Results 51 to 60 of about 12,026,666 (219)

The Activation of Mucosal-Associated Invariant T (MAIT) Cells Is Affected by Microbial Diversity and Riboflavin Utilization in vitro

Frontiers in Microbiology, 2020
Recent research has demonstrated that MAIT cells are activated by individual bacterial or yeasts species that possess the riboflavin biosynthesis pathway.
Jannike L. Krause, Stephanie S. Schäpe, Florian Schattenberg, Susann Müller, Grit Ackermann, Ulrike E. Rolle-Kampczyk, Nico Jehmlich, Arkadiusz Pierzchalski, Martin von Bergen, Martin von Bergen, Gunda Herberth   +10 more
doaj   +1 more source

MAIT cells regulate NK cell-mediated tumor immunity [PDF]

, 2021
The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT cell-deficient mice have enhanced NK cell-dependent control of metastatic B16F10 tumor growth relative to control mice ...
Todd, KL, Kearney, CJ, Oliver, AJ, Pizzolla, A, Godfrey, DI, Li, J, Millen, R, McCulloch, TR, Chen, AXY, Oliaro, J, Giuffrida, L, Beavis, PA, Ramsay, RG, Mak, JYW, Petley, EV, Lai, J, Sek, K, Souza-Fonseca-Guimaraes, F, Michie, J, McCluskey, J, Keam, SP, Koay, HF, Fairlie, DP, Neeson, PJ, Zethoven, M, Freeman, AJ, House, IG, Darcy, PK, Huntington, ND, Henderson, MA, Chan, JD   +30 more
core   +1 more source

A Role for MAIT Cells in Colorectal Cancer [PDF]

Frontiers in Immunology, 2020
MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT cells within the microenvironment of colorectal tumors, but there is conjecture about the nature of their response and whether they are ...
Stuart P. Berzins, Stuart P. Berzins, Stuart P. Berzins, Morgan E. Wallace, Morgan E. Wallace, George Kannourakis, George Kannourakis, Jason Kelly, Jason Kelly   +8 more
openaire   +4 more sources

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

Frontiers in Immunology, 2021
Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi.
Sharon Khuzwayo, Sharon Khuzwayo, Maphe Mthembu, Maphe Mthembu, Erin W. Meermeier, Sanjay M. Prakadan, Sanjay M. Prakadan, Sanjay M. Prakadan, Samuel W. Kazer, Samuel W. Kazer, Samuel W. Kazer, Thierry Bassett, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Moosa Suleman, Moosa Suleman, Zoey Mhlane, Dirhona Ramjit, Farina Karim, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, David M. Lewinsohn, David M. Lewinsohn, David M. Lewinsohn, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Emily B. Wong, Emily B. Wong, Emily B. Wong, Emily B. Wong   +36 more
doaj   +1 more source

MAIT cell activation is associated with disease severity markers in acute hantavirus infection

, 2021
Hantaviruses are zoonotic RNA viruses that cause severe acute disease in humans. Infected individuals have strong inflammatory responses that likely cause immunopathology.
Ljunggren, Hans-Gustaf, Hans-Gustaf Ljunggren, Ahlm, Clas, Edwin Leeansyah, Joana Dias, García, M., Klingström, J., Christ, Wanda, Björkström, Niklas K., Sandberg, Johan K.,, Maleki, Kimia T., Klingström, Jonas, Forsell, Mattias N., Dias, Joana, Kerkman, Priscilla,, Clas Ahlm, Tauriainen, Johanna, Ljunggren, Hans-Gustaf,, Dias, Joana,, Maleki, Kimia T.,, Klingström, Jonas,, Björkström, N.K., Julia Wigren Byström, García, Marina,, Niklas K. Björkström, García, Marina, Forsell, Mattias N. E., Kerkman, Priscilla, Björkström, Niklas K.,, Johan K. Sandberg, Ahlm, Clas,, Kimia T. Maleki, Marina García, Mattias N. Forsell, Tauriainen, Johanna,, Priscilla F. Kerkman, Wigren, Julia, Johanna Tauriainen, Wanda Christ, Jonas Klingström, Wigren Byström, J., Kerkman, Priscilla F., Leeansyah, Edwin,, Christ, Wanda,, Wigren, Julia,, Forsell, Mattias N. E.,, Leeansyah, Edwin, Sandberg, Johan K.   +47 more
core   +1 more source

Leveraging Public Single-Cell and Bulk Transcriptomic Datasets to Delineate MAIT Cell Roles and Phenotypic Characteristics in Human Malignancies

Frontiers in Immunology, 2020
Mucosa-associated invariant T (MAIT) cells are unconventional, innate-like T lymphocytes that recognize vitamin B metabolites of microbial origin among other antigens displayed by the monomorphic molecule MHC class I-related protein 1 (MR1).
Tony Yao, Parisa Shooshtari, Parisa Shooshtari, S. M. Mansour Haeryfar, S. M. Mansour Haeryfar, S. M. Mansour Haeryfar, S. M. Mansour Haeryfar, S. M. Mansour Haeryfar   +7 more
doaj   +1 more source

MAIT cells in liver inflammation and fibrosis

Seminars in Immunopathology, 2022
AbstractMucosal-associated invariant T cells or MAIT cells are an abundant cell type in humans and especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge between innate and adaptive immunity, so-called innate-like or “unconventional” T cells.
Mehta, H, Lett, MJ, Klenerman, P, Filipowicz Sinnreich, M   +3 more
openaire   +2 more sources

Activation, Impaired Tumor Necrosis Factor-α Production, and Deficiency of Circulating Mucosal-Associated Invariant T Cells in Patients with Scrub Typhus. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections. However, little is known about the role of MAIT cells in Orientia tsutsugamushi infection.
Seung-Ji Kang, Hye-Mi Jin, Eun Jeong Won, Young-Nan Cho, Hyun-Ju Jung, Yong-Soo Kwon, Hae Jin Kee, Jae Kyun Ju, Jung-Chul Kim, Uh Jin Kim, Hee-Chang Jang, Sook-In Jung, Seung-Jung Kee, Yong-Wook Park   +13 more
doaj   +1 more source

Mucosal-Associated Invariant T Cell Features and TCR Repertoire Characteristics During the Course of Multiple Sclerosis

Frontiers in Immunology, 2019
Objective: To investigate the frequency, phenotype, function, and longitudinal repertoire of mucosal-associated invariant T (MAIT) cells in relapsing remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS) patients.Methods ...
Edgar Carnero Contentti, Mauricio F. Farez, Jorge Correale, Jorge Correale   +3 more
doaj   +1 more source

Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection [PDF]

Viruses, 2021
There were an estimated 10 million new cases of tuberculosis (TB) disease in 2019. While over 90% of individuals successfully control Mycobacterium tuberculosis (Mtb) infection, which causes TB disease, HIV co-infection often leads to active TB disease.
Ryan V. Moriarty, Amy L. Ellis, Shelby L. O’Connor   +2 more
openaire   +3 more sources