Results 131 to 140 of about 12,026,666 (219)

Herpes simplex virus type 1 impairs mucosal-associated invariant T cells

mBio
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that infects mucosal sites and adopts an arsenal of strategies to manipulate host immunity.
Lauren Stern, Zoe Emanuel, Renee Traves, Katherine Willis, Shivam K. Purohit, Carolyn Samer, Jeffrey Y. W. Mak, David P. Fairlie, David C. Tscharke, Alexandra J. Corbett, Allison Abendroth, Barry Slobedman   +11 more
doaj   +1 more source

Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling

Frontiers in Immunology, 2020
IL-23 is considered a critical regulator of IL-17 in Th17 cells; however, its requirement for inducing IL-17 production in other human immune subsets remains incompletely understood.
S. Cole, J. Murray, C. Simpson, R. Okoye, K. Tyson, M. Griffiths, D. Baeten, S. Shaw, A. Maroof   +8 more
semanticscholar   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Vascular Immune Remodeling: A CD4+ T Cell–Driven Immune Trajectory Associated With Arterial Stiffness

Aging Cell, Volume 25, Issue 6, June 2026.
This study integrated arterial stiffness with peripheral TCRβ repertoire and single‐cell transcriptomics in adults without cardiovascular disease, revealing a CD4+ T cell–driven “vascular immune remodeling” trajectory distinct from classical immunosenescence: increased TCR diversity, broad expansion of low‐frequency public clones and virus‐associated ...
Yu Miao, Bangwei Chen, Changqing Zeng, Xiaofen Wu, Minglei Yang, Cuntai Zhang, Jianguo Zhang, Yutao Du, Tao Li, Lei Ruan   +9 more
wiley   +1 more source

T‐Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection

American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.
ABSTRACT Worldwide, most HIV infections occur across a mucosal surface during sexual contact, with women accounting for nearly half of reported new HIV infections across the globe in 2024. Most new infections in women and girls are believed to involve transmission across mucosal surfaces of the lower reproductive tract, which includes the vagina and ...
Barbara L. Shacklett, Ramatoulaye H. Ouattara, April L. Ferre   +2 more
wiley   +1 more source

MAIT cell diversity, function and impact on dendritic cells [PDF]

, 2019
Completed under a Cotutelle arrangement between the University of Melbourne and Bonn University© 2019 Marie-Sophie PhilippT cells represent an important component of the immune system.
Philipp, Marie-Sophie
core  

The Rise and Fall of MAIT Cells with Age

Scandinavian Journal of Immunology, 2014
To the Editor We read with interest the article by Novak et al. recently published in the Scandinavian Journal of Immunology and write in support of their data. The authors describe the profound changes with age of peripheral circulating mucosal associated invariant T (MAIT) cells in a cohort of patients whose samples were obtained post-clinical ...
Walker LJ, Thamalingam H, Klennerman P
openaire   +3 more sources

The Role of Mucosal-Associated Invariant T Cells in Viral Infections and Their Function in Vaccine Development

Vaccines
Mucosal-Associated Invariant T (MAIT) cells, which bridge innate and adaptive immunity, have emerged as an important player in viral infections despite their inability to directly recognize viral antigens. This review provides a comprehensive analysis of
Chie Sugimoto, Hiroshi Wakao
doaj   +1 more source

Mucosal Associated Invariant T cells in the human gastric mucosa and blood: Role in Helicobacter pylori infection

Frontiers in Immunology, 2015
Mucosal-associated invariant T (MAIT) cells represent a class of antimicrobial innate-like T cells that have been characterized in human blood, liver, lungs and intestine.
Jayaum S Booth, Jayaum S Booth, Rosangela eSalerno-Goncalves, Rosangela eSalerno-Goncalves, Thomas G Blanchard, Seema A. Patil, Seema A. Patil, Howard A. Kader, Anca M. Safta, Lindsay M. Morningstar, Steven J. Czinn, Bruce D. Greenwald, Bruce D. Greenwald, Marcelo B. Sztein, Marcelo B. Sztein, Marcelo B. Sztein   +15 more
doaj   +1 more source

Innate-like T cell subset commitment in the murine thymus is independent of TCR characteristics and occurs during proliferation

International audienceHow T-cell receptor (TCR) characteristics determine subset commitment during T-cell development is still unclear. Here, we addressed this question for innate-like T cells, mucosal-associated invariant T (MAIT) cells, and invariant ...
Perrin, Laetitia, Legoux, Francois, Aleksandra, Walczak, Mutala, Linda, Bilonda, Darbois, Aurelie, Mora, Thierry, Lantz, Olivier, K. Karnaukhov, Vadim, Le Gac, Anne‐laure   +8 more
core   +1 more source