Results 151 to 160 of about 12,026,666 (219)

Mucosal-associated invariant T cells in cancer: dual roles, complex interactions and therapeutic potential

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells play diverse roles in cancer, infectious diseases, and immunotherapy. This review explores their intricate involvement in cancer, from early detection to their dual functions in promoting inflammation and ...
Mesut Yigit, Omer Faruk Basoglu, Derya Unutmaz   +2 more
doaj   +1 more source

Study of MAIT cell activation in viral infections in vivo

, 2019
MAIT cells are abundant, highly evolutionarily conserved innate-like lymphocytes expressing a semi-invariant T cell receptor (TCR), which recognizes microbially derived small intermediate molecules from the riboflavin biosynthetic pathway.
Chen, Z, van Wilgenburg, Bonnie, Huimeng Wang, Alexandra J. Corbett, Wang, Huimeng, Koutsakos, M, Zhenjun Chen, Loh, Liyen, van Wilgenburg, B, Koutsakos, Marios, Loh, L, Wang, H, Katherine Kedzierska, Hinks, TSC, Corbett, AJ, Kedzierska, Katherine, Corbett, Alexandra J, Chen, Zhenjun, Hinks, Timothy SC, Timothy S. C. Hinks, Bonnie van Wilgenburg, Kedzierska, K, Liyen Loh, Marios Koutsakos   +23 more
core   +1 more source

Antibody opsonization enhances MAIT cell responsiveness to bacteria via a TNF-dependent mechanism

, 2019
Mucosal-associated invariant T (MAIT) cells are an abundant human T-cell subset with antimicrobial properties. They can respond to bacteria presented via antigen-presenting cells (APCs) such as macrophages, which present bacterially derived ligands from ...
Mehta, H, Brigitte Müllauer, Paul Klenerman, Müllauer, B, Simon Kruis, Kruis, S, Klaver, Dominik, Krabbendam, L, Mehta, Hema, Willberg, C, Klenerman, Paul, Krabbendam, Lisette, Stoiber, Heribert, Orth-Höller, D, Tianqi Leng, Klenerman, P, Dorothea Orth‐Höller, Müllauer, Brigitte, Heribert Stoiber, Bánki, Zoltán, Lisette Krabbendam, Willberg, Christian, Stoiber, H, Zoltán Bánki, Christian B Willberg, Hema Mehta, Banki, Z, Klaver, D, Dominik Klaver, Orth-Höller, Dorothea, Leng, Tianqi, Kruis, Simon, Willberg, Christian B., Leng, T   +33 more
core   +1 more source

MAIT cells in the liver environment

, 2020
MAIT cells are an important innate T cell population capable of recognising riboflavin-derived ligands presented by the evolutionary conserved MR1 molecule. The ability to activate MAIT cells either through their TCR or cytokines alone enables them to respond to both bacterial and viral infections.
openaire   +1 more source

MAIT Cells with High PFN1 Expression Mediate Immune Activation and Metabolic Reprogramming in Psoriasis

Man-Ning Wu,1– 3 Yue-Min Zou,1– 3 Xiang-Nan Zhou,2,3 Sangwon Hong,1– 3 Lei Wang,2,3 Yan-Ping Bai2,3 1Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China; 2Department of Dermatology, China-Japan Friendship Hospital ...
Zou YM, Zhou XN, Bai YP, Wu MN, Hong S, Wang L   +5 more
core  

Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation.

, 2018
Human mucosal-associated invariant T (MAIT) cell receptors (TCRs) recognize bacterial riboflavin pathway metabolites through the MHC class 1-related molecule MR1.
Oh, Julia, Unutmaz, Derya, Wang, Lei, Horne, Meghan, Kozhaya, Lina, Voigt, Anita Y, Yao, Xudong, Zhou, Wei, Fleming, Elizabeth, Tastan, Cihan, Karhan, Ece, Placek, Lindsey   +11 more
core   +1 more source

Editorial: MAIT cells come of age

Frontiers in Immunology, 2023
Corbett, AJ, Ussher, JE, Hinks, TSC
openaire   +4 more sources

Single-cell RNA sequencing reveals heterogeneity of mucosa-associated invariant T cells in donor grafts and its diagnostic relevance in gastrointestinal graft-versus-host disease

Haematologica
Granulocyte colony-stimulating factor (G-CSF) enhances acute graft-versus-host disease (aGVHD) prophylaxis in allogeneic hematopoietic stem cell transplantation (allo-HSCT) by inducing T cell tolerance and altering graft cell composition.
Mengge Gao, Kainan Zhang, Siqi Li, Huidong Guo, Yuqian Sun, Jun Kong, Tingting Han, Yingjun Chang, Xiaojun Huang, Xiaosu Zhao   +9 more
doaj   +1 more source

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

A conserved transcriptional program for MAIT cells across mammalian evolution

International audienceMucosal-associated invariant T (MAIT) cells harbor evolutionarily conserved TCRs, suggesting important functions. As human and mouse MAIT functional programs appear distinct, the evolutionarily conserved MAIT functional features ...
A. Paiva, Rafael, Mestdagh, Martin, Chaiyasitdhi, Atitheb, Piquet, Julie, Legoux, Francois, Smadja, David M, Maciulyte, Valdone, Darbois, Aurelie, El Marjou, Ahmed, Montagutelli, Xavier, Perrin, Laetitia, Bernardeau, Karine, Mutala, Linda, Bilonda, Ryffel, Bernhard, Cieslak, Agata, Furstenheim, Mariela, Turner, James M. A., Lantz, Olivier, El Morr, Yara, Guerin, Coralie, Bugaut, Helene, Salou, Marion, Du Halgouet, Anastasia, Le Gac, Anne‐laure, Arnaud, Manon   +24 more
core   +1 more source