Results 141 to 150 of about 12,026,666 (219)

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.

PLoS Pathogens, 2015
Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules. MAIT cells
Edwin Leeansyah, Jenny Svärd, Joana Dias, Marcus Buggert, Jessica Nyström, Máire F Quigley, Markus Moll, Anders Sönnerborg, Piotr Nowak, Johan K Sandberg   +9 more
doaj   +1 more source

Mucosal-associated invariant T (MAIT) cell contributions to mucosal immunity

, 2016
Thesis (Ph.D.)--University of Washington, 2016-10Mucosal-associated invariant T (MAIT) cells are a semi-invariant T cell subset that are located in blood, liver and mucosal tissues.
Slichter, Chloe Knights
core  

Aberrant MAIT cell transcription factor expression in chronic HIV-1 infection correlates with MAIT cell effector dysfunction.

, 2015
(A) Unstimulated PBMCs from 10 healthy controls and 17 HIV-1 infected, ART-untreated patients were stained for transcription factors, and their MAIT cell T-bet and Eomes expression profile was determined.
Joana Dias (786016), Jessica Nyström (277460), Markus Moll (109640), Edwin Leeansyah (366399), Marcus Buggert (153550), Máire F. Quigley (786017), Piotr Nowak (277458), Jenny Svärd (786015), Johan K. Sandberg (353026), Anders Sönnerborg (153581)   +9 more
core   +1 more source

IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

Science immunology, 2019
ICOS- and IL-23–mediated costimulation are important for driving in vivo activation of antigen-specific MAIT cells. In vivo costimulators for MAIT cells Mucosal-associated invariant T (MAIT) cells contribute to immune defense against a broad range of ...
Huimeng Wang, L. Kjer-Nielsen, M. Shi, C. D’Souza, Troi J Pediongco, H. Cao, L. Kostenko, X. Lim, S. Eckle, Bronwyn S. Meehan, Tianyuan Zhu, Bingjie Wang, Zhe Zhao, Jeffrey Y. W. Mak, D. Fairlie, M. Teng, J. Rossjohn, Di Yu, B. F. de St. Groth, G. Lovrecz, Louis Lu, J. McCluskey, R. Strugnell, A. Corbett, Zhenjun Chen   +24 more
semanticscholar   +1 more source

Functions of mucosal associated invariant T cells in eye diseases

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells
Chihiro Fukui, Satoshi Yamana, Yanqi Xue, Mariko Shirane, Hiroki Tsutsui, Kenichiro Asahara, Keiko Yoshitomi, Takako Ito, Tantri Lestari, Eiichi Hasegawa, Nobuyo Yawata, Atsunobu Takeda, Koh-Hei Sonoda, Kensuke Shibata, Kensuke Shibata, Kensuke Shibata   +15 more
doaj   +1 more source

IL-7 arms MAIT cell cytotoxic capacity.

, 2015
(A) Freshly isolated PBMCs from healthy blood donors were left untreated (black) or treated with IL-7 (red) for 48 h, and the expression levels of cytolytic proteins, pro-inflammatory cytokines, and innate and classical T cell transcription factors were ...
Joana Dias (786016), Jessica Nyström (277460), Markus Moll (109640), Edwin Leeansyah (366399), Marcus Buggert (153550), Máire F. Quigley (786017), Piotr Nowak (277458), Jenny Svärd (786015), Johan K. Sandberg (353026), Anders Sönnerborg (153581)   +9 more
core   +1 more source

A Critical Role for Mucosal-Associated Invariant T Cells as Regulators and Therapeutic Targets in Systemic Lupus Erythematosus

Frontiers in Immunology, 2019
Mucosal-associated invariant T (MAIT) cells are a subset of innate-like lymphocytes that are restricted by major histocompatibility complex-related molecule 1 (MR1).
Goh Murayama, Goh Murayama, Asako Chiba, Hitoshi Suzuki, Atsushi Nomura, Tomohiro Mizuno, Taiga Kuga, Taiga Kuga, Shinji Nakamura, Hirofumi Amano, Sachiko Hirose, Ken Yamaji, Yusuke Suzuki, Naoto Tamura, Sachiko Miyake   +14 more
doaj   +1 more source

IL-7 restores MAIT cell effector dysfunction.

, 2015
(A) MAIT cell arming following IL-7 treatment in vitro for 48 h in healthy controls (n = 8), and HIV-1 infected ART-untreated patients (n = 6). GrzA and Prf upregulation was determined as fold-change of geometric MFI to that of IL-7-untreated cells ...
Joana Dias (786016), Jessica Nyström (277460), Markus Moll (109640), Edwin Leeansyah (366399), Marcus Buggert (153550), Máire F. Quigley (786017), Piotr Nowak (277458), Jenny Svärd (786015), Johan K. Sandberg (353026), Anders Sönnerborg (153581)   +9 more
core   +1 more source

A shotgun proteomic dataset of human mucosal-associated invariant T cells

Data in Brief
Mucosal-associated invariant T (MAIT) cells represent a unique unconventional T cell population important in eliciting immunomodulatory responses in a range of diseases, including infectious diseases, autoimmunity and cancer.
Harshi Weerakoon, John J. Miles, Michelle M. Hill, Ailin Lepletier   +3 more
doaj   +1 more source

Diagnostic accuracy of interferon-gamma release assay and mucosal-associated invariant T cells in spinal tuberculosis

Scientific Reports
Conventional diagnostic methods for tuberculous spondylodiscitis (TS) require tissue biopsy, which can delay diagnosis. Immunodiagnostic approaches, including interferon-gamma release assays (IGRAs), have shown potential for improving TS diagnosis ...
Korawish Mekariya, Pisanukiet Saneewong Na Ayutthaya, Akkaraporn Naowanirut, Artit Wongsa, Boonrat Tassaneetrithep, Wiwit Tantibhedhyangkul, Popchai Ngamskulrungroj, Sorranart Muangsomboon, Pipat Cheiwvit, Sirichai Wilartratsami, Panya Luksanapruksa, Nasuda Danchaivijitr, Kitidete Boonchai, Apisit Rattanatanasarn, Monchai Ruangchainikom   +14 more
doaj   +1 more source