Results 21 to 30 of about 13,362 (213)

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

Frontiers in Immunology, 2021
Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi.
Sharon Khuzwayo, Sharon Khuzwayo, Maphe Mthembu, Maphe Mthembu, Erin W. Meermeier, Sanjay M. Prakadan, Sanjay M. Prakadan, Sanjay M. Prakadan, Samuel W. Kazer, Samuel W. Kazer, Samuel W. Kazer, Thierry Bassett, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Moosa Suleman, Moosa Suleman, Zoey Mhlane, Dirhona Ramjit, Farina Karim, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, David M. Lewinsohn, David M. Lewinsohn, David M. Lewinsohn, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Emily B. Wong, Emily B. Wong, Emily B. Wong, Emily B. Wong   +36 more
doaj   +1 more source

MAIT cells come to the rescue in cancer immunotherapy? [PDF]

, 2020
Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk, Venken, Koen, Łukasik, Zuzanna   +2 more
core   +2 more sources

MAIT cells regulate NK cell-mediated tumor immunity [PDF]

Nature Communications, 2021
Abstract The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT cell-deficient mice have enhanced NK cell-dependent control of metastatic B16F10 tumor growth relative to control mice.
Emma V. Petley, Hui-Fern Koay, Melissa A. Henderson, Kevin Sek, Kirsten L. Todd, Simon P. Keam, Junyun Lai, Imran G. House, Jasmine Li, Magnus Zethoven, Amanda X. Y. Chen, Amanda J. Oliver, Jessica Michie, Andrew J. Freeman, Lauren Giuffrida, Jack D. Chan, Angela Pizzolla, Jeffrey Y. W. Mak, Timothy R. McCulloch, Fernando Souza-Fonseca-Guimaraes, Conor J. Kearney, Rosemary Millen, Robert G. Ramsay, Nicholas D. Huntington, James McCluskey, Jane Oliaro, David P. Fairlie, Paul J. Neeson, Dale I. Godfrey, Paul A. Beavis, Phillip K. Darcy   +30 more
openaire   +4 more sources

Leveraging Public Single-Cell and Bulk Transcriptomic Datasets to Delineate MAIT Cell Roles and Phenotypic Characteristics in Human Malignancies

Frontiers in Immunology, 2020
Mucosa-associated invariant T (MAIT) cells are unconventional, innate-like T lymphocytes that recognize vitamin B metabolites of microbial origin among other antigens displayed by the monomorphic molecule MHC class I-related protein 1 (MR1).
Tony Yao, Parisa Shooshtari, Parisa Shooshtari, S. M. Mansour Haeryfar, S. M. Mansour Haeryfar, S. M. Mansour Haeryfar, S. M. Mansour Haeryfar, S. M. Mansour Haeryfar   +7 more
doaj   +1 more source

Signals that control MAIT cell function in healthy and inflamed human tissues. [PDF]

Immunol Rev
Konecny AJ, Huang Y, Setty M, Prlic M.
europepmc   +2 more sources

Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis [PDF]

, 2019
OBJECTIVES: Alcoholic hepatitis (AH) develops in approximately 30% of chronic heavy drinkers. The immune system of patients with AH is hyperactivated, yet ineffective against infectious diseases.
Bolte, Bottcher, Chan, Chayanupatkul, Chiba, Corbett, Cosgrove, Degre, Dhanda, Dusseaux, Eckle, Fergusson, Fung, Gao, Gao, Gerart, Hegde, Hengst, Jampana, Jeffery, Jiang, Kjer-Nielsen, Kurioka, Leclercq, Leeansyah, Leeansyah, Li, Liangpunsakul, Liangpunsakul, Loh, Markwick, Mutlu, Nagy, O'Shea, Pasala, Patel, Puri, Rao, Reantragoon, Riva, Saberi, Slichter, Spaan, Tang, Tilloy, Ussher, van Wilgenburg, Wong, Yong   +48 more
core   +1 more source

Mucosal-Associated Invariant T Cell Features and TCR Repertoire Characteristics During the Course of Multiple Sclerosis

Frontiers in Immunology, 2019
Objective: To investigate the frequency, phenotype, function, and longitudinal repertoire of mucosal-associated invariant T (MAIT) cells in relapsing remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS) patients.Methods ...
Edgar Carnero Contentti, Mauricio F. Farez, Jorge Correale, Jorge Correale   +3 more
doaj   +1 more source

Activation, Impaired Tumor Necrosis Factor-α Production, and Deficiency of Circulating Mucosal-Associated Invariant T Cells in Patients with Scrub Typhus. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections. However, little is known about the role of MAIT cells in Orientia tsutsugamushi infection.
Seung-Ji Kang, Hye-Mi Jin, Eun Jeong Won, Young-Nan Cho, Hyun-Ju Jung, Yong-Soo Kwon, Hae Jin Kee, Jae Kyun Ju, Jung-Chul Kim, Uh Jin Kim, Hee-Chang Jang, Sook-In Jung, Seung-Jung Kee, Yong-Wook Park   +13 more
doaj   +1 more source

Use of a MAIT Activating Ligand, 5-OP-RU, as a Mucosal Adjuvant in a Murine Model of Vibrio cholerae O1 Vaccination

Pathogens and Immunity, 2022
Background: Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in the mucosa with capacity for B-cell help. We hypothesize that targeting MAIT cells, using a MAIT-activating ligand as an adjuvant, could improve mucosal vaccine ...
Owen Jensen, Shubhanshi Trivedi, Kelin Li, Jeffrey Aubé, J. Scott Hale, Edward T. Ryan, Daniel T Leung   +6 more
doaj   +1 more source

MAIT cells boost adenovirus-induced CD8+ T cells [PDF]

Nature Reviews Immunology, 2021
MAIT cells found to have central role in the induction of CD8(+) T cell immunity in response to vaccination with ChAdOx1 adenoviral vectors.
openaire   +2 more sources