Results 111 to 120 of about 27,223 (192)

Selective inhibition of MR1-restricted T cell activation by a novel MR1-targeting nanobody

AbstractMR1 is a non-polymorphic, ubiquitously expressed, MHC class I-like antigen-presenting molecule that presents small-molecule metabolites to T cells. Studies have shown that MR1 plays a role in microbial infection, inflammation, and tumor immunity. The antigens it presents include metabolites of microbial and self-origin as well as small-molecule
Timothy Bates, Corinna Kulicke, Sintayehu Gurmessa, Se-Jin Kim, Sushant Suresh, Jules Reyes-Weinstein, Audrey Hinchliff, John Burke, David Lewinsohn, Fikadu G. Tafesse   +9 more
openaire   +1 more source

MR1 blockade drives differential impact on integrative signatures based on circuits of circulating immune cells and soluble mediators in visceral leishmaniasis

Frontiers in Immunology
IntroductionVisceral leishmaniasis (VL) is an important tropical and neglected disease and represents a serious global health problem. The initial interaction between the phagocytes and the parasite is crucial to determine the pathogen’s capacity to ...
Luana Oliveira Borges-Fernandes, Marcela de Lima Moreira, Victória Hellena Silva Pereira, Marcelo Antônio Pascoal-Xavier, Marcelo Antônio Pascoal-Xavier, Ágata Lopes Ribeiro, Ágata Lopes Ribeiro, Ismael Artur da Costa-Rocha, Ludmila Rosa Lopes, Guilherme Telles Cristo Moreira, Márcio Sobreira da Silva Araújo, Andréa Teixeira-Carvalho, Joaquim Pedro Brito-de-Sousa, Andrea Lucchesi de Carvalho, Maria Vitória Assumpção Mourão, Flávia Alves Campos, Marineide Borges, Mariângela Carneiro, Moriya Tsuji, Moriya Tsuji, Olindo Assis Martins-Filho, Jordana Grazziela Alves Coelho-dos-Reis, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhães   +23 more
doaj   +1 more source

MR1 wt Allele [PDF]

, 2020
openaire   +1 more source

362 Allelic variants of MR1 drive cancer and allo-reactivity by MR1-restricted T cells

Regular and Young Investigator Award Abstracts, 2023
Sophie Papa, Luke Williams, Joseph Dukes, Jamie Rossjohn, Jonathan D Silk, Suzanne Cole, Emily Lam, Samit Kundu, Katarzyna Ward, Duncan Howie, Terri V Cornforth, Nathifa Moyo, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Eleanor M Denham, Gurdyal S Besra, Patricia Illing, Bruce MacLachlan, Julian Vivian, Jeremy Raynes, Jerome Le Nours, Anthony Purcell   +22 more
openaire   +2 more sources

Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens. [PDF]

J Biol Chem
Kulicke CA, Lemon C, Krawic JR, Nieto Ramirez LM, Kim SJ, Narayanan G, Tafesse FG, Hildebrand WH, Dobos KM, Lewinsohn DM.   +9 more
europepmc   +1 more source

Editorial: Community series in the role of CD1- and MR1-restricted T cells in immunity and disease: volume III. [PDF]

Front Immunol
Iwabuchi K, Van Kaer L.
europepmc   +1 more source

Dual Roles of MAIT Cells in the Tumor Microenvironment: Implications for Cancer Immunity and Therapy. [PDF]

Immune Netw
Choi J, Lee YJ.
europepmc   +1 more source

Brain-Resident MAIT Cells Infiltrate GL261 Tumors, and Activated MAIT Cell Signatures Are Associated With Improved Outcomes in Glioma. [PDF]

Neurol Neuroimmunol Neuroinflamm
Eddy EM, Khan MAAK, Patton T, Moi D, Wang H, Le JP, Souter MNT, Nelson AG, Dewar PM, Li S, McCluskey J, Mazzieri R, Dolcetti R, Chen Z, Barrow AD, Corbett AJ.   +15 more
europepmc   +1 more source

Interpolating coefficient systems and p-ordinary cohomology of arithmetic groups

, 2011
Harder, G.
core   +1 more source

Targeting the MR1-MAIT Cell Axis for Vaccination Against Infectious Disease. [PDF]

Vaccines (Basel)
Timmer MSM, Connor LM, Stocker BL.
europepmc   +1 more source