Results 81 to 90 of about 6,919 (168)

Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1

Journal for ImmunoTherapy of Cancer
Human leukocyte antigen (HLA) restriction of conventional T-cell targeting introduces complexity in generating T-cell therapy strategies for patients with cancer with diverse HLA-backgrounds.
Aimee du Chatinier, Zsolt Sebestyen, Jürgen Kuball, Stefan Nierkens, Anja Krippner-Heidenreich, Yuyan Lu, Ana P Lopes, Ester Dunnebach, Denise A M H van den Beemt, Sebastiaan van Heesch, Annelisa M. Cornel, Loutje van der Sman, Jip T van Dinter, Marta Arrabito, Marliek van Hoesel, Thomas A Kluiver, Noël M M Dautzenberg, Linde Dekker, Jorik M van Rijn, Juliane L Buhl, Farnaz Barneh, Luca Lo Nigro, Esther Hulleman, Jarno Drost, Olaf T Heidenreich, Weng Chuan Peng   +25 more
doaj   +1 more source

MHC-related protein 1–restricted recognition of cancer via a semi-invariant TCR-α chain

The Journal of Clinical Investigation
The T cell antigen presentation platform MR1 consists of 6 allomorphs in humans that differ by no more than 5 amino acids. The principal function of this highly conserved molecule involves presenting microbial metabolites to the abundant mucosal ...
Garry Dolton, Hannah Thomas, Li Rong Tan, Cristina Rius Rafael, Stephanie Doetsch, Giulia-Andreea Ionescu, Lucia F. Cardo, Michael D. Crowther, Enas Behiry, Théo Morin, Marine E. Caillaud, Devinder Srai, Lucia Parolini, Md Samiul Hasan, Anna Fuller, Katie Topley, Aaron Wall, Jade R. Hopkins, Nader Omidvar, Caroline Alvares, Joanna Zabkiewicz, John Frater, Barbara Szomolay, Andrew K. Sewell   +23 more
doaj   +1 more source

Unconventional T cells in anti-cancer immunity

Frontiers in Immunology
Unlike conventional T cells that detect peptide antigens loaded to major histocompatibility complex (MHC) molecules, unconventional T cells respond to non-peptidic metabolite antigens presented by MHC class I-like proteins, such as CD1 and MHC-related ...
Ariel Laub, Ariel Laub, Nathalia Rodrigues de Almeida, Shouxiong Huang, Shouxiong Huang   +4 more
doaj   +1 more source

MR1 blockade drives differential impact on integrative signatures based on circuits of circulating immune cells and soluble mediators in visceral leishmaniasis

Frontiers in Immunology
IntroductionVisceral leishmaniasis (VL) is an important tropical and neglected disease and represents a serious global health problem. The initial interaction between the phagocytes and the parasite is crucial to determine the pathogen’s capacity to ...
Luana Oliveira Borges-Fernandes, Marcela de Lima Moreira, Victória Hellena Silva Pereira, Marcelo Antônio Pascoal-Xavier, Marcelo Antônio Pascoal-Xavier, Ágata Lopes Ribeiro, Ágata Lopes Ribeiro, Ismael Artur da Costa-Rocha, Ludmila Rosa Lopes, Guilherme Telles Cristo Moreira, Márcio Sobreira da Silva Araújo, Andréa Teixeira-Carvalho, Joaquim Pedro Brito-de-Sousa, Andrea Lucchesi de Carvalho, Maria Vitória Assumpção Mourão, Flávia Alves Campos, Marineide Borges, Mariângela Carneiro, Moriya Tsuji, Moriya Tsuji, Olindo Assis Martins-Filho, Jordana Grazziela Alves Coelho-dos-Reis, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhães   +23 more
doaj   +1 more source

362 Allelic variants of MR1 drive cancer and allo-reactivity by MR1-restricted T cells

Regular and Young Investigator Award Abstracts, 2023
Sophie Papa, Luke Williams, Joseph Dukes, Jamie Rossjohn, Jonathan D Silk, Suzanne Cole, Emily Lam, Samit Kundu, Katarzyna Ward, Duncan Howie, Terri V Cornforth, Nathifa Moyo, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Eleanor M Denham, Gurdyal S Besra, Patricia Illing, Bruce MacLachlan, Julian Vivian, Jeremy Raynes, Jerome Le Nours, Anthony Purcell   +22 more
openaire   +2 more sources

The MHC-I related protein 1 MR1 can bind host purine catabolites. [PDF]

J Biol Chem
Abdelaal MR, Lim XY, Mak JYW, Fairlie DP, McCluskey J, Corbett AJ, Gherardin NA, Awad W, Rossjohn J.   +8 more
europepmc   +1 more source

Select intratumoral riboflavin-auxotrophic <i>Enterococcus</i> species enhance cell surface MR1 expression and MAIT TCR activation in lung cancer. [PDF]

Proc Natl Acad Sci U S A
Birla P, Yang L, Shan W, Minamisawa S, Dhaygude O, Manoj H, Lee AJ, Ferri J, Zheng Y, Northcutt A, Fan H, Beauregard H, Zeng Z, Smith KN, Shaikh FY, Sears CL, Pardoll DM, Housseau F.   +17 more
europepmc   +1 more source

The MR1/MAIT cell axis has limited effects on the start of tau pathology in a mouse model of tauopathy. [PDF]

Brain Behav Immun
Wyatt-Johnson SK, Joshi S, Blair M, Desai JM, Haeryfar SMM, Lasagna-Reeves CA, Brutkiewicz RR.   +6 more
europepmc   +1 more source

MR1 wt Allele [PDF]

, 2020
openaire   +1 more source

Unconventional guardians of the brain: MAIT cells as emerging players in glioblastoma immunity. [PDF]

Front Immunol
Eddy EM, Patton T, Barrow AD, Corbett AJ.   +3 more
europepmc   +1 more source