Results 31 to 40 of about 13,362 (213)

Polyclonal mucosa-associated invariant T cells have unique innate functions in bacterial infection [PDF]

, 2012
Mucosa-associated invariant T (MAIT) cells are a unique population of αβ T cells in mammals that reside preferentially in mucosal tissues and express an invariant Vα paired with limited Vβ T-cell receptor (TCR) chains.
Andersen, Annibali, Azra Blazevic, Berrington, Berzins, Billerbeck, Borg, Brennan, Brigl, Brigl, Chiba, Cho, Christopher S. Eickhoff, Chua, Chua, Cogen, Cohen, Cooper, Cooper, Cowley, Cowley, Croxford, Cua, Curtis, D'Souza, D'Souza, Daniel F. Hoft, Dusseaux, Elkins, Feng, Flesch, Flynn, Flynn, Gansert, Georgel, Gold, Gold, Goldfinch, Gopal, Green, Hansen, Huang, Huang, Huang, J. L. Flynn, Jovanovic, Junqueira-Kipnis, Kariyone, Kawachi, Khader, Khader, Kinjo, Ladel, Le Bourhis, Lin, Lockhart, Lozes, MacMicking, Martin, Miley, Misko, Miyazaki, Nagarajan, Parker, Parra, Pollock, Qian, Riegert, Rodgers, Sada-Ovalle, Schoenborn, Shimamura, Skold, Sousa, Steven M. Truscott, Ted H. Hansen, Tilloy, Treiner, Treiner, Tupin, Tyznik, Urdahl, Wei-Jen Chua, Worku, Yamaguchi, Yamaguchi, Zhang   +86 more
core   +2 more sources

Factors Influencing Functional Heterogeneity in Human Mucosa-Associated Invariant T Cells

Frontiers in Immunology, 2018
Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the monomorphic MHC class I-related (MR1) molecule.
Joana Dias, Caroline Boulouis, Michał J. Sobkowiak, Kerri G. Lal, Kerri G. Lal, Kerri G. Lal, Johanna Emgård, Marcus Buggert, Tiphaine Parrot, Jean-Baptiste Gorin, Edwin Leeansyah, Edwin Leeansyah, Johan K. Sandberg   +12 more
doaj   +1 more source

CD161+ MAIT cells are severely reduced in peripheral blood and lymph nodes of HIV-infected individuals independently of disease progression. [PDF]

PLoS ONE, 2014
Mucosal-associated invariant T (MAIT) cells are characterized by the combined expression of the semi-invariant T cell receptor (TCR) Vα7.2, the lectin receptor CD161, as well as IL-18R, and play an important role in antibacterial host defense of the gut.
Johanna Maria Eberhard, Philip Hartjen, Silke Kummer, Reinhold E Schmidt, Maximilian Bockhorn, Clara Lehmann, Ashwin Balagopal, Joachim Hauber, Jan van Lunzen, Julian Schulze zur Wiesch   +9 more
doaj   +1 more source

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells [PDF]

, 2017
Mucosal-associated invariant T (MAIT) cells are activated by unstable antigens formed by reactions of 5-amino-6-D-ribitylaminouracil (a vitamin B2 biosynthetic intermediate) with glycolysis metabolites such as methylglyoxal.
Chen, Zhenjun, Corbett, Alexandra J., Fairlie, David P., Liu, Ligong, Mak, Jeffrey Y. W., McCluskey, James, Meehan, Bronwyn S., Reid, Robert C., Rossjohn, Jamie, Wang, Huimeng, Xu, Weijun   +10 more
core   +4 more sources

Varicella Zoster Virus infects mucosal associated Invariant T cells

Frontiers in Immunology, 2023
IntroductionMucosal Associated Invariant T (MAIT) cells are innate-like T cells that respond to conserved pathogen-derived vitamin B metabolites presented by the MHC class I related-1 molecule (MR1) antigen presentation pathway.
Shivam K. Purohit, Alexandra J. Corbett, Barry Slobedman, Allison Abendroth   +3 more
doaj   +1 more source

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18–dependent activation [PDF]

