Results 51 to 60 of about 13,362 (213)

Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses [PDF]

, 2014
Background: Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface. Methods: We measured MAIT cell frequencies and antibody
Aktar, Amena, Bhuiyan, Taufiqur R., Calderwood, Stephen B., Charles, Richelle C., Chowdhury, Fahima, Harris, Jason B., Hoq, Mohammad Rubel, Khan, Ashraful I., Leung, Daniel T., Nishat, Naoshin S., Qadri, Firdausi, Rahman, M. Arifur, Ryan, Edward T., Uddin, Taher   +13 more
core   +3 more sources

Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells [PDF]

, 2016
Mucosal-Associated Invariant T (MAIT) cells, present in high frequency in airway and other mucosal tissues, have Th1 effector capacity positioning them to play a critical role in the early immune response to intracellular pathogens, including ...
A Meierovics, A Shitara, AJ Corbett, AJ Okumura, Ansen Burr, AS Heinzel, C Soudais, David M. Lewinsohn, DB Moody, DC Barral, DM Lewinsohn, DM Lewinsohn, E Treiner, Elham Karamooz, Elizabeth T. Canfield, J Neefjes, JE Grotzke, K Hatsuzawa, K Hatsuzawa, KJ Livak, L Kjer-Nielsen, L Le Bourhis, L Shen, Luis F. Moita, M Dusseaux, MC Gold, MC Gold, Melanie J. Harriff, Michelle L. Sorensen, MJ Harriff, P Georgel, P Riegert, Padmini Salgame, S Huang, S Huang, S Huang, SB Eckle, T Aoki, T Iinuma, W Hong, Wilmon F. Grant, WJ Chua, Y Sun   +42 more
core   +7 more sources

Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis [PDF]

, 2018
Subclinical gut inflammation occurring in patients affected by spondyloarthritis (SpA) is correlated with the severity of spine inflammation. Several evidences indicate that dysbiosis occurs in SpA, and that may modulate intestinal permeability and ...
Ciccia F., Ferrante A., Guggino G., Rizzo A.   +3 more
core   +1 more source

Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection [PDF]

Viruses, 2021
There were an estimated 10 million new cases of tuberculosis (TB) disease in 2019. While over 90% of individuals successfully control Mycobacterium tuberculosis (Mtb) infection, which causes TB disease, HIV co-infection often leads to active TB disease.
Ryan V. Moriarty, Amy L. Ellis, Shelby L. O’Connor   +2 more
openaire   +3 more sources

MAIT cells in liver inflammation and fibrosis

Seminars in Immunopathology, 2022
AbstractMucosal-associated invariant T cells or MAIT cells are an abundant cell type in humans and especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge between innate and adaptive immunity, so-called innate-like or “unconventional” T cells.
Hema Mehta, Martin Joseph Lett, Paul Klenerman, Magdalena Filipowicz Sinnreich   +3 more
openaire   +2 more sources

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers [PDF]

, 2015
Studies on the biology of mucosal-associated invariant T cells (MAIT cells) in mice have been hampered by a lack of specific reagents. Using MR1-antigen (Ag) tetramers that specifically bind to the MR1-restricted MAIT T cell receptors (TCRs), we ...
Chen, Zhenjun, Clanchy, Rhiannon, Eckle, Sidonia B. G., Enders, Anselm, Fairlie, David P., Godfrey, Dale I., Goodnow, Chris C., Koay, Hui Fern, Liu, Ligong, McCluskey, James, Meehan, Bronwyn, Pellicci, Daniel G., Rahimpour, Azad, Rossjohn, Jamie, Uldrich, Adam P., Whittle, Belinda   +15 more
core   +3 more sources

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

MAIT cells in autoimmunity

Japanese Journal of Clinical Immunology, 2012
Mucosal associated invariant T (MAIT) cells are restricted by a nonpolymorphic MHC-related molecule-1 (MR1), and express an invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are selected in the thymus, but, interestingly, MAIT cells require B cells as well as commensal flora for their peripheral expansion.
openaire   +5 more sources

Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges. [PDF]

, 2019
Introduction: Tuberculosis (TB) remains a major health threat and it is now clear that the current vaccine, BCG, is unable to arrest the global TB epidemic. A new vaccine is needed to either replace or boost BCG so that a better level of protection could
Barclay WR, Elena Stylianou, Helen McShane, Matthew J. Paul, Rajko Reljic, Resende Co T, Rodriguez A, Uranga S, Wong EA   +8 more
core   +1 more source

Recognition of vitamin B metabolites by mucosal-associated invariant T cells [PDF]

, 2013
The mucosal-associated invariant T-cell antigen receptor (MAIT TCR) recognizes MR1 presenting vitamin B metabolites. Here we describe the structures of a human MAIT TCR in complex with human MR1 presenting a non-stimulatory ligand derived from folic acid
A Bendelac, AG Leslie, AW Schuttelkopf, C Cosgrove, DG Pellicci, DI Godfrey, DI Godfrey, DI Godfrey, DI Godfrey, DN Garboczi, E Girardi, E Girardi, E Leeansyah, E Treiner, F Tilloy, FE Tynan, G Vera, J Rossjohn, KS Wun, L Kjer-Nielsen, L Kjer-Nielsen, L Le Bourhis, L Le Bourhis, MC Gold, MC Gold, NA Borg, O Patel, PH Zwart, R Reantragoon, S Gras, S Huang, S Huang, SJ Turner, TS Mikkelsen, WJ Chua, X-Z Tang, Y Miyazaki   +36 more
core   +1 more source