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MR1-dependent antigen presentation [PDF]

Seminars in Cell and Developmental Biology, 2018
MR1 is a non-classical class I molecule that is highly conserved among mammals. Though discovered in 1995, only recently have MR1 ligands and antigens for MR1-restricted T cells been described. Unlike the traditional class I molecules HLA-A, -B, and -C, little MR1 is on the cell surface.
David M. Lewinsohn, Melanie J Harriff, Elham Karamooz   +2 more
exaly   +3 more sources

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MR1 antigen presentation to MAIT cells and other MR1-restricted T cells

Nature Reviews Immunology, 2023
MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell immunity. Distinct MHC molecules bind antigens that differ in chemical structure, origin and location and present them to specialized T cells. MHC class I-related protein 1 (MR1) presents a range of small molecule antigens to MR1-restricted T (MR1T) lymphocytes. The
Hamish E. G. McWilliam, Jose A. Villadangos   +1 more
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Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

2023
Abstract Major histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, has until recently been reported to be monomorphic. Tumor cell-specific MR1 restricted T cell receptors (TCRs) have been described, offering potential therapeutic application for cancer treatment.
Terri V Cornforth, Nathifa Moyo, Suzanne Cole, Emily Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M Denham, Gurdyal S Besra, Natacha Veerapen, Patricia T Illing, Julian P Vivian, Jeremy M Raynes, Jérôme Le Nours, Anthony W Purcell, Samit Kundu, Jonathan D Silk, Luke Williams, Sophie Papa, Jamie Rossjohn, Duncan Howie, Joseph Dukes   +22 more
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Establishment of an MR1 Presentation Reporter Screening System and Identification of Phenylpropanoid Derivatives as MR1 Ligands

Journal of Medicinal Chemistry, 2023
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are modulated by ligands presented on MHC class I-related proteins (MR1). These cells have attracted attention as potential drug targets because of their involvement in the initial response to infection and various disorders.
Takuro Matsuoka, Akira Hattori, Shinya Oishi, Mitsugu Araki, Biao Ma, Toshiki Fujii, Norihito Arichi, Yasushi Okuno, Hideaki Kakeya, Sho Yamasaki, Hiroaki Ohno, Shinsuke Inuki   +11 more
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MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cells

Proceedings of the National Academy of Sciences of the United States of America
The major histocompatibility complex class I related protein (MR1) presents microbially derived vitamin B2 precursors to mucosal-associated invariant T (MAIT) cells. MR1 can also present other metabolites to activate MR1-restricted T cells expressing more diverse T cell receptors (TCRs), some with anti-tumor reactivity.
Ching-Seng Ang, Mohamed Abdelaal, Michael N T Souter   +2 more
exaly   +5 more sources

MR1 discovery

Immunogenetics, 2016
The moment of MR1 discovery is described. The MR1 gene is the first and the last reported human MHC-related gene intentionally isolated from the human genome composed of three billion base pairs. Evolutionary considerations formed the basis of its isolation.
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A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene

Tissue Antigens, 2000
Human MR1 is a recently discovered, ubiquitously transcribed gene very similar to the HLA class I loci and of unknown function. Mouse and rat MR1 sequences have also been described showing high similarity with the human gene. The goal of this work was to investigate if human MR1 was polymorphic.
Isabel Mirones, Eduardo Martinez-naves, Marta Oteo   +2 more
exaly   +3 more sources

Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells

Science Immunology
MR1T cells are a recently found class of T cells that recognize antigens presented by the major histocompatibility complex-I–related molecule MR1 in the absence of microbial infection. The nature of the self-antigens that stimulate MR1T cells remains unclear, hampering our understanding of their physiological role and therapeutic potential.
Alessandro Vacchini, Andrew Chancellor, Qinmei Yang, Rodrigo Colombo, Julian Spagnuolo, Giuliano Berloffa, Daniel Joss, Ove Øyås, Chiara Lecchi, Giulia De Simone, Aisha Beshirova, Vladimir Nosi, José Pedro Loureiro, Aurelia Morabito, Corinne De Gregorio, Michael Pfeffer, Verena Schaefer, Gennaro Prota, Alfred Zippelius, Jörg Stelling, Daniel Häussinger, Laura Brunelli, Peter Villalta, Marco Lepore, Enrico Davoli, Silvia Balbo, Lucia Mori, Gennaro De Libero   +27 more
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MAITs, MR1 and vitamin B metabolites

Current Opinion in Immunology, 2014
αβT-cell mediated immunity is traditionally characterised by recognition of peptides or lipids presented by the major histocompatibility complex (MHC) or the CD1 family respectively. Recently the antigenic repertoire of αβT-cells has been expanded with the observation that mucosal-associated invariant T-cells (MAIT cells), an abundant population of ...
Richard W, Birkinshaw, Lars, Kjer-Nielsen, Sidonia B G, Eckle, James, McCluskey, Jamie, Rossjohn   +4 more
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Cardiac MR1 and peripartum cardiomyopathy

International Journal of Cardiology, 2010
Cardiac MRI brings great benefits in the comprehension of the mechanism(s) involved in the genesis of peripartum cardiomyopathy (PPC). Cardiac MRI may also procure prognostic information. Because this is a rare affection, it seems necessary to systematically study PPC with this safe, non invasive and reliable tool.
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