Results 121 to 130 of about 13,362 (213)

A shotgun proteomic dataset of human mucosal-associated invariant T cells

Data in Brief
Mucosal-associated invariant T (MAIT) cells represent a unique unconventional T cell population important in eliciting immunomodulatory responses in a range of diseases, including infectious diseases, autoimmunity and cancer.
Harshi Weerakoon, John J. Miles, Michelle M. Hill, Ailin Lepletier   +3 more
doaj   +1 more source

Diagnostic accuracy of interferon-gamma release assay and mucosal-associated invariant T cells in spinal tuberculosis

Scientific Reports
Conventional diagnostic methods for tuberculous spondylodiscitis (TS) require tissue biopsy, which can delay diagnosis. Immunodiagnostic approaches, including interferon-gamma release assays (IGRAs), have shown potential for improving TS diagnosis ...
Korawish Mekariya, Pisanukiet Saneewong Na Ayutthaya, Akkaraporn Naowanirut, Artit Wongsa, Boonrat Tassaneetrithep, Wiwit Tantibhedhyangkul, Popchai Ngamskulrungroj, Sorranart Muangsomboon, Pipat Cheiwvit, Sirichai Wilartratsami, Panya Luksanapruksa, Nasuda Danchaivijitr, Kitidete Boonchai, Apisit Rattanatanasarn, Monchai Ruangchainikom   +14 more
doaj   +1 more source

Potential of MAIT cells to modulate asthma

Allergology International
Despite recent advances in asthma treatments, the search for novel therapies remains necessary because there are still patients with recurrent asthma exacerbations and poor responses to the existing treatments. Since group 2 innate lymphoid cells (ILC2) play a pivotal role in asthma by triggering and exacerbating type 2 inflammation, controlling ILC2s ...
Yasuo Shimizu, Chie Sugimoto, Hiroshi Wakao   +2 more
openaire   +3 more sources

Mucosal-Associated Invariant T (MAIT) cells are impaired in Th17 associated primary and secondary immunodeficiencies

The recently described Mucosal Associated Invariant T (MAIT) cells mediate specific recognition of bacterial and fungal vitamin B2 metabolites. As innate T cells, they possess broad effector responses, including IFN- including Iproduction, that are ...
Barcenas-Morales, Gabriela, Döffinger, Rainer, Eren, Efrem, Faust, Saul N., Gao, Yifang, Ottensmeier, Christian H., Rae, William, Ramakrishnan, Keseva, Williams, Anthony P.   +8 more
core   +1 more source

Mucosal-associated invariant T cells in cancer: dual roles, complex interactions and therapeutic potential

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells play diverse roles in cancer, infectious diseases, and immunotherapy. This review explores their intricate involvement in cancer, from early detection to their dual functions in promoting inflammation and ...
Mesut Yigit, Omer Faruk Basoglu, Derya Unutmaz   +2 more
doaj   +1 more source

MAIT cells: Conserved watchers on the wall

Journal of Experimental Medicine
MAIT cells are innate-like T cells residing in barrier tissues such as the lung, skin, and intestine. Both the semi-invariant T cell receptor of MAIT cells and the restricting element MR1 are deeply conserved across mammals, indicating non-redundant functions linked to antigenic specificity.
Lilou Germain, Pablo Veloso, Olivier Lantz, François Legoux   +3 more
openaire   +3 more sources

MAIT cells protect against sterile lung injury

Cell Reports
AbstractMucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, have been recently linked to tissue protection and repair. Their role, especially in sterile lung injury, is unknown. Using single cell RNA sequencing (scRNA-seq), spectral analysis and adoptive transfer in a bleomycin-induced sterile lung injury,
Xiawei Zhang, Shuailin Li, Wojciech Lason, Maria Greco, Paul Klenerman, Timothy SC Hinks   +5 more
openaire   +3 more sources

Editorial: MAIT cells come of age

Frontiers in Immunology, 2023
Corbett, AJ, Ussher, JE, Hinks, TSC
openaire   +4 more sources

Dynamic Perturbations of the T-Cell Receptor Repertoire in Chronic HIV Infection and following Antiretroviral Therapy [PDF]

, 2015
HIV infection profoundly affects many parameters of the immune system and ultimately leads to AIDS, yet which factors are most important for determining resistance, pathology, and response to antiretroviral treatment - and how best to monitor them ...
Best, K, Chain, B, Friedman, N, Gray, ER, Heather, JM, Noursadeghi, M, Oakes, T, Roe, JK, Thomas, N   +8 more
core  

Single-cell RNA sequencing reveals heterogeneity of mucosa-associated invariant T cells in donor grafts and its diagnostic relevance in gastrointestinal graft-versus-host disease

Haematologica
Granulocyte colony-stimulating factor (G-CSF) enhances acute graft-versus-host disease (aGVHD) prophylaxis in allogeneic hematopoietic stem cell transplantation (allo-HSCT) by inducing T cell tolerance and altering graft cell composition.
Mengge Gao, Kainan Zhang, Siqi Li, Huidong Guo, Yuqian Sun, Jun Kong, Tingting Han, Yingjun Chang, Xiaojun Huang, Xiaosu Zhao   +9 more
doaj   +1 more source