Results 31 to 40 of about 4,910,474 (212)
MAIT cells in liver inflammation and fibrosis
Seminars in Immunopathology, 2022 AbstractMucosal-associated invariant T cells or MAIT cells are an abundant cell type in humans and especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge between innate and adaptive immunity, so-called innate-like or “unconventional” T cells.
Mehta, H +3 more
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Frontiers in Immunology, 2019 Objective: To investigate the frequency, phenotype, function, and longitudinal repertoire of mucosal-associated invariant T (MAIT) cells in relapsing remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS) patients.Methods ...
Edgar Carnero Contentti +3 more
doaj +1 more source
CD161+ MAIT cells are severely reduced in peripheral blood and lymph nodes of HIV-infected individuals independently of disease progression. [PDF]
PLoS ONE, 2014 Mucosal-associated invariant T (MAIT) cells are characterized by the combined expression of the semi-invariant T cell receptor (TCR) Vα7.2, the lectin receptor CD161, as well as IL-18R, and play an important role in antibacterial host defense of the gut.
Johanna Maria Eberhard +9 more
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Varicella Zoster Virus infects mucosal associated Invariant T cells
Frontiers in Immunology, 2023 IntroductionMucosal Associated Invariant T (MAIT) cells are innate-like T cells that respond to conserved pathogen-derived vitamin B metabolites presented by the MHC class I related-1 molecule (MR1) antigen presentation pathway.
Shivam K. Purohit +3 more
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Factors Influencing Functional Heterogeneity in Human Mucosa-Associated Invariant T Cells
Frontiers in Immunology, 2018 Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the monomorphic MHC class I-related (MR1) molecule.
Joana Dias +12 more
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Pathogens and Immunity, 2022 Background: Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in the mucosa with capacity for B-cell help. We hypothesize that targeting MAIT cells, using a MAIT-activating ligand as an adjuvant, could improve mucosal vaccine ...
Owen Jensen +6 more
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Biological functions of MAIT cells in tissues
Molecular Immunology, 2021 Mucosal associated invariant T (MAIT) cells have a recognised innate-like capacity for antibacterial host defence, consequent on the specificity of their T cell receptor (TCR) for small molecule metabolites produced by a range of prokaryotic and fungal species, their effector memory phenotype, and their expression of cytotoxic molecules.
Klenerman, Paul +2 more
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Frontiers in Immunology, 2017 Mucosal-associated invariant T (MAIT) cells are innate-like T cells which are important in the defense against certain bacteria and yeast. The reconstitution of MAIT cells after allogeneic hematopoietic stem cell transplantation (HSCT) is not known.
Martin Solders +8 more
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MAIT cells in metabolic diseases
Molecular Metabolism, 2019 Metabolic diseases represent a wide category of alterations affecting metabolism. These pathologies are notably marked by inflammation that implicates the immune system. Mucosal Associated Invariant (MAI)T cells are immune cells expressing a semi-invariant TCR able to recognize bacterial and fungal vitamin B metabolites.
Bertrand, Léo, Lehuen, Agnès
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Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection [PDF]
Viruses, 2021 There were an estimated 10 million new cases of tuberculosis (TB) disease in 2019. While over 90% of individuals successfully control Mycobacterium tuberculosis (Mtb) infection, which causes TB disease, HIV co-infection often leads to active TB disease.
Ryan V. Moriarty +2 more
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