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Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells
Science ImmunologyMR1T cells are a recently found class of T cells that recognize antigens presented by the major histocompatibility complex-I–related molecule MR1 in the absence of microbial infection. The nature of the self-antigens that stimulate MR1T cells remains unclear, hampering our understanding of their physiological role and therapeutic potential.
Alessandro Vacchini +27 more
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MAIT cells and MR1-antigen recognition
Current Opinion in Immunology, 2017Mucosal-associated invariant T cells (MAIT cells) are innate-like T cells that recognise antigens presented by the monomorphic MHC-I related molecule, MR1. Distinct from the conventional MHC-restricted T cell system, MR1 presents small-molecule precursors, derived from microbial biosynthesis of riboflavin, to activate the innate MAIT cell effector ...
Andrew N, Keller +4 more
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MAITs, MR1 and vitamin B metabolites
Current Opinion in Immunology, 2014αβT-cell mediated immunity is traditionally characterised by recognition of peptides or lipids presented by the major histocompatibility complex (MHC) or the CD1 family respectively. Recently the antigenic repertoire of αβT-cells has been expanded with the observation that mucosal-associated invariant T-cells (MAIT cells), an abundant population of ...
Richard W, Birkinshaw +4 more
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Cardiac MR1 and peripartum cardiomyopathy
International Journal of Cardiology, 2010Cardiac MRI brings great benefits in the comprehension of the mechanism(s) involved in the genesis of peripartum cardiomyopathy (PPC). Cardiac MRI may also procure prognostic information. Because this is a rare affection, it seems necessary to systematically study PPC with this safe, non invasive and reliable tool.
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2023
The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
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The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
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2016
MR1 (major histocompatibility complex (MHC)-related protein 1) is a nonpolymorphic class Ib antigen presenting molecule recognized by the innate-like mucosal-associated invariant T cell subset. MR1 is highly conserved across all mammals, implying an essential role in host defense. It presents nonprotein antigens which include precursors and derivatives
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MR1 (major histocompatibility complex (MHC)-related protein 1) is a nonpolymorphic class Ib antigen presenting molecule recognized by the innate-like mucosal-associated invariant T cell subset. MR1 is highly conserved across all mammals, implying an essential role in host defense. It presents nonprotein antigens which include precursors and derivatives
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Production of MR1 Tetramers Loaded with Microbial Ligands
2019In lieu of peptides, the monomorphic MHC-I-like molecule MR1 presents small molecule antigens to stimulate a subset of αβ T cells known as mucosal-associated (semi-) invariant T (MAIT) cells or, more broadly, MR1-restricted (MR1T) cells. The MR1 ligands identified to date are limited to derivatives and intermediates of the riboflavin and folate ...
Nicole A, Ladd +2 more
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Subbottom swath mapping with HAWAII MR1
OCEANS 96 MTS/IEEE Conference Proceedings. The Coastal Ocean - Prospects for the 21st Century, 2002The HIGP Acoustic Wide Angle Imaging Instrument Mapping Researcher 1 (HAWAII MR1) swath mapping sonar system was used to conduct an experiment applying synthetic aperture sonar (SAS) techniques to imaging objects beneath the seafloor. Potential applications of this technology include locating buried toxic wastes and removal of unexploded ordnance from ...
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The MR1/MAIT cell axis in CNS diseases
Brain, Behavior, and ImmunityMucosal-associated invariant T (MAIT) cells are a subpopulation of innate-like T cells that can be found throughout the body, predominantly in mucosal sites, the lungs and in the peripheral blood. MAIT cells recognize microbial-derived vitamin B (e.g., riboflavin) metabolite antigens that are presented by the major histocompatibility complex class I ...
Rashmi Shrinivasan +2 more
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MR1-Restricted Immunity in Hematologic Malignancy
BloodIntroduction: Immunotherapy has revolutionized the treatment of many cancer types, yet approved agents such as immune checkpoint inhibitors have shown inconsistent efficacy against blood cancers. There are inherent limitations to targeting conventional peptide-specific T cells as they produce variable, patient ...
Danielle Xie +8 more
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