Results 11 to 20 of about 12,026,666 (219)

MAIT Cell Activation and Functions. [PDF]

Front Immunol, 2020
Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict conservation across 150 million years of mammalian evolution, implying they must fulfill critical immunological function(s).
Hinks TSC, Zhang XW.
europepmc   +9 more sources

Type I interferons drive MAIT cell functions against bacterial pneumonia. [PDF]

J Exp Med, 2023
This report identifies a central role for type I interferons in governing the activation and effector functions of murine and human MAIT cells during pulmonary infection with Klebsiella pneumoniae.
López-Rodríguez JC, Hancock SJ, Li K, Crotta S, Barrington C, Suárez-Bonnet A, Priestnall SL, Aubé J, Wack A, Klenerman P, Bengoechea JA, Barral P.   +11 more
europepmc   +5 more sources

The MR1/MAIT cell axis in CNS diseases. [PDF]

Brain Behav Immun, 2023
Mucosal-associated invariant T (MAIT) cells are a subpopulation of innate-like T cells that can be found throughout the body, predominantly in mucosal sites, the lungs and in the peripheral blood.
Shrinivasan R, Wyatt-Johnson SK, Brutkiewicz RR.   +2 more
europepmc   +3 more sources

iNKT and MAIT cell alterations in diabetes [PDF]

Frontiers in Immunology, 2015
T1D and T2D are multifactorial diseases with different etiologies in which chronic inflammation takes place. Defects in iNKT cell populations have been reported in both T1D and T2D patients, mouse models and our recent study revealed MAIT cell defects in
Isabelle eMagalhaes, Badr eKiaf, Agnes eLehuen   +2 more
doaj   +6 more sources

RIPK3 controls MAIT cell accumulation during development but not during infection. [PDF]

Cell Death Dis, 2023
Cell death mechanisms in T lymphocytes vary according to their developmental stage, cell subset and activation status. The cell death control mechanisms of mucosal-associated invariant T (MAIT) cells, a specialized T cell population, are largely unknown.
Patton T, Zhao Z, Lim XY, Eddy E, Wang H, Nelson AG, Ennis B, Eckle SBG, Souter MNT, Pediongco TJ, Koay HF, Zhang JG, Djajawi TM, Louis C, Lalaoui N, Jacquelot N, Lew AM, Pellicci DG, McCluskey J, Zhan Y, Chen Z, Lawlor KE, Corbett AJ.   +22 more
europepmc   +3 more sources

Human blood MAIT cell subsets defined using MR1 tetramers [PDF]

Immunology and Cell Biology, 2018
Mucosal‐associated invariant T (MAIT) cells represent up to 10% of circulating human T cells. They are usually defined using combinations of non‐lineage‐specific (surrogate) markers such as anti‐TRAV1‐2, CD161, IL‐18Rα and CD26. The development of MR1‐Ag
Nicholas A Gherardin, Kirstie M Mangas, Torsten Seemann   +2 more
exaly   +3 more sources

MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles. [PDF]

Sci Immunol
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 molecules.
Kammann T, Cai C, Sekine T, Mouchtaridi E, Boulouis C, Nilsén V, Ballesteros OR, Müller TR, Gao Y, Raineri EJM, Mily A, Adamo S, Constantz C, Niessl J, Weigel W, Kokkinou E, Stamper C, Marchalot A, Bassett J, Ferreira S, Rødahl I, Wild N, Brownlie D, Tibbitt C, Mak JYW, Fairlie DP, Leeansyah E, Michaelsson J, Marquardt N, Mjösberg J, Jorns C, Buggert M, Sandberg JK.   +32 more
europepmc   +3 more sources

Mouse models illuminate MAIT cell biology. [PDF]

Mol Immunol, 2021
The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based antigens recognised by these specialised T cells.
Wang H, Chen Z, McCluskey J, Corbett AJ.
europepmc   +3 more sources

The Emerging Role of MAIT Cell Responses in Viral Infections. [PDF]

J Immunol, 2023
Mucosal-associated invariant T (MAIT) cells are unconventional T cells with innate-like antimicrobial responsiveness. MAIT cells are known for MR1 (MHC class I-related protein 1)-restricted recognition of microbial riboflavin metabolites giving them the ...
Sandberg JK, Leeansyah E, Eller MA, Shacklett BL, Paquin-Proulx D.   +4 more
europepmc   +2 more sources

Control of the temporal development of Alzheimer's disease pathology by the MR1/MAIT cell axis. [PDF]

J Neuroinflammation, 2023
Background Neuroinflammation is an important feature of Alzheimer’s disease (AD). Understanding which aspects of the immune system are important in AD may lead to new therapeutic approaches.
Wyatt-Johnson SK, Kersey HN, Codocedo JF, Newell KL, Landreth GE, Lamb BT, Oblak AL, Brutkiewicz RR.   +7 more
europepmc   +2 more sources