Results 71 to 80 of about 27,223 (192)

Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection

iScience
Summary: The major histocompatibility complex (MHC), Class-I-related (MR1) molecule presents microbiome-synthesized metabolites to Mucosal-associated invariant T (MAIT) cells, present at sites of herpes simplex virus (HSV) infection.
Carolyn Samer, Hamish E.G. McWilliam, Brian P. McSharry, Thilaga Velusamy, James G. Burchfield, Richard J. Stanton, David C. Tscharke, Jamie Rossjohn, Jose A. Villadangos, Allison Abendroth, Barry Slobedman   +10 more
doaj   +1 more source

A non perturbative approach of the principal chiral model between two and four dimensions

, 1999
We investigate the principal chiral model between two and four dimensions by means of a non perturbative Wilson-like renormalization group equation. We are thus able to follow the evolution of the effective coupling constants within this whole range of ...
A. Hasenfratz, A. M. Polyakov, B. Bergerhoff, B. Bergerhoff, B. Delamotte, B. I. Halperin, B. I. Halperin, C. Dasgupta, C. Wetterich, C. Wetterich, C. Wetterich, D. Bailin, D. H. Friedan, D. Mouhanna, D. R. T. Jones, D.-U. Jungnickel, E. Brézin, F. J. Wegner, G. Zumbach, H. Kawamura, H. Kawamura, H. Kunz, I. D. Lawrie, J. Berges, J. J. Polchinski, J. March-Russel, J. Zinn-Justin, K. G. Wilson, L. Radzihovsky, M. Grater, M. Laine, M. Tissier, M. Yosefin, N. Tetradis, P. Azaria, P. Ginsparg, S. A. Antonenko, S. Teitel, T. Dombre, T. Garel, T. R. Morris, T. R. Morris, T. R. Morris, U. Ellwanger   +43 more
core   +1 more source

Non-perturbative Renormalization Constants using Ward Identities [PDF]

, 1998
We extend the application of vector and axial Ward identities to calculate $b_A$, $b_P$ and $b_T$, coefficients that give the mass dependence of the renormalization constants of the corresponding bilinear operators in the quenched theory.
Bhattacharya, T., Chandrasekharan, S., Gupta, R., Lee, W., Sharpe, S.   +4 more
core   +4 more sources

Single Cell Multi‐Omics Revealing the Important Role of MR1 Mediated MAIT Cells in Maintaining Rejection for Liver Transplantation

Cell Proliferation, EarlyView.
This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai, Xinqiang Li, Xin Zhou, Xueteng Wang, Zhuoyu Jia, Ruidong Ding, Yurong Luo, Ye Wang, Shipeng Li, Wenxing Sun, Dongxing Wu, Dahong Teng, Kai Zhao, Guanghui Pei, Jinzhen Cai, Bin Wu   +15 more
wiley   +1 more source

Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis [PDF]

, 2019
OBJECTIVES: Alcoholic hepatitis (AH) develops in approximately 30% of chronic heavy drinkers. The immune system of patients with AH is hyperactivated, yet ineffective against infectious diseases.
Bolte, Bottcher, Chan, Chayanupatkul, Chiba, Corbett, Cosgrove, Degre, Dhanda, Dusseaux, Eckle, Fergusson, Fung, Gao, Gao, Gerart, Hegde, Hengst, Jampana, Jeffery, Jiang, Kjer-Nielsen, Kurioka, Leclercq, Leeansyah, Leeansyah, Li, Liangpunsakul, Liangpunsakul, Loh, Markwick, Mutlu, Nagy, O'Shea, Pasala, Patel, Puri, Rao, Reantragoon, Riva, Saberi, Slichter, Spaan, Tang, Tilloy, Ussher, van Wilgenburg, Wong, Yong   +48 more
core   +1 more source

Cognitive and neurodevelopmental disorders in spinal muscular atrophy type I at the time of disease‐modifying therapies

Developmental Medicine &Child Neurology, EarlyView.
Abstract After treatment with new disease‐modifying therapies, cognitive and neurodevelopmental aspects have been observed in individuals with spinal muscular atrophy (SMA). Emerging evidence suggests that children with SMA type 1 may experience cognitive, language, and behavioural delays, with reported rates of neurodevelopmental difficulties ranging ...
Giorgia Coratti, Bianca Buchignani, Eugenio Mercuri   +2 more
wiley   +1 more source

Lipid specific and vitamin specific non-MHC restricted T cells: new players in human pathophysiology.

Frontiers in Immunology, 2015
Since initial reports, more than 25 years ago, that T cells recognise lipids in the context on non-polymorphic CD1 molecules, our understanding of antigen presentation to non-peptide specific T cell populations has deepened.
Mariolina eSalio, Vincenzo eCerundolo
doaj   +1 more source

Biased MAIT TCR Usage Poised for Limited Antigen Diversity?

Frontiers in Immunology, 2020
Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize the evolutionarily conserved major histocompatibility complex (MHC) class I-like antigen-presenting molecule known as MHC class I related protein 1 (MR1 ...
Michael N. T. Souter, Sidonia B. G. Eckle   +1 more
doaj   +1 more source

Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells. [PDF]

Proc Natl Acad Sci U S A
Mitochondria coordinate several metabolic pathways, producing metabolites that influence the immune response in various ways. It remains unclear whether mitochondria impact antigen presentation by the MHC-class-I-related antigen-presenting molecule, MR1, which presents small molecules to MR1-restricted T-lymphocytes.
Prota G, Berloffa G, Awad W, Vacchini A, Chancellor A, Schaefer V, Constantin D, Littler DR, Colombo R, Nosi V, Mori L, Rossjohn J, De Libero G.   +12 more
europepmc   +3 more sources

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source