Results 81 to 90 of about 8,186 (190)

Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in AppNL‐G‐F KI mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Whether cholinergic activity in the septohippocampal network affects cognitive dysfunction via hippocampal cholinergic neurostimulating peptide (HCNP) in Alzheimer's pathogenesis remains unclear. METHODS An Alzheimer's pathogenesis by mutation in amyloid‐beta precursor protein gene (AppNL‐G‐F) knock‐in (KI) and HCNP precursor ...
Yo Tsuda, Yuta Madokoro, Kengo Suzuki, Takuya Ooba, Toyohiro Sato, Yuto Uchida, Itsumi Nagai‐Arakawa, Takashi Saito, Hideaki Hara, Hideki Hida, Noriyuki Matsukawa   +10 more
wiley   +1 more source

Olp-Associated Fibroblasts Stimulate Mait Cells Via Mr1 Pathway

International Dental Journal
Aim or purpose: This study aimed to examine the level and function of mucosal associated invariant T (MAIT) cells in Oral lichen planus (OLP) tissues and further explore the activation of MAIT cells by OLP-associated myofibroblasts (OLP/MFs).
Qian Mi, Wenxia Meng, Xiaoli Wu
doaj   +1 more source

MR1: a multi-faceted metabolite sensor for T cell activation [PDF]

, 2020
The major histocompatibility complex class I-related molecule MR1 captures and presents small metabolites to MR1- restricted T cells including Mucosal Associated Invariant T (MAIT) cells.
McWilliam, HEG, Villadangos, JA
core   +1 more source

Interleukin‐18 Levels Are Associated With Disease Course in Patients With Still Disease Treated With Interleukin‐1 Inhibitors

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1327-1338, June 2026.
Objective To evaluate the prognostic utility of circulating interleukin‐18 (IL‐18) levels in predicting disease activity, macrophage activation syndrome (MAS), and disease course in patients with Still disease (SD) receiving first‐line IL‐1 inhibitors (IL‐1i).
Matteo Trevisan, Manuela Pardeo, Ivan Caiello, Claudia Bracaglia, Arianna De Matteis, Valentina Matteo, Elena Loricchio, Fabrizio De Benedetti, Giusi Prencipe   +8 more
wiley   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Tissue specific localization of iNKT cells modulates regional cytokine milieu

, 2015
Previously, we and others identified three subsets of iNKT cells; NKT1, NKT2 and NKT17, which produce distinct cytokines when stimulated. In this study, we defined the anatomic localization and systemic distribution of these subsets, and showed that ...
LEE, You Jeong
core  

Recommendations for structural magnetic resonance imaging in infants with first afebrile seizure or new onset epilepsy: Evidence‐based recommendations from the ILAE Neuroimaging Task Force

Epilepsia, Volume 67, Issue 6, Page 2725-2738, June 2026.
Abstract Infants aged 1–24 months with new onset epilepsy frequently present with structural brain abnormalities, yet no updated evidence‐based magnetic resonance imaging (MRI) guidelines exist for this population. The International League Against Epilepsy (ILAE) Neuroimaging Task Force developed evidence‐based recommendations for structural brain MRI ...
Gavin P. Winston, Simone Salemme, Gaetano Cantalupo, Fernando Cendes, Felice D′Arco, Paolo Federico, William D. Gaillard, Eliane Kobayashi, Edward J. Novotny, Godwin Ogbole, Abdul Kareem Pullattayil, Domenico Tortora, Matthew T. Whitehead, Taoyun Yi, Francesco Brigo, Anna Elisabetta Vaudano   +15 more
wiley   +1 more source

MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic mice

Journal of Neuroinflammation
Background The role of immune cells in neurodegeneration remains incompletely understood. Accumulation of misfolded tau proteins is a hallmark of neurodegenerative diseases.
Yuanyue Zhang, Zhi Yang, Na Jiang, Xiaosheng Tan, Peng Jiang, Gaoyuan Cao, Qi Yang   +6 more
doaj   +1 more source

Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans

Frontiers in Immunology, 2020
MR1-restricted T (MR1T) cells are defined by their recognition of metabolite antigens presented by the monomorphic MHC class 1-related molecule, MR1, the most highly conserved MHC class I related molecule in mammalian species.
Gwendolyn M. Swarbrick, Gwendolyn M. Swarbrick, Anele Gela, Meghan E. Cansler, Megan D. Null, Rowan B. Duncan, Elisa Nemes, Muki Shey, Muki Shey, Mary Nsereko, Harriet Mayanja-Kizza, Harriet Mayanja-Kizza, Sarah Kiguli, Sarah Kiguli, Jeffrey Koh, Willem A. Hanekom, Mark Hatherill, Christina Lancioni, David M. Lewinsohn, David M. Lewinsohn, Thomas J. Scriba, Deborah A. Lewinsohn   +21 more
doaj   +1 more source

Therapeutic Poxviruses Induce the Secretion of Immunostimulating and Anti‐Tumoral Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Immune cells infected by therapeutic poxviruses release increased amounts of extracellular vesicles bearing viral proteins and therapeutic payloads. Such EVs have the ability to activate a CD8+ T‐cell mediated antitumoral immune response and decrease tumor growth.
Lucas Walther, Vincent Mittelheisser, Marie‐Christine Claudepierre, Louis Bochler, Magali Rompais, Jules Deforges, Nathalie Silvestre, Annabel Larnicol, Christine Carapito, Eric Quémeneur, Jacky G Goetz, Karola Rittner, Vincent Hyenne   +12 more
wiley   +1 more source