Results 21 to 30 of about 12,026,666 (219)

Control of MAIT cell functions by cytokines in health and disease. [PDF]

Front Immunol
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that express a semi-invariant T cell receptor (TCR). These cells predominantly reside in tissues, such as the liver, lung, skin and the gastrointestinal tract.
Camard L, Bianchi E, Rogge L.
europepmc   +2 more sources

Augmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence

mBio, 2022
Mucosa-associated invariant T (MAIT) cells play a critical role in antimicrobial defense. Despite increased understanding of their mycobacterial ligands and the clinical association of MAIT cells with tuberculosis (TB), their function in protection ...
Ruchi Jain Dey, Bappaditya Dey, Melanie Harriff, Elizabeth T. Canfield, David M. Lewinsohn, William R. Bishai   +5 more
doaj   +2 more sources

IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection [PDF]

Frontiers in Immunology, 2022
MAIT cells are persistently depleted and functionally exhausted in HIV-1-infected patients despite long-term combination antiretroviral therapy (cART). IL-7 treatment supports MAIT cell reconstitution in vivo HIV-1-infected individuals and rescues their ...
Fei Han, Fei Han, Muhammad Yaaseen Gulam, Yichao Zheng, Yichao Zheng, Nurul Syuhada Zulhaimi, Nurul Syuhada Zulhaimi, Wan Rong Sia, Dan He, Dan He, Amanda Ho, Amanda Ho, Leila Hadadi, Zhenyu Liu, Zhenyu Liu, Peiwu Qin, Peiwu Qin, Peter E. Lobie, Peter E. Lobie, Adeeba Kamarulzaman, Adeeba Kamarulzaman, Lin-Fa Wang, Johan K. Sandberg, Sharon R. Lewin, Reena Rajasuriar, Reena Rajasuriar, Reena Rajasuriar, Edwin Leeansyah, Edwin Leeansyah, Edwin Leeansyah, Edwin Leeansyah   +30 more
doaj   +2 more sources

Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu. [PDF]

Proc Natl Acad Sci U S A
Significance Mucosal-associated invariant T (MAIT) cells are unconventional T lymphocytes present in all healthy humans and play an important role in immunity via recognition of antigens that are shared between many microbes.
Boulouis C, Mouchtaridi E, Müller TR, Mak JYW, Fairlie DP, Bergman P, Michaëlsson J, Halfvarson J, Mjösberg J, Buggert M, Sandberg JK.   +10 more
europepmc   +2 more sources

Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19

Frontiers in Immunology, 2021
BackgroundMucosal-associated invariant T (MAIT) cells are considered to participate of the host immune response against acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, single-cell transcriptomic profiling of MAIT ...
Jijing Shi, Jijing Shi, Jianglin Zhou, Xiaochang Zhang, Wei Hu, Wei Hu, Jin-Fang Zhao, Shengqi Wang, Fu-Sheng Wang, Fu-Sheng Wang, Ji-Yuan Zhang   +10 more
doaj   +3 more sources

Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells [PDF]

Gut, 2022
Objective Mucosal-associated invariant T (MAIT) cells are the most abundant T cells in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1.
M. Lett, Hema Mehta, A. Keogh, Tina Jaeger, M. Jacquet, K. Powell, Marie-Anne Meier, Isabel Fofana, H. Melhem, J. Vosbeck, G. Cathomas, A. Heigl, M. Heim, E. Burri, K. Mertz, J. Niess, O. Kollmar, C. Zech, R. Ivanek, Urs Duthaler, P. Klenerman, D. Stroka, Magdalena Filipowicz Sinnreich   +22 more
semanticscholar   +2 more sources

MAIT cells and the microbiome

Frontiers in Immunology, 2023
Mucosal associated invariant T (MAIT) cells are innate-like T lymphocytes, strikingly enriched at mucosal surfaces and characterized by a semi-invariant αβ T cell receptor (TCR) recognizing microbial derived intermediates of riboflavin synthesis ...
Maisha F. Jabeen, Maisha F. Jabeen, Timothy S. C. Hinks, Timothy S. C. Hinks   +3 more
doaj   +5 more sources

Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation. [PDF]

Front Immunol, 2023
Introduction The antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells (MAIT cells).
Ashley CL, McSharry BP, McWilliam HEG, Stanton RJ, Fielding CA, Mathias RA, Fairlie DP, McCluskey J, Villadangos JA, Rossjohn J, Abendroth A, Slobedman B.   +11 more
europepmc   +2 more sources

Mucosal-Associated Invariant T (MAIT) Cell-Mediated Immune Mechanisms of Peritoneal Dialysis-Induced Peritoneal Fibrosis and Therapeutic Targeting. [PDF]

J Am Soc Nephrol
Visual Abstract Key Points Peritoneal mucosal-associated invariant T (MAIT) cells were characterized by single-cell RNA sequencing, histological imaging, and flow cytometry.
Sun Y, Huang Q, Sun J, Zhou H, Guo D, Peng L, Lin H, Li C, Shang H, Wang T, Chen Y, Huang Y, Hu C, Hu Z, Lu Y, Peng H.   +15 more
europepmc   +2 more sources

Dynamic MAIT Cell Recovery after Severe COVID-19 Is Transient with Signs of Heterogeneous Functional Anomalies. [PDF]

J Immunol, 2023
Mucosal-associated invariant T (MAIT) cells are an abundant population of unconventional T cells in humans and play important roles in immune defence against microbial infections.
Kammann T, Gorin JB, Parrot T, Gao Y, Ponzetta A, Emgård J, Maleki KT, Sekine T, Rivera-Ballesteros O, Karolinska COVID-19 Study Group, Gredmark-Russ S, Rooyackers O, Skagerberg M, Eriksson LI, Norrby-Teglund A, Mak JYW, Fairlie DP, Björkström NK, Klingström J, Ljunggren HG, Aleman S, Buggert M, Strålin K, Sandberg JK, Sandberg JK.   +24 more
europepmc   +2 more sources