Results 71 to 80 of about 8,186 (190)

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini, E. Tartaglia, F. Cristofanelli, S. Gili, F. Maggi   +4 more
wiley   +1 more source

Image_1_Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation.tif

, 2023
IntroductionThe antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells (MAIT cells ...
Caroline L. Ashley (10882632), James McCluskey (1845217), Rommel A. Mathias (2321233), Allison Abendroth (5155166), Richard J. Stanton (9030887), Ceri A. Fielding (14597126), Hamish E. G. McWilliam (6746912), David P. Fairlie (180958), Jamie Rossjohn (127997), Jose A. Villadangos (6746939), Barry Slobedman (5155160), Brian P. McSharry (9110760)   +11 more
core   +1 more source

Cognitive and neurodevelopmental disorders in spinal muscular atrophy type I at the time of disease‐modifying therapies

Developmental Medicine &Child Neurology, Volume 68, Issue 7, Page 909-915, July 2026.
Abstract After treatment with new disease‐modifying therapies, cognitive and neurodevelopmental aspects have been observed in individuals with spinal muscular atrophy (SMA). Emerging evidence suggests that children with SMA type 1 may experience cognitive, language, and behavioural delays, with reported rates of neurodevelopmental difficulties ranging ...
Giorgia Coratti, Bianca Buchignani, Eugenio Mercuri   +2 more
wiley   +1 more source

A Critical Role for Mucosal-Associated Invariant T Cells as Regulators and Therapeutic Targets in Systemic Lupus Erythematosus

Frontiers in Immunology, 2019
Mucosal-associated invariant T (MAIT) cells are a subset of innate-like lymphocytes that are restricted by major histocompatibility complex-related molecule 1 (MR1).
Goh Murayama, Goh Murayama, Asako Chiba, Hitoshi Suzuki, Atsushi Nomura, Tomohiro Mizuno, Taiga Kuga, Taiga Kuga, Shinji Nakamura, Hirofumi Amano, Sachiko Hirose, Ken Yamaji, Yusuke Suzuki, Naoto Tamura, Sachiko Miyake   +14 more
doaj   +1 more source

Dosimetric effects of adaptive prostate cancer radiotherapy in an MR-linac workflow

Radiation Oncology, 2020
Background The purpose was to evaluate the dosimetric effects in prostate cancer treatment caused by anatomical changes occurring during the time frame of adaptive replanning in a magnetic resonance linear accelerator (MR-linac) workflow.
Annika Mannerberg, Emilia Persson, Joakim Jonsson, Christian Jamtheim Gustafsson, Adalsteinn Gunnlaugsson, Lars E. Olsson, Sofie Ceberg   +6 more
doaj   +1 more source

Cigarette smoke components modulate the MR1–MAIT axis

Tobacco smoking is prevalent across the world and causes numerous diseases. Cigarette smoke (CS) compromises immunity, yet little is known of the components of CS that impact T cell function.
Haw, TJ, Hansbro, Philip M, Hansbro, Nicole G, Awad, Wael, Gillis, Caitlin M, Galvao, Izabela, Howson, Lauren J, Mak, JYW, Albers, GJ, Corbett, AJ, Fairlie, David P, Corbett, Alexandra J, Hortle, Elinor, Donovan, Chantal, Hansbro, PM, Pai, TY, Horvat, Jay C, Johansen, MD, Xu, W, Howson, LJ, Haw, Tatt Jhong, Gillis, CM, Galvao, I, Pai, Tsung-Yu, Mayall, Jemma R, Rossjohn, Jamie, Patton, T, Das, S, Awad, W, Liu, Ligong, McCluskey, James, Mak, Jeffrey Y W, Liu, L, Xu, Weijun, Patton, Timothy, Donovan, C, Lim, Xin Yi, Albers, Gesa J, Hortle, E, Brown, AC, McCluskey, J, Fairlie, DP, Brown, Alexandra C, Rossjohn, J, Johansen, Matt D, Mayall, JR, Horvat, JC, Das, Shatarupa, Hansbro, NG, Lim, XY   +49 more
core   +1 more source

Unravelling the Genetic Mechanisms of Litter Traits in a Maternal Line of Pigs

Journal of Animal Breeding and Genetics, Volume 143, Issue 4, Page 560-580, July 2026.
ABSTRACT Reproductive traits related to litter size are the main indicators of reproductive efficiency in pig production and are continuously evaluated for the selection of maternal lines. Several environmental and genetic factors are involved with the development of these traits.
Guilherme Oselame, Suelen Fernandes Padilha, Maurício Egídio Cantão, Jane de Oliveira Peixoto, Aline Zampar, Adriana Mércia Guaratini Ibelli, Luis Orlando Duitama Carreño, Jader Silva Lopes, Pedro Henrique Ferreira Freitas, Marcelo Silva Freitas, Mônica Corrêa Ledur   +10 more
wiley   +1 more source

Adoptive T Cell Therapy Targeting CD1 and MR1 [PDF]

Frontiers in Immunology, 2015
Adoptive T cell immunotherapy has demonstrated clinically relevant efficacy in treating malignant and infectious diseases. However, much of these therapies have been focused on enhancing, or generating de novo, effector functions of conventional T cells recognizing HLA molecules.
Tingxi eGuo, Tingxi eGuo, Kenji eChamoto, Naoto eHirano, Naoto eHirano   +4 more
openaire   +3 more sources

Simultaneous Electrochemical Detection of NGF and proNGF Under Native Conditions Using Molecularly Imprinted Polymers: Toward Point‐of‐Care Diagnosis of Alzheimer's Disease

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
This study relies on the development of a new sensor that can detect two closely related proteins involved in Alzheimer's disease at the same time. Unlike traditional methods, it works in natural conditions and does not require sample pretreatment. The device is highly sensitive and was successfully tested on patient samples, offering promises for ...
Giulia Siciliano, Alfredo De Cillis, Elena Clabassi, Francesco Ferrara, Maria Serena Chiriacò, Antonio Turco, Clarissa Loiola, Chiara Zecca, Maria Teresa Dell'Abate, Giancarlo Logroscino, Giuseppe Gigli, Francesca Malerba, Elisabetta Primiceri   +12 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source