Results 141 to 150 of about 6,919 (168)

MAIT cells and MR1-antigen recognition

Current Opinion in Immunology, 2017
Mucosal-associated invariant T cells (MAIT cells) are innate-like T cells that recognise antigens presented by the monomorphic MHC-I related molecule, MR1. Distinct from the conventional MHC-restricted T cell system, MR1 presents small-molecule precursors, derived from microbial biosynthesis of riboflavin, to activate the innate MAIT cell effector ...
Andrew N, Keller, Alexandra J, Corbett, Jacinta M, Wubben, James, McCluskey, Jamie, Rossjohn   +4 more
openaire   +2 more sources

Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells

Proceedings of the National Academy of Sciences of the United States of America
Mitochondria coordinate several metabolic pathways, producing metabolites that influence the immune response in various ways. It remains unclear whether mitochondria impact antigen presentation by the MHC-class-I-related antigen-presenting molecule, MR1, which presents small molecules to MR1-restricted T-lymphocytes.
Alessandro Vacchini, Dene Littler, Jamie Rossjohn   +2 more
exaly   +3 more sources

MR1 (in Mouse and Man)

2016
MR1 (major histocompatibility complex (MHC)-related protein 1) is a nonpolymorphic class Ib antigen presenting molecule recognized by the innate-like mucosal-associated invariant T cell subset. MR1 is highly conserved across all mammals, implying an essential role in host defense. It presents nonprotein antigens which include precursors and derivatives
openaire   +2 more sources

The Immunology of CD1- and MR1-Restricted T Cells

Annual Review of Immunology, 2016
CD1- and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic antigens, such as lipids and small metabolites, and account for a major fraction of circulating and tissue-resident T cells. They represent a readily activated, long-lasting population of effector cells and contribute to the early phases of immune response ...
Mori, L., Lepore, M., De Libero, G.
openaire   +4 more sources

Production of MR1 Tetramers Loaded with Microbial Ligands

2019
In lieu of peptides, the monomorphic MHC-I-like molecule MR1 presents small molecule antigens to stimulate a subset of αβ T cells known as mucosal-associated (semi-) invariant T (MAIT) cells or, more broadly, MR1-restricted (MR1T) cells. The MR1 ligands identified to date are limited to derivatives and intermediates of the riboflavin and folate ...
Nicole A, Ladd, Cara A, Froyd, Erin J, Adams   +2 more
openaire   +2 more sources

The MR1/MAIT cell axis in CNS diseases

Brain, Behavior, and Immunity
Mucosal-associated invariant T (MAIT) cells are a subpopulation of innate-like T cells that can be found throughout the body, predominantly in mucosal sites, the lungs and in the peripheral blood. MAIT cells recognize microbial-derived vitamin B (e.g., riboflavin) metabolite antigens that are presented by the major histocompatibility complex class I ...
Rashmi Shrinivasan, Season K. Wyatt-Johnson, Randy R. Brutkiewicz   +2 more
openaire   +2 more sources

The MR1-UAV

2023
openaire   +1 more source

Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I–related protein 1 MR1

Journal of Biological Chemistry, 2022
Jérôme Le Nours, Patricia T Illing, Gurdyal Besra   +2 more
exaly  

MR1 encompasses at least six allele groups with coding region alterations

Hla, 2021
Sidonia Eckle, Sake van Wageningen, Erik Rozemuller   +2 more
exaly  

MR1 overexpression correlates with poor clinical prognosis in glioma patients.

Neuro-Oncology Advances, 2021
Mahua Dey, Randy R Brutkiewicz, Raj Priya   +2 more
exaly