Results 161 to 170 of about 8,186 (190)

MR1 (in Mouse and Man)

, 2016
MR1 (major histocompatibility complex (MHC)-related protein 1) is a nonpolymorphic class Ib antigen presenting molecule recognized by the innate-like mucosal-associated invariant T cell subset. MR1 is highly conserved across all mammals, implying an essential role in host defense. It presents nonprotein antigens which include precursors and derivatives
Timothy S.C. Hinks, Hinks, Timothy S.C., Hinks, TSC, Hinks, Timothy   +3 more
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A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene

Tissue Antigens, 2000
Human MR1 is a recently discovered, ubiquitously transcribed gene very similar to the HLA class I loci and of unknown function. Mouse and rat MR1 sequences have also been described showing high similarity with the human gene. The goal of this work was to investigate if human MR1 was polymorphic.
Paloma Navarro, Isabel Mirones, Marta Oteo   +2 more
exaly   +3 more sources

Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

2023
Abstract Major histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, has until recently been reported to be monomorphic. Tumor cell-specific MR1 restricted T cell receptors (TCRs) have been described, offering potential therapeutic application for cancer treatment.
Terri V Cornforth, Nathifa Moyo, Suzanne Cole, Emily Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M Denham, Gurdyal S Besra, Natacha Veerapen, Patricia T Illing, Julian P Vivian, Jeremy M Raynes, Jérôme Le Nours, Anthony W Purcell, Samit Kundu, Jonathan D Silk, Luke Williams, Sophie Papa, Jamie Rossjohn, Duncan Howie, Joseph Dukes   +22 more
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MR1 discovery

Immunogenetics, 2016
The moment of MR1 discovery is described. The MR1 gene is the first and the last reported human MHC-related gene intentionally isolated from the human genome composed of three billion base pairs. Evolutionary considerations formed the basis of its isolation.
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Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells

Science Immunology
MR1T cells are a recently found class of T cells that recognize antigens presented by the major histocompatibility complex-I–related molecule MR1 in the absence of microbial infection. The nature of the self-antigens that stimulate MR1T cells remains unclear, hampering our understanding of their physiological role and therapeutic potential.
Alessandro Vacchini, Andrew Chancellor, Qinmei Yang, Rodrigo Colombo, Julian Spagnuolo, Giuliano Berloffa, Daniel Joss, Ove Øyås, Chiara Lecchi, Giulia De Simone, Aisha Beshirova, Vladimir Nosi, José Pedro Loureiro, Aurelia Morabito, Corinne De Gregorio, Michael Pfeffer, Verena Schaefer, Gennaro Prota, Alfred Zippelius, Jörg Stelling, Daniel Häussinger, Laura Brunelli, Peter Villalta, Marco Lepore, Enrico Davoli, Silvia Balbo, Lucia Mori, Gennaro De Libero   +27 more
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MAITs, MR1 and vitamin B metabolites

Current Opinion in Immunology, 2014
αβT-cell mediated immunity is traditionally characterised by recognition of peptides or lipids presented by the major histocompatibility complex (MHC) or the CD1 family respectively. Recently the antigenic repertoire of αβT-cells has been expanded with the observation that mucosal-associated invariant T-cells (MAIT cells), an abundant population of ...
Richard W, Birkinshaw, Lars, Kjer-Nielsen, Sidonia B G, Eckle, James, McCluskey, Jamie, Rossjohn   +4 more
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MAIT cells and MR1-antigen recognition

Current Opinion in Immunology, 2017
Mucosal-associated invariant T cells (MAIT cells) are innate-like T cells that recognise antigens presented by the monomorphic MHC-I related molecule, MR1. Distinct from the conventional MHC-restricted T cell system, MR1 presents small-molecule precursors, derived from microbial biosynthesis of riboflavin, to activate the innate MAIT cell effector ...
Andrew N, Keller, Alexandra J, Corbett, Jacinta M, Wubben, James, McCluskey, Jamie, Rossjohn   +4 more
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Cardiac MR1 and peripartum cardiomyopathy

International Journal of Cardiology, 2010
Cardiac MRI brings great benefits in the comprehension of the mechanism(s) involved in the genesis of peripartum cardiomyopathy (PPC). Cardiac MRI may also procure prognostic information. Because this is a rare affection, it seems necessary to systematically study PPC with this safe, non invasive and reliable tool.
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MR1 presents microbial vitamin B metabolites to MAIT cells

Nature, 2012
Antigen-presenting molecules, encoded by the major histocompatibility complex (MHC) and CD1 family, bind peptide- and lipid-based antigens, respectively, for recognition by T cells.
Lars Kjer-Nielsen, Onisha Patel, Alexandra J Corbett   +2 more
exaly   +2 more sources

The Immunology of CD1- and MR1-Restricted T Cells

Annual Review of Immunology, 2016
CD1- and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic antigens, such as lipids and small metabolites, and account for a major fraction of circulating and tissue-resident T cells. They represent a readily activated, long-lasting population of effector cells and contribute to the early phases of immune response ...
Mori, L., Lepore, M., De Libero, G.
openaire   +4 more sources