Results 71 to 80 of about 6,919 (168)

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Flight of the dragons: a global review of migration in Odonata

Biological Reviews, Volume 101, Issue 5, Page 2134-2157, October 2026.
ABSTRACT Insects are the most abundant and ecologically important animal migrants. Yet, we know relatively little about the patterns and processes underlying insect migration. Dragonflies (Anisoptera) and damselflies (Zygoptera) comprise the ancient insect order Odonata, whose ancestors were the first organisms to fly on Earth.
Johanna S.U. Hedlund, Myles Menz, Jason W. Chapman, Alexander Hayward   +3 more
wiley   +1 more source

MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic mice

Journal of Neuroinflammation
Background The role of immune cells in neurodegeneration remains incompletely understood. Accumulation of misfolded tau proteins is a hallmark of neurodegenerative diseases.
Yuanyue Zhang, Zhi Yang, Na Jiang, Xiaosheng Tan, Peng Jiang, Gaoyuan Cao, Qi Yang   +6 more
doaj   +1 more source

Olp-Associated Fibroblasts Stimulate Mait Cells Via Mr1 Pathway

International Dental Journal
Aim or purpose: This study aimed to examine the level and function of mucosal associated invariant T (MAIT) cells in Oral lichen planus (OLP) tissues and further explore the activation of MAIT cells by OLP-associated myofibroblasts (OLP/MFs).
Qian Mi, Wenxia Meng, Xiaoli Wu
doaj   +1 more source

Advances in γδ T Cells: Cutaneous Biology and Therapeutic Potential for Skin Neoplasms

The Journal of Dermatology, Volume 53, Issue 10, Page 1415-1428, October 2026.
ABSTRACT γδ T cells represent an increasingly important subset of T lymphocytes in the immune response to cancer and as a platform for novel immunotherapies. The aim of this review is to synthesize recent insights into the biology and advances in therapeutic applications of γδ T cells in cutaneous malignancies, especially melanoma, within a framework ...
Simo Du, Anika Jallorina, Toru Yoshino, Lingyu Bao, Han Bao, Victor Chang, Henry K. Wong, Derek V. Chan, Stephen K. Richardson, Mary F. Lee‐Wong   +9 more
wiley   +1 more source

Biology of CD1- and MR1-Restricted T Cells

Annual Review of Immunology, 2014
Over the past 15 years, investigators have shown that T lymphocytes can recognize not only peptides in the context of MHC class I and class II molecules but also foreign and self-lipids in association with the nonclassical MHC class I–like molecules, CD1 proteins. In this review, we describe the most recent events in the field, with particular emphasis
Salio, M, Silk, J, Jones, E, Cerundolo, V   +3 more
openaire   +2 more sources

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

Nature Communications, 2016
Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S.
Erin W. Meermeier, Bruno F. Laugel, Andrew K. Sewell, Alexandra J. Corbett, Jamie Rossjohn, James McCluskey, Melanie J. Harriff, Tamera Franks, Marielle C. Gold, David M. Lewinsohn   +9 more
doaj   +1 more source

Nitrogen-doped mesoporous activated carbon from Lentinus edodes residue: an optimized adsorbent for pharmaceuticals in aqueous solutions

Frontiers in Chemistry
In this study, phosphoric acid activation was employed to synthesize nitrogen-doped mesoporous activated carbon (designated as MR1) from Lentinus edodes (shiitake mushroom) residue, while aiming to efficiently remove acetaminophen (APAP), carbamazepine ...
Bei Chu, Yichen Lou, Yixin Tan, Jiawei Lin, Xingcheng Liu   +4 more
doaj   +1 more source

Selective inhibition of MR1-restricted T cell activation by a novel MR1-targeting nanobody

Abstract MR1 is a non-polymorphic, ubiquitously expressed, MHC class I-like antigen-presenting molecule that presents small-molecule metabolites to T cells. Studies have shown that MR1 plays a role in microbial infection, inflammation, and tumor immunity.
Timothy Bates, Corinna Kulicke, Sintayehu Gurmessa, Se-Jin Kim, Sushant Suresh, Jules Reyes-Weinstein, Audrey Hinchliff, John Burke, David Lewinsohn, Fikadu G. Tafesse   +9 more
openaire   +2 more sources

Differentiation and fiber type-specific activity of a muscle creatine kinase intronic enhancer

Skeletal Muscle, 2011
Background Hundreds of genes, including muscle creatine kinase (MCK), are differentially expressed in fast- and slow-twitch muscle fibers, but the fiber type-specific regulatory mechanisms are not well understood. Results Modulatory region 1 (MR1) is a 1-
Tai Phillip WL, Fisher-Aylor Katherine I, Himeda Charis L, Smith Catherine L, MacKenzie Alexandra P, Helterline Deri L, Angello John C, Welikson Robert E, Wold Barbara J, Hauschka Stephen D   +9 more
doaj   +1 more source