Results 21 to 30 of about 4,910,474 (212)

Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19

Frontiers in Immunology, 2021
BackgroundMucosal-associated invariant T (MAIT) cells are considered to participate of the host immune response against acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, single-cell transcriptomic profiling of MAIT ...
Jijing Shi, Jijing Shi, Jianglin Zhou, Xiaochang Zhang, Wei Hu, Wei Hu, Jin-Fang Zhao, Shengqi Wang, Fu-Sheng Wang, Fu-Sheng Wang, Ji-Yuan Zhang   +10 more
doaj   +1 more source

Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity. [PDF]

Nat Immunol, 2023
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial metabolites through a semi-invariant T cell receptor (TCR). Major questions remain regarding the extent of human MAIT cell functional and clonal diversity.
Garner LC, Amini A, FitzPatrick MEB, Lett MJ, Hess GF, Filipowicz Sinnreich M, Provine NM, Klenerman P.   +7 more
europepmc   +2 more sources

MicroRNA-155 Regulates MAIT1 and MAIT17 Cell Differentiation

Frontiers in Cell and Developmental Biology, 2021
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that develop in the thymus through three maturation stages to acquire effector function and differentiate into MAIT1 (T-bet+) and MAIT17 (RORγt+) subsets.
Tingting Liu, Tingting Liu, Tingting Liu, Jie Wang, Jie Wang, Kalpana Subedi, Kalpana Subedi, Qijun Yi, Qijun Yi, Li Zhou, Li Zhou, Qing-Sheng Mi, Qing-Sheng Mi   +12 more
doaj   +1 more source

A Role for MAIT Cells in Colorectal Cancer [PDF]

Frontiers in Immunology, 2020
MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT cells within the microenvironment of colorectal tumors, but there is conjecture about the nature of their response and whether they are ...
Stuart P. Berzins, Stuart P. Berzins, Stuart P. Berzins, Morgan E. Wallace, Morgan E. Wallace, George Kannourakis, George Kannourakis, Jason Kelly, Jason Kelly   +8 more
openaire   +4 more sources

MAIT cells regulate NK cell-mediated tumor immunity [PDF]

, 2021
The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT cell-deficient mice have enhanced NK cell-dependent control of metastatic B16F10 tumor growth relative to control mice ...
Todd, KL, Kearney, CJ, Oliver, AJ, Pizzolla, A, Godfrey, DI, Li, J, Millen, R, McCulloch, TR, Chen, AXY, Oliaro, J, Giuffrida, L, Beavis, PA, Ramsay, RG, Mak, JYW, Petley, EV, Lai, J, Sek, K, Souza-Fonseca-Guimaraes, F, Michie, J, McCluskey, J, Keam, SP, Koay, HF, Fairlie, DP, Neeson, PJ, Zethoven, M, Freeman, AJ, House, IG, Darcy, PK, Huntington, ND, Henderson, MA, Chan, JD   +30 more
core   +1 more source

Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells [PDF]

, 2022
OBJECTIVE Mucosal-associated invariant T (MAIT) cells are the most abundant T cells in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1.
Magdalena Filipowicz Sinnreich, Christoph J Zech, Paul Klenerman, Jaeger, Tina, Heigl, Andres, Tina Jaeger, Urs Duthaler, Ivanek, Robert, Kate Powell, Martin J Lett, Jürg Vosbeck, Jacquet, Maxime, Deborah Stroka, Mehta, Hema, Jan Hendrik Niess, Maxime Jacquet, Klenerman, Paul, Isabel Fofana, Niess, Jan Hendrik, Robert Ivanek, Stroka, Deborah, Kollmar, Otto, Hassan Melhem, Zech, Christoph J, Mertz, Kirsten D, Burri, Emanuel, Emanuel Burri, Powell, Kate, Hema Mehta, Keogh, Adrian, Marie-Anne Meier, Fofana, Isabel, Gieri Cathomas, Meier, Marie-Anne, Cathomas, Gieri, Vosbeck, Jürg, Filipowicz Sinnreich, Magdalena, Melhem, Hassan, Andres Heigl, Markus H Heim, Otto Kollmar, Lett, Martin J, Adrian Keogh, Heim, Markus H, Duthaler, Urs, Kirsten D Mertz   +45 more
core   +2 more sources

