, Corbett, Alexandra J, Hortle, Elinor, Donovan, Chantal, Hansbro, PM, Pai, TY, Horvat, Jay C, Johansen, MD, Xu, W, Howson, LJ, Haw, Tatt Jhong, Gillis, CM, Galvao, I, Pai, Tsung-Yu, Mayall, Jemma R, Rossjohn, Jamie, Patton, T, Das, S, Awad, W, Liu, Ligong, McCluskey, James, Mak, Jeffrey Y W, Liu, L, Xu, Weijun, Patton, Timothy, Donovan, C, Lim, Xin Yi, Albers, Gesa J, Hortle, E, Brown, AC, McCluskey, J, Fairlie, DP, Brown, Alexandra C, Rossjohn, J, Johansen, Matt D, Mayall, JR, Horvat, JC, Das, Shatarupa, Hansbro, NG, Lim, XY   +49 more
core   +1 more source

Hantaan virus infection induces human mucosal-associated invariant T cell pyroptosis through IRE1α pathway

Communications Biology
Hantaan virus (HTNV) triggers an epidemic of hemorrhagic fever with renal syndrome (HFRS), which is predominantly prevalent in Asia. Mucosal-associated invariant T (MAIT) cells, categorized as innate-like T lymphocytes, perform crucial functions in the ...
Yusi Zhang, He Liu, Dalu Liu, Huiyuan Zhang, Ying Ma, Na Li, Chunmei Zhang, Manling Xue, Fenglan Wang, Xiaozhou Jia, Hui Zhang, Kang Tang, Xiaoyue Xu, Shijia Wang, Yiwen Wei, Xiaojing Yang, Jiajia Zuo, Lihua Chen, Boquan Jin, Yun Zhang   +19 more
doaj   +1 more source

Potential of MAIT cells to modulate asthma

Allergology International
Despite recent advances in asthma treatments, the search for novel therapies remains necessary because there are still patients with recurrent asthma exacerbations and poor responses to the existing treatments. Since group 2 innate lymphoid cells (ILC2) play a pivotal role in asthma by triggering and exacerbating type 2 inflammation, controlling ILC2s ...
Yasuo Shimizu, Chie Sugimoto, Hiroshi Wakao   +2 more
openaire   +3 more sources