Results 11 to 20 of about 13,362 (213)
Mouse models illuminate MAIT cell biology. [PDF]
Mol Immunol, 2021 The field of mucosal-associated invariant T cell (MAIT) biology has grown rapidly since the identification of the vitamin-B-based antigens recognised by these specialised T cells. Over the past few years, our understanding of the complexities of MAIT cell function has developed, as they find their place among the other better known cells of the immune ...
Wang H, Chen Z, McCluskey J, Corbett AJ.
europepmc +6 more sources
Frontiers in Immunology, 2023 Mucosal associated invariant T (MAIT) cells are innate-like T lymphocytes, strikingly enriched at mucosal surfaces and characterized by a semi-invariant αβ T cell receptor (TCR) recognizing microbial derived intermediates of riboflavin synthesis ...
Maisha F. Jabeen +3 more
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iNKT and MAIT cell alterations in diabetes [PDF]
Frontiers in Immunology, 2015 T1D and T2D are multifactorial diseases with different etiologies in which chronic inflammation takes place. Defects in iNKT cell populations have been reported in both T1D and T2D patients, mouse models and our recent study revealed MAIT cell defects in
Isabelle eMagalhaes +2 more
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Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal-Associated Invariant T (MAIT) Cell Function. [PDF]
ImmunologyIntegrated transcriptomic, proteomic and flow cytometry analyses reveal that STAT1 negatively regulates MAIT cell effector and glycolytic functions, while STAT3, STAT5 and HIF1α act as positive modulators. Targeting these pathways may offer new strategies to restore MAIT cell function in immune dysregulation and cancer.
Cheng OJ +7 more
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mBio, 2022 Mucosa-associated invariant T (MAIT) cells play a critical role in antimicrobial defense. Despite increased understanding of their mycobacterial ligands and the clinical association of MAIT cells with tuberculosis (TB), their function in protection ...
Ruchi Jain Dey +5 more
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MAIT Cell Activation and Functions. [PDF]
Front Immunol, 2020 Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict conservation across 150 million years of mammalian evolution, implying they must fulfill critical immunological function(s). MAIT cells are defined by their expression of a semi-invariant αβ TCR which recognizes biosynthetic derivatives of riboflavin synthesis ...
Hinks TSC, Zhang XW.
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Frontiers in Cellular and Infection Microbiology, 2023 Mucosal-associated invariant T (MAIT) cells are protective against tuberculous and non-tuberculous mycobacterial infections with poorly understood mechanisms. Despite an innate-like nature, MAIT cell responses remain heterogeneous in bacterial infections.
Manju Sharma +3 more
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Frontiers in Immunology, 2021 Mucosal-associated invariant T (MAIT) cells have been implicated in various forms of autoimmunity, including type 1 diabetes (T1D). Here, we tested the hypothesis that CD8 and double negative (DN) MAIT cell frequencies were altered among diagnosed T1D ...
Robert Z. Harms +9 more
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Immunology & Cell Biology, 2018 AbstractMucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially derived metabolites. Functionally, they respond to bacteria and yeasts, which possess the riboflavin pathway, essential for production of such metabolites and which are presented on MR1.
James E Ussher +2 more
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Frontiers in Microbiology, 2020 Recent research has demonstrated that MAIT cells are activated by individual bacterial or yeasts species that possess the riboflavin biosynthesis pathway.
Jannike L. Krause +10 more
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