CXCL16 Stimulates Antigen-Induced MAIT Cell Accumulation but Trafficking During Lung Infection Is CXCR6-Independent

Frontiers in Immunology, 2020
Mucosa-associated invariant T (MAIT) cells are a unique T cell subset that contributes to protective immunity against microbial pathogens, but little is known about the role of chemokines in recruiting MAIT cells to the site of infection.
Huifeng Yu, Amy Yang, Ligong Liu, Ligong Liu, Jeffrey Y. W. Mak, Jeffrey Y. W. Mak, David P. Fairlie, David P. Fairlie, Siobhan Cowley   +8 more
doaj   +1 more source

MAIT cell activation is associated with disease severity markers in acute hantavirus infection

, 2021
Hantaviruses are zoonotic RNA viruses that cause severe acute disease in humans. Infected individuals have strong inflammatory responses that likely cause immunopathology.
Ljunggren, Hans-Gustaf, Hans-Gustaf Ljunggren, Ahlm, Clas, Edwin Leeansyah, Joana Dias, García, M., Klingström, J., Christ, Wanda, Björkström, Niklas K., Sandberg, Johan K.,, Maleki, Kimia T., Klingström, Jonas, Forsell, Mattias N., Dias, Joana, Kerkman, Priscilla,, Clas Ahlm, Tauriainen, Johanna, Ljunggren, Hans-Gustaf,, Dias, Joana,, Maleki, Kimia T.,, Klingström, Jonas,, Björkström, N.K., Julia Wigren Byström, García, Marina,, Niklas K. Björkström, García, Marina, Forsell, Mattias N. E., Kerkman, Priscilla, Björkström, Niklas K.,, Johan K. Sandberg, Ahlm, Clas,, Kimia T. Maleki, Marina García, Mattias N. Forsell, Tauriainen, Johanna,, Priscilla F. Kerkman, Wigren, Julia, Johanna Tauriainen, Wanda Christ, Jonas Klingström, Wigren Byström, J., Kerkman, Priscilla F., Leeansyah, Edwin,, Christ, Wanda,, Wigren, Julia,, Forsell, Mattias N. E.,, Leeansyah, Edwin, Sandberg, Johan K.   +47 more
core   +1 more source

Leveraging Public Single-Cell and Bulk Transcriptomic Datasets to Delineate MAIT Cell Roles and Phenotypic Characteristics in Human Malignancies

Frontiers in Immunology, 2020
Mucosa-associated invariant T (MAIT) cells are unconventional, innate-like T lymphocytes that recognize vitamin B metabolites of microbial origin among other antigens displayed by the monomorphic molecule MHC class I-related protein 1 (MR1).
Tony Yao, Parisa Shooshtari, Parisa Shooshtari, S. M. Mansour Haeryfar, S. M. Mansour Haeryfar, S. M. Mansour Haeryfar, S. M. Mansour Haeryfar, S. M. Mansour Haeryfar   +7 more
doaj   +1 more source

Activation, Impaired Tumor Necrosis Factor-α Production, and Deficiency of Circulating Mucosal-Associated Invariant T Cells in Patients with Scrub Typhus. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections. However, little is known about the role of MAIT cells in Orientia tsutsugamushi infection.
Seung-Ji Kang, Hye-Mi Jin, Eun Jeong Won, Young-Nan Cho, Hyun-Ju Jung, Yong-Soo Kwon, Hae Jin Kee, Jae Kyun Ju, Jung-Chul Kim, Uh Jin Kim, Hee-Chang Jang, Sook-In Jung, Seung-Jung Kee, Yong-Wook Park   +13 more
doaj   +1 more source