Results 111 to 120 of about 13,362 (213)

Herpes simplex virus type 1 impairs mucosal-associated invariant T cells

mBio
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that infects mucosal sites and adopts an arsenal of strategies to manipulate host immunity.
Lauren Stern, Zoe Emanuel, Renee Traves, Katherine Willis, Shivam K. Purohit, Carolyn Samer, Jeffrey Y. W. Mak, David P. Fairlie, David C. Tscharke, Alexandra J. Corbett, Allison Abendroth, Barry Slobedman   +11 more
doaj   +1 more source

Conventional, regulatory, and unconventional T cells in the immunologic response to helicobacter pylori [PDF]

, 2008
Infection by the gastroduodenal pathogen Helicobacter pylori elicits a complex immunologic response in the mucosa involving neutrophils, plasma cells, eosinophils, and lymphocytes, of which T cells are the principal orchestrators of immunity.
Moran, Anthony P., O'Keeffe, Joan
core   +1 more source

Integrated Bulk and Single‐Cell RNA‐Seq Analysis Reveals Transcriptional Activation of PTGS2 by FOS in Progression From T2DM to T2DM‐Associated NAFLD

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) frequently coexist, exacerbating disease burden. However, the molecular mechanisms underlying the progression from T2DM to T2DM‐associated NAFLD remain unclear. This study investigated the regulatory function of FOS‐mediated PTGS2 activation in this transition.
Rong Lin, Leqin Xu, Yi Zhou, Yanjing Fan, Huan Xie, Wanzhang Li, Tianchi Hu, Chao Liu   +7 more
wiley   +1 more source

The Role of Mucosal-Associated Invariant T Cells in Viral Infections and Their Function in Vaccine Development

Vaccines
Mucosal-Associated Invariant T (MAIT) cells, which bridge innate and adaptive immunity, have emerged as an important player in viral infections despite their inability to directly recognize viral antigens. This review provides a comprehensive analysis of
Chie Sugimoto, Hiroshi Wakao
doaj   +1 more source

Complex Adaptive Immunity to Enteric Fevers in Humans: Lessons Learned and the Path Forward [PDF]

, 2014
Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, and S. Paratyphi A and B, causative agents of paratyphoid fever, are major public health threats throughout the world.
Marcelo B. Sztein, Monica A. McArthur, Rosangela Salerno-Goncalves   +2 more
core   +2 more sources

Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential [PDF]

, 2016
Ajudes rebudes: Marie Curie Career Integration Grant; Dexeus Foundation for Women's Health Research; i Contratos Ramón y CajalCD11c is an α integrin classically employed to define myeloid dendritic cells.
A Arakelyan, Annie Rodolosse, Antoni Tarrats, B Ljutic, C Sadhu, CC Denucci, CE Egan, D Fujiwara, D Ganguly, DC Bullard, DI Godfrey, DJ Pennington, DL Farber, DM Williams, E Billerbeck, E Gonzalez-Roca, GK Smyth, J Del Campo, Jamal Qualai, JC Grivel, JD Haas, JJ Moon, JM Fuller, Jon Cantero, JR Fergusson, JW Huleatt, K Kubota, LA Cooney, Lauro Sumoy, Lin-Xi Li, LS Cauley, LX Li, M Beyer, M Brandes, M Eberl, M Kuka, M Roederer, Marco Antonio Fernández, Meritxell Genescà, N Lycke, NA Bezman, OS Qureshi, PA Romagnoli, R. Keith Reeves, RT Trifonova, S Paul, S Tsai, SM Tan, Stephen J. McSorley, T Vorup-Jensen, YH Kim, Z Chen   +51 more
core   +5 more sources

Functions of mucosal associated invariant T cells in eye diseases

Frontiers in Immunology
Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells
Chihiro Fukui, Satoshi Yamana, Yanqi Xue, Mariko Shirane, Hiroki Tsutsui, Kenichiro Asahara, Keiko Yoshitomi, Takako Ito, Tantri Lestari, Eiichi Hasegawa, Nobuyo Yawata, Atsunobu Takeda, Koh-Hei Sonoda, Kensuke Shibata, Kensuke Shibata, Kensuke Shibata   +15 more
doaj   +1 more source

Multiple sclerosis: Immunopathology and treatment update [PDF]

, 2017
The treatment of multiple sclerosis (MS) has changed over the last 20 years. All immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a medical challenge in MS to develop a treatment for progressive forms.
Bielekova, Correale, Dressel, Jarius, Jiang, Kappos, Katsara, Lenk, Noyes, Palmer   +9 more
core   +2 more sources

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.

PLoS Pathogens, 2015
Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules. MAIT cells
Edwin Leeansyah, Jenny Svärd, Joana Dias, Marcus Buggert, Jessica Nyström, Máire F Quigley, Markus Moll, Anders Sönnerborg, Piotr Nowak, Johan K Sandberg   +9 more
doaj   +1 more source

Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma? [PDF]

, 2016
Natural killer T (NKT) cells constitute a unique subset of innate-like T lymphocytes which differ from conventional T cells by recognizing lipid antigens presented by the non-polymorphic major histocompatibility complex (MHC) I-like molecule CD1d ...
Elewaut, Dirk, Favreau, Mérédis, Menu, Eline, Vanderkerken, Karin, Venken, Koen   +4 more
core   +2 more sources