Results 91 to 100 of about 8,186 (190)

Biology of CD1- and MR1-Restricted T Cells

Annual Review of Immunology, 2014
Over the past 15 years, investigators have shown that T lymphocytes can recognize not only peptides in the context of MHC class I and class II molecules but also foreign and self-lipids in association with the nonclassical MHC class I–like molecules, CD1 proteins. In this review, we describe the most recent events in the field, with particular emphasis
Salio, M, Silk, J, Jones, E, Cerundolo, V   +3 more
openaire   +2 more sources

MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis

, 2022
MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from Mycobacterium tuberculosis to a distinct subset of MR1-restricted or HLA-restricted CD8+ T cells.
Kim, Se-Jin, Karamooz, Elham, Elham Karamooz, Se-Jin Kim   +3 more
core   +1 more source

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

Nature Communications, 2016
Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S.
Erin W. Meermeier, Bruno F. Laugel, Andrew K. Sewell, Alexandra J. Corbett, Jamie Rossjohn, James McCluskey, Melanie J. Harriff, Tamera Franks, Marielle C. Gold, David M. Lewinsohn   +9 more
doaj   +1 more source

Differentiation and fiber type-specific activity of a muscle creatine kinase intronic enhancer

Skeletal Muscle, 2011
Background Hundreds of genes, including muscle creatine kinase (MCK), are differentially expressed in fast- and slow-twitch muscle fibers, but the fiber type-specific regulatory mechanisms are not well understood. Results Modulatory region 1 (MR1) is a 1-
Tai Phillip WL, Fisher-Aylor Katherine I, Himeda Charis L, Smith Catherine L, MacKenzie Alexandra P, Helterline Deri L, Angello John C, Welikson Robert E, Wold Barbara J, Hauschka Stephen D   +9 more
doaj   +1 more source

Nitrogen-doped mesoporous activated carbon from Lentinus edodes residue: an optimized adsorbent for pharmaceuticals in aqueous solutions

Frontiers in Chemistry
In this study, phosphoric acid activation was employed to synthesize nitrogen-doped mesoporous activated carbon (designated as MR1) from Lentinus edodes (shiitake mushroom) residue, while aiming to efficiently remove acetaminophen (APAP), carbamazepine ...
Bei Chu, Yichen Lou, Yixin Tan, Jiawei Lin, Xingcheng Liu   +4 more
doaj   +1 more source

Understanding and modulating the MR1 metabolite antigen presentation pathway

, 2020
The MHC class I-related protein, MR1, presents small metabolite antigens to an unusual subset of innate-like T cells. Herein, we highlight recent progress in our understanding of MR1’s unique antigen presenting pathway, with features of both MHC class I ...
McWilliam, Hamish EG, Salio, Mariolina
core   +1 more source

Selective inhibition of MR1-restricted T cell activation by a novel MR1-targeting nanobody

Abstract MR1 is a non-polymorphic, ubiquitously expressed, MHC class I-like antigen-presenting molecule that presents small-molecule metabolites to T cells. Studies have shown that MR1 plays a role in microbial infection, inflammation, and tumor immunity.
Timothy Bates, Corinna Kulicke, Sintayehu Gurmessa, Se-Jin Kim, Sushant Suresh, Jules Reyes-Weinstein, Audrey Hinchliff, John Burke, David Lewinsohn, Fikadu G. Tafesse   +9 more
openaire   +2 more sources

MR1-067 - Malol, Ali (wordlists)

A: Malol A B C_part (female consultant) B: Malol more_of_C (female consultant); Ali A (male consultant) The Malol lists correspond to the written list MR1-066-malol. There is further checking of this list on tape MR1-073-B.

core   +1 more source

Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells [PDF]

, 2016
The nonclassical HLA molecule MHC-related protein 1 (MR1) presents metabolites of the vitamin B synthesis pathways to mucosal-associated invariant T (MAIT) cells and other MR1-restricted T cells.
Miles, John James, Burrows, Scott R., Connor, Thomas, Lewinsohn, David M., Connor, Thomas R., Dolton, Garry Michael, Miles, John J., Laugel, Bruno, Gold, Marielle C., Sewell, Andrew K., Dolton, Garry, Lloyd, Angharad, Meermeier, Erin W., Crowther, Michael D.   +13 more
core   +1 more source

Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1

Journal for ImmunoTherapy of Cancer
Human leukocyte antigen (HLA) restriction of conventional T-cell targeting introduces complexity in generating T-cell therapy strategies for patients with cancer with diverse HLA-backgrounds.
Aimee du Chatinier, Zsolt Sebestyen, Jürgen Kuball, Stefan Nierkens, Anja Krippner-Heidenreich, Yuyan Lu, Ana P Lopes, Ester Dunnebach, Denise A M H van den Beemt, Sebastiaan van Heesch, Annelisa M. Cornel, Loutje van der Sman, Jip T van Dinter, Marta Arrabito, Marliek van Hoesel, Thomas A Kluiver, Noël M M Dautzenberg, Linde Dekker, Jorik M van Rijn, Juliane L Buhl, Farnaz Barneh, Luca Lo Nigro, Esther Hulleman, Jarno Drost, Olaf T Heidenreich, Weng Chuan Peng   +25 more
doaj   +1 more source