Results 121 to 130 of about 4,910,474 (212)

IL-7 arms MAIT cell cytotoxic capacity.

, 2015
(A) Freshly isolated PBMCs from healthy blood donors were left untreated (black) or treated with IL-7 (red) for 48 h, and the expression levels of cytolytic proteins, pro-inflammatory cytokines, and innate and classical T cell transcription factors were ...
Joana Dias (786016), Jessica Nyström (277460), Markus Moll (109640), Edwin Leeansyah (366399), Marcus Buggert (153550), Máire F. Quigley (786017), Piotr Nowak (277458), Jenny Svärd (786015), Johan K. Sandberg (353026), Anders Sönnerborg (153581)   +9 more
core   +1 more source

Mucosal-associated invariant T cells in cancer: dual roles, complex interactions and therapeutic potential

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells play diverse roles in cancer, infectious diseases, and immunotherapy. This review explores their intricate involvement in cancer, from early detection to their dual functions in promoting inflammation and ...
Mesut Yigit, Omer Faruk Basoglu, Derya Unutmaz   +2 more
doaj   +1 more source

MAIT cells in the liver environment

, 2020
MAIT cells are an important innate T cell population capable of recognising riboflavin-derived ligands presented by the evolutionary conserved MR1 molecule. The ability to activate MAIT cells either through their TCR or cytokines alone enables them to respond to both bacterial and viral infections.
openaire   +1 more source

Editorial: MAIT cells come of age

Frontiers in Immunology, 2023
Corbett, AJ, Ussher, JE, Hinks, TSC
openaire   +4 more sources

Characterisation of the MAIT cell immune response to malaria parasites

© 2024 Phoebe DewarMucosal-associated invariant T (MAIT) cells are a subset of pro-inflammatory innate-like T cells that are highly abundant in human tissues.
Dewar, Phoebe
core   +1 more source

The Emerging Role of MAIT Cell Responses in Viral Infections. [PDF]

J Immunol, 2023
Sandberg JK, Leeansyah E, Eller MA, Shacklett BL, Paquin-Proulx D.   +4 more
europepmc   +1 more source

4-1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions. [PDF]

Immunol Cell Biol
R L, J W, C T, R F, LE W, A P, Mc W, Rf H, Je U.   +8 more
europepmc   +1 more source

Current Perspectives and Challenges of MAIT Cell-Directed Therapy for Tuberculosis Infection. [PDF]

Pathogens, 2023
Chengalroyen MD.
europepmc   +1 more source

A conserved transcriptional program for MAIT cells across mammalian evolution

International audienceMucosal-associated invariant T (MAIT) cells harbor evolutionarily conserved TCRs, suggesting important functions. As human and mouse MAIT functional programs appear distinct, the evolutionarily conserved MAIT functional features ...
A. Paiva, Rafael, Mestdagh, Martin, Chaiyasitdhi, Atitheb, Piquet, Julie, Legoux, Francois, Smadja, David M, Maciulyte, Valdone, Darbois, Aurelie, El Marjou, Ahmed, Montagutelli, Xavier, Perrin, Laetitia, Bernardeau, Karine, Mutala, Linda, Bilonda, Ryffel, Bernhard, Cieslak, Agata, Furstenheim, Mariela, Turner, James M. A., Lantz, Olivier, El Morr, Yara, Guerin, Coralie, Bugaut, Helene, Salou, Marion, Du Halgouet, Anastasia, Le Gac, Anne‐laure, Arnaud, Manon   +24 more
core   +1 more source

The MR1/MAIT cell axis has limited effects on the start of tau pathology in a mouse model of tauopathy. [PDF]

Brain Behav Immun
Wyatt-Johnson SK, Joshi S, Blair M, Desai JM, Haeryfar SMM, Lasagna-Reeves CA, Brutkiewicz RR.   +6 more
europepmc   +1 more source