Results 51 to 60 of about 4,910,474 (212)

Mucosal-associated invariant T (MAIT) cells produce growth factors and influence the regeneration of hepatic spheroids [PDF]

, 2022
openContesto: Il fegato è un importante sito immunologico che riceve prodotti batterici, tossine e antigeni di varia natura dal tratto gastrointestinale. Per operare una difesa efficace si basa principalmente su un solido sistema immunitario innato e il
TASIN, IRENE
core  

The MR1/MAIT cell axis in CNS diseases. [PDF]

Brain Behav Immun
Mucosal-associated invariant T (MAIT) cells are a subpopulation of innate-like T cells that can be found throughout the body, predominantly in mucosal sites, the lungs and in the peripheral blood.
Shrinivasan R, Wyatt-Johnson SK, Brutkiewicz RR.   +2 more
europepmc   +2 more sources

MAIT cells in autoimmunity

Japanese Journal of Clinical Immunology, 2012
Mucosal associated invariant T (MAIT) cells are restricted by a nonpolymorphic MHC-related molecule-1 (MR1), and express an invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are selected in the thymus, but, interestingly, MAIT cells require B cells as well as commensal flora for their peripheral expansion.
openaire   +5 more sources

Understanding the Role of Mucosal-Associated Invariant T-Cells in Non-human Primate Models of HIV Infection

Frontiers in Immunology, 2020
Chronic HIV infection causes systemic immune activation and dysregulation, resulting in the impairment of most T-cell subsets including MAIT cells. Multiple human cohort studies demonstrate MAIT cells are selectively depleted in the peripheral blood and ...
Isaac M. Barber-Axthelm, Stephen J. Kent, Stephen J. Kent, Stephen J. Kent, Jennifer A. Juno   +4 more
doaj   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

MAIT cells and microbial immunity [PDF]

Immunology & Cell Biology, 2018
AbstractMucosal‐associated invariant T (MAIT) cells, the most abundant T‐cell subset in humans, are increasingly being recognized for their importance in microbial immunity. MAIT cells accumulate in almost every mucosal tissue examined, including the lung, liver and intestinal tract, where they can be activated through T‐cell receptor (TCR) triggering ...
Erin W Meermeier, Melanie J Harriff, Elham Karamooz, David M Lewinsohn   +3 more
openaire   +2 more sources

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

MAIT cells protect against sterile lung injury [PDF]

Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, can exhibit a wide range of functional responses to different triggers via their T cell receptor (TCR) and/or cytokines.
Klenerman, Paul, Lason, Wojciech, Hinks, Timothy, Li, Shuailin, Greco, Maria, Zhang, Xiawei   +5 more
core   +1 more source

CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study

Reproductive Biology and Endocrinology, 2019
Background Immune dysregulation is one of the mechanisms to promote endometriosis (EMS). Various T cell subpopulations have been reported to play different roles in the development of EMS.
Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Yuping Xu, Peipei Guo, Ya Chen, Ping Zhou, Zhaolian Wei, Huanhuan Jiang, Yunxia Cao   +10 more
doaj   +1 more source

MAIT cells altered phenotype and cytotoxicity in lupus patients are linked to renal disease severity and outcome

Frontiers in Immunology, 2023
IntroductionSystemic lupus erythematosus (SLE) is an autoimmune disease in which circulating immune complexes can cause different types of glomerulonephritis, according to immune deposits and to the type of glomerular cell injury.
Elena Litvinova, Carine Bounaix, Guillaume Hanouna, Jennifer Da Silva, Laura Noailles, Lucie Beaudoin, Michael Padden, Nessrine Bellamri, Agnès Lehuen, Eric Daugas, Eric Daugas, Renato C. Monteiro, Renato C. Monteiro, Héloïse Flament, Héloïse Flament   +14 more
doaj   +1 more source