Results 11 to 20 of about 4,910,474 (212)

iNKT and MAIT cell alterations in diabetes [PDF]

Frontiers in Immunology, 2015
T1D and T2D are multifactorial diseases with different etiologies in which chronic inflammation takes place. Defects in iNKT cell populations have been reported in both T1D and T2D patients, mouse models and our recent study revealed MAIT cell defects in
Isabelle eMagalhaes, Badr eKiaf, Agnes eLehuen   +2 more
doaj   +6 more sources

MAIT Cell Activation and Functions [PDF]

Frontiers in Immunology, 2020
Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict conservation across 150 million years of mammalian evolution, implying they must fulfill critical immunological function(s). MAIT cells are defined by their expression of a semi-invariant αβ TCR which recognizes biosynthetic derivatives of riboflavin synthesis ...
Timothy S. C. Hinks, Xia-Wei Zhang, Xia-Wei Zhang   +2 more
openaire   +6 more sources

MAIT cells and the microbiome

Frontiers in Immunology, 2023
Mucosal associated invariant T (MAIT) cells are innate-like T lymphocytes, strikingly enriched at mucosal surfaces and characterized by a semi-invariant αβ T cell receptor (TCR) recognizing microbial derived intermediates of riboflavin synthesis ...
Maisha F. Jabeen, Maisha F. Jabeen, Timothy S. C. Hinks, Timothy S. C. Hinks   +3 more
doaj   +5 more sources

MAIT cell subtypes in multiple sclerosis

Journal of Neuroimmunology, 2020
In patients with multiple sclerosis (MS) and healthy controls (HC) we studied circulating MAIT cells and MAIT cell subtypes expressing CXCR3 and CCR6 by flow cytometry. Absolute numbers of MAIT cells and specifically Tc17-like MAIT cells were lower in patients with primary progressive MS (PPMS) than in controls. Low numbers of Tc17-like MAIT cells were
Ammitzbøll, Cecilie, von Essen, Marina R., Chow, Helene Højsgaard, McWilliam, Oskar, Holm Hansen, Rikke, Sellebjerg, Finn   +5 more
openaire   +4 more sources

Human MAIT Cell Activation In Vitro [PDF]

, 2019
Mucosal-associated invariant T (MAIT) cells are an abundant innate-like T cell subset in humans, enriched in mucosal tissues and the liver. MAIT cells express a semi-invariant T cell receptor (TCR) and recognize microbial-derived riboflavin metabolites presented on the MHC Class I-like molecule MR1. In addition to activation via the TCR, MAIT cells can
Hagel, JP, Garner, LC, Bilton, M, Mehta, H, Leng, T, Hackstein, C-P, Phalora, P, Amini, A, Akther, HD, Provine, NM, Edmans, M, Willberg, CB, Klenerman, P   +12 more
openaire   +5 more sources

MAIT cells: Conserved watchers on the wall

Journal of Experimental Medicine
MAIT cells are innate-like T cells residing in barrier tissues such as the lung, skin, and intestine. Both the semi-invariant T cell receptor of MAIT cells and the restricting element MR1 are deeply conserved across mammals, indicating non-redundant functions linked to antigenic specificity.
Lilou Germain, Pablo Veloso, Olivier Lantz, François Legoux   +3 more
openaire   +4 more sources

An overview on the identification of MAIT cell antigens [PDF]

Immunology & Cell Biology, 2018
AbstractMucosal associated invariant T (MAIT) cells are restricted by the monomorphic MHC class I‐like molecule, MHC‐related protein‐1 (MR1). Until 2012, the origin of the MAIT cell antigens (Ags) was unknown, although it was established that MAIT cells could be activated by a broad range of bacteria and yeasts, possibly suggesting a conserved Ag ...
Kjer-Nielsen, L, Corbett, AJ, Chen, Z, Liu, L, Mak, JYW, Godfrey, DI, Rossjohn, J, Fairlie, DP, McCluskey, J, Eckle, SBG   +9 more
openaire   +7 more sources

Type I interferons drive MAIT cell functions against bacterial pneumonia. [PDF]

J Exp Med, 2023
Mucosal-associated invariant T (MAIT) cells are abundant in the lung and contribute to host defense against infections. During bacterial infections, MAIT cell activation has been proposed to require T cell receptor (TCR)-mediated recognition of antigens ...
López-Rodríguez JC, Hancock SJ, Li K, Crotta S, Barrington C, Suárez-Bonnet A, Priestnall SL, Aubé J, Wack A, Klenerman P, Bengoechea JA, Barral P.   +11 more
europepmc   +3 more sources

The Activation of Mucosal-Associated Invariant T (MAIT) Cells Is Affected by Microbial Diversity and Riboflavin Utilization in vitro

Frontiers in Microbiology, 2020
Recent research has demonstrated that MAIT cells are activated by individual bacterial or yeasts species that possess the riboflavin biosynthesis pathway.
Jannike L. Krause, Stephanie S. Schäpe, Florian Schattenberg, Susann Müller, Grit Ackermann, Ulrike E. Rolle-Kampczyk, Nico Jehmlich, Arkadiusz Pierzchalski, Martin von Bergen, Martin von Bergen, Gunda Herberth   +10 more
doaj   +1 more source

Transcriptomes and metabolism define mouse and human MAIT cell populations. [PDF]

Sci Immunol, 2023
Mucosal-associated invariant T (MAIT) cells are a subset of T lymphocytes that respond to microbial metabolites. We defined MAIT cell populations in different organs and characterized the developmental pathway of mouse and human MAIT cells in the thymus ...
Chandra S, Ascui G, Riffelmacher T, Chawla A, Ramírez-Suástegui C, Castelan VC, Seumois G, Simon H, Murray MP, Seo GY, Premlal ALR, Schmiedel B, Verstichel G, Li Y, Lin CH, Greenbaum J, Lamberti J, Murthy R, Nigro J, Cheroutre H, Ottensmeier CH, Hedrick SM, Lu LF, Vijayanand P, Kronenberg M.   +24 more
europepmc   +2 more sources