, 2016
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes known to elicit potent immunity to a broad range of bacteria, mainly via the rapid production of inflammatory cytokines. Whether MAIT cells contribute to antiviral immunity is less
Corbett, Alexandra J., Crowe, Jane, Doherty, Peter C., Fairlie, David P., Jegaskanda, Sinthujan, Kedzierska, Katherine, Koutsakos, Marios, Liu, Ligong, Loh, Liyen, McCluskey, James, Rossjohn, Jamie, Sant, Sneha, Wang, Zhongfang, Xu, Jianqing   +13 more
core   +2 more sources

MAIT cells in metabolic diseases

Molecular Metabolism, 2019
Metabolic diseases represent a wide category of alterations affecting metabolism. These pathologies are notably marked by inflammation that implicates the immune system. Mucosal Associated Invariant (MAI)T cells are immune cells expressing a semi-invariant TCR able to recognize bacterial and fungal vitamin B metabolites.
Bertrand, Léo, Lehuen, Agnès
openaire   +4 more sources

Human MAIT Cell Activation In Vitro [PDF]

, 2019
Mucosal-associated invariant T (MAIT) cells are an abundant innate-like T cell subset in humans, enriched in mucosal tissues and the liver. MAIT cells express a semi-invariant T cell receptor (TCR) and recognize microbial-derived riboflavin metabolites presented on the MHC Class I-like molecule MR1. In addition to activation via the TCR, MAIT cells can
Hagel, JP, Garner, LC, Bilton, M, Mehta, H, Leng, T, Hackstein, C-P, Phalora, P, Amini, A, Akther, HD, Provine, NM, Edmans, M, Willberg, CB, Klenerman, P   +12 more
openaire   +3 more sources

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression [PDF]

, 2017
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically ...
A Kurioka, A Mavropoulos, A Sattler, A Sattler, AJ Corbett, AL Taylor, Alexandra J. Corbett, AR Lussow, Arash Memarnejadian, Avinash Bhandoola, AY Tilahun, B Liang, C Carnaud, C Soudais, Christopher R. Shaler, CT Morita, D Grimaldi, D Robinson, E Lappin, E Leeansyah, E Leeansyah, EM Danielsen, F Guerville, F Tilloy, J Bae, J Jo, J Lopez-Sagaseta, J White, JA Mollick, James McCluskey, Jamie Rossjohn, JE Ussher, JJ Subleski, JK McCormick, JL Hayworth, JL Hayworth, JN Brouillard, John K. McCormick, Joshua Choi, K Ito, K Nakamura, K Takeda, K Tominaga, KJ Kasper, KJ Kasper, L Kjer-Nielsen, L Le Bourhis, L Leder, L Li, LA Edwards, LJ Howson, LS Berenson, M Dusseaux, M Lepore, M Maeurer, M Nakahira, M Reglinski, M Spaan, Mauro E. Tun-Abraham, MC Gold, N Seach, Olivier Lantz, P Dellabona, PA Szabo, PA Szabo, Patrick T. Rudak, Peter A. Szabo, R Podschun, R Reantragoon, RJ Napier, Roberto Hernandez-Alejandro, S Huang, S Porcelli, S.M. Mansour Haeryfar, SA Rieder, SM Borchardt, SM Haeryfar, TA Chau, W Salgado-Pabon, XZ Tang, Y Cui, Y Gao   +81 more
core   +12 more sources

Stepwise development of MAIT cells in mouse and human. [PDF]

PLoS Biology, 2009
Mucosal-associated invariant T (MAIT) cells display two evolutionarily conserved features: an invariant T cell receptor (TCR)alpha (iTCRalpha) chain and restriction by the nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC ...
Emmanuel Martin, Emmanuel Treiner, Livine Duban, Lucia Guerri, Hélène Laude, Cécile Toly, Virginie Premel, Anne Devys, Ivan C Moura, Florence Tilloy, Stéphane Cherif, Gabriella Vera, Sylvain Latour, Claire Soudais, Olivier Lantz   +14 more
doaj   +1 more source