Results 31 to 40 of about 12,026,666 (219)

Current Perspectives and Challenges of MAIT Cell-Directed Therapy for Tuberculosis Infection. [PDF]

Pathogens, 2023
Mucosal-associated invariant T (MAIT) cells are a distinct population of non-conventional T cells that have been preserved through evolution and possess properties of both innate and adaptive immune cells.
Chengalroyen MD.
europepmc   +2 more sources

Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis. [PDF]

Nat Commun
Mucosal-associated invariant T (MAIT) cells express semi-invariant T cell receptors (TCR) for recognizing bacterial and yeast antigens derived from riboflavin metabolites presented on the non-polymorphic MHC class I-related protein 1 (MR1 ...
Walkenhorst M, Sonner JK, Meurs N, Engler JB, Bauer S, Winschel I, Woo MS, Raich L, Winkler I, Vieira V, Unger L, Salinas G, Lantz O, Friese MA, Willing A.   +14 more
europepmc   +2 more sources

Liver transplant-facilitated CD161⁺Vα7.2⁺ MAIT cell recovery demonstrates clinical benefits in hepatic failure patients. [PDF]

Nat Commun
Mucosal-associated invariant T (MAIT) cells exert multifaceted effects such as anti-microbial activity, tissue repair, and pro-fibrotic effects across various disease settings. Nonetheless, their role in liver injury and hemostasis remains debated. Here,
Wang W, Dai C, Zhu P, Wu M, Zhang H, Wei Q, Zhou T, Tan X, Jiang Y, Cheng X, Liang Z, Wu X, Chen Z, Weng X.   +13 more
europepmc   +2 more sources

MAIT cell subtypes in multiple sclerosis

Journal of Neuroimmunology, 2020
In patients with multiple sclerosis (MS) and healthy controls (HC) we studied circulating MAIT cells and MAIT cell subtypes expressing CXCR3 and CCR6 by flow cytometry.
Holm Hansen, Rikke, Sellebjerg, Finn, von Essen, Marina R., Chow, Helene Højsgaard, McWilliam, Oskar, Ammitzbøll, Cecilie   +5 more
core   +4 more sources

CXCL16 Stimulates Antigen-Induced MAIT Cell Accumulation but Trafficking During Lung Infection Is CXCR6-Independent

Frontiers in Immunology, 2020
Mucosa-associated invariant T (MAIT) cells are a unique T cell subset that contributes to protective immunity against microbial pathogens, but little is known about the role of chemokines in recruiting MAIT cells to the site of infection.
Huifeng Yu, Amy Yang, Ligong Liu, Ligong Liu, Jeffrey Y. W. Mak, Jeffrey Y. W. Mak, David P. Fairlie, David P. Fairlie, Siobhan Cowley   +8 more
doaj   +3 more sources

Human MAIT cell activation in vitro [PDF]

, 2019
Item description: Chapter 7 in book 'MAIT Cells' (2020), ed H Kaipe and I Magalhaes. Methods in Molecular Biology, volume 2098. Mucosal-associated invariant T (MAIT) cells are an abundant innate-like T cell subset in humans, enriched in mucosal tissues ...
Paul Klenerman, Amini, Ali, Mehta, Hema, Nicholas M. Provine, Klenerman, Paul, Christian B. Willberg, Tianqi Leng, Matthew Bilton, Lucy C. Garner, Ali Amini, Garner, Lucy C, Carl-Philipp Hackstein, Prabhjeet Phalora, Matthew Edmans, Hema Mehta, Joachim P. Hagel, Phalora, Prabhjeet, Bilton, Matthew, Hagel, Joachim P, Provine, Nicholas M, Edmans, Matthew, Hackstein, Carl-Philipp, Leng, Tianqi, Akther, Hossain D, Willberg, Christian B, Hossain D. Akther   +25 more
core   +4 more sources

MicroRNA-155 Regulates MAIT1 and MAIT17 Cell Differentiation

Frontiers in Cell and Developmental Biology, 2021
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that develop in the thymus through three maturation stages to acquire effector function and differentiate into MAIT1 (T-bet+) and MAIT17 (RORγt+) subsets.
Tingting Liu, Tingting Liu, Tingting Liu, Jie Wang, Jie Wang, Kalpana Subedi, Kalpana Subedi, Qijun Yi, Qijun Yi, Li Zhou, Li Zhou, Qing-Sheng Mi, Qing-Sheng Mi   +12 more
doaj   +3 more sources

Synthetic 5-amino-6-D-ribitylaminouracil paired with inflammatory stimuli facilitates MAIT cell expansion in vivo. [PDF]

Front Immunol, 2023
Introduction Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells, which mediate host immunity to microbial infection by recognizing metabolite antigens derived from microbial riboflavin synthesis presented by the MHC-I ...
Nelson AG, Wang H, Dewar PM, Eddy EM, Li S, Lim XY, Patton T, Zhou Y, Pediongco TJ, Meehan LJ, Meehan BS, Mak JYW, Fairlie DP, Stent AW, Kjer-Nielsen L, McCluskey J, Eckle SBG, Corbett AJ, Souter MNT, Chen Z.   +19 more
europepmc   +2 more sources

MAIT cell-MR1 reactivity is highly conserved across multiple divergent species. [PDF]

J Biol Chem
Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize small molecule metabolites presented by major histocompatibility complex class I related protein 1 (MR1), via an αβ T cell receptor (TCR). MAIT TCRs feature
Edmans MD, Connelley TK, Morgan S, Pediongco TJ, Jayaraman S, Juno JA, Meehan BS, Dewar PM, Maze EA, Roos EO, Paudyal B, Mak JYW, Liu L, Fairlie DP, Wang H, Corbett AJ, McCluskey J, Benedictus L, Tchilian E, Klenerman P, Eckle SBG.   +20 more
europepmc   +2 more sources

Improved MAIT cell functions following fecal microbiota transplantation for metastatic renal cell carcinoma. [PDF]

Cancer Immunol Immunother, 2023
Strategies to modify the gut microbiome in cancer patients using fecal microbiota transplantation (FMT) have gained momentum as a therapeutic intervention. However, how FMT impacts innate-like, antimicrobial T lymphocytes is unclear.
Ninkov M, Schmerk CL, Moradizadeh M, Parvathy SN, Figueredo R, Burton JP, Silverman MS, Fernandes R, Maleki Vareki S, Haeryfar SMM.   +9 more
europepmc   +2 more